Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families.

abstract：:Microdeletions of chromosomal region 2q23.1 that disrupt MBD5 (methyl-CpG-binding domain protein 5) contribute to a spectrum of neurodevelopmental phenotypes; however, the impact of this locus on human psychopathology has not been fully explored. To characterize the structural variation landscape of MBD5 disruptions a...

journal_title：Molecular psychiatry

authors： Hodge JC,Mitchell E,Pillalamarri V,Toler TL,Bartel F,Kearney HM,Zou YS,Tan WH,Hanscom C,Kirmani S,Hanson RR,Skinner SA,Rogers RC,Everman DB,Boyd E,Tapp C,Mullegama SV,Keelean-Fuller D,Powell CM,Elsea SH,Morton CC

更新日期：2014-03-01 00:00:00

abstract：:The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equ...

journal_title：Molecular psychiatry

authors： Alachkar A,Wang L,Yoshimura R,Hamzeh AR,Wang Z,Sanathara N,Lee SM,Xu X,Abbott GW,Civelli O

更新日期：2018-02-01 00:00:00

abstract：:Previous work has demonstrated associations between lower cognitive ability and childhood and adult non-psychotic psychopathology. As both cognitive ability (CA) and child psychopathology (CP) are influenced by genetic factors, one explanation for the association is that they are the pleiotropic manifestations of the ...

journal_title：Molecular psychiatry

authors： Jacobs N,Rijsdijk F,Derom C,Danckaerts M,Thiery E,Derom R,Vlietinck R,van Os J

更新日期：2002-01-01 00:00:00

abstract：:The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate,...

journal_title：Molecular psychiatry

authors： Serretti A,Kato M,De Ronchi D,Kinoshita T

更新日期：2007-03-01 00:00:00

abstract：:Current antidepressants act principally by blocking monoamine reuptake by high-affinity transporters in the brain. However, these antidepressants show important shortcomings such as slow action onset and limited efficacy in nearly a third of patients with major depression disorder. Here, we report the development of a...

journal_title：Molecular psychiatry

authors： Orrico-Sanchez A,Chausset-Boissarie L,Alves de Sousa R,Coutens B,Rezai Amin S,Vialou V,Louis F,Hessani A,Dansette PM,Zornoza T,Gruszczynski C,Giros B,Guiard BP,Acher F,Pietrancosta N,Gautron S

更新日期：2020-06-01 00:00:00

abstract：:Several lines of evidence implicate dopa decarboxylase (DDC) with schizophrenia. By analysis of two putative functional DDC variants in 173 schizophrenic patients and 204 controls we tested the hypotheses that DDC is involved in: (1) predisposition to schizophrenia; and (2) modulation of age at disease onset. No assoc...

journal_title：Molecular psychiatry

authors： Børglum AD,Hampson M,Kjeldsen TE,Muir W,Murray V,Ewald H,Mors O,Blackwood D,Kruse TA

更新日期：2001-11-01 00:00:00

abstract：:The term 'mood stabilizer' has been applied to a number of medications for the treatment of patients with bipolar disorder. The operational definition of the properties of a mood-stabilizing medication has varied according to the properties of specific medications and the clinical characteristics of the illness. Rando...

journal_title：Molecular psychiatry

authors： Keck PE Jr,McElroy SL,Richtand N,Tohen M

更新日期：2002-01-01 00:00:00

abstract：:The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such l...

journal_title：Molecular psychiatry

authors： Vélez JI,Chandrasekharappa SC,Henao E,Martinez AF,Harper U,Jones M,Solomon BD,Lopez L,Garcia G,Aguirre-Acevedo DC,Acosta-Baena N,Correa JC,Lopera-Gómez CM,Jaramillo-Elorza MC,Rivera D,Kosik KS,Schork NJ,Swanson JM,Lop

更新日期：2013-05-01 00:00:00

abstract：:The effect of endogenous dopamine (DA) on neostriatal DA D(1) and D(2) receptor binding potentials (D(1)RBP and D(2)RBP, respectively) in vivo was evaluated with positron emission tomography (PET) and the radiotracers [(11)C]SCH23390 and [(11)C]raclopride, respectively, by comparing the D(1)RBP and D(2)RBP before and ...

journal_title：Molecular psychiatry

authors： Verhoeff NP,Hussey D,Lee M,Tauscher J,Papatheodorou G,Wilson AA,Houle S,Kapur S

更新日期：2002-01-01 00:00:00

abstract：:Eating disorders are complex heritable conditions influenced by both genetic and environmental factors. Given the progress of genomic discovery in anorexia nervosa, with the identification of the first genome-wide significant locus, as well as animated discussion of epigenetic mechanisms in linking environmental facto...

journal_title：Molecular psychiatry

authors： Hübel C,Marzi SJ,Breen G,Bulik CM

更新日期：2019-06-01 00:00:00

abstract：:Although therapeutic interventions in attention-deficit/hyperactivity disorder (ADHD) still focus on the dopaminergic system, recent studies indicate a serotonergic dysfunction in this disease as well. In that respect, several variants of the tryptophan hydroxylase gene (TPH2), which codes for the rate-limiting enzyme...

journal_title：Molecular psychiatry

authors： Baehne CG,Ehlis AC,Plichta MM,Conzelmann A,Pauli P,Jacob C,Gutknecht L,Lesch KP,Fallgatter AJ

更新日期：2009-11-01 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cyto...

journal_title：Molecular psychiatry

authors： Hornig M,Gottschalk G,Peterson DL,Knox KK,Schultz AF,Eddy ML,Che X,Lipkin WI

更新日期：2016-02-01 00:00:00

abstract：:The role of innate immunity and microglia in the brain is currently a matter of great debate and controversy. While several studies have provided evidence that they contribute to neurodegeneration in various animal models of brain diseases and traumas, others have shown that their inhibition may in contrast be associa...

journal_title：Molecular psychiatry

authors： Simard AR,Rivest S

更新日期：2006-04-01 00:00:00

abstract：:Poorly regulated reward seeking is a central feature of substance use disorder. Recent research shows that rewarding drug-related experiences induce synchronous activation of a discrete number of neurons in the nucleus accumbens that are causally linked to reward-related contexts. Here we comprehensively characterize ...

journal_title：Molecular psychiatry

authors： Bobadilla AC,Dereschewitz E,Vaccaro L,Heinsbroek JA,Scofield MD,Kalivas PW

更新日期：2020-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is associated with neuropathology in patients with impaired immunity and/or inflammatory diseases. However, the association between gray matter volume (GMV) and HCMV has never been examined in major depressive disorder (MDD) despite the presence of inflammation and impaired viral...

journal_title：Molecular psychiatry

authors： Zheng H,Ford BN,Bergamino M,Kuplicki R,Tulsa 1000 Investigators.,Hunt PW,Bodurka J,Teague TK,Irwin MR,Yolken RH,Paulus MP,Savitz J

更新日期：2020-11-22 00:00:00

abstract：:Niemann-Pick disease type A (NPA) is a rare lysosomal storage disorder characterized by severe neurological alterations that leads to death in childhood. Loss-of-function mutations in the acid sphingomyelinase (ASM) gene cause NPA, and result in the accumulation of sphingomyelin (SM) in lysosomes and plasma membrane o...

journal_title：Molecular psychiatry

authors： Pérez-Cañamás A,Benvegnù S,Rueda CB,Rábano A,Satrústegui J,Ledesma MD

更新日期：2017-05-01 00:00:00

abstract：:Circular RNAs (circRNAs), highly expressed in the central nervous system, are involved in various regulatory processes and implicated in some pathophysiology. However, the potential role of circRNAs in psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown. Here, we demonstrated th...

journal_title：Molecular psychiatry

authors： Zhang Y,Du L,Bai Y,Han B,He C,Gong L,Huang R,Shen L,Chao J,Liu P,Zhang H,Zhang H,Gu L,Li J,Hu G,Xie C,Zhang Z,Yao H

更新日期：2020-06-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA(A)) receptors are thought to play an important role in modulating the central nervous system in response to stress. Animal data have shown alterations in the GABA(A) receptor complex by uncontrollable stressors. SPECT imaging with benzodiazepine ligands showed lower distribution volumes o...

journal_title：Molecular psychiatry

authors： Geuze E,van Berckel BN,Lammertsma AA,Boellaard R,de Kloet CS,Vermetten E,Westenberg HG

更新日期：2008-01-01 00:00:00

abstract：:Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Here, we present data from independent large-scale clinical data sets (including 29 557 cases and 32 056 controls) rev...

journal_title：Molecular psychiatry

authors： Chang H,Hoshina N,Zhang C,Ma Y,Cao H,Wang Y,Wu DD,Bergen SE,Landén M,Hultman CM,Preisig M,Kutalik Z,Castelao E,Grigoroiu-Serbanescu M,Forstner AJ,Strohmaier J,Hecker J,Schulze TG,Müller-Myhsok B,Reif A,Mitchell PB

更新日期：2018-02-01 00:00:00

abstract：:To examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-matched controls in the Japanese population. Allelic and genotypic distributions of ...

journal_title：Molecular psychiatry

authors： Ujike H,Takaki M,Nakata K,Tanaka Y,Takeda T,Kodama M,Fujiwara Y,Sakai A,Kuroda S

更新日期：2002-01-01 00:00:00

abstract：:Cigarette smoking is more prevalent in subjects with schizophrenia compared to those with other psychiatric disorders or the general population and could therefore affect molecular pathways that impact the pathophysiology of this disorder. As smoking is also known to suppress immune responses, we investigated the effe...

journal_title：Molecular psychiatry

authors： Herberth M,Krzyszton DN,Koethe D,Craddock MR,Bulger E,Schwarz E,Guest P,Leweke FM,Bahn S

更新日期：2010-04-01 00:00:00

abstract：:Linkage studies of mental illness have provided suggestive evidence of susceptibility loci over many broad chromosomal regions. Pinpointing causative gene mutations by conventional linkage strategies alone is problematic. The breakpoints of chromosomal abnormalities occurring in patients with mental illness may be mor...

journal_title：Molecular psychiatry

authors： MacIntyre DJ,Blackwood DH,Porteous DJ,Pickard BS,Muir WJ

更新日期：2003-03-01 00:00:00

abstract：:A recent study has suggested a possible association of a polymorphism near the dopamine D5 receptor gene (DRD5) and attention-deficit hyperactivity disorder. The polymorphism studied was a (CA)n repeat located in the cosmid containing the D5 receptor gene2 and the allele that was reported to be associated with attenti...

journal_title：Molecular psychiatry

authors： Barr CL,Wigg KG,Feng Y,Zai G,Malone M,Roberts W,Schachar R,Tannock R,Kennedy JL

更新日期：2000-09-01 00:00:00

abstract：:We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...

journal_title：Molecular psychiatry

authors： Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

更新日期：2020-11-11 00:00:00

abstract：:Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The pathophysiology of the illness is not understood, but is thought to have a strong genetic component with some environmental influences on aetiology. To gain further insight into disease mechanism, we used microarray technology to de...

journal_title：Molecular psychiatry

authors： Maycox PR,Kelly F,Taylor A,Bates S,Reid J,Logendra R,Barnes MR,Larminie C,Jones N,Lennon M,Davies C,Hagan JJ,Scorer CA,Angelinetta C,Akbar MT,Hirsch S,Mortimer AM,Barnes TR,de Belleroche J

更新日期：2009-12-01 00:00:00

abstract：:Although inherited DNA sequences have a well-demonstrated role in psychiatric disease risk, for even the most heritable mental disorders, monozygotic twins are discordant at a significant rate. The genetic variation associated with mental disorders has heretofore been based on the search for rare or common variation i...

journal_title：Molecular psychiatry

authors： Insel TR

更新日期：2014-02-01 00:00:00

abstract：:There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesity. This study aimed to investigate the genetic influence of polymorphisms in FTO in relation to body mass ...

journal_title：Molecular psychiatry

authors： Rivera M,Cohen-Woods S,Kapur K,Breen G,Ng MY,Butler AW,Craddock N,Gill M,Korszun A,Maier W,Mors O,Owen MJ,Preisig M,Bergmann S,Tozzi F,Rice J,Rietschel M,Rucker J,Schosser A,Aitchison KJ,Uher R,Craig IW,Lewis

更新日期：2012-06-01 00:00:00

abstract：:Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encod...

journal_title：Molecular psychiatry

authors： Toda T,Parylak SL,Linker SB,Gage FH

更新日期：2019-01-01 00:00:00

abstract：:There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. We studied the association of CR...

journal_title：Molecular psychiatry

authors： Licinio J,O'Kirwan F,Irizarry K,Merriman B,Thakur S,Jepson R,Lake S,Tantisira KG,Weiss ST,Wong ML

更新日期：2004-12-01 00:00:00

abstract：:Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysi...

journal_title：Molecular psychiatry

authors： Hollingworth P,Sweet R,Sims R,Harold D,Russo G,Abraham R,Stretton A,Jones N,Gerrish A,Chapman J,Ivanov D,Moskvina V,Lovestone S,Priotsi P,Lupton M,Brayne C,Gill M,Lawlor B,Lynch A,Craig D,McGuinness B,Johnston J

更新日期：2012-12-01 00:00:00