Abstract:
:The role of innate immunity and microglia in the brain is currently a matter of great debate and controversy. While several studies have provided evidence that they contribute to neurodegeneration in various animal models of brain diseases and traumas, others have shown that their inhibition may in contrast be associated with more damages or less repair. We have recently reported the existence of two different types of microglia, the resident and the newly differentiated microglia that derive from the bone marrow stem cells. Of great interest is the fact that blood-derived microglial cells are associated with amyloid plaques and these cells are able to prevent the formation or eliminate the presence of amyloid deposits in mice that develop the major hallmark of Alzheimer's disease (AD). These newly recruited cells are specifically attracted to the beta-amyloid 40/42 isoforms in vivo and they participate in the elimination of these proteins by phagocytosis. This review presents the mechanisms involved in the control of the innate immune response by microglia and the beneficial properties of such a response in brain diseases, such as AD.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Simard AR,Rivest Sdoi
10.1038/sj.mp.4001809subject
Has Abstractpub_date
2006-04-01 00:00:00pages
327-35issue
4eissn
1359-4184issn
1476-5578pii
4001809journal_volume
11pub_type
杂志文章,评审abstract::Retinoid metabolites of vitamin A are intrinsically linked to neural development, connectivity and plasticity, and have been implicated in the pathophysiology of schizophrenia. We hypothesised that a greater burden of common and rare genomic variation in genes involved with retinoid biogenesis and signalling could be ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0305-0
更新日期:2020-04-01 00:00:00
abstract::Bipolar affective disorder (BPAD) is a common psychiatric disorder with complex genetic aetiology. We have undertaken a genome-wide scan in one of the largest samples of bipolar affected sibling pairs (ASPs) using a two-stage approach combining sample splitting and marker grid tightening. In this second stage analysis...
journal_title:Molecular psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.mp.4001684
更新日期:2005-09-01 00:00:00
abstract::Serotonin (5-HT) neurons project from the raphe nuclei throughout the brain where they act to maintain homeostasis. Here, we study 5-HT inputs into the bed nucleus of the stria terminalis (BNST), a major subdivision of the extended amygdala that has been proposed to regulate responses to anxiogenic environments in hum...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2017.165
更新日期:2018-10-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.157
更新日期:2016-08-01 00:00:00
abstract::Identifying genes for bipolar mood disorders through classic genetics has proven difficult. Here, we present a comprehensive convergent approach that translationally integrates brain gene expression data from a relevant pharmacogenomic mouse model (involving treatments with a stimulant--methamphetamine, and a mood sta...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001547
更新日期:2004-11-01 00:00:00
abstract::Human cytomegalovirus (HCMV) infection is associated with neuropathology in patients with impaired immunity and/or inflammatory diseases. However, the association between gray matter volume (GMV) and HCMV has never been examined in major depressive disorder (MDD) despite the presence of inflammation and impaired viral...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-00932-y
更新日期:2020-11-22 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.97
更新日期:2010-06-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000902
更新日期:2001-11-01 00:00:00
abstract::Significant heterogeneity across aetiologies, neurobiology and clinical phenotypes have been observed in individuals with autism spectrum disorder (ASD). Neuroimaging-based neuroanatomical studies of ASD have often reported inconsistent findings which may, in part, be attributable to an insufficient understanding of t...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0420-6
更新日期:2020-03-01 00:00:00
abstract::Activation of the inflammatory response system has been related to the pathophysiology of schizophrenia by several recent studies. Schizophrenic patients have varied levels of proinflammatory cytokines, such as interleukin (IL)-1, -6, and tumor necrosis factor (TNF)alpha in their peripheral blood or cerebrospinal flui...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000483
更新日期:1999-03-01 00:00:00
abstract::Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other members of the neurotrophin family, are central mediators of the activity-dependent plasticity through which environmental experiences, such as sensory information are translated into the structure and function of neuronal networks. ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2017.61
更新日期:2017-08-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.60
更新日期:2012-02-01 00:00:00
abstract::Psychiatric disorders are a group of genetically related diseases with highly polygenic architectures. Genome-wide association analyses have made substantial progress towards understanding the genetic architecture of these disorders. More recently, exome- and whole-genome sequencing of cases and families have identifi...
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pub_type: 杂志文章
doi:10.1038/s41380-018-0087-4
更新日期:2018-12-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.63
更新日期:2011-02-01 00:00:00
abstract::Several studies have indicated that patients with bipolar disorder (BD) who respond well to lithium prophylaxis constitute a biologically distinct subgroup. Lithium is thought to stabilize mood by acting at the phosphoinositide cycle. We have investigated a polymorphism located in the gene (PLCG1) that codes for a gam...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000447
更新日期:1998-11-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Molecular psychiatry
pub_type: 已发布勘误
doi:10.1038/s41380-020-00919-9
更新日期:2020-10-14 00:00:00
abstract::Schizophrenia is a neurodevelopmental disorder that affects up to 1% of the general population. Various genes show associations with schizophrenia and a very weak nominal association with the tight junction protein, claudin-5, has previously been identified. Claudin-5 is expressed in endothelial cells forming part of ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2017.156
更新日期:2018-11-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001029
更新日期:2002-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0422-4
更新日期:2019-04-16 00:00:00
abstract::A whole genome association study was performed in a phase 3 clinical trial conducted to evaluate a novel antipsychotic, iloperidone, administered to treat patients with schizophrenia. Genotypes of 407 patients were analyzed for 334,563 single nucleotide polymorphisms (SNPs). SNPs associated with iloperidone efficacy w...
journal_title:Molecular psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/mp.2008.56
更新日期:2009-08-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2017.155
更新日期:2018-07-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-08-11 00:00:00
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pub_type: 杂志文章,已发布勘误
doi:10.1038/s41380-018-0301-4
更新日期:2019-03-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1038/sj.mp.4001336
更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1038/mp.2008.31
更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/mp.2008.141
更新日期:2010-07-01 00:00:00
abstract::A genetic predisposition to the development of neuroleptic malignant syndrome (NMS) has been suggested by clinical studies. Although the molecular basis of NMS is unclear, a dopaminergic blockade mechanism has been considered the main cause. We therefore investigated the association between NMS and three functional po...
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pub_type: 杂志文章
doi:10.1038/sj.mp.4001422
更新日期:2004-03-01 00:00:00
abstract::In developing his mature concept of hebephrenic dementia praecox (DP) in his 4th (1893) through 6th textbook editions (1899), Kraepelin worked from the hebephrenic syndrome first described by Hecker (1871) and then carefully studied by his student Daraszkiewicz (1892). Working under Kraepelin's supervision, Daraszkiew...
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pub_type: 历史文章,杂志文章,评审
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