Correction: Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis.

abstract：:To examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-matched controls in the Japanese population. Allelic and genotypic distributions of ...

journal_title：Molecular psychiatry

authors： Ujike H,Takaki M,Nakata K,Tanaka Y,Takeda T,Kodama M,Fujiwara Y,Sakai A,Kuroda S

更新日期：2002-01-01 00:00:00

abstract：:The prefrontal cortex (PFC), seat of the highest-order cognitive functions, constitutes a conglomerate of highly specialized brain areas and has been implicated to have a role in the onset and installation of various neurodevelopmental disorders. The development of a properly functioning PFC is directed by transcripti...

journal_title：Molecular psychiatry

authors： Schubert D,Martens GJ,Kolk SM

更新日期：2015-07-01 00:00:00

abstract：:The amygdala is a key brain region that is critically involved in the processing and expression of anxiety and fear-related signals. In parallel, a growing number of preclinical and human studies have implicated the microbiome-gut-brain in regulating anxiety and stress-related responses. However, the role of the micro...

journal_title：Molecular psychiatry

authors： Hoban AE,Stilling RM,Moloney G,Shanahan F,Dinan TG,Clarke G,Cryan JF

更新日期：2018-05-01 00:00:00

abstract：:How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA-assessed from SA in s...

journal_title：Molecular psychiatry

authors： Kendler KS,Ohlsson H,Keefe RSE,Sundquist K,Sundquist J

更新日期：2018-04-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in motivation. Using positron emission tomography (PET), we showed decreased function in the brain dopamine reward pathway in adults with AD...

journal_title：Molecular psychiatry

authors： Volkow ND,Wang GJ,Newcorn JH,Kollins SH,Wigal TL,Telang F,Fowler JS,Goldstein RZ,Klein N,Logan J,Wong C,Swanson JM

更新日期：2011-11-01 00:00:00

abstract：:High impulsive and aggressive traits associate with poor behavioural self-control. Despite their importance in predicting behavioural negative outcomes including suicide, the molecular mechanisms underlying the expression of impulsive and aggressive traits remain poorly understood. Here, we identified and characterize...

journal_title：Molecular psychiatry

authors： Labonté B,Abdallah K,Maussion G,Yerko V,Yang J,Bittar T,Quessy F,Golden SA,Navarro L,Checknita D,Gigek C,Lopez JP,Neve RL,Russo SJ,Tremblay RE,Côté G,Meaney MJ,Mechawar N,Nestler EJ,Turecki G

更新日期：2020-01-06 00:00:00

abstract：:Chronic methamphetamine use poses potentially devastating consequences for directly affected individuals and for society. Lower dopamine D2-type receptor availability has been observed in striata of methamphetamine users as compared with controls, but an analogous comparison of D1-type receptors has been conducted onl...

journal_title：Molecular psychiatry

authors： Okita K,Morales AM,Dean AC,Johnson MC,Lu V,Farahi J,Mandelkern MA,London ED

更新日期：2018-05-01 00:00:00

abstract：:Genetic and pharmacological studies have emphasised the role of serotonin 5-hydroxytryptamine (5-HT) as a possible etiologic factor in the development of attention-deficit hyperactivity disorder (ADHD). Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the biosynthesis of serotonin from tryptophan. Originally,...

journal_title：Molecular psychiatry

authors： Sheehan K,Lowe N,Kirley A,Mullins C,Fitzgerald M,Gill M,Hawi Z

更新日期：2005-10-01 00:00:00

abstract：:Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encod...

journal_title：Molecular psychiatry

authors： Toda T,Parylak SL,Linker SB,Gage FH

更新日期：2019-01-01 00:00:00

abstract：:Previous studies have shown inconsistent results regarding the actions of antidepressants on glucocorticoid receptor (GR) signalling. To resolve these inconsistencies, we used a lentiviral-based reporter system to directly monitor rat hippocampal GR activity during stress adaptation. Temporal GR activation was induced...

journal_title：Molecular psychiatry

authors： Lee MS,Kim YH,Park WS,Park OK,Kwon SH,Hong KS,Rhim H,Shim I,Morita K,Wong DL,Patel PD,Lyons DM,Schatzberg AF,Her S

更新日期：2016-02-01 00:00:00

abstract：:Recent studies have shown an association between trinucleotide repeat expansions (TREs) and adult-onset schizophrenia (AOS). Childhood-onset schizophrenia (COS) is a severe variant of schizophrenia with onset of symptoms before age 12 years. We have used the repeat expansion detection (RED) method to investigate the o...

journal_title：Molecular psychiatry

authors： Burgess CE,Lindblad K,Sidransky E,Yuan QP,Long RT,Breschel T,Ross CA,McInnis M,Lee P,Ginns EI,Lenane M,Kumra S,Jacobsen L,Rapoport JL,Schalling M

更新日期：1998-07-01 00:00:00

abstract：:In this article, we review some of the data that contribute to our understanding of the genetic architecture of psychiatric disorders. These include results from evolutionary modelling (hence no data), the observed recurrence risk to relatives and data from molecular markers. We briefly discuss the common-disease comm...

journal_title：Molecular psychiatry

authors： Visscher PM,Goddard ME,Derks EM,Wray NR

更新日期：2012-05-01 00:00:00

abstract：:Genetic factors do not fully account for the relatively high heritability of neurodevelopmental conditions, suggesting that non-genetic heritable factors contribute to their etiology. To evaluate the potential contribution of aberrant thyroid hormone status to the epigenetic inheritance of neurological phenotypes, we ...

journal_title：Molecular psychiatry

authors： Martinez ME,Duarte CW,Stohn JP,Karaczyn A,Wu Z,DeMambro VE,Hernandez A

更新日期：2020-05-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated HPA axis overactivity in major depression, a relationship of HPA axis activity to cognitive performance and a potential role of HPA axis geneti...

journal_title：Molecular psychiatry

authors： Keller J,Gomez R,Williams G,Lembke A,Lazzeroni L,Murphy GM Jr,Schatzberg AF

更新日期：2017-04-01 00:00:00

abstract：:The network theory conceptualizes mental disorders as complex networks of symptoms influencing each other by creating feedback loops, leading to a self-sustained syndromic constellation. Symptoms central to the network have the greatest impact in sustaining the rest of symptoms. This analysis focused on the network st...

journal_title：Molecular psychiatry

authors： Belvederi Murri M,Amore M,Respino M,Alexopoulos GS

更新日期：2020-07-01 00:00:00

abstract：:The hippocampus is critical to healthy cognition, yet results in the current study show that action video game players have reduced grey matter within the hippocampus. A subsequent randomised longitudinal training experiment demonstrated that first-person shooting games reduce grey matter within the hippocampus in par...

journal_title：Molecular psychiatry

authors： West GL,Konishi K,Diarra M,Benady-Chorney J,Drisdelle BL,Dahmani L,Sodums DJ,Lepore F,Jolicoeur P,Bohbot VD

更新日期：2018-07-01 00:00:00

abstract：:Bipolar disorder is a major medical, social and economic burden worldwide. However, the mechanisms of action of effective antibipolar disorder drugs remain elusive. In this paper, we review studies using a neuropharmacological approach in unanesthetized rats, combined with kinetic, biochemical and molecular biology te...

journal_title：Molecular psychiatry

authors： Rao JS,Lee HJ,Rapoport SI,Bazinet RP

更新日期：2008-06-01 00:00:00

abstract：:The 102-T/C polymorphism of the 5-HT(2A) receptor gene was analysed in 159 patients with major depression and 164 unrelated and healthy controls using a case-control design. Allele and genotype frequencies did not differ between cases and controls. No differences according to sex, age of onset, melancholia, suicidal b...

journal_title：Molecular psychiatry

authors： Arias B,Gutiérrez B,Pintor L,Gastó C,Fañanás L

更新日期：2001-03-01 00:00:00

abstract：:The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene. Although its role in increasing schizophrenia susceptibility has been conflicting, recent studies suggest the valine allele may contribute to poor cognitive function in schizophrenia. V(158)M COMT genotype was obtained ...

journal_title：Molecular psychiatry

authors： Ho BC,Wassink TH,O'Leary DS,Sheffield VC,Andreasen NC

更新日期：2005-03-01 00:00:00

abstract：:Medical treatment with various cytokines can provoke psychiatric symptoms. Conversely, psychiatric patients can display abnormalities in cytokine and neurotrophic factor expression. Such observations have pointed to the potential contribution of cytokines and growth factors to schizophrenic pathology and/or etiology. ...

journal_title：Molecular psychiatry

authors： Nawa H,Takahashi M,Patterson PH

更新日期：2000-11-01 00:00:00

abstract：:A recent study has suggested a possible association of a polymorphism near the dopamine D5 receptor gene (DRD5) and attention-deficit hyperactivity disorder. The polymorphism studied was a (CA)n repeat located in the cosmid containing the D5 receptor gene2 and the allele that was reported to be associated with attenti...

journal_title：Molecular psychiatry

authors： Barr CL,Wigg KG,Feng Y,Zai G,Malone M,Roberts W,Schachar R,Tannock R,Kennedy JL

更新日期：2000-09-01 00:00:00

abstract：:Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of Polg1, a mitochondrial DNA (mtDNA...

journal_title：Molecular psychiatry

authors： Kasahara T,Takata A,Kato TM,Kubota-Sakashita M,Sawada T,Kakita A,Mizukami H,Kaneda D,Ozawa K,Kato T

更新日期：2016-01-01 00:00:00

abstract：:Cariprazine (CAR) is a strong inhibitor of the Dhcr7 enzyme, the last enzyme in the cholesterol biosynthesis pathway. We assessed the effects of CAR on maternally exposed Dhcr7+/- and wild-type mouse offspring, and tested the biochemical effects of CAR in human serum samples. Dhcr7+/- and wild-type time-pregnant mice ...

journal_title：Molecular psychiatry

authors： Genaro-Mattos TC,Anderson A,Allen LB,Tallman KA,Porter NA,Korade Z,Mirnics K

更新日期：2020-11-01 00:00:00

abstract：:Although schizophrenia is considered a brain disorder, the role of brain organization for symptomatic improvement remains inadequately defined. We investigated the relationship between baseline brain morphology, resting-state network connectivity and clinical response after 24-weeks of antipsychotic treatment in patie...

journal_title：Molecular psychiatry

authors： Doucet GE,Moser DA,Luber MJ,Leibu E,Frangou S

更新日期：2020-04-01 00:00:00

abstract：:Disruption of persistent, stress-associated memories is relevant for treating posttraumatic stress disorder (PTSD) and related syndromes, which develop in a subset of individuals following a traumatic event. We previously developed a stress-enhanced fear learning (SEFL) paradigm in inbred mice that produces PTSD-like ...

journal_title：Molecular psychiatry

authors： Sillivan SE,Jamieson S,de Nijs L,Jones M,Snijders C,Klengel T,Joseph NF,Krauskopf J,Kleinjans J,Vinkers CH,Boks MPM,Geuze E,Vermetten E,Berretta S,Ressler KJ,Rutten BPF,Rumbaugh G,Miller CA

更新日期：2020-05-01 00:00:00

abstract：:Among the most consistent results of studies of post-mortem brain tissue from schizophrenia patients (SZP) is the finding that in this disease, several genes expressed by GABAergic neurons are downregulated. This downregulation may be caused by hypermethylation of the relevant promoters in affected neurons. Indeed, in...

journal_title：Molecular psychiatry

authors： Ruzicka WB,Zhubi A,Veldic M,Grayson DR,Costa E,Guidotti A

更新日期：2007-04-01 00:00:00

abstract：:Higher scores on the personality trait of neuroticism, the tendency to experience negative emotions, are associated with worse mental and physical health. Studies examining links between neuroticism and health typically operationalize neuroticism by summing the items from a neuroticism scale. However, neuroticism is m...

journal_title：Molecular psychiatry

authors： Hill WD,Weiss A,Liewald DC,Davies G,Porteous DJ,Hayward C,McIntosh AM,Gale CR,Deary IJ

更新日期：2020-11-01 00:00:00

abstract：:The serotonergic neurotransmitter system has been widely implicated in the pathophysiology of mood-related disorders such as anxiety and major depressive disorder (MDD). The onset of therapeutic efficacy of traditional antidepressants is delayed by several weeks. The 5-HT4 receptor has emerged as a new therapeutic tar...

journal_title：Molecular psychiatry

authors： Castello J,LeFrancois B,Flajolet M,Greengard P,Friedman E,Rebholz H

更新日期：2018-04-01 00:00:00

abstract：:Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations betwee...

journal_title：Molecular psychiatry

authors： Sammallahti S,Cortes Hidalgo AP,Tuominen S,Malmberg A,Mulder RH,Brunst KJ,Alemany S,McBride NS,Yousefi P,Heiss JA,McRae N,Page CM,Jin J,Pesce G,Caramaschi D,Rifas-Shiman SL,Koen N,Adams CD,Magnus MC,Baïz N,Ratanat

更新日期：2021-01-07 00:00:00

abstract：:Exposure to severe stressors increases the risk for psychiatric disorders in vulnerable individuals, but can lead to positive outcomes for others. However, it remains unknown how severe stress affects neural functioning in humans and what factors mediate individual differences in the neural sequelae of stress. The amy...

journal_title：Molecular psychiatry

authors： van Wingen GA,Geuze E,Vermetten E,Fernández G

更新日期：2011-06-01 00:00:00