Examination of the current top candidate genes for AD in a genome-wide association study.

abstract：:Depression is a heritable disorder that is often precipitated by stress. Abnormalities of the stress-reactive hypothalamic-pituitary-adrenal (HPA) axis are also common in depressed patients. In animal models, the forced swim test (FST) is the most frequently used test of depressive-like behavior. We have used a propos...

journal_title：Molecular psychiatry

authors： Solberg LC,Ahmadiyeh N,Baum AE,Vitaterna MH,Takahashi JS,Turek FW,Redei EE

更新日期：2003-04-01 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the m...

journal_title：Molecular psychiatry

authors： Chase HW,Boudewyn MA,Carter CS,Phillips ML

更新日期：2020-02-01 00:00:00

abstract：:The role of innate immunity and microglia in the brain is currently a matter of great debate and controversy. While several studies have provided evidence that they contribute to neurodegeneration in various animal models of brain diseases and traumas, others have shown that their inhibition may in contrast be associa...

journal_title：Molecular psychiatry

authors： Simard AR,Rivest S

更新日期：2006-04-01 00:00:00

abstract：:Several microbes have been suspected as pathogenetic factors in schizophrenia. We have previously observed increased frequencies of chlamydial infections and of human lymphocyte antigen (HLA)-A10 in independent studies of schizophrenia. Our aim here was to analyze frequencies of three types of Chlamydiaceae in schizop...

journal_title：Molecular psychiatry

authors： Fellerhoff B,Laumbacher B,Mueller N,Gu S,Wank R

更新日期：2007-03-01 00:00:00

abstract：:A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is a...

journal_title：Molecular psychiatry

authors： Wollmer MA,Streffer JR,Tsolaki M,Grimaldi LM,Lütjohann D,Thal D,von Bergmann K,Nitsch RM,Hock C,Papassotiropoulos A

更新日期：2003-06-01 00:00:00

abstract：:Linkage disequilibrium (LD) mapping was used to follow up reports of linkage between reading disability (RD) and an 18 cM region of chromosome 6p21.3-22. Using a two-stage approach, we tested for association between RD and 22 microsatellite markers in two independent samples of 101 (Stage 1) and 77 (Stage 2) parent/pr...

journal_title：Molecular psychiatry

authors： Turic D,Robinson L,Duke M,Morris DW,Webb V,Hamshere M,Milham C,Hopkin E,Pound K,Fernando S,Grierson A,Easton M,Williams N,Van Den Bree M,Chowdhury R,Gruen J,Stevenson J,Krawczak M,Owen MJ,O'Donovan MC,Williams J

更新日期：2003-02-01 00:00:00

abstract：:Intellectual disability (ID) is a measurable phenotypic consequence of genetic and environmental factors. In this study, we prospectively assessed the diagnostic yield of genomic tools (molecular karyotyping, multi-gene panel and exome sequencing) in a cohort of 337 ID subjects as a first-tier test and compared it wit...

journal_title：Molecular psychiatry

authors： Anazi S,Maddirevula S,Faqeih E,Alsedairy H,Alzahrani F,Shamseldin HE,Patel N,Hashem M,Ibrahim N,Abdulwahab F,Ewida N,Alsaif HS,Al Sharif H,Alamoudi W,Kentab A,Bashiri FA,Alnaser M,AlWadei AH,Alfadhel M,Eyaid W,Has

更新日期：2017-04-01 00:00:00

abstract：:Anxiety disorders constitute a major disease and social burden worldwide; however, many questions concerning the underlying molecular mechanisms still remain open. Besides the involvement of the major excitatory (glutamate) and inhibitory (gamma aminobutyric acid (GABA)) neurotransmitter circuits in anxiety disorders,...

journal_title：Molecular psychiatry

authors： Hartmann J,Dedic N,Pöhlmann ML,Häusl A,Karst H,Engelhardt C,Westerholz S,Wagner KV,Labermaier C,Hoeijmakers L,Kertokarijo M,Chen A,Joëls M,Deussing JM,Schmidt MV

更新日期：2017-03-01 00:00:00

abstract：:Anxiety-related behaviors are closely linked to neural circuits relaying fear-specific information to the amygdala. Many of these circuits, like those underlying processing of innate fear, are remarkably well understood. Recent imaging studies have contributed to this knowledge by discriminating more detailed corticoa...

journal_title：Molecular psychiatry

authors： Brocke B,Armbruster D,Muller J,Hensch T,Jacob CP,Lesch KP,Kirschbaum C,Strobel A

更新日期：2006-12-01 00:00:00

abstract：:The etiology of schizophrenia is unclear, although family, twin, and linkage studies implicate genetic factors. Here, we identified adenomatous polyposis coli (APC), a tumor suppressor gene, as a risk factor for schizophrenia. We compared leukocytic gene expression patterns of six pairs of patients with schizophrenia ...

journal_title：Molecular psychiatry

authors： Cui DH,Jiang KD,Jiang SD,Xu YF,Yao H

更新日期：2005-07-01 00:00:00

abstract：:We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...

journal_title：Molecular psychiatry

authors： Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

更新日期：2020-11-11 00:00:00

abstract：:Schizophrenia is a highly heritable disorder for which anatomical brain alterations have been repeatedly reported in clinical samples. Unaffected at-risk groups have also been studied in an attempt to identify brain changes that do not reflect reverse causation or treatment effects. However, no robust associations hav...

journal_title：Molecular psychiatry

authors： Warland A,Kendall KM,Rees E,Kirov G,Caseras X

更新日期：2020-04-01 00:00:00

abstract：:Low dietary folate intake has been implicated as a risk factor for depression. However, observational epidemiological studies are plagued by problems of confounding, reverse causality and measurement error. A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and ...

journal_title：Molecular psychiatry

authors： Lewis SJ,Lawlor DA,Davey Smith G,Araya R,Timpson N,Day IN,Ebrahim S

更新日期：2006-04-01 00:00:00

abstract：:Identifying biological mechanisms through which the experience of adversity emerges as individual risk for mental illness is an important step toward developing strategies for personalized treatment and, ultimately, prevention. Preclinical studies have identified epigenetic modification of gene expression as one such ...

journal_title：Molecular psychiatry

authors： Swartz JR,Hariri AR,Williamson DE

更新日期：2017-02-01 00:00:00

abstract：:The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed within the central nervous system. Previous work showed that this protein is upregulated in Alzheimer's disease (AD), and plays an active role in the development of brain amyloidosis in amyloid beta (Aβ)-precursor protein transgenic mice (Tg2576). In the pr...

journal_title：Molecular psychiatry

authors： Chu J,Li JG,Giannopoulos PF,Blass BE,Childers W,Abou-Gharbia M,Praticò D

更新日期：2015-11-01 00:00:00

abstract：:A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memory reconsolidation represents a potential therapeutic strategy,...

journal_title：Molecular psychiatry

authors： Boury-Jamot B,Carrard A,Martin JL,Halfon O,Magistretti PJ,Boutrel B

更新日期：2016-08-01 00:00:00

abstract：:Induction of neuroprotective heat-shock proteins via pharmacological Hsp90 inhibitors is currently being investigated as a potential treatment for neurodegenerative diseases. Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicity and limited central nervous system permeability. We demonstrate ...

journal_title：Molecular psychiatry

authors： Wang B,Liu Y,Huang L,Chen J,Li JJ,Wang R,Kim E,Chen Y,Justicia C,Sakata K,Chen H,Planas A,Ostrom RS,Li W,Yang G,McDonald MP,Chen R,Heck DH,Liao FF

更新日期：2017-07-01 00:00:00

abstract：:Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially) recessive deleterious mutations. Even among outbred populations, auto...

journal_title：Molecular psychiatry

authors： Howrigan DP,Simonson MA,Davies G,Harris SE,Tenesa A,Starr JM,Liewald DC,Deary IJ,McRae A,Wright MJ,Montgomery GW,Hansell N,Martin NG,Payton A,Horan M,Ollier WE,Abdellaoui A,Boomsma DI,DeRosse P,Knowles EE,Glahn DC

更新日期：2016-06-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/mp.2016.107. ...

journal_title：Molecular psychiatry

authors： Selzam S,Krapohl E,von Stumm S,O'Reilly PF,Rimfeld K,Kovas Y,Dale PS,Lee JJ,Plomin R

更新日期：2018-01-01 00:00:00

abstract：:The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equ...

journal_title：Molecular psychiatry

authors： Alachkar A,Wang L,Yoshimura R,Hamzeh AR,Wang Z,Sanathara N,Lee SM,Xu X,Abbott GW,Civelli O

更新日期：2018-02-01 00:00:00

abstract：:Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation, making them highly useful adjuncts to animal models. Here, we ex...

journal_title：Molecular psychiatry

authors： Konopka G,Wexler E,Rosen E,Mukamel Z,Osborn GE,Chen L,Lu D,Gao F,Gao K,Lowe JK,Geschwind DH

更新日期：2012-02-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in motivation. Using positron emission tomography (PET), we showed decreased function in the brain dopamine reward pathway in adults with AD...

journal_title：Molecular psychiatry

authors： Volkow ND,Wang GJ,Newcorn JH,Kollins SH,Wigal TL,Telang F,Fowler JS,Goldstein RZ,Klein N,Logan J,Wong C,Swanson JM

更新日期：2011-11-01 00:00:00

abstract：:The Wistar-Kyoto (WKY) rat strain demonstrates endogenous hormonal and behavioral abnormalities that emulate many of those found in symptom-presenting depressive patients. Evidence suggests that the WKY strain may harbor heterogeneity not found in other inbred strains, including greater behavioral and genetic variabil...

journal_title：Molecular psychiatry

authors： Will CC,Aird F,Redei EE

更新日期：2003-11-01 00:00:00

abstract：:Although schizophrenia is generally considered to occur as a consequence of multiple genes that interact with one another, very few methods have been developed to model epistasis. Phenotype definition has also been a major challenge for research on the genetics of schizophrenia. In this report, we use novel statistica...

journal_title：Molecular psychiatry

authors： Andreasen NC,Wilcox MA,Ho BC,Epping E,Ziebell S,Zeien E,Weiss B,Wassink T

更新日期：2012-11-01 00:00:00

abstract：:Between 1997 and 2002, 48 data sets from the hippocampus were produced on samples from the Stanley Neuropathology Consortium. From these data sets, 224 total measures were available from the various subdivisions of the hippocampus. An integrative analysis of these measures was performed using a multivariate, nonparame...

journal_title：Molecular psychiatry

authors： Knable MB,Barci BM,Webster MJ,Meador-Woodruff J,Torrey EF,Stanley Neuropathology Consortium.

更新日期：2004-06-01 00:00:00

abstract：:Binge drinking is associated with disease and death, and developing tools to identify risky drinkers could mitigate its damage. Brain processes underlie risky drinking, so we examined whether neural and psychosocial markers could identify binge drinkers. Reward is the most widely studied neural process in addiction, b...

journal_title：Molecular psychiatry

authors： Gowin JL,Manza P,Ramchandani VA,Volkow ND

更新日期：2020-05-12 00:00:00

abstract：:Converging advances in the fields of molecular biology, molecular genetics, cellular biology and embryology have given researchers the tools for the targeted delivery and stable germline transmission of foreign genes (transgenes) in the mouse. In the realm of neuropsychiatry, this so-named transgenic technology has be...

journal_title：Molecular psychiatry

authors： Campbell IL,Gold LH

更新日期：1996-05-01 00:00:00

abstract：:This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Haure-Mirande JV,Wang M,Audrain M,Fanutza T,Kim SH,Heja S,Readhead B,Dudley JT,Blitzer RD,Schadt EE,Zhang B,Gandy S,Ehrlich ME

更新日期：2019-03-01 00:00:00

abstract：:Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-inv...

journal_title：Molecular psychiatry

authors： Hadar R,Winter R,Edemann-Callesen H,Wieske F,Habelt B,Khadka N,Felgel-Farnholz V,Barroeta-Hlusicka E,Reis J,Tatarau CA,Funke K,Fritsch B,Bernhardt N,Bikson M,Nitsche MA,Winter C

更新日期：2020-04-01 00:00:00

abstract：:An increase in corticotropin-releasing factor (CRF) is a putative factor in the pathophysiology of stress-related disorders. As CRF expression in the central nucleus of the amygdala (CeA) is important in adaptation to chronic stress, we hypothesized that unrestrained synthesis of CRF in CeA would mimic the consequence...

journal_title：Molecular psychiatry

authors： Keen-Rhinehart E,Michopoulos V,Toufexis DJ,Martin EI,Nair H,Ressler KJ,Davis M,Owens MJ,Nemeroff CB,Wilson ME

更新日期：2009-01-01 00:00:00