The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis.

abstract：:A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is a...

journal_title：Molecular psychiatry

authors： Wollmer MA,Streffer JR,Tsolaki M,Grimaldi LM,Lütjohann D,Thal D,von Bergmann K,Nitsch RM,Hock C,Papassotiropoulos A

更新日期：2003-06-01 00:00:00

abstract：:We posit in this article that hierarchical temporal processing deficit is the underlying basis of reality distortion and psychoses. Schizophrenia is a prototypical reality distortion disorder in which the patient manifests with auditory hallucinations, delusions, disorganized speech and thinking, cognitive impairment,...

journal_title：Molecular psychiatry

authors： Krishnan RR,Fivaz M,Kraus MS,Keefe RS

更新日期：2011-02-01 00:00:00

abstract：:A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memory reconsolidation represents a potential therapeutic strategy,...

journal_title：Molecular psychiatry

authors： Boury-Jamot B,Carrard A,Martin JL,Halfon O,Magistretti PJ,Boutrel B

更新日期：2016-08-01 00:00:00

abstract：:Abnormalities in prefrontal gamma aminobutyric acid (GABA)ergic transmission, particularly in fast-spiking interneurons that express parvalbumin (PV), are hypothesized to contribute to the pathophysiology of multiple psychiatric disorders, including schizophrenia, bipolar disorder, anxiety disorders and depression. Wh...

journal_title：Molecular psychiatry

authors： Canetta S,Bolkan S,Padilla-Coreano N,Song LJ,Sahn R,Harrison NL,Gordon JA,Brown A,Kellendonk C

更新日期：2016-07-01 00:00:00

abstract：:Schizophrenia and bipolar disorder have both been linked to structural abnormalities of the hippocampus, which is consistent with a neurodevelopmental anomaly. One isoform of the neural cell adhesion molecule (N-CAM) protein, cytosolic N-CAM 105-115 kDa, was previously shown to be increased in schizophrenia in the hip...

journal_title：Molecular psychiatry

authors： Vawter MP,Howard AL,Hyde TM,Kleinman JE,Freed WJ

更新日期：1999-09-01 00:00:00

abstract：:Folate receptor alpha (FRα) autoantibodies have been associated with fetal abnormalities and cerebral folate deficiency-related developmental disorders. Over 70% of the children with autism spectrum disorders (ASD) are positive for these autoantibodies and high-dose folinic acid is beneficial in treating these childre...

journal_title：Molecular psychiatry

authors： Desai A,Sequeira JM,Quadros EV

更新日期：2017-09-01 00:00:00

abstract：:The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equ...

journal_title：Molecular psychiatry

authors： Alachkar A,Wang L,Yoshimura R,Hamzeh AR,Wang Z,Sanathara N,Lee SM,Xu X,Abbott GW,Civelli O

更新日期：2018-02-01 00:00:00

abstract：:Panic disorder (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide geno...

journal_title：Molecular psychiatry

authors： Forstner AJ,Awasthi S,Wolf C,Maron E,Erhardt A,Czamara D,Eriksson E,Lavebratt C,Allgulander C,Friedrich N,Becker J,Hecker J,Rambau S,Conrad R,Geiser F,McMahon FJ,Moebus S,Hess T,Buerfent BC,Hoffmann P,Herms S,He

更新日期：2019-11-11 00:00:00

abstract：:The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such l...

journal_title：Molecular psychiatry

authors： Vélez JI,Chandrasekharappa SC,Henao E,Martinez AF,Harper U,Jones M,Solomon BD,Lopez L,Garcia G,Aguirre-Acevedo DC,Acosta-Baena N,Correa JC,Lopera-Gómez CM,Jaramillo-Elorza MC,Rivera D,Kosik KS,Schork NJ,Swanson JM,Lop

更新日期：2013-05-01 00:00:00

abstract：:Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia. This study comprises genome-wide association (GWA) and follow-up analyses of all individuals born in Denmark since 1...

journal_title：Molecular psychiatry

authors： Børglum AD,Demontis D,Grove J,Pallesen J,Hollegaard MV,Pedersen CB,Hedemand A,Mattheisen M,GROUP investigators10.,Uitterlinden A,Nyegaard M,Ørntoft T,Wiuf C,Didriksen M,Nordentoft M,Nöthen MM,Rietschel M,Ophoff RA,Cic

更新日期：2014-03-01 00:00:00

abstract：:People who experience childhood abuse are at increased risk of mental illness. Twin studies suggest that inherited genetic risk for mental illness may account for some of these associations. Yet, the hypothesis that individuals who have experienced childhood abuse may carry genetic loading for mental illness has never...

journal_title：Molecular psychiatry

authors： Ratanatharathorn A,Koenen KC,Chibnik LB,Weisskopf MG,Rich-Edwards JW,Roberts AL

更新日期：2021-01-22 00:00:00

abstract：:With the advent of technologies that allow simultaneous genotyping of thousands of single-nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex diseases can be explored at an unprecedented detail. This study is among the first to apply the genome-wide association study (GWAS) approach...

journal_title：Molecular psychiatry

authors： Feulner TM,Laws SM,Friedrich P,Wagenpfeil S,Wurst SH,Riehle C,Kuhn KA,Krawczak M,Schreiber S,Nikolaus S,Förstl H,Kurz A,Riemenschneider M

更新日期：2010-07-01 00:00:00

abstract：:Use of substances such as cannabis, alcohol, and tobacco, has been associated with increased risk of suicide attempt in several observational studies. However, establishing whether these associations are causal is challenging when using observational designs. To evaluate the potential causal contributions of cannabis ...

journal_title：Molecular psychiatry

authors： Orri M,Séguin JR,Castellanos-Ryan N,Tremblay RE,Côté SM,Turecki G,Geoffroy MC

更新日期：2020-06-08 00:00:00

abstract：:Hyperactivation of the amygdala following chronic stress is believed to be one of the primary mechanisms underlying the increased propensity for anxiety-like behaviors and pathological states; however, the mechanisms by which chronic stress modulates amygdalar function are not well characterized. The aim of the curren...

journal_title：Molecular psychiatry

authors： Hill MN,Kumar SA,Filipski SB,Iverson M,Stuhr KL,Keith JM,Cravatt BF,Hillard CJ,Chattarji S,McEwen BS

更新日期：2013-10-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is associated with neuropathology in patients with impaired immunity and/or inflammatory diseases. However, the association between gray matter volume (GMV) and HCMV has never been examined in major depressive disorder (MDD) despite the presence of inflammation and impaired viral...

journal_title：Molecular psychiatry

authors： Zheng H,Ford BN,Bergamino M,Kuplicki R,Tulsa 1000 Investigators.,Hunt PW,Bodurka J,Teague TK,Irwin MR,Yolken RH,Paulus MP,Savitz J

更新日期：2020-11-22 00:00:00

abstract：:Binge drinking is associated with disease and death, and developing tools to identify risky drinkers could mitigate its damage. Brain processes underlie risky drinking, so we examined whether neural and psychosocial markers could identify binge drinkers. Reward is the most widely studied neural process in addiction, b...

journal_title：Molecular psychiatry

authors： Gowin JL,Manza P,Ramchandani VA,Volkow ND

更新日期：2020-05-12 00:00:00

abstract：:Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the hypothesis that rare variants in many different genes, including de novo variants, could predispose to these conditions i...

journal_title：Molecular psychiatry

authors： Piton A,Gauthier J,Hamdan FF,Lafrenière RG,Yang Y,Henrion E,Laurent S,Noreau A,Thibodeau P,Karemera L,Spiegelman D,Kuku F,Duguay J,Destroismaisons L,Jolivet P,Côté M,Lachapelle K,Diallo O,Raymond A,Marineau C,Cham

更新日期：2011-08-01 00:00:00

abstract：:Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncoding RNAs. RNA-binding protein (RBP) is a key factor of the regulation. Regulator of calcineurin 1 (RCAN1) is a multifunctional protein involved in neurodegeneration, mit...

journal_title：Molecular psychiatry

authors： Yun Y,Zhang Y,Zhang C,Huang L,Tan S,Wang P,Vilariño-Gúell C,Song W,Sun X

更新日期：2019-08-27 00:00:00

abstract：:Previous studies have shown inconsistent results regarding the actions of antidepressants on glucocorticoid receptor (GR) signalling. To resolve these inconsistencies, we used a lentiviral-based reporter system to directly monitor rat hippocampal GR activity during stress adaptation. Temporal GR activation was induced...

journal_title：Molecular psychiatry

authors： Lee MS,Kim YH,Park WS,Park OK,Kwon SH,Hong KS,Rhim H,Shim I,Morita K,Wong DL,Patel PD,Lyons DM,Schatzberg AF,Her S

更新日期：2016-02-01 00:00:00

abstract：:Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underp...

journal_title：Molecular psychiatry

authors： Luykx JJ,Bakker SC,Lentjes E,Neeleman M,Strengman E,Mentink L,DeYoung J,de Jong S,Sul JH,Eskin E,van Eijk K,van Setten J,Buizer-Voskamp JE,Cantor RM,Lu A,van Amerongen M,van Dongen EP,Keijzers P,Kappen T,Borgdorff P

更新日期：2014-02-01 00:00:00

abstract：:Bipolar affective disorder is one of the most common mental illnesses with a population prevalence of approximately 1%. The disorder is genetically complex, with an increasing number of loci being implicated through genetic linkage studies. However, the specific genetic variations and molecules involved in bipolar sus...

journal_title：Molecular psychiatry

authors： Blair IP,Adams LJ,Badenhop RF,Moses MJ,Scimone A,Morris JA,Ma L,Austin CP,Donald JA,Mitchell PB,Schofield PR

更新日期：2002-01-01 00:00:00

abstract：:To quantify aging- and disease-associated alterations in the integrative and interactive components of a pulsatile neuroendocrine axis, novel biomathematical strategies are required. Here, I illustrate as an investigative paradigm otherwise subtle aging-dependent disturbances of the gonadotropin-releasing-hormone (GnR...

journal_title：Molecular psychiatry

authors： Veldhuis JD

更新日期：1997-01-01 00:00:00

abstract：:Previous work has demonstrated associations between lower cognitive ability and childhood and adult non-psychotic psychopathology. As both cognitive ability (CA) and child psychopathology (CP) are influenced by genetic factors, one explanation for the association is that they are the pleiotropic manifestations of the ...

journal_title：Molecular psychiatry

authors： Jacobs N,Rijsdijk F,Derom C,Danckaerts M,Thiery E,Derom R,Vlietinck R,van Os J

更新日期：2002-01-01 00:00:00

abstract：:Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with ...

journal_title：Molecular psychiatry

authors： Coleman JRI,Bryois J,Gaspar HA,Jansen PR,Savage JE,Skene N,Plomin R,Muñoz-Manchado AB,Linnarsson S,Crawford G,Hjerling-Leffler J,Sullivan PF,Posthuma D,Breen G

更新日期：2019-02-01 00:00:00

abstract：:Folic acid supplementation confers modest benefit in schizophrenia, but its effectiveness is influenced by common genetic variants in the folate pathway that hinder conversion to its active form. We examined physiological and clinical effects of l-methylfolate, the fully reduced and bioactive form of folate, in schizo...

journal_title：Molecular psychiatry

authors： Roffman JL,Petruzzi LJ,Tanner AS,Brown HE,Eryilmaz H,Ho NF,Giegold M,Silverstein NJ,Bottiglieri T,Manoach DS,Smoller JW,Henderson DC,Goff DC

更新日期：2018-02-01 00:00:00

abstract：:The aim of the study is to compare the prevalence of suicidal ideation and attempts in the United States in 1991-1992 and 2001-2002, and identify sociodemographic groups at increased risk for suicidal ideation and attempts. Data were drawn from the National Institute on Alcohol Abuse and Alcoholism 1991-1992 National ...

journal_title：Molecular psychiatry

authors： Baca-Garcia E,Perez-Rodriguez MM,Keyes KM,Oquendo MA,Hasin DS,Grant BF,Blanco C

更新日期：2010-03-01 00:00:00

abstract：:Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized that maternal departures from the optimum of dietary methyl donor intake can increase the risk for mental health issues and neurological disorders in offspring,...

journal_title：Molecular psychiatry

authors： Ryan DP,Henzel KS,Pearson BL,Siwek ME,Papazoglou A,Guo L,Paesler K,Yu M,Müller R,Xie K,Schröder S,Becker L,Garrett L,Hölter SM,Neff F,Rácz I,Rathkolb B,Rozman J,Ehninger G,Klingenspor M,Klopstock T,Wolf E,Wurs

更新日期：2018-05-01 00:00:00

abstract：:Cariprazine (CAR) is a strong inhibitor of the Dhcr7 enzyme, the last enzyme in the cholesterol biosynthesis pathway. We assessed the effects of CAR on maternally exposed Dhcr7+/- and wild-type mouse offspring, and tested the biochemical effects of CAR in human serum samples. Dhcr7+/- and wild-type time-pregnant mice ...

journal_title：Molecular psychiatry

authors： Genaro-Mattos TC,Anderson A,Allen LB,Tallman KA,Porter NA,Korade Z,Mirnics K

更新日期：2020-11-01 00:00:00

abstract：:Bipolar disorder (BD) is a progressive psychiatric disorder with more than 3% prevalence worldwide. Affected individuals experience recurrent episodes of depression and mania, disrupting normal life and increasing the risk of suicide greatly. The complexity and genetic heterogeneity of psychiatric disorders have chall...

journal_title：Molecular psychiatry

authors： Stern S,Santos R,Marchetto MC,Mendes APD,Rouleau GA,Biesmans S,Wang QW,Yao J,Charnay P,Bang AG,Alda M,Gage FH

更新日期：2018-06-01 00:00:00

abstract：:Environmental enrichment (EE) is known to have an anxiolytic effect in several animal models; however, the molecular mechanisms underlying these behavioral changes are not understood. In this study, we have shown that the anxiolytic effect of EE is associated with alterations in the corticotropin-releasing factor rece...

journal_title：Molecular psychiatry

authors： Sztainberg Y,Kuperman Y,Tsoory M,Lebow M,Chen A

更新日期：2010-09-01 00:00:00