Abstract:
:Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the method might have such an effect, and uncertainties surrounding its influence on neural activity, and human cognition and functioning. In the present critical review, we identify key priorities for future research into major depression and schizophrenia, including studies of the mechanism(s) of action of tDCS at the neuronal and systems levels, the establishment of the cognitive impact of tDCS, as well as investigations of the potential clinical efficacy of tDCS. We highlight areas of progress in each of these domains, including data that appear to favor an effect of tDCS on neural oscillations rather than spiking, and findings that tDCS administration to the prefrontal cortex during task training may be an effective way to enhance behavioral performance. Finally, we provide suggestions for further empirical study that will elucidate the impact of tDCS on brain and behavior, and may pave the way for efficacious clinical treatments for psychiatric disorders.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Chase HW,Boudewyn MA,Carter CS,Phillips MLdoi
10.1038/s41380-019-0499-9subject
Has Abstractpub_date
2020-02-01 00:00:00pages
397-407issue
2eissn
1359-4184issn
1476-5578pii
10.1038/s41380-019-0499-9journal_volume
25pub_type
杂志文章,评审abstract::Cigarette smoking is more prevalent in subjects with schizophrenia compared to those with other psychiatric disorders or the general population and could therefore affect molecular pathways that impact the pathophysiology of this disorder. As smoking is also known to suppress immune responses, we investigated the effe...
journal_title:Molecular psychiatry
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journal_title:Molecular psychiatry
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 已发布勘误
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journal_title:Molecular psychiatry
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular psychiatry
pub_type: 杂志文章
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journal_title:Molecular psychiatry
pub_type: 杂志文章
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更新日期:1998-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001496
更新日期:2004-09-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001404
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/mp.2015.130
更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41380-020-01009-6
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pub_type: 杂志文章
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journal_title:Molecular psychiatry
pub_type: 杂志文章
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journal_title:Molecular psychiatry
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular psychiatry
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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