Abstract:
:Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other members of the neurotrophin family, are central mediators of the activity-dependent plasticity through which environmental experiences, such as sensory information are translated into the structure and function of neuronal networks. Synthesis, release and action of BDNF is regulated by neuronal activity and BDNF in turn leads to trophic effects such as formation, stabilization and potentiation of synapses through its high-affinity TrkB receptors. Several clinically available drugs activate neurotrophin signaling and neuronal plasticity. In particular, antidepressant drugs rapidly activate TrkB signaling and gradually increase BDNF expression, and the behavioral effects of antidepressants are mediated by and dependent on BDNF signaling through TrkB at least in rodents. These findings indicate that antidepressants, widely used drugs, effectively act as TrkB activators. They further imply that neuronal plasticity is a central mechanism in the action of antidepressant drugs. Indeed, it was recently discovered that antidepressants reactivate a state of plasticity in the adult cerebral cortex that closely resembles the enhanced plasticity normally observed during postnatal critical periods. This state of induced plasticity, known as iPlasticity, allows environmental stimuli to beneficially reorganize networks abnormally wired during early life. iPlasticity has been observed in cortical as well as subcortical networks and is induced by several pharmacological and non-pharmacological treatments. iPlasticity is a new pharmacological principle where drug treatment and rehabilitation cooperate; the drug acts permissively to enhance plasticity and rehabilitation provides activity to guide the appropriate wiring of the plastic network. Optimization of iPlastic drug treatment with novel means of rehabilitation may help improve the efficacy of available drug treatments and expand the use of currently existing drugs into new indications.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Castrén E,Antila Hdoi
10.1038/mp.2017.61subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1085-1095issue
8eissn
1359-4184issn
1476-5578pii
mp201761journal_volume
22pub_type
杂志文章abstract::Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy number variations (CNVs) in SCZ cases and identified multiple rare recurrent CNVs that increase risk of SCZ although with incomplete penetranc...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.40
更新日期:2014-07-01 00:00:00
abstract::Microdeletions of chromosomal region 2q23.1 that disrupt MBD5 (methyl-CpG-binding domain protein 5) contribute to a spectrum of neurodevelopmental phenotypes; however, the impact of this locus on human psychopathology has not been fully explored. To characterize the structural variation landscape of MBD5 disruptions a...
journal_title:Molecular psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1038/mp.2013.42
更新日期:2014-03-01 00:00:00
abstract::Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder. Genetic loci have not yet been identified by genome-wide association studies. Rare copy number variations (CNVs), such as chromosomal deletions or duplications, have been implicated in ADHD and other neurodevelop...
journal_title:Molecular psychiatry
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0207-1
更新日期:2019-04-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2011.65
更新日期:2012-05-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.18
更新日期:2009-12-01 00:00:00
abstract::In developing his mature concept of hebephrenic dementia praecox (DP) in his 4th (1893) through 6th textbook editions (1899), Kraepelin worked from the hebephrenic syndrome first described by Hecker (1871) and then carefully studied by his student Daraszkiewicz (1892). Working under Kraepelin's supervision, Daraszkiew...
journal_title:Molecular psychiatry
pub_type: 历史文章,杂志文章,评审
doi:10.1038/s41380-019-0411-7
更新日期:2020-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0580-4
更新日期:2020-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000485
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.148
更新日期:2017-05-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000563
更新日期:2000-01-01 00:00:00
abstract::To examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-matched controls in the Japanese population. Allelic and genotypic distributions of ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001029
更新日期:2002-01-01 00:00:00
abstract::The classic diathesis-stress framework, which views some individuals as particularly vulnerable to adversity, informs virtually all psychiatric research on behavior-gene-environment (G x E) interaction. An alternative framework of 'differential susceptibility' is proposed, one which regards those most susceptible to a...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2009.44
更新日期:2009-08-01 00:00:00
abstract::We earlier reported a genome-wide significant linkage to schizophrenia at chromosome 17 that was identified in a single pedigree (C702) consisting of six affected, male siblings with DSM-IV schizophrenia and prominent mood symptoms. In this study, we adopted several approaches in an attempt to map the putative disease...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.96
更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.126
更新日期:2012-12-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2017.155
更新日期:2018-07-01 00:00:00
abstract::Previous studies have shown inconsistent results regarding the actions of antidepressants on glucocorticoid receptor (GR) signalling. To resolve these inconsistencies, we used a lentiviral-based reporter system to directly monitor rat hippocampal GR activity during stress adaptation. Temporal GR activation was induced...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.137
更新日期:2016-02-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000744
更新日期:2000-07-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000258
更新日期:1997-03-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41380-020-01005-w
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.82
更新日期:2017-02-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001081
更新日期:2002-01-01 00:00:00
abstract::(+) 3,4-Methylenedioxymethamphetamine (MDMA) is a psychedelic drug of abuse that causes selective degeneration of serotonergic fibers of dorsal raphe neurons that project throughout the forebrain. Previous studies using pharmacological and behavioral approaches suggested that MDMA treatment leads to desensitization of...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000574
更新日期:1999-11-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001158
更新日期:2002-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
abstract::The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate,...
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pub_type: 杂志文章,meta分析
doi:10.1038/sj.mp.4001926
更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1038/sj.mp.4000898
更新日期:2001-09-01 00:00:00