Abstract：
:Medical treatment with various cytokines can provoke psychiatric symptoms. Conversely, psychiatric patients can display abnormalities in cytokine and neurotrophic factor expression. Such observations have pointed to the potential contribution of cytokines and growth factors to schizophrenic pathology and/or etiology. The cellular targets of the relevant factors and the nature of their actions remain to be explored in mental illness, however. Recent physiological studies demonstrate that cytokines and neurotrophic factors can markedly influence synaptic transmission and plasticity upon acute or chronic application. Moreover, many of the molecular alterations observed in the schizophrenic brain are consistent with abnormalities in cytokine and neurotrophic factor regulation of these molecules. In this review, we summarize these molecular pathology findings for schizophrenia and highlight the neurodevelopmental activities of cytokines and neurotrophic factors that may contribute to the etiology or pathology of this illness.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Nawa H,Takahashi M,Patterson PHdoi
10.1038/sj.mp.4000730subject
Has Abstractpub_date
2000-11-01 00:00:00pages
594-603issue
6eissn
1359-4184issn
1476-5578journal_volume
5pub_type
杂志文章,评审abstract：:The urocortin (Ucn) family of neuropeptides is suggested to be involved in homeostatic coping mechanisms of the central stress response through the activation of corticotropin-releasing factor receptor type 2 (CRFR2). The neuropeptides, Ucn1 and Ucn2, serve as endogenous ligands for the CRFR2, which is highly expresse...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2009.115
更新日期：2010-04-01 00:00:00
abstract：:Mental disorders cause more disability than any other class of medical illness in Americans between ages 15 and 44 years. The suicide rate is higher than the annual mortality from homicide, AIDS, and most forms of cancer. In contrast to nearly all communicable and most non-communicable diseases, there is little eviden...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/sj.mp.4001777
更新日期：2006-01-01 00:00:00
abstract：:The s allele variant of the serotonin transporter gene (5-HTT) has recently been observed to moderate the relationship of stress to depression and anxiety. To date no study has considered interactive effects of 5-HTT genotype, stress and hypothalamic-pituitary-adrenal (HPA) function on cognition in healthy, older adul...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001978
更新日期：2007-06-01 00:00:00
abstract：:This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...
journal_title：Molecular psychiatry
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41380-018-0301-4
更新日期：2019-03-01 00:00:00
abstract：:Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people to cognitively defined subgroups on the b...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0298-8
更新日期：2020-11-01 00:00:00
abstract：:Genomic risk profile scores (GRPSs) have been shown to predict case-control status of schizophrenia (SCZ), albeit with varying sensitivity and specificity. The extent to which this variability in prediction accuracy is related to differences in sampling strategies is unknown. Danish population-based registers and Neon...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2015.130
更新日期：2016-07-01 00:00:00
abstract：:Abnormalities in prefrontal gamma aminobutyric acid (GABA)ergic transmission, particularly in fast-spiking interneurons that express parvalbumin (PV), are hypothesized to contribute to the pathophysiology of multiple psychiatric disorders, including schizophrenia, bipolar disorder, anxiety disorders and depression. Wh...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2015.222
更新日期：2016-07-01 00:00:00
abstract：:Long-term weight-restored patients with anorexia nervosa (AN) have lower norepinephrine levels than controls. Since this may reflect altered reuptake by the norepinephrine transporter (NET), we hypothesised that the NET gene was involved in the genetic component of AN. PCR-amplification of an AAGG repeat island (AAGG1...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001080
更新日期：2002-01-01 00:00:00
abstract：:A whole genome association study was performed in a phase 3 clinical trial conducted to evaluate a novel antipsychotic, iloperidone, administered to treat patients with schizophrenia. Genotypes of 407 patients were analyzed for 334,563 single nucleotide polymorphisms (SNPs). SNPs associated with iloperidone efficacy w...
journal_title：Molecular psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/mp.2008.56
更新日期：2009-08-01 00:00:00
abstract：:Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. In this study, we examined th...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001845
更新日期：2006-08-01 00:00:00
abstract：:Suicide is a major public health concern and a leading cause of death in most societies. Suicidal behaviour is complex and heterogeneous, likely resulting from several causes. It associates with multiple factors, including psychopathology, personality traits, early-life adversity and stressful life events, among other...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/mp.2017.141
更新日期：2017-10-01 00:00:00
abstract：:Bipolar affective disorder (BPAD) is a common psychiatric disorder with complex genetic aetiology. We have undertaken a genome-wide scan in one of the largest samples of bipolar affected sibling pairs (ASPs) using a two-stage approach combining sample splitting and marker grid tightening. In this second stage analysis...
journal_title：Molecular psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.mp.4001684
更新日期：2005-09-01 00:00:00
abstract：:Retinoid metabolites of vitamin A are intrinsically linked to neural development, connectivity and plasticity, and have been implicated in the pathophysiology of schizophrenia. We hypothesised that a greater burden of common and rare genomic variation in genes involved with retinoid biogenesis and signalling could be ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0305-0
更新日期：2020-04-01 00:00:00
abstract：:Linkage studies of mental illness have provided suggestive evidence of susceptibility loci over many broad chromosomal regions. Pinpointing causative gene mutations by conventional linkage strategies alone is problematic. The breakpoints of chromosomal abnormalities occurring in patients with mental illness may be mor...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/sj.mp.4001232
更新日期：2003-03-01 00:00:00
abstract：:Schizophrenia and bipolar disorder have both been linked to structural abnormalities of the hippocampus, which is consistent with a neurodevelopmental anomaly. One isoform of the neural cell adhesion molecule (N-CAM) protein, cytosolic N-CAM 105-115 kDa, was previously shown to be increased in schizophrenia in the hip...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000547
更新日期：1999-09-01 00:00:00
abstract：:Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmen...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-019-0635-6
更新日期：2020-01-03 00:00:00
abstract：:Induction of neuroprotective heat-shock proteins via pharmacological Hsp90 inhibitors is currently being investigated as a potential treatment for neurodegenerative diseases. Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicity and limited central nervous system permeability. We demonstrate ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2016.104
更新日期：2017-07-01 00:00:00
abstract：:Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABAARs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsant and hypnotic effec...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0100-y
更新日期：2018-09-01 00:00:00
abstract：:Traumatic life experiences are associated with alcohol use problems, an association that is likely to be moderated by genetic predisposition. To understand these interactions, we conducted a gene-by-environment genome-wide interaction study (GEWIS) of alcohol use problems in two independent samples, the Army STARRS (S...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.24
更新日期：2018-01-01 00:00:00
abstract：:Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with ...
journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析
doi：10.1038/s41380-018-0040-6
更新日期：2019-02-01 00:00:00
abstract：:Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysi...
journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析,多中心研究
doi：10.1038/mp.2011.125
更新日期：2012-12-01 00:00:00
abstract：:Among the different initiating events in Alzheimer's disease (AD) pathogenesis, oxidative stress and neuroinflammation are some of the most iimportant. In the central nervous system, the 12/15Lipoxygenase (12/15LO) enzyme is the source of potent pro-oxidants and inflammatory lipid mediators. Previous works showed that...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0268-1
更新日期：2018-10-02 00:00:00
abstract：:The network theory conceptualizes mental disorders as complex networks of symptoms influencing each other by creating feedback loops, leading to a self-sustained syndromic constellation. Symptoms central to the network have the greatest impact in sustaining the rest of symptoms. This analysis focused on the network st...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0232-0
更新日期：2020-07-01 00:00:00
abstract：:With the advent of technologies that allow simultaneous genotyping of thousands of single-nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex diseases can be explored at an unprecedented detail. This study is among the first to apply the genome-wide association study (GWAS) approach...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2008.141
更新日期：2010-07-01 00:00:00
abstract：:Older patients with severe physical trauma are at high risk of developing neuropsychiatric syndromes with global impairment of cognition, attention, and consciousness. We employed a thoracic trauma (TxT) mouse model and thoroughly analyzed age-dependent spatial and temporal posttraumatic alterations in the central ner...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-020-0659-y
更新日期：2020-02-12 00:00:00
abstract：:The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although meta-analyses do confirm associations between depression and these biological systems, effect sizes vary greatl...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2012.144
更新日期：2013-06-01 00:00:00
abstract：:The serotonergic neurotransmitter system has been widely implicated in the pathophysiology of mood-related disorders such as anxiety and major depressive disorder (MDD). The onset of therapeutic efficacy of traditional antidepressants is delayed by several weeks. The 5-HT4 receptor has emerged as a new therapeutic tar...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.240
更新日期：2018-04-01 00:00:00
abstract：:Several microbes have been suspected as pathogenetic factors in schizophrenia. We have previously observed increased frequencies of chlamydial infections and of human lymphocyte antigen (HLA)-A10 in independent studies of schizophrenia. Our aim here was to analyze frequencies of three types of Chlamydiaceae in schizop...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001925
更新日期：2007-03-01 00:00:00
abstract：:With the fast advance of connectome imaging techniques, we have the opportunity of mapping the human brain pathways in vivo at unprecedented resolution. In this article we review the current developments of diffusion magnetic resonance imaging (MRI) for the reconstruction of anatomical pathways in connectome studies. ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.92
更新日期：2017-09-01 00:00:00
abstract：:A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstrea...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001496
更新日期：2004-09-01 00:00:00
