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Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.

Abstract：

:Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated with intelligence. GWAS data for IQ (N = 78,308) were meta-analyzed with a study comparing 1247 individuals with mean IQ ~170 to 8185 controls. Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment for frontal cortex brain expressed genes. These results suggest specific neuronal cell types and genes may be involved in intelligence and provide new hypotheses for neuroscience experiments using model systems.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Coleman JRI,Bryois J,Gaspar HA,Jansen PR,Savage JE,Skene N,Plomin R,Muñoz-Manchado AB,Linnarsson S,Crawford G,Hjerling-Leffler J,Sullivan PF,Posthuma D,Breen G

doi

10.1038/s41380-018-0040-6

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

182-197

issue

2

eissn

1359-4184

issn

1476-5578

pii

10.1038/s41380-018-0040-6

journal_volume

24

pub_type

杂志文章,meta分析

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