当前位置： SCI文献检索 > MOLECULAR PSYCHIATRY期刊下所有文献 > Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons.

Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons.

Abstract：

:Abnormalities in prefrontal gamma aminobutyric acid (GABA)ergic transmission, particularly in fast-spiking interneurons that express parvalbumin (PV), are hypothesized to contribute to the pathophysiology of multiple psychiatric disorders, including schizophrenia, bipolar disorder, anxiety disorders and depression. While primarily histological abnormalities have been observed in patients and in animal models of psychiatric disease, evidence for abnormalities in functional neurotransmission at the level of specific interneuron populations has been lacking in animal models and is difficult to establish in human patients. Using an animal model of a psychiatric disease risk factor, prenatal maternal immune activation (MIA), we found reduced functional GABAergic transmission in the medial prefrontal cortex (mPFC) of adult MIA offspring. Decreased transmission was selective for interneurons expressing PV, resulted from a decrease in release probability and was not observed in calretinin-expressing neurons. This deficit in PV function in MIA offspring was associated with increased anxiety-like behavior and impairments in attentional set shifting, but did not affect working memory. Furthermore, cell-type specific optogenetic inhibition of mPFC PV interneurons was sufficient to impair attentional set shifting and enhance anxiety levels. Finally, we found that in vivo mPFC gamma oscillations, which are supported by PV interneuron function, were linearly correlated with the degree of anxiety displayed in adult mice, and that this correlation was disrupted in MIA offspring. These results demonstrate a selective functional vulnerability of PV interneurons to MIA, leading to affective and cognitive symptoms that have high relevance for schizophrenia and other psychiatric disorders.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Canetta S,Bolkan S,Padilla-Coreano N,Song LJ,Sahn R,Harrison NL,Gordon JA,Brown A,Kellendonk C

doi

10.1038/mp.2015.222

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

956-68

issue

7

eissn

1359-4184

issn

1476-5578

pii

mp2015222

journal_volume

21

pub_type

杂志文章

相关文献

MOLECULAR PSYCHIATRY文献大全
  • Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5.

    abstract：:Attention-deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders. Genetic factors contribute to the underlying liability to develop ADHD. Reports implicate variants of genes important for the synthesis, uptake, transport and receptor binding of dopamine in the etiology of ADHD, ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001466

    authors： Kustanovich V,Ishii J,Crawford L,Yang M,McGough JJ,McCracken JT,Smalley SL,Nelson SF

    更新日期：2004-07-01 00:00:00

  • Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer's disease mouse model.

    abstract：:Circulating adiponectin (APN) levels decrease with age and obesity. On the other hand, a reduction in APN levels is associated with neurodegeneration and neuroinflammation. We previously showed that aged adiponectin knockout (APN-/-) mice developed Alzheimer's like pathologies, cerebral insulin resistance, and cogniti...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-0701-0

    authors： Ng RC,Jian M,Ma OK,Bunting M,Kwan JS,Zhou GJ,Senthilkumar K,Iyaswamy A,Chan PK,Li M,Leung KM,Kumar Durairajan SS,Lam KS,Chu LW,Festenstein R,Chung SK,Chan KH

    更新日期：2020-03-04 00:00:00

  • Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits.

    abstract：:The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2017.164

    authors： Alachkar A,Wang L,Yoshimura R,Hamzeh AR,Wang Z,Sanathara N,Lee SM,Xu X,Abbott GW,Civelli O

    更新日期：2018-02-01 00:00:00

  • What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit.

    abstract：:The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as extending the evidence that glutamatergic abnormalities have a key role in the disorder, this finding draws attention to the behavioural phenotype of Gria1 knoc...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/mp.2014.91

    authors： Barkus C,Sanderson DJ,Rawlins JN,Walton ME,Harrison PJ,Bannerman DM

    更新日期：2014-10-01 00:00:00

  • The development of Kraepelin's mature diagnostic concept of hebephrenia: a close reading of relevant texts of Hecker, Daraszkiewicz, and Kraepelin.

    abstract：:In developing his mature concept of hebephrenic dementia praecox (DP) in his 4th (1893) through 6th textbook editions (1899), Kraepelin worked from the hebephrenic syndrome first described by Hecker (1871) and then carefully studied by his student Daraszkiewicz (1892). Working under Kraepelin's supervision, Daraszkiew...

    journal_title：Molecular psychiatry

    pub_type： 历史文章,杂志文章,评审

    doi：10.1038/s41380-019-0411-7

    authors： Kendler KS

    更新日期：2020-01-01 00:00:00

  • The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia.

    abstract：:The G-protein coupled metabotropic glutamate receptors (GRMs/mGluRs) have been implicated in the aetiology of schizophrenia as they modulate the NMDA response and that of other neurotransmitters including dopamine and GABA.(1-3) Electrophysiological studies in GRM subtype 5 knockout mice reveal, in one study, a sensor...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000848

    authors： Devon RS,Anderson S,Teague PW,Muir WJ,Murray V,Pelosi AJ,Blackwood DH,Porteous DJ

    更新日期：2001-05-01 00:00:00

  • Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice.

    abstract：:Serum antibodies against amyloid-β peptide (Aβ) in humans with or without diagnosis of Alzheimer's disease (AD) indicate the possibility of immune responses against brain antigens. In an unbiased screening for antibodies directed against brain proteins, we found in AD patients high serum levels of antibodies against t...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2012.70

    authors： Santuccione AC,Merlini M,Shetty A,Tackenberg C,Bali J,Ferretti MT,McAfoose J,Kulic L,Bernreuther C,Welt T,Grimm J,Glatzel M,Rajendran L,Hock C,Nitsch RM

    更新日期：2013-03-01 00:00:00

  • Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder.

    abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder. Genetic loci have not yet been identified by genome-wide association studies. Rare copy number variations (CNVs), such as chromosomal deletions or duplications, have been implicated in ADHD and other neurodevelop...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2012.161

    authors： Jarick I,Volckmar AL,Pütter C,Pechlivanis S,Nguyen TT,Dauvermann MR,Beck S,Albayrak Ö,Scherag S,Gilsbach S,Cichon S,Hoffmann P,Degenhardt F,Nöthen MM,Schreiber S,Wichmann HE,Jöckel KH,Heinrich J,Tiesler CM,Faraone S

    更新日期：2014-01-01 00:00:00

  • Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11

    abstract：:Mol Psychiatry 2000; 5: 77-84 ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000752

    authors： Li T,Ball D,Zhao J,Murray RM,Liu X,Sham PC,Collier DA

    更新日期：2000-07-01 00:00:00

  • Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS.

    abstract：:Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship with psychotic symptoms. The 22q11.2 deletion syndrome (22q11DS) has proven to be a remarkable model for the pro...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0443-z

    authors： Mancini V,Sandini C,Padula MC,Zöller D,Schneider M,Schaer M,Eliez S

    更新日期：2020-11-01 00:00:00

  • FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications.

    abstract：:Psychotropic medications target glycogen synthase kinase 3β (GSK3β), but the functional integration with other factors relevant for drug efficacy is poorly understood. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3β at serine 9 (pGSK3β(S9))....

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2015.38

    authors： Gassen NC,Hartmann J,Zannas AS,Kretzschmar A,Zschocke J,Maccarrone G,Hafner K,Zellner A,Kollmannsberger LK,Wagner KV,Mehta D,Kloiber S,Turck CW,Lucae S,Chrousos GP,Holsboer F,Binder EB,Ising M,Schmidt MV,Rein T

    更新日期：2016-02-01 00:00:00

  • A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication.

    abstract：:Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8), suggesting that about 80% of phenotypic variance is due to genetic factors. We used the integration of statistical and functional approaches to discover a novel gene that contributes to ADHD. For our statistical approach, we started wi...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2010.6

    authors： Arcos-Burgos M,Jain M,Acosta MT,Shively S,Stanescu H,Wallis D,Domené S,Vélez JI,Karkera JD,Balog J,Berg K,Kleta R,Gahl WA,Roessler E,Long R,Lie J,Pineda D,Londoño AC,Palacio JD,Arbelaez A,Lopera F,Elia J,Hakon

    更新日期：2010-11-01 00:00:00

  • Schizophrenia-associated genomic copy number variants and subcortical brain volumes in the UK Biobank.

    abstract：:Schizophrenia is a highly heritable disorder for which anatomical brain alterations have been repeatedly reported in clinical samples. Unaffected at-risk groups have also been studied in an attempt to identify brain changes that do not reflect reverse causation or treatment effects. However, no robust associations hav...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0355-y

    authors： Warland A,Kendall KM,Rees E,Kirov G,Caseras X

    更新日期：2020-04-01 00:00:00

  • Clinical genomics expands the morbid genome of intellectual disability and offers a high diagnostic yield.

    abstract：:Intellectual disability (ID) is a measurable phenotypic consequence of genetic and environmental factors. In this study, we prospectively assessed the diagnostic yield of genomic tools (molecular karyotyping, multi-gene panel and exome sequencing) in a cohort of 337 ID subjects as a first-tier test and compared it wit...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.113

    authors： Anazi S,Maddirevula S,Faqeih E,Alsedairy H,Alzahrani F,Shamseldin HE,Patel N,Hashem M,Ibrahim N,Abdulwahab F,Ewida N,Alsaif HS,Al Sharif H,Alamoudi W,Kentab A,Bashiri FA,Alnaser M,AlWadei AH,Alfadhel M,Eyaid W,Has

    更新日期：2017-04-01 00:00:00

  • Muscarinic1 and 2 receptor mRNA in the human caudate-putamen: no change in m1 mRNA in schizophrenia.

    abstract：:Studies using tissue obtained at autopsy suggest that changes in cholinergic neurons could be important in the pathology of schizophrenia.1-4 We have previously reported a decrease in [3H]pirenzepine binding5 and [3H]AF-DX 384 binding6 to caudate-putamen (CP) from subjects who had schizophrenia. Under the conditions c...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000684

    authors： Dean B,Crook JM,Pavey G,Opeskin K,Copolov DL

    更新日期：2000-03-01 00:00:00

  • Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function.

    abstract：:Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The pathophysiology of the illness is not understood, but is thought to have a strong genetic component with some environmental influences on aetiology. To gain further insight into disease mechanism, we used microarray technology to de...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2009.18

    authors： Maycox PR,Kelly F,Taylor A,Bates S,Reid J,Logendra R,Barnes MR,Larminie C,Jones N,Lennon M,Davies C,Hagan JJ,Scorer CA,Angelinetta C,Akbar MT,Hirsch S,Mortimer AM,Barnes TR,de Belleroche J

    更新日期：2009-12-01 00:00:00

  • Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.

    abstract：:We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25-q26 that had been typed in a genome-wide association study (GWAS) of schi...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2008.108

    authors： O'Donovan MC,Norton N,Williams H,Peirce T,Moskvina V,Nikolov I,Hamshere M,Carroll L,Georgieva L,Dwyer S,Holmans P,Marchini JL,Spencer CC,Howie B,Leung HT,Giegling I,Hartmann AM,Möller HJ,Morris DW,Shi Y,Feng G,H

    更新日期：2009-01-01 00:00:00

  • COMT haplotypes suggest P2 promoter region relevance for schizophrenia.

    abstract：:A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstrea...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001496

    authors： Palmatier MA,Pakstis AJ,Speed W,Paschou P,Goldman D,Odunsi A,Okonofua F,Kajuna S,Karoma N,Kungulilo S,Grigorenko E,Zhukova OV,Bonne-Tamir B,Lu RB,Parnas J,Kidd JR,DeMille MM,Kidd KK

    更新日期：2004-09-01 00:00:00

  • Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding.

    abstract：:Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association is presently unknown. Both diseases are considered protein misfolding disorders associated with...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.230

    authors： Moreno-Gonzalez I,Edwards Iii G,Salvadores N,Shahnawaz M,Diaz-Espinoza R,Soto C

    更新日期：2017-09-01 00:00:00

  • Detection of polyglutamine expansion in a new acidic protein: a candidate for childhood onset schizophrenia?

    abstract：:Polyglutamine expansion (PGE) encoded by a CAG repeat underlies eight inherited neurodegenerative diseases, among which is Huntington's disease. CAG expansion has also been reported in schizophrenia, suggesting a role for PGE. To investigate the potential role of PGE as a candidate for schizophrenia, we searched for P...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000448

    authors： Moriniere S,Saada C,Holbert S,Sidransky E,Galat A,Ginns E,Rapoport JL,Neri C

    更新日期：1999-01-01 00:00:00

  • Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10.

    abstract：:Several microbes have been suspected as pathogenetic factors in schizophrenia. We have previously observed increased frequencies of chlamydial infections and of human lymphocyte antigen (HLA)-A10 in independent studies of schizophrenia. Our aim here was to analyze frequencies of three types of Chlamydiaceae in schizop...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001925

    authors： Fellerhoff B,Laumbacher B,Mueller N,Gu S,Wank R

    更新日期：2007-03-01 00:00:00

  • (+) 3,4-methylenedioxymethamphetamine ('ecstasy') transiently increases striatal 5-HT1B binding sites without altering 5-HT1B mRNA in rat brain.

    abstract：:(+) 3,4-Methylenedioxymethamphetamine (MDMA) is a psychedelic drug of abuse that causes selective degeneration of serotonergic fibers of dorsal raphe neurons that project throughout the forebrain. Previous studies using pharmacological and behavioral approaches suggested that MDMA treatment leads to desensitization of...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000574

    authors： Sexton TJ,McEvoy C,Neumaier JF

    更新日期：1999-11-01 00:00:00

  • Correction: Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Molecular psychiatry

    pub_type： 已发布勘误

    doi：10.1038/s41380-020-00919-9

    authors： Haarsma J,Fletcher PC,Griffin JD,Taverne HJ,Ziauddeen H,Spencer TJ,Miller C,Katthagen T,Goodyer I,Diederen KMJ,Murray GK

    更新日期：2020-10-14 00:00:00

  • Brain somatic mutations: the dark matter of psychiatric genetics?

    abstract：:Although inherited DNA sequences have a well-demonstrated role in psychiatric disease risk, for even the most heritable mental disorders, monozygotic twins are discordant at a significant rate. The genetic variation associated with mental disorders has heretofore been based on the search for rare or common variation i...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2013.168

    authors： Insel TR

    更新日期：2014-02-01 00:00:00

  • Nuclear receptor corepressors in intellectual disability and autism.

    abstract：:Autism spectrum disorder (ASD) is characterized by neurocognitive dysfunctions, such as impaired social interaction and language learning. Gene-environment interactions have a pivotal role in ASD pathogenesis. Nuclear receptor corepressors (NCORs) are transcription co-regulators physically associated with histone deac...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/s41380-020-0667-y

    authors： Kong Y,Zhou W,Sun Z

    更新日期：2020-10-01 00:00:00

  • Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders.

    abstract：:Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhanci...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-01002-z

    authors： Radonjić NV,Hess JL,Rovira P,Andreassen O,Buitelaar JK,Ching CRK,Franke B,Hoogman M,Jahanshad N,McDonald C,Schmaal L,Sisodiya SM,Stein DJ,van den Heuvel OA,van Erp TGM,van Rooij D,Veltman DJ,Thompson P,Faraone SV

    更新日期：2021-01-17 00:00:00

  • Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain.

    abstract：:In mammals, most adult neural stem cells (NSCs) are located in the ventricular-subventricular zone (V-SVZ) along the wall of the lateral ventricles and they are the source of olfactory bulb interneurons. Adult NSCs exhibit an apico-basal polarity; they harbor a short apical process and a long basal process, reminiscen...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-0823-4

    authors： García-González D,Dumitru I,Zuccotti A,Yen TY,Herranz-Pérez V,Tan LL,Neitz A,García-Verdugo JM,Kuner R,Alfonso J,Monyer H

    更新日期：2020-07-01 00:00:00

  • Child psychopathology and lower cognitive ability: a general population twin study of the causes of association.

    abstract：:Previous work has demonstrated associations between lower cognitive ability and childhood and adult non-psychotic psychopathology. As both cognitive ability (CA) and child psychopathology (CP) are influenced by genetic factors, one explanation for the association is that they are the pleiotropic manifestations of the ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000971

    authors： Jacobs N,Rijsdijk F,Derom C,Danckaerts M,Thiery E,Derom R,Vlietinck R,van Os J

    更新日期：2002-01-01 00:00:00

  • Modeling the functional genomics of autism using human neurons.

    abstract：:Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation, making them highly useful adjuncts to animal models. Here, we ex...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2011.60

    authors： Konopka G,Wexler E,Rosen E,Mukamel Z,Osborn GE,Chen L,Lu D,Gao F,Gao K,Lowe JK,Geschwind DH

    更新日期：2012-02-01 00:00:00

  • Mood stabilizers and/or antipsychotics for bipolar disorder in the maintenance phase: a systematic review and network meta-analysis of randomized controlled trials.

    abstract：:We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-00946-6

    authors： Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

    更新日期：2020-11-11 00:00:00