Abstract：
:In mammals, most adult neural stem cells (NSCs) are located in the ventricular-subventricular zone (V-SVZ) along the wall of the lateral ventricles and they are the source of olfactory bulb interneurons. Adult NSCs exhibit an apico-basal polarity; they harbor a short apical process and a long basal process, reminiscent of radial glia morphology. In the adult mouse brain, we detected extremely long radial glia-like fibers that originate from the anterior-ventral V-SVZ and that are directed to the ventral striatum. Interestingly, a fraction of adult V-SVZ-derived neuroblasts dispersed in close association with the radial glia-like fibers in the nucleus accumbens (NAc). Using several in vivo mouse models, we show that newborn neurons integrate into preexisting circuits in the NAc where they mature as medium spiny neurons (MSNs), i.e., a type of projection neurons formerly believed to be generated only during embryonic development. Moreover, we found that the number of newborn neurons in the NAc is dynamically regulated by persistent pain, suggesting that adult neurogenesis of MSNs is an experience-modulated process.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
García-González D,Dumitru I,Zuccotti A,Yen TY,Herranz-Pérez V,Tan LL,Neitz A,García-Verdugo JM,Kuner R,Alfonso J,Monyer Hdoi
10.1038/s41380-020-0823-4subject
Has Abstractpub_date
2020-07-01 00:00:00eissn
1359-4184issn
1476-5578pii
10.1038/s41380-020-0823-4pub_type
杂志文章abstract：:The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.164
更新日期：2018-02-01 00:00:00
abstract：:Chronic methamphetamine use poses potentially devastating consequences for directly affected individuals and for society. Lower dopamine D2-type receptor availability has been observed in striata of methamphetamine users as compared with controls, but an analogous comparison of D1-type receptors has been conducted onl...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.172
更新日期：2018-05-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/mp.2016.107. ...
journal_title：Molecular psychiatry
pub_type： 杂志文章,已发布勘误
doi：10.1038/mp.2017.203
更新日期：2018-01-01 00:00:00
abstract：:Nitric oxide (NO) is a widespread and multifunctional biological messenger molecule. It mediates vasodilation of blood vessels, host defence against infectious agents and tumors, and neurotransmission of the central and peripheral nervous systems. In the nervous system, NO is generated by three nitric oxide synthase (...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/sj.mp.4000272
更新日期：1997-07-01 00:00:00
abstract：:The aim of the study is to compare the prevalence of suicidal ideation and attempts in the United States in 1991-1992 and 2001-2002, and identify sociodemographic groups at increased risk for suicidal ideation and attempts. Data were drawn from the National Institute on Alcohol Abuse and Alcoholism 1991-1992 National ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2008.98
更新日期：2010-03-01 00:00:00
abstract：:Schizophrenia is a neurodevelopmental disorder that affects up to 1% of the general population. Various genes show associations with schizophrenia and a very weak nominal association with the tight junction protein, claudin-5, has previously been identified. Claudin-5 is expressed in endothelial cells forming part of ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.156
更新日期：2018-11-01 00:00:00
abstract：:We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of p...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0345-5
更新日期：2019-04-01 00:00:00
abstract：:The dopamine transporter (DAT) plays a central role in dopaminergic neurotransmission in the human brain. Genetic association studies have used a variable number of tandem repeat (VNTR) polymorphism in the 3'-flanking region of the dopamine transporter gene (DAT1) to implicate the DAT in the development of various neu...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000711
更新日期：2000-05-01 00:00:00
abstract：:Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4002047
更新日期：2008-07-01 00:00:00
abstract：:Neurobiological disorders have diverse manifestations and symptomology. Neurodegenerative disorders, such as Alzheimer's disease, manifest late in life and are characterized by, among other symptoms, progressive loss of synaptic markers. Developmental disorders, such as autism spectrum, appear in childhood. Neuropsych...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2009.82
更新日期：2009-11-01 00:00:00
abstract：:The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with 'Western' diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched 'Western' ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-019-0580-4
更新日期：2020-01-01 00:00:00
abstract：:Early-life disruption of the parent-child relationship, for example, in the form of abuse, neglect or loss, dramatically increases risk for psychiatric, as well as certain medical, disorders in adulthood. The neuropeptide oxytocin (OT) plays a seminal role in mediating social affiliation, attachment, social support, m...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2008.112
更新日期：2009-10-01 00:00:00
abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cyto...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2015.29
更新日期：2016-02-01 00:00:00
abstract：:The 'neurodegeneration with brain iron accumulation' (NBIA) disease family entails movement or cognitive impairment, often with psychiatric features. To understand how iron loading affects the brain, we studied mice with disruption of two iron regulatory genes, hemochromatosis (Hfe) and transferrin receptor 2 (Tfr2). ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2015.192
更新日期：2016-11-01 00:00:00
abstract：:The network theory conceptualizes mental disorders as complex networks of symptoms influencing each other by creating feedback loops, leading to a self-sustained syndromic constellation. Symptoms central to the network have the greatest impact in sustaining the rest of symptoms. This analysis focused on the network st...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0232-0
更新日期：2020-07-01 00:00:00
abstract：:Studies using tissue obtained at autopsy suggest that changes in cholinergic neurons could be important in the pathology of schizophrenia.1-4 We have previously reported a decrease in [3H]pirenzepine binding5 and [3H]AF-DX 384 binding6 to caudate-putamen (CP) from subjects who had schizophrenia. Under the conditions c...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000684
更新日期：2000-03-01 00:00:00
abstract：:The epigenome is associated with biological factors, such as disease status, and environmental factors, such as smoking, alcohol consumption and body mass index. Although there is a widespread perception that environmental influences on the epigenome are pervasive and profound, there has been little evidence to date i...
journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析
doi：10.1038/mp.2017.210
更新日期：2017-12-01 00:00:00
abstract：:The serotonergic neurotransmitter system has been widely implicated in the pathophysiology of mood-related disorders such as anxiety and major depressive disorder (MDD). The onset of therapeutic efficacy of traditional antidepressants is delayed by several weeks. The 5-HT4 receptor has emerged as a new therapeutic tar...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.240
更新日期：2018-04-01 00:00:00
abstract：:The core nature of nicotine dependence is evident in wide variations in how individuals become and remain smokers. Individuals with pre-existing behavioral traits are more likely to develop nicotine dependence and experience difficulty when attempting to quit. Many molecular factors likely contribute to individual var...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/mp.2009.16
更新日期：2009-07-01 00:00:00
abstract：:We conducted a 10 centimorgan (cM) linkage genome scan in a set of American extended pedigrees ascertained through probands with panic disorder. Several anxiety disorders segregate in these families. In this article, we describe results for simple phobia from 14 of these families (including 129 subjects of whom 57 are...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001224
更新日期：2003-01-01 00:00:00
abstract：:Large numbers of single nucleotide polymorphisms (SNPs) are being identified by several laboratories for the purpose of developing dense genetic maps. Single-strand conformation polymorphism (SSCP) analysis has been widely used as a method for detecting novel sequence variations in PCR products. Differences in migrati...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000564
更新日期：1999-07-01 00:00:00
abstract：:The term 'mood stabilizer' has been applied to a number of medications for the treatment of patients with bipolar disorder. The operational definition of the properties of a mood-stabilizing medication has varied according to the properties of specific medications and the clinical characteristics of the illness. Rando...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/sj.mp.4001013
更新日期：2002-01-01 00:00:00
abstract：:Corticotropin-releasing hormone (CRH) is the principal regulator of the hypothalamic-pituitary-adrenal (HPA) axis and an activator of the sympathoadrenal (SA) and systemic sympathetic (SS) systems. Mental disorders, including major depression and, more recently, Alzheimer's disease have been associated with dysregulat...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000720
更新日期：2000-03-01 00:00:00
abstract：:Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD compared with controls, but consistent evidence is lacking. Few s...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2015.12
更新日期：2016-03-01 00:00:00
abstract：:Anxiety-related behaviors are closely linked to neural circuits relaying fear-specific information to the amygdala. Many of these circuits, like those underlying processing of innate fear, are remarkably well understood. Recent imaging studies have contributed to this knowledge by discriminating more detailed corticoa...
journal_title：Molecular psychiatry
pub_type： 临床试验,杂志文章
doi：10.1038/sj.mp.4001908
更新日期：2006-12-01 00:00:00
abstract：:There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesity. This study aimed to investigate the genetic influence of polymorphisms in FTO in relation to body mass ...
journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析
doi：10.1038/mp.2011.45
更新日期：2012-06-01 00:00:00
abstract：:Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncoding RNAs. RNA-binding protein (RBP) is a key factor of the regulation. Regulator of calcineurin 1 (RCAN1) is a multifunctional protein involved in neurodegeneration, mit...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-019-0487-0
更新日期：2019-08-27 00:00:00
abstract：:How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA-assessed from SA in s...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.78
更新日期：2018-04-01 00:00:00
abstract：:Attention-deficit/hyperactivity disorder (ADHD) is the most common behavioral disorder in childhood with substantial heritability. Pharmacological and molecular genetic studies as well as characterization of animal models have implicated serotonergic dysfunction in the pathophysiology of ADHD. Here, we investigated th...
journal_title：Molecular psychiatry
pub_type： 临床试验,杂志文章
doi：10.1038/sj.mp.4001734
更新日期：2005-12-01 00:00:00
abstract：:Polymorphism in the human dopamine D4 receptor gene (DRD4) exon III has been associated in some but not all studies of the human personality trait of Novelty Seeking. We searched for polymorphisms in the 5' region of DRD4 and identified six polymorphisms as follows: -1217G Ins/Del, -809G/A, -616C/G, -603T Ins/Del, -60...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000563
更新日期：2000-01-01 00:00:00
