Schizophrenia-associated genomic copy number variants and subcortical brain volumes in the UK Biobank.

abstract：:Several studies have indicated that patients with bipolar disorder (BD) who respond well to lithium prophylaxis constitute a biologically distinct subgroup. Lithium is thought to stabilize mood by acting at the phosphoinositide cycle. We have investigated a polymorphism located in the gene (PLCG1) that codes for a gam...

journal_title：Molecular psychiatry

authors： Turecki G,Grof P,Cavazzoni P,Duffy A,Grof E,Ahrens B,Berghöfer A,Müller-Oerlinghausen B,Dvoráková M,Libigerová E,Vojtechovský M,Zvolský P,Joober R,Nilsson A,Prochazka H,Licht RW,Rasmussen NA,Schou M,Vestergaard P,Ho

更新日期：1998-11-01 00:00:00

abstract：:The Wistar-Kyoto (WKY) rat strain demonstrates endogenous hormonal and behavioral abnormalities that emulate many of those found in symptom-presenting depressive patients. Evidence suggests that the WKY strain may harbor heterogeneity not found in other inbred strains, including greater behavioral and genetic variabil...

journal_title：Molecular psychiatry

authors： Will CC,Aird F,Redei EE

更新日期：2003-11-01 00:00:00

abstract：:Semi-starvation induced hyperactivity (SIH) occurs in rodents upon caloric restriction. We hypothesized that SIH is triggered by the decline in leptin secretion associated with food restriction. To test this hypothesis, rats, which had established a stable level of activity, were treated with leptin or vehicle via imp...

journal_title：Molecular psychiatry

authors： Exner C,Hebebrand J,Remschmidt H,Wewetzer C,Ziegler A,Herpertz S,Schweiger U,Blum WF,Preibisch G,Heldmaier G,Klingenspor M

更新日期：2000-09-01 00:00:00

abstract：:To identify loci associated with Alzheimer disease, we conducted a three-stage analysis using existing genome-wide association studies (GWAS) and genotyping in a new sample. In Stage I, all suggestive single-nucleotide polymorphisms (at P<0.001) in a previously reported GWAS of seven independent studies (8082 Alzheime...

journal_title：Molecular psychiatry

authors： Boada M,Antúnez C,Ramírez-Lorca R,DeStefano AL,González-Pérez A,Gayán J,López-Arrieta J,Ikram MA,Hernández I,Marín J,Galán JJ,Bis JC,Mauleón A,Rosende-Roca M,Moreno-Rey C,Gudnasson V,Morón FJ,Velasco J,Carrasco JM,A

更新日期：2014-06-01 00:00:00

abstract：:Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...

journal_title：Molecular psychiatry

authors： Wedenoja J,Loukola A,Tuulio-Henriksson A,Paunio T,Ekelund J,Silander K,Varilo T,Heikkilä K,Suvisaari J,Partonen T,Lönnqvist J,Peltonen L

更新日期：2008-07-01 00:00:00

abstract：:The long alleles (> or =6 repeats) of the dopamine D4 dopamine receptor exon III polymorphism have been linked in some, but not all, studies to Novelty Seeking (NS), one of four personality traits defined by Cloninger's tridimensional personality questionnarie (TPQ). In order to further examine the robustness of our o...

journal_title：Molecular psychiatry

authors： Ebstein RP,Nemanov L,Klotz I,Gritsenko I,Belmaker RH

更新日期：1997-10-01 00:00:00

abstract：:Various neuropathological findings have been reported in bipolar disorder (BD). However, it is unclear which findings are well established. To address this gap, we carried out a systematic review of the literature. We searched over 5000 publications, identifying 103 data papers, of which 81 were eligible for inclusion...

journal_title：Molecular psychiatry

authors： Harrison PJ,Colbourne L,Harrison CH

更新日期：2020-08-01 00:00:00

abstract：:Dysthymia is characterized by long-lasting periods of lowered mood. Epidemiological studies in the USA and Europe have demonstrated that the prevalence of dysthymia is at least 3% of the general population. Its pervasive occurrence makes dysthymia a public health problem worldwide. One feature of this disorder is its ...

journal_title：Molecular psychiatry

authors： Akiskal HS,Bolis CL,Cazzullo C,Costa e Silva JA,Gentil V,Lecrubier Y,Licinio J,Linden M,Lopez-Ibor JJ,Ndiaye IP,Pani L,Prilipko L,Robertson MM,Robinson RG,Starkstein SE,Thomas P,Wang Y,Wong ML

更新日期：1996-12-01 00:00:00

abstract：:The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta, which encode 411, 415 and 431 amino acid proteins and transduce signals via the stimulation of intracellular cAMP production. The recent identification of high-af...

journal_title：Molecular psychiatry

authors： Behan DP,Grigoriadis DE,Lovenberg T,Chalmers D,Heinrichs S,Liaw C,De Souza EB

更新日期：1996-09-01 00:00:00

abstract：:Identifying biological mechanisms through which the experience of adversity emerges as individual risk for mental illness is an important step toward developing strategies for personalized treatment and, ultimately, prevention. Preclinical studies have identified epigenetic modification of gene expression as one such ...

journal_title：Molecular psychiatry

authors： Swartz JR,Hariri AR,Williamson DE

更新日期：2017-02-01 00:00:00

abstract：:Here, we report a novel target of the drug memantine, ATP-sensitive K+ (KATP) channels, potentially relevant to memory improvement. We confirmed that memantine antagonizes memory impairment in Alzheimer's model APP23 mice. Memantine increased CaMKII activity in the APP23 mouse hippocampus, and memantine-induced enhanc...

journal_title：Molecular psychiatry

authors： Moriguchi S,Ishizuka T,Yabuki Y,Shioda N,Sasaki Y,Tagashira H,Yawo H,Yeh JZ,Sakagami H,Narahashi T,Fukunaga K

更新日期：2018-02-01 00:00:00

abstract：:Environmental enrichment (EE) is known to have an anxiolytic effect in several animal models; however, the molecular mechanisms underlying these behavioral changes are not understood. In this study, we have shown that the anxiolytic effect of EE is associated with alterations in the corticotropin-releasing factor rece...

journal_title：Molecular psychiatry

authors： Sztainberg Y,Kuperman Y,Tsoory M,Lebow M,Chen A

更新日期：2010-09-01 00:00:00

abstract：:Endogenous opioid and non-opioid mechanisms (for example, dopamine (DA), endocannabinoids (eCB)) have been implicated in the formation of placebo analgesic effects, with initial reports dating back three decades. Besides the perspective that placebo effects confound randomized clinical trials, the information so far a...

journal_title：Molecular psychiatry

authors： Peciña M,Zubieta JK

更新日期：2015-04-01 00:00:00

abstract：:Adults with psychotic disorders have dysconnectivity in critical brain networks, including the default mode (DM) and the cingulo-opercular (CO) networks. However, it is unknown whether such deficits are present in youth with less severe symptoms. We conducted a multivariate connectome-wide association study examining ...

journal_title：Molecular psychiatry

authors： Satterthwaite TD,Vandekar SN,Wolf DH,Bassett DS,Ruparel K,Shehzad Z,Craddock RC,Shinohara RT,Moore TM,Gennatas ED,Jackson C,Roalf DR,Milham MP,Calkins ME,Hakonarson H,Gur RC,Gur RE

更新日期：2015-12-01 00:00:00

abstract：:Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patie...

journal_title：Molecular psychiatry

authors： Albrecht DS,Kim M,Akeju O,Torrado-Carvajal A,Edwards RR,Zhang Y,Bergan C,Protsenko E,Kucyi A,Wasan AD,Hooker JM,Napadow V,Loggia ML

更新日期：2019-05-28 00:00:00

abstract：:The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equ...

journal_title：Molecular psychiatry

authors： Alachkar A,Wang L,Yoshimura R,Hamzeh AR,Wang Z,Sanathara N,Lee SM,Xu X,Abbott GW,Civelli O

更新日期：2018-02-01 00:00:00

abstract：:The different serotonin (5-HT) receptors, including the serotonin transporter (5-HTT), are excellent candidate genes for suicide and suicidal behavior, and thus, they have been investigated in a large number of allelic association studies. The individual results of these studies have been inconsistent and definite con...

journal_title：Molecular psychiatry

authors： Anguelova M,Benkelfat C,Turecki G

更新日期：2003-07-01 00:00:00

abstract：:There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. We studied the association of CR...

journal_title：Molecular psychiatry

authors： Licinio J,O'Kirwan F,Irizarry K,Merriman B,Thakur S,Jepson R,Lake S,Tantisira KG,Weiss ST,Wong ML

更新日期：2004-12-01 00:00:00

abstract：:Latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDACi), are being investigated as a strategy to eliminate latency in HIV-infected patients on suppressive antiretroviral therapy. The effectiveness of LRAs in activating latent infection in HIV strains derived from the central nervous system (C...

journal_title：Molecular psychiatry

authors： Gray LR,Cowley D,Welsh C,Lu HK,Brew BJ,Lewin SR,Wesselingh SL,Gorry PR,Churchill MJ

更新日期：2016-04-01 00:00:00

abstract：:Identifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group performed a large-scale meta-analysis and reported widespread white matter microstructural alterations in schizophr...

journal_title：Molecular psychiatry

authors： Koshiyama D,Fukunaga M,Okada N,Morita K,Nemoto K,Usui K,Yamamori H,Yasuda Y,Fujimoto M,Kudo N,Azechi H,Watanabe Y,Hashimoto N,Narita H,Kusumi I,Ohi K,Shimada T,Kataoka Y,Yamamoto M,Ozaki N,Okada G,Okamoto Y,Ha

更新日期：2020-04-01 00:00:00

abstract：:Disturbances of the serotoninergic neutrotransmitter system have been implicated in the pathogenesis of mood disorders. A functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) has been recently reported to be associated with both unipolar and bipolar disorder. In this s...

journal_title：Molecular psychiatry

authors： Seretti A,Cusin C,Lattuada E,Di Bella D,Catalano M,Smeraldi E

更新日期：1999-05-01 00:00:00

abstract：:Episodic memory, a fundamental component of human cognition, is significantly impaired in autism. We believe we report the first evidence for this problem in the Fmr1-knockout (KO) mouse model of Fragile X syndrome and describe potentially treatable underlying causes. The hippocampus is critical for the formation and ...

journal_title：Molecular psychiatry

authors： Wang W,Cox BM,Jia Y,Le AA,Cox CD,Jung KM,Hou B,Piomelli D,Gall CM,Lynch G

更新日期：2018-08-01 00:00:00

abstract：:Myo-inositol exerts behavioral effects in animal models of psychiatric disorders and is effective in clinical trials in psychiatric patients. Interestingly, epi-inositol exerts behavioral effects similar to myo-inositol, even though epi-inositol is not a substrate for synthesis of phosphatidylinositol. We postulated t...

journal_title：Molecular psychiatry

authors： Shaldubina A,Ju S,Vaden DL,Ding D,Belmaker RH,Greenberg ML

更新日期：2002-01-01 00:00:00

abstract：:A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is a...

journal_title：Molecular psychiatry

authors： Wollmer MA,Streffer JR,Tsolaki M,Grimaldi LM,Lütjohann D,Thal D,von Bergmann K,Nitsch RM,Hock C,Papassotiropoulos A

更新日期：2003-06-01 00:00:00

abstract：:Cariprazine (CAR) is a strong inhibitor of the Dhcr7 enzyme, the last enzyme in the cholesterol biosynthesis pathway. We assessed the effects of CAR on maternally exposed Dhcr7+/- and wild-type mouse offspring, and tested the biochemical effects of CAR in human serum samples. Dhcr7+/- and wild-type time-pregnant mice ...

journal_title：Molecular psychiatry

authors： Genaro-Mattos TC,Anderson A,Allen LB,Tallman KA,Porter NA,Korade Z,Mirnics K

更新日期：2020-11-01 00:00:00

abstract：:Identifying biomarkers in schizophrenia during the first episode without the confounding effects of treatment has been challenging. Leveraging these biomarkers to establish diagnosis and make individualized predictions of future treatment responses to antipsychotics would be of great value, but there has been limited ...

journal_title：Molecular psychiatry

authors： Cao B,Cho RY,Chen D,Xiu M,Wang L,Soares JC,Zhang XY

更新日期：2020-04-01 00:00:00

abstract：:A polymorphism in the serotonin (5-HT) transporter gene regulatory region (5-HTTLPR) is associated with measures of 5-HT transporter (5-HTT) expression and 5-HT-mediated behaviors in humans. An analogous length variation of the 5-HTTLPR has been reported in rhesus monkeys (rh5-HTTLPR). A retrospective association stud...

journal_title：Molecular psychiatry

authors： Champoux M,Bennett A,Shannon C,Higley JD,Lesch KP,Suomi SJ

更新日期：2002-01-01 00:00:00

abstract：:Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABAARs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsant and hypnotic effec...

journal_title：Molecular psychiatry

authors： Nicholson MW,Sweeney A,Pekle E,Alam S,Ali AB,Duchen M,Jovanovic JN

更新日期：2018-09-01 00:00:00

abstract：:We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25-q26 that had been typed in a genome-wide association study (GWAS) of schi...

journal_title：Molecular psychiatry

authors： O'Donovan MC,Norton N,Williams H,Peirce T,Moskvina V,Nikolov I,Hamshere M,Carroll L,Georgieva L,Dwyer S,Holmans P,Marchini JL,Spencer CC,Howie B,Leung HT,Giegling I,Hartmann AM,Möller HJ,Morris DW,Shi Y,Feng G,H

更新日期：2009-01-01 00:00:00

abstract：:High impulsive and aggressive traits associate with poor behavioural self-control. Despite their importance in predicting behavioural negative outcomes including suicide, the molecular mechanisms underlying the expression of impulsive and aggressive traits remain poorly understood. Here, we identified and characterize...

journal_title：Molecular psychiatry

authors： Labonté B,Abdallah K,Maussion G,Yerko V,Yang J,Bittar T,Quessy F,Golden SA,Navarro L,Checknita D,Gigek C,Lopez JP,Neve RL,Russo SJ,Tremblay RE,Côté G,Meaney MJ,Mechawar N,Nestler EJ,Turecki G

更新日期：2020-01-06 00:00:00