A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism.

abstract：:The epigenome is associated with biological factors, such as disease status, and environmental factors, such as smoking, alcohol consumption and body mass index. Although there is a widespread perception that environmental influences on the epigenome are pervasive and profound, there has been little evidence to date i...

journal_title：Molecular psychiatry

authors： Karlsson Linnér R,Marioni RE,Rietveld CA,Simpkin AJ,Davies NM,Watanabe K,Armstrong NJ,Auro K,Baumbach C,Bonder MJ,Buchwald J,Fiorito G,Ismail K,Iurato S,Joensuu A,Karell P,Kasela S,Lahti J,McRae AF,Mandaviya PR,Se

更新日期：2017-12-01 00:00:00

abstract：:Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments manage the positive symptoms, yet have minimal effects on the negative and cognitive symptoms, two prominent features of the disease with critical impact on the long-term morbidity. In addition, antipsychotic treatments trigger se...

journal_title：Molecular psychiatry

authors： Revel FG,Moreau JL,Pouzet B,Mory R,Bradaia A,Buchy D,Metzler V,Chaboz S,Groebke Zbinden K,Galley G,Norcross RD,Tuerck D,Bruns A,Morairty SR,Kilduff TS,Wallace TL,Risterucci C,Wettstein JG,Hoener MC

更新日期：2013-05-01 00:00:00

abstract：:Corticotropin-releasing hormone (CRH) is both a main regulator of the hypothalamic-pituitary-adrenocortical axis and the autonomic nervous system. CRH receptor type 1 (CRHR1)-deficient mice demonstrate alterations in behavior, impaired stress responses with adrenocortical insufficiency and aberrant neuroendocrine deve...

journal_title：Molecular psychiatry

authors： Yoshida-Hiroi M,Bradbury MJ,Eisenhofer G,Hiroi N,Vale WW,Novotny GE,Hartwig HG,Scherbaum WA,Bornstein SR

更新日期：2002-01-01 00:00:00

abstract：:Gonadal hormones influence neuronal organization and plasticity. Yet the consequences of altering their concentrations by administering contraceptive agents, which are used by most reproductive-age women in the United States, are unclear. Cross-sectional studies have found both larger and smaller cortical regions alon...

journal_title：Molecular psychiatry

authors： Petersen N,Kearley NW,Ghahremani DG,Pochon JB,Fry ME,Rapkin AJ,London ED

更新日期：2021-01-08 00:00:00

abstract：:Critical periods are temporary windows of heightened neural plasticity early in development. For example, fear memories in juvenile rodents are subject to erasure following extinction training, while after closure of this critical period, extinction training only temporarily and weakly suppresses fear memories. Persis...

journal_title：Molecular psychiatry

authors： Bhagat SM,Butler SS,Taylor JR,McEwen BS,Strittmatter SM

更新日期：2016-09-01 00:00:00

abstract：:There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesity. This study aimed to investigate the genetic influence of polymorphisms in FTO in relation to body mass ...

journal_title：Molecular psychiatry

authors： Rivera M,Cohen-Woods S,Kapur K,Breen G,Ng MY,Butler AW,Craddock N,Gill M,Korszun A,Maier W,Mors O,Owen MJ,Preisig M,Bergmann S,Tozzi F,Rice J,Rietschel M,Rucker J,Schosser A,Aitchison KJ,Uher R,Craig IW,Lewis

更新日期：2012-06-01 00:00:00

abstract：:Cariprazine (CAR) is a strong inhibitor of the Dhcr7 enzyme, the last enzyme in the cholesterol biosynthesis pathway. We assessed the effects of CAR on maternally exposed Dhcr7+/- and wild-type mouse offspring, and tested the biochemical effects of CAR in human serum samples. Dhcr7+/- and wild-type time-pregnant mice ...

journal_title：Molecular psychiatry

authors： Genaro-Mattos TC,Anderson A,Allen LB,Tallman KA,Porter NA,Korade Z,Mirnics K

更新日期：2020-11-01 00:00:00

abstract：:Various neuropathological findings have been reported in bipolar disorder (BD). However, it is unclear which findings are well established. To address this gap, we carried out a systematic review of the literature. We searched over 5000 publications, identifying 103 data papers, of which 81 were eligible for inclusion...

journal_title：Molecular psychiatry

authors： Harrison PJ,Colbourne L,Harrison CH

更新日期：2020-08-01 00:00:00

abstract：:Adults with psychotic disorders have dysconnectivity in critical brain networks, including the default mode (DM) and the cingulo-opercular (CO) networks. However, it is unknown whether such deficits are present in youth with less severe symptoms. We conducted a multivariate connectome-wide association study examining ...

journal_title：Molecular psychiatry

authors： Satterthwaite TD,Vandekar SN,Wolf DH,Bassett DS,Ruparel K,Shehzad Z,Craddock RC,Shinohara RT,Moore TM,Gennatas ED,Jackson C,Roalf DR,Milham MP,Calkins ME,Hakonarson H,Gur RC,Gur RE

更新日期：2015-12-01 00:00:00

abstract：:Biological characterization of genetic variants identified in genome-wide association studies (GWAS) remains a substantial challenge. Here we used human-induced pluripotent stem cells (iPSC) and their neural derivatives to characterize common variants on chromosome 3p22 that have been associated by GWAS with major men...

journal_title：Molecular psychiatry

authors： Jiang X,Detera-Wadleigh SD,Akula N,Mallon BS,Hou L,Xiao T,Felsenfeld G,Gu X,McMahon FJ

更新日期：2019-04-01 00:00:00

abstract：:Several reports have suggested the presence of anticipation in bipolar affective disorder (BPAD). In addition, independent studies using the RED (repeat expansion detection) have shown association between BPAD and longer CAG/CTG repeats. Therefore loci with large CAG/CTG repeats are plausible candidates in the inherit...

journal_title：Molecular psychiatry

authors： Meira-Lima IV,Zhao J,Sham P,Pereira AC,Krieger JE,Vallada H

更新日期：2001-09-01 00:00:00

abstract：:Recent studies have revealed that the gut microbiota modulates brain development and behavior, but the underlying mechanisms are still poorly understood. Here, we show that bacterial peptidoglycan (PGN) derived from the commensal gut microbiota can be translocated into the brain and sensed by specific pattern-recognit...

journal_title：Molecular psychiatry

authors： Arentsen T,Qian Y,Gkotzis S,Femenia T,Wang T,Udekwu K,Forssberg H,Diaz Heijtz R

更新日期：2017-02-01 00:00:00

abstract：:To quantify aging- and disease-associated alterations in the integrative and interactive components of a pulsatile neuroendocrine axis, novel biomathematical strategies are required. Here, I illustrate as an investigative paradigm otherwise subtle aging-dependent disturbances of the gonadotropin-releasing-hormone (GnR...

journal_title：Molecular psychiatry

authors： Veldhuis JD

更新日期：1997-01-01 00:00:00

abstract：:People who experience childhood abuse are at increased risk of mental illness. Twin studies suggest that inherited genetic risk for mental illness may account for some of these associations. Yet, the hypothesis that individuals who have experienced childhood abuse may carry genetic loading for mental illness has never...

journal_title：Molecular psychiatry

authors： Ratanatharathorn A,Koenen KC,Chibnik LB,Weisskopf MG,Rich-Edwards JW,Roberts AL

更新日期：2021-01-22 00:00:00

abstract：:The network theory conceptualizes mental disorders as complex networks of symptoms influencing each other by creating feedback loops, leading to a self-sustained syndromic constellation. Symptoms central to the network have the greatest impact in sustaining the rest of symptoms. This analysis focused on the network st...

journal_title：Molecular psychiatry

authors： Belvederi Murri M,Amore M,Respino M,Alexopoulos GS

更新日期：2020-07-01 00:00:00

abstract：:Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structural and chemical alterations in specific neural substrates. Here we show that adult rats that had been exposed to in utero GCs (iuGC) display increased preference for opiates and ethanol, a...

journal_title：Molecular psychiatry

authors： Rodrigues AJ,Leão P,Pêgo JM,Cardona D,Carvalho MM,Oliveira M,Costa BM,Carvalho AF,Morgado P,Araújo D,Palha JA,Almeida OF,Sousa N

更新日期：2012-12-01 00:00:00

abstract：:Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. In this study, we examined th...

journal_title：Molecular psychiatry

authors： Hettema JM,An SS,Neale MC,Bukszar J,van den Oord EJ,Kendler KS,Chen X

更新日期：2006-08-01 00:00:00

abstract：:Hyperactivation of the amygdala following chronic stress is believed to be one of the primary mechanisms underlying the increased propensity for anxiety-like behaviors and pathological states; however, the mechanisms by which chronic stress modulates amygdalar function are not well characterized. The aim of the curren...

journal_title：Molecular psychiatry

authors： Hill MN,Kumar SA,Filipski SB,Iverson M,Stuhr KL,Keith JM,Cravatt BF,Hillard CJ,Chattarji S,McEwen BS

更新日期：2013-10-01 00:00:00

abstract：:Autistic individuals experience significantly elevated rates of childhood trauma, self-harm and suicidal behaviour and ideation (SSBI). Is this purely the result of negative environmental experiences, or does this interact with genetic predisposition? In this study we investigated if a genetic predisposition for autis...

journal_title：Molecular psychiatry

authors： Warrier V,Baron-Cohen S

更新日期：2019-10-29 00:00:00

abstract：:Here, we report a novel target of the drug memantine, ATP-sensitive K+ (KATP) channels, potentially relevant to memory improvement. We confirmed that memantine antagonizes memory impairment in Alzheimer's model APP23 mice. Memantine increased CaMKII activity in the APP23 mouse hippocampus, and memantine-induced enhanc...

journal_title：Molecular psychiatry

authors： Moriguchi S,Ishizuka T,Yabuki Y,Shioda N,Sasaki Y,Tagashira H,Yawo H,Yeh JZ,Sakagami H,Narahashi T,Fukunaga K

更新日期：2018-02-01 00:00:00

abstract：:To examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-matched controls in the Japanese population. Allelic and genotypic distributions of ...

journal_title：Molecular psychiatry

authors： Ujike H,Takaki M,Nakata K,Tanaka Y,Takeda T,Kodama M,Fujiwara Y,Sakai A,Kuroda S

更新日期：2002-01-01 00:00:00

abstract：:Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncoding RNAs. RNA-binding protein (RBP) is a key factor of the regulation. Regulator of calcineurin 1 (RCAN1) is a multifunctional protein involved in neurodegeneration, mit...

journal_title：Molecular psychiatry

authors： Yun Y,Zhang Y,Zhang C,Huang L,Tan S,Wang P,Vilariño-Gúell C,Song W,Sun X

更新日期：2019-08-27 00:00:00

abstract：:5-HT(2C) receptor (5HT(2C)R, serotonin-2C) RNA undergoes editing to produce several receptor variants, some with pharmacological differences. This investigation comprised two parts: the characterisation of 5-HT(2C)R RNA editing in a larger human control sample than previously examined, and a comparative study in subje...

journal_title：Molecular psychiatry

authors： Sodhi MS,Burnet PW,Makoff AJ,Kerwin RW,Harrison PJ

更新日期：2001-07-01 00:00:00

abstract：:Many human hereditary neurodegenerative diseases are caused by expanded CAG repeats, and anonymous CAG expansions have also been described in schizophrenia and bipolar disorder. We have isolated and sequenced a novel human cDNA encoding a neuronal, small conductance calcium-activated potassium channel (hSKCa3) that co...

journal_title：Molecular psychiatry

authors： Chandy KG,Fantino E,Wittekindt O,Kalman K,Tong LL,Ho TH,Gutman GA,Crocq MA,Ganguli R,Nimgaonkar V,Morris-Rosendahl DJ,Gargus JJ

更新日期：1998-01-01 00:00:00

abstract：:Exposure to severe stressors increases the risk for psychiatric disorders in vulnerable individuals, but can lead to positive outcomes for others. However, it remains unknown how severe stress affects neural functioning in humans and what factors mediate individual differences in the neural sequelae of stress. The amy...

journal_title：Molecular psychiatry

authors： van Wingen GA,Geuze E,Vermetten E,Fernández G

更新日期：2011-06-01 00:00:00

abstract：:The astrocytic cystine/glutamate antiporter system xc- represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance in brain physiology remain incompletely understood. Employing slice electrophysiology a...

journal_title：Molecular psychiatry

authors： Bentea E,Villers A,Moore C,Funk AJ,O'Donovan SM,Verbruggen L,Lara O,Janssen P,De Pauw L,Declerck NB,DePasquale EAK,Churchill MJ,Sato H,Hermans E,Arckens L,Meshul CK,Ris L,McCullumsmith RE,Massie A

更新日期：2020-05-04 00:00:00

abstract：:Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysi...

journal_title：Molecular psychiatry

authors： Hollingworth P,Sweet R,Sims R,Harold D,Russo G,Abraham R,Stretton A,Jones N,Gerrish A,Chapman J,Ivanov D,Moskvina V,Lovestone S,Priotsi P,Lupton M,Brayne C,Gill M,Lawlor B,Lynch A,Craig D,McGuinness B,Johnston J

更新日期：2012-12-01 00:00:00

abstract：:Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD compared with controls, but consistent evidence is lacking. Few s...

journal_title：Molecular psychiatry

authors： Clarke TK,Lupton MK,Fernandez-Pujals AM,Starr J,Davies G,Cox S,Pattie A,Liewald DC,Hall LS,MacIntyre DJ,Smith BH,Hocking LJ,Padmanabhan S,Thomson PA,Hayward C,Hansell NK,Montgomery GW,Medland SE,Martin NG,Wright MJ

更新日期：2016-03-01 00:00:00

abstract：:Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized that maternal departures from the optimum of dietary methyl donor intake can increase the risk for mental health issues and neurological disorders in offspring,...

journal_title：Molecular psychiatry

authors： Ryan DP,Henzel KS,Pearson BL,Siwek ME,Papazoglou A,Guo L,Paesler K,Yu M,Müller R,Xie K,Schröder S,Becker L,Garrett L,Hölter SM,Neff F,Rácz I,Rathkolb B,Rozman J,Ehninger G,Klingenspor M,Klopstock T,Wolf E,Wurs

更新日期：2018-05-01 00:00:00

abstract：:Cigarette smoking is more prevalent in subjects with schizophrenia compared to those with other psychiatric disorders or the general population and could therefore affect molecular pathways that impact the pathophysiology of this disorder. As smoking is also known to suppress immune responses, we investigated the effe...

journal_title：Molecular psychiatry

authors： Herberth M,Krzyszton DN,Koethe D,Craddock MR,Bulger E,Schwarz E,Guest P,Leweke FM,Bahn S

更新日期：2010-04-01 00:00:00