Abstract：
:Exposure to severe stressors increases the risk for psychiatric disorders in vulnerable individuals, but can lead to positive outcomes for others. However, it remains unknown how severe stress affects neural functioning in humans and what factors mediate individual differences in the neural sequelae of stress. The amygdala is a key brain region involved in threat detection and fear regulation, and previous animal studies have suggested that stress sensitizes amygdala responsivity and reduces its regulation by the prefrontal cortex. In this study, we used a prospective design to investigate the consequences of severe stress in soldiers before and after deployment to a combat zone. We found that combat stress increased amygdala and insula reactivity to biologically salient stimuli across the group of combat-exposed individuals. In contrast, its influence on amygdala coupling with the insula and dorsal anterior cingulate cortex was dependent on perceived threat, rather than actual exposure, suggesting that threat appraisal affects interoceptive awareness and amygdala regulation. Our results demonstrate that combat stress has sustained consequences on neural responsivity, and suggest a key role for the appraisal of threat on an amygdala-centered neural network in the aftermath of severe stress.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
van Wingen GA,Geuze E,Vermetten E,Fernández Gdoi
10.1038/mp.2010.132subject
Has Abstractpub_date
2011-06-01 00:00:00pages
664-71issue
6eissn
1359-4184issn
1476-5578pii
mp2010132journal_volume
16pub_type
杂志文章abstract：:Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...
journal_title：Molecular psychiatry
pub_type： 杂志文章
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journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：
更新日期：1996-09-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
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更新日期：2009-08-01 00:00:00
abstract：:This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...
journal_title：Molecular psychiatry
pub_type： 杂志文章,已发布勘误
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更新日期：2019-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Molecular psychiatry
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pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2008.39
更新日期：2009-11-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2012.2
更新日期：2013-01-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001296
更新日期：2003-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.mp.4001744
更新日期：2006-01-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/mp.2014.147
更新日期：2015-07-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2011.87
更新日期：2012-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41380-020-00888-z
更新日期：2020-12-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Molecular psychiatry
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更新日期：2018-11-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000920
更新日期：2001-07-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
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更新日期：2020-09-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001925
更新日期：2007-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2021-01-22 00:00:00
abstract：:Mol Psychiatry 2000; 5: 77-84 ...
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pub_type： 杂志文章
doi：10.1038/sj.mp.4000752
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