Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population.

abstract：:Bipolar affective disorder is one of the most common mental illnesses with a population prevalence of approximately 1%. The disorder is genetically complex, with an increasing number of loci being implicated through genetic linkage studies. However, the specific genetic variations and molecules involved in bipolar sus...

journal_title：Molecular psychiatry

authors： Blair IP,Adams LJ,Badenhop RF,Moses MJ,Scimone A,Morris JA,Ma L,Austin CP,Donald JA,Mitchell PB,Schofield PR

更新日期：2002-01-01 00:00:00

abstract：:Impulsivity, a multifaceted behavioral hallmark of attention-deficit/hyperactivity disorder (ADHD), strongly influences addiction vulnerability and other psychiatric disorders that incur enormous medical and societal burdens yet the neurobiological underpinnings linking impulsivity to disease remain poorly understood....

journal_title：Molecular psychiatry

authors： Miller ML,Ren Y,Szutorisz H,Warren NA,Tessereau C,Egervari G,Mlodnicka A,Kapoor M,Chaarani B,Morris CV,Schumann G,Garavan H,Goate AM,Bannon MJ,IMAGEN Consortium.,Halperin JM,Hurd YL

更新日期：2018-05-01 00:00:00

abstract：:Early-life disruption of the parent-child relationship, for example, in the form of abuse, neglect or loss, dramatically increases risk for psychiatric, as well as certain medical, disorders in adulthood. The neuropeptide oxytocin (OT) plays a seminal role in mediating social affiliation, attachment, social support, m...

journal_title：Molecular psychiatry

authors： Heim C,Young LJ,Newport DJ,Mletzko T,Miller AH,Nemeroff CB

更新日期：2009-10-01 00:00:00

abstract：:Identifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group performed a large-scale meta-analysis and reported widespread white matter microstructural alterations in schizophr...

journal_title：Molecular psychiatry

authors： Koshiyama D,Fukunaga M,Okada N,Morita K,Nemoto K,Usui K,Yamamori H,Yasuda Y,Fujimoto M,Kudo N,Azechi H,Watanabe Y,Hashimoto N,Narita H,Kusumi I,Ohi K,Shimada T,Kataoka Y,Yamamoto M,Ozaki N,Okada G,Okamoto Y,Ha

更新日期：2020-04-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not ju...

journal_title：Molecular psychiatry

authors： Dean KR,Hammamieh R,Mellon SH,Abu-Amara D,Flory JD,Guffanti G,Wang K,Daigle BJ Jr,Gautam A,Lee I,Yang R,Almli LM,Bersani FS,Chakraborty N,Donohue D,Kerley K,Kim TK,Laska E,Young Lee M,Lindqvist D,Lori A,Lu L,M

更新日期：2020-12-01 00:00:00

abstract：:The Wistar-Kyoto (WKY) rat strain demonstrates endogenous hormonal and behavioral abnormalities that emulate many of those found in symptom-presenting depressive patients. Evidence suggests that the WKY strain may harbor heterogeneity not found in other inbred strains, including greater behavioral and genetic variabil...

journal_title：Molecular psychiatry

authors： Will CC,Aird F,Redei EE

更新日期：2003-11-01 00:00:00

abstract：:The molecular genetic research on panic disorder (PD) has grown tremendously in the past decade. Although the data from twin and family studies suggest an involvement of genetic factors in the familial transmission of PD with the heritability estimate near 40%, the genetic substrate underlying panicogenesis is not yet...

journal_title：Molecular psychiatry

authors： Maron E,Hettema JM,Shlik J

更新日期：2010-07-01 00:00:00

abstract：:Exposure to traumatic events is common. While many individuals recover following trauma exposure, a substantial subset develop adverse posttraumatic neuropsychiatric sequelae (APNS) such as posttraumatic stress, major depression, and regional or widespread chronic musculoskeletal pain. APNS cause substantial burden to...

journal_title：Molecular psychiatry

authors： Linnstaedt SD,Zannas AS,McLean SA,Koenen KC,Ressler KJ

更新日期：2020-09-01 00:00:00

abstract：:Mental disorders cause more disability than any other class of medical illness in Americans between ages 15 and 44 years. The suicide rate is higher than the annual mortality from homicide, AIDS, and most forms of cancer. In contrast to nearly all communicable and most non-communicable diseases, there is little eviden...

journal_title：Molecular psychiatry

authors： Insel TR,Scolnick EM

更新日期：2006-01-01 00:00:00

abstract：:Previous studies have implicated DTNBP1 as a schizophrenia susceptibility gene and its encoded protein, dysbindin, as a potential regulator of synaptic vesicle physiology. In this study, we found that endogenous levels of the dysbindin protein in the mouse brain are developmentally regulated, with higher levels observ...

journal_title：Molecular psychiatry

authors： Ghiani CA,Starcevic M,Rodriguez-Fernandez IA,Nazarian R,Cheli VT,Chan LN,Malvar JS,de Vellis J,Sabatti C,Dell'Angelica EC

更新日期：2010-02-01 00:00:00

abstract：:Identifying biological mechanisms through which the experience of adversity emerges as individual risk for mental illness is an important step toward developing strategies for personalized treatment and, ultimately, prevention. Preclinical studies have identified epigenetic modification of gene expression as one such ...

journal_title：Molecular psychiatry

authors： Swartz JR,Hariri AR,Williamson DE

更新日期：2017-02-01 00:00:00

abstract：:Cannabis is one of the most commonly and widely used psychoactive drugs. The rates of cannabis misuse have been increasing. Therefore, understanding the effects of cannabis use on the brain is important. Adolescent and adult rodents exposed to repeated administration of cannabinoids show persistent microstructural cha...

journal_title：Molecular psychiatry

authors： D'Souza DC,Radhakrishnan R,Naganawa M,Ganesh S,Nabulsi N,Najafzadeh S,Ropchan J,Ranganathan M,Cortes-Briones J,Huang Y,Carson RE,Skosnik P

更新日期：2020-09-24 00:00:00

abstract：:Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale c...

journal_title：Molecular psychiatry

authors： Purves KL,Coleman JRI,Meier SM,Rayner C,Davis KAS,Cheesman R,Bækvad-Hansen M,Børglum AD,Wan Cho S,Jürgen Deckert J,Gaspar HA,Bybjerg-Grauholm J,Hettema JM,Hotopf M,Hougaard D,Hübel C,Kan C,McIntosh AM,Mors O,Bo Mort

更新日期：2020-12-01 00:00:00

abstract：:Gonadal hormones influence neuronal organization and plasticity. Yet the consequences of altering their concentrations by administering contraceptive agents, which are used by most reproductive-age women in the United States, are unclear. Cross-sectional studies have found both larger and smaller cortical regions alon...

journal_title：Molecular psychiatry

authors： Petersen N,Kearley NW,Ghahremani DG,Pochon JB,Fry ME,Rapkin AJ,London ED

更新日期：2021-01-08 00:00:00

abstract：:Several lines of evidence have suggested altered functions of the brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). In the search for polymorphisms in the 5'-flanking and 5'-noncoding regions of the BDNF gene, we found a novel nucleotide subs...

journal_title：Molecular psychiatry

authors： Kunugi H,Ueki A,Otsuka M,Isse K,Hirasawa H,Kato N,Nabika T,Kobayashi S,Nanko S

更新日期：2001-01-01 00:00:00

abstract：:This Article was originally published under Nature Research's License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the Article have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Perry A,Roberts G,Mitchell PB,Breakspear M

更新日期：2019-09-01 00:00:00

abstract：:The etiology of schizophrenia is unclear, although family, twin, and linkage studies implicate genetic factors. Here, we identified adenomatous polyposis coli (APC), a tumor suppressor gene, as a risk factor for schizophrenia. We compared leukocytic gene expression patterns of six pairs of patients with schizophrenia ...

journal_title：Molecular psychiatry

authors： Cui DH,Jiang KD,Jiang SD,Xu YF,Yao H

更新日期：2005-07-01 00:00:00

abstract：:Critical periods are temporary windows of heightened neural plasticity early in development. For example, fear memories in juvenile rodents are subject to erasure following extinction training, while after closure of this critical period, extinction training only temporarily and weakly suppresses fear memories. Persis...

journal_title：Molecular psychiatry

authors： Bhagat SM,Butler SS,Taylor JR,McEwen BS,Strittmatter SM

更新日期：2016-09-01 00:00:00

abstract：:Significant heterogeneity across aetiologies, neurobiology and clinical phenotypes have been observed in individuals with autism spectrum disorder (ASD). Neuroimaging-based neuroanatomical studies of ASD have often reported inconsistent findings which may, in part, be attributable to an insufficient understanding of t...

journal_title：Molecular psychiatry

authors： Bedford SA,Park MTM,Devenyi GA,Tullo S,Germann J,Patel R,Anagnostou E,Baron-Cohen S,Bullmore ET,Chura LR,Craig MC,Ecker C,Floris DL,Holt RJ,Lenroot R,Lerch JP,Lombardo MV,Murphy DGM,Raznahan A,Ruigrok ANV,Smith E

更新日期：2020-03-01 00:00:00

abstract：:People who experience childhood abuse are at increased risk of mental illness. Twin studies suggest that inherited genetic risk for mental illness may account for some of these associations. Yet, the hypothesis that individuals who have experienced childhood abuse may carry genetic loading for mental illness has never...

journal_title：Molecular psychiatry

authors： Ratanatharathorn A,Koenen KC,Chibnik LB,Weisskopf MG,Rich-Edwards JW,Roberts AL

更新日期：2021-01-22 00:00:00

abstract：:Linkage disequilibrium (LD) mapping was used to follow up reports of linkage between reading disability (RD) and an 18 cM region of chromosome 6p21.3-22. Using a two-stage approach, we tested for association between RD and 22 microsatellite markers in two independent samples of 101 (Stage 1) and 77 (Stage 2) parent/pr...

journal_title：Molecular psychiatry

authors： Turic D,Robinson L,Duke M,Morris DW,Webb V,Hamshere M,Milham C,Hopkin E,Pound K,Fernando S,Grierson A,Easton M,Williams N,Van Den Bree M,Chowdhury R,Gruen J,Stevenson J,Krawczak M,Owen MJ,O'Donovan MC,Williams J

更新日期：2003-02-01 00:00:00

abstract：:Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with ...

journal_title：Molecular psychiatry

authors： Coleman JRI,Bryois J,Gaspar HA,Jansen PR,Savage JE,Skene N,Plomin R,Muñoz-Manchado AB,Linnarsson S,Crawford G,Hjerling-Leffler J,Sullivan PF,Posthuma D,Breen G

更新日期：2019-02-01 00:00:00

abstract：:This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Haure-Mirande JV,Wang M,Audrain M,Fanutza T,Kim SH,Heja S,Readhead B,Dudley JT,Blitzer RD,Schadt EE,Zhang B,Gandy S,Ehrlich ME

更新日期：2019-03-01 00:00:00

abstract：:The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as extending the evidence that glutamatergic abnormalities have a key role in the disorder, this finding draws attention to the behavioural phenotype of Gria1 knoc...

journal_title：Molecular psychiatry

authors： Barkus C,Sanderson DJ,Rawlins JN,Walton ME,Harrison PJ,Bannerman DM

更新日期：2014-10-01 00:00:00

abstract：:Peripheral blood brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in bipolar disorder, speculated to mirror alterations in brain expression of BDNF. The research area is rapidly evolving; however, recent investigations have yielded con...

journal_title：Molecular psychiatry

authors： Munkholm K,Vinberg M,Kessing LV

更新日期：2016-02-01 00:00:00

abstract：:Eating disorders are complex heritable conditions influenced by both genetic and environmental factors. Given the progress of genomic discovery in anorexia nervosa, with the identification of the first genome-wide significant locus, as well as animated discussion of epigenetic mechanisms in linking environmental facto...

journal_title：Molecular psychiatry

authors： Hübel C,Marzi SJ,Breen G,Bulik CM

更新日期：2019-06-01 00:00:00

abstract：:Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of CNTN5 and CNTN6 have previously been reported in individuals with autism spectrum disorders (ASDs), but very little is known on their prevalence and clinical impact....

journal_title：Molecular psychiatry

authors： Mercati O,Huguet G,Danckaert A,André-Leroux G,Maruani A,Bellinzoni M,Rolland T,Gouder L,Mathieu A,Buratti J,Amsellem F,Benabou M,Van-Gils J,Beggiato A,Konyukh M,Bourgeois JP,Gazzellone MJ,Yuen RK,Walker S,Delépine M

更新日期：2017-04-01 00:00:00

abstract：:Signalling by retinoid compounds is vital for embryonic development, with particular importance for neurogenesis in the human brain. Retinoids, metabolites of vitamin A, exert influence over the expression of thousands of transcripts genome wide, and thus, act as master regulators of many important biological processe...

journal_title：Molecular psychiatry

authors： Reay WR,Cairns MJ

更新日期：2020-04-01 00:00:00

abstract：:Identifying biomarkers in schizophrenia during the first episode without the confounding effects of treatment has been challenging. Leveraging these biomarkers to establish diagnosis and make individualized predictions of future treatment responses to antipsychotics would be of great value, but there has been limited ...

journal_title：Molecular psychiatry

authors： Cao B,Cho RY,Chen D,Xiu M,Wang L,Soares JC,Zhang XY

更新日期：2020-04-01 00:00:00

abstract：:In developing his mature concept of hebephrenic dementia praecox (DP) in his 4th (1893) through 6th textbook editions (1899), Kraepelin worked from the hebephrenic syndrome first described by Hecker (1871) and then carefully studied by his student Daraszkiewicz (1892). Working under Kraepelin's supervision, Daraszkiew...

journal_title：Molecular psychiatry

authors： Kendler KS

更新日期：2020-01-01 00:00:00