Differential effects on T-cell function following exposure to serum from schizophrenia smokers.


:Cigarette smoking is more prevalent in subjects with schizophrenia compared to those with other psychiatric disorders or the general population and could therefore affect molecular pathways that impact the pathophysiology of this disorder. As smoking is also known to suppress immune responses, we investigated the effects of 'smoking-conditioned' serum obtained from schizophrenia and control subjects on healthy T cell in vitro. We found that T-cell proliferation was significantly increased following exposure to serum from smoking schizophrenia patients whereas no effect was observed when using serum from smoking control subjects or non-smoking patients and controls. We eliminated the possibility that these effects were due to quantitative differences in cigarette consumption as serum levels of the stable nicotine metabolite cotinine were similar in schizophrenic and control smokers. Molecular characterization showed that serum from patient smokers increased expression of T-cell activation markers CD69(high), CD25(high), co-stimulatory molecules CD26+, CD27+ and CD28+, and decreased T-cell receptor complex components TCRalpha/beta and CD3. Moreover, analysis of supernatants collected after T-cell exposure to serum from smoking patients showed a time-dependent decline in interleukin (IL)-2 levels, suggesting that the proliferation effect is promoted by enhanced IL-2 processing. These results suggest that cigarette smoking has selective effects on serum components that, in turn, lead to altered immune function in schizophrenia patients relative to healthy subjects. Further studies aimed at characterizing these components could result in a better understanding of the onset and aetiology of schizophrenia and potentially lead to novel therapeutic strategies.


Mol Psychiatry


Molecular psychiatry


Herberth M,Krzyszton DN,Koethe D,Craddock MR,Bulger E,Schwarz E,Guest P,Leweke FM,Bahn S




Has Abstract


2010-04-01 00:00:00














  • Correction to: Psychiatric genetics and the structure of psychopathology.

    abstract::In the Table 1 legend, the reference numbers and symbols were not correctly presented in the footnotes. The corrected footnotes are presented below. ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,已发布勘误


    authors: Smoller JW,Andreassen OA,Edenberg HJ,Faraone SV,Glatt SJ,Kendler KS

    更新日期:2019-03-01 00:00:00

  • Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes.

    abstract::Although schizophrenia is generally considered to occur as a consequence of multiple genes that interact with one another, very few methods have been developed to model epistasis. Phenotype definition has also been a major challenge for research on the genetics of schizophrenia. In this report, we use novel statistica...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Andreasen NC,Wilcox MA,Ho BC,Epping E,Ziebell S,Zeien E,Weiss B,Wassink T

    更新日期:2012-11-01 00:00:00

  • Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects.

    abstract::Only in the past decade has a role of heredity in substance abuse been established as a result of extensive twin and family studies. More recently, several candidate genes have been investigated for their possible role in alcoholism and cocaine abuse. Specific genetic factors in opioid substance abuse have not been in...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Kotler M,Cohen H,Segman R,Gritsenko I,Nemanov L,Lerer B,Kramer I,Zer-Zion M,Kletz I,Ebstein RP

    更新日期:1997-05-01 00:00:00

  • Evidence for a role of phospholipase C-gamma1 in the pathogenesis of bipolar disorder.

    abstract::Several studies have indicated that patients with bipolar disorder (BD) who respond well to lithium prophylaxis constitute a biologically distinct subgroup. Lithium is thought to stabilize mood by acting at the phosphoinositide cycle. We have investigated a polymorphism located in the gene (PLCG1) that codes for a gam...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Turecki G,Grof P,Cavazzoni P,Duffy A,Grof E,Ahrens B,Berghöfer A,Müller-Oerlinghausen B,Dvoráková M,Libigerová E,Vojtechovský M,Zvolský P,Joober R,Nilsson A,Prochazka H,Licht RW,Rasmussen NA,Schou M,Vestergaard P,Ho

    更新日期:1998-11-01 00:00:00

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    abstract::Autistic individuals experience significantly elevated rates of childhood trauma, self-harm and suicidal behaviour and ideation (SSBI). Is this purely the result of negative environmental experiences, or does this interact with genetic predisposition? In this study we investigated if a genetic predisposition for autis...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Warrier V,Baron-Cohen S

    更新日期:2019-10-29 00:00:00

  • High throughput fluorescent CE-SSCP SNP genotyping.

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Gonen D,Veenstra-VanderWeele J,Yang Z,Leventhal B,Cook EH Jr

    更新日期:1999-07-01 00:00:00

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Urwin RE,Bennetts B,Wilcken B,Lampropoulos B,Beumont P,Clarke S,Russell J,Tanner S,Nunn KP

    更新日期:2002-01-01 00:00:00

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Yoshida-Hiroi M,Bradbury MJ,Eisenhofer G,Hiroi N,Vale WW,Novotny GE,Hartwig HG,Scherbaum WA,Bornstein SR

    更新日期:2002-01-01 00:00:00

  • The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia.

    abstract::The G-protein coupled metabotropic glutamate receptors (GRMs/mGluRs) have been implicated in the aetiology of schizophrenia as they modulate the NMDA response and that of other neurotransmitters including dopamine and GABA.(1-3) Electrophysiological studies in GRM subtype 5 knockout mice reveal, in one study, a sensor...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Devon RS,Anderson S,Teague PW,Muir WJ,Murray V,Pelosi AJ,Blackwood DH,Porteous DJ

    更新日期:2001-05-01 00:00:00

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Keen-Rhinehart E,Michopoulos V,Toufexis DJ,Martin EI,Nair H,Ressler KJ,Davis M,Owens MJ,Nemeroff CB,Wilson ME

    更新日期:2009-01-01 00:00:00

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审


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    更新日期:1996-11-01 00:00:00

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审


    authors: Hebebrand J,Muller TD,Holtkamp K,Herpertz-Dahlmann B

    更新日期:2007-01-01 00:00:00

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Yoon Y,Voloudakis G,Doran N,Zhang E,Dimovasili C,Chen L,Shao Z,Darmanis S,Tang C,Tang J,Wang VX,Hof PR,Robakis NK,Georgakopoulos A

    更新日期:2020-06-15 00:00:00

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

    更新日期:2020-11-11 00:00:00

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章,meta分析


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    更新日期:2012-06-01 00:00:00

  • Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.

    abstract::The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta, which encode 411, 415 and 431 amino acid proteins and transduce signals via the stimulation of intracellular cAMP production. The recent identification of high-af...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审


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    更新日期:1996-09-01 00:00:00

  • Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5.

    abstract::Attention-deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders. Genetic factors contribute to the underlying liability to develop ADHD. Reports implicate variants of genes important for the synthesis, uptake, transport and receptor binding of dopamine in the etiology of ADHD, ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Kustanovich V,Ishii J,Crawford L,Yang M,McGough JJ,McCracken JT,Smalley SL,Nelson SF

    更新日期:2004-07-01 00:00:00

  • Correction: Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Molecular psychiatry

    pub_type: 已发布勘误


    authors: Haarsma J,Fletcher PC,Griffin JD,Taverne HJ,Ziauddeen H,Spencer TJ,Miller C,Katthagen T,Goodyer I,Diederen KMJ,Murray GK

    更新日期:2020-10-14 00:00:00

  • Advances in molecular genetics of panic disorder.

    abstract::The molecular genetic research on panic disorder (PD) has grown tremendously in the past decade. Although the data from twin and family studies suggest an involvement of genetic factors in the familial transmission of PD with the heritability estimate near 40%, the genetic substrate underlying panicogenesis is not yet...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审


    authors: Maron E,Hettema JM,Shlik J

    更新日期:2010-07-01 00:00:00

  • The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis.

    abstract::Low dietary folate intake has been implicated as a risk factor for depression. However, observational epidemiological studies are plagued by problems of confounding, reverse causality and measurement error. A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,meta分析,评审


    authors: Lewis SJ,Lawlor DA,Davey Smith G,Araya R,Timpson N,Day IN,Ebrahim S

    更新日期:2006-04-01 00:00:00

  • Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial.

    abstract::Folic acid supplementation confers modest benefit in schizophrenia, but its effectiveness is influenced by common genetic variants in the folate pathway that hinder conversion to its active form. We examined physiological and clinical effects of l-methylfolate, the fully reduced and bioactive form of folate, in schizo...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,随机对照试验


    authors: Roffman JL,Petruzzi LJ,Tanner AS,Brown HE,Eryilmaz H,Ho NF,Giegold M,Silverstein NJ,Bottiglieri T,Manoach DS,Smoller JW,Henderson DC,Goff DC

    更新日期:2018-02-01 00:00:00

  • Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatment.

    abstract::Many antidepressants stimulate adult hippocampal neurogenesis, but the mechanisms by which they increase neurogenesis and modulate behavior are incompletely understood. Here we show that hippocampal bone morphogenetic protein (BMP) signaling is modulated by antidepressant treatment, and that the changes in BMP signali...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Brooker SM,Gobeske KT,Chen J,Peng CY,Kessler JA

    更新日期:2017-06-01 00:00:00

  • Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding.

    abstract::Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association is presently unknown. Both diseases are considered protein misfolding disorders associated with...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Moreno-Gonzalez I,Edwards Iii G,Salvadores N,Shahnawaz M,Diaz-Espinoza R,Soto C

    更新日期:2017-09-01 00:00:00

  • The role of adult hippocampal neurogenesis in brain health and disease.

    abstract::Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encod...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审


    authors: Toda T,Parylak SL,Linker SB,Gage FH

    更新日期:2019-01-01 00:00:00

  • A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt.

    abstract::Use of substances such as cannabis, alcohol, and tobacco, has been associated with increased risk of suicide attempt in several observational studies. However, establishing whether these associations are causal is challenging when using observational designs. To evaluate the potential causal contributions of cannabis ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Orri M,Séguin JR,Castellanos-Ryan N,Tremblay RE,Côté SM,Turecki G,Geoffroy MC

    更新日期:2020-06-08 00:00:00

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Futamura T,Toyooka K,Iritani S,Niizato K,Nakamura R,Tsuchiya K,Someya T,Kakita A,Takahashi H,Nawa H

    更新日期:2002-01-01 00:00:00

  • A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication.

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Arcos-Burgos M,Jain M,Acosta MT,Shively S,Stanescu H,Wallis D,Domené S,Vélez JI,Karkera JD,Balog J,Berg K,Kleta R,Gahl WA,Roessler E,Long R,Lie J,Pineda D,Londoño AC,Palacio JD,Arbelaez A,Lopera F,Elia J,Hakon

    更新日期:2010-11-01 00:00:00

  • Dissecting bipolar disorder complexity through epigenomic approach.

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审


    authors: Ludwig B,Dwivedi Y

    更新日期:2016-11-01 00:00:00

  • Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain.

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: González S,Rangel-Barajas C,Peper M,Lorenzo R,Moreno E,Ciruela F,Borycz J,Ortiz J,Lluís C,Franco R,McCormick PJ,Volkow ND,Rubinstein M,Floran B,Ferré S

    更新日期:2012-06-01 00:00:00

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    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: DiSabato DJ,Nemeth DP,Liu X,Witcher KG,O'Neil SM,Oliver B,Bray CE,Sheridan JF,Godbout JP,Quan N

    更新日期:2020-05-22 00:00:00