CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia.

abstract：:The role of innate immunity and microglia in the brain is currently a matter of great debate and controversy. While several studies have provided evidence that they contribute to neurodegeneration in various animal models of brain diseases and traumas, others have shown that their inhibition may in contrast be associa...

journal_title：Molecular psychiatry

authors： Simard AR,Rivest S

更新日期：2006-04-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders. Genetic factors contribute to the underlying liability to develop ADHD. Reports implicate variants of genes important for the synthesis, uptake, transport and receptor binding of dopamine in the etiology of ADHD, ...

journal_title：Molecular psychiatry

authors： Kustanovich V,Ishii J,Crawford L,Yang M,McGough JJ,McCracken JT,Smalley SL,Nelson SF

更新日期：2004-07-01 00:00:00

abstract：:The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene. Although its role in increasing schizophrenia susceptibility has been conflicting, recent studies suggest the valine allele may contribute to poor cognitive function in schizophrenia. V(158)M COMT genotype was obtained ...

journal_title：Molecular psychiatry

authors： Ho BC,Wassink TH,O'Leary DS,Sheffield VC,Andreasen NC

更新日期：2005-03-01 00:00:00

abstract：:In developing his mature concept of hebephrenic dementia praecox (DP) in his 4th (1893) through 6th textbook editions (1899), Kraepelin worked from the hebephrenic syndrome first described by Hecker (1871) and then carefully studied by his student Daraszkiewicz (1892). Working under Kraepelin's supervision, Daraszkiew...

journal_title：Molecular psychiatry

authors： Kendler KS

更新日期：2020-01-01 00:00:00

abstract：:A recent study has suggested a possible association of a polymorphism near the dopamine D5 receptor gene (DRD5) and attention-deficit hyperactivity disorder. The polymorphism studied was a (CA)n repeat located in the cosmid containing the D5 receptor gene2 and the allele that was reported to be associated with attenti...

journal_title：Molecular psychiatry

authors： Barr CL,Wigg KG,Feng Y,Zai G,Malone M,Roberts W,Schachar R,Tannock R,Kennedy JL

更新日期：2000-09-01 00:00:00

abstract：:Psychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors in germ cells. Initial evidence suggested that sperm RNA is causally linked to the transmission of symptoms induced by traumatic experiences. Here, we...

journal_title：Molecular psychiatry

authors： Gapp K,van Steenwyk G,Germain PL,Matsushima W,Rudolph KLM,Manuella F,Roszkowski M,Vernaz G,Ghosh T,Pelczar P,Mansuy IM,Miska EA

更新日期：2020-09-01 00:00:00

abstract：:Significant heterogeneity across aetiologies, neurobiology and clinical phenotypes have been observed in individuals with autism spectrum disorder (ASD). Neuroimaging-based neuroanatomical studies of ASD have often reported inconsistent findings which may, in part, be attributable to an insufficient understanding of t...

journal_title：Molecular psychiatry

authors： Bedford SA,Park MTM,Devenyi GA,Tullo S,Germann J,Patel R,Anagnostou E,Baron-Cohen S,Bullmore ET,Chura LR,Craig MC,Ecker C,Floris DL,Holt RJ,Lenroot R,Lerch JP,Lombardo MV,Murphy DGM,Raznahan A,Ruigrok ANV,Smith E

更新日期：2020-03-01 00:00:00

abstract：:The serotonergic neurons of the dorsal raphe (DR) nucleus in the CNS are involved in fear, anxiety and depression. Depression and anxiety occur quite frequently in postmenopausal women, but estrogen replacement to correct these CNS disorders is at present not favored because estrogen carries with it an increased risk ...

journal_title：Molecular psychiatry

authors： Suzuki H,Barros RP,Sugiyama N,Krishnan V,Yaden BC,Kim HJ,Warner M,Gustafsson JÅ

更新日期：2013-06-01 00:00:00

abstract：:While localizing sensory and motor deficits is one of the cornerstones of clinical neurology, behavioral and cognitive deficits in psychiatry remain impervious to this approach. In psychiatry, major challenges include the relative subtlety by which neural circuits are perturbed, and the limited understanding of how ba...

journal_title：Molecular psychiatry

authors： Schmitt LI,Halassa MM

更新日期：2017-02-01 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) is the most common behavioral disorder in childhood with substantial heritability. Pharmacological and molecular genetic studies as well as characterization of animal models have implicated serotonergic dysfunction in the pathophysiology of ADHD. Here, we investigated th...

journal_title：Molecular psychiatry

authors： Walitza S,Renner TJ,Dempfle A,Konrad K,Wewetzer Ch,Halbach A,Herpertz-Dahlmann B,Remschmidt H,Smidt J,Linder M,Flierl L,Knölker U,Friedel S,Schäfer H,Gross C,Hebebrand J,Warnke A,Lesch KP

更新日期：2005-12-01 00:00:00

abstract：:Several microbes have been suspected as pathogenetic factors in schizophrenia. We have previously observed increased frequencies of chlamydial infections and of human lymphocyte antigen (HLA)-A10 in independent studies of schizophrenia. Our aim here was to analyze frequencies of three types of Chlamydiaceae in schizop...

journal_title：Molecular psychiatry

authors： Fellerhoff B,Laumbacher B,Mueller N,Gu S,Wank R

更新日期：2007-03-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated HPA axis overactivity in major depression, a relationship of HPA axis activity to cognitive performance and a potential role of HPA axis geneti...

journal_title：Molecular psychiatry

authors： Keller J,Gomez R,Williams G,Lembke A,Lazzeroni L,Murphy GM Jr,Schatzberg AF

更新日期：2017-04-01 00:00:00

abstract：:Bipolar disorder (BPD) is characterized by vulnerability to episodic depression and mania and spontaneous cycling. Because of marked advances in candidate-gene and genome-wide association studies, the list of risk genes for BPD is growing rapidly, creating an unprecedented opportunity to understand the pathophysiology...

journal_title：Molecular psychiatry

authors： Chen G,Henter ID,Manji HK

更新日期：2010-09-01 00:00:00

abstract：:Anxiety-related behaviors are closely linked to neural circuits relaying fear-specific information to the amygdala. Many of these circuits, like those underlying processing of innate fear, are remarkably well understood. Recent imaging studies have contributed to this knowledge by discriminating more detailed corticoa...

journal_title：Molecular psychiatry

authors： Brocke B,Armbruster D,Muller J,Hensch T,Jacob CP,Lesch KP,Kirschbaum C,Strobel A

更新日期：2006-12-01 00:00:00

abstract：:Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association is presently unknown. Both diseases are considered protein misfolding disorders associated with...

journal_title：Molecular psychiatry

authors： Moreno-Gonzalez I,Edwards Iii G,Salvadores N,Shahnawaz M,Diaz-Espinoza R,Soto C

更新日期：2017-09-01 00:00:00

abstract：:A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memory reconsolidation represents a potential therapeutic strategy,...

journal_title：Molecular psychiatry

authors： Boury-Jamot B,Carrard A,Martin JL,Halfon O,Magistretti PJ,Boutrel B

更新日期：2016-08-01 00:00:00

abstract：:Given the manifold ways that depression impairs Darwinian fitness, the persistence in the human genome of risk alleles for the disorder remains a much debated mystery. Evolutionary theories that view depressive symptoms as adaptive fail to provide parsimonious explanations for why even mild depressive symptoms impair ...

journal_title：Molecular psychiatry

authors： Raison CL,Miller AH

更新日期：2013-01-01 00:00:00

abstract：:There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. We studied the association of CR...

journal_title：Molecular psychiatry

authors： Licinio J,O'Kirwan F,Irizarry K,Merriman B,Thakur S,Jepson R,Lake S,Tantisira KG,Weiss ST,Wong ML

更新日期：2004-12-01 00:00:00

abstract：:The hippocampus is critical to healthy cognition, yet results in the current study show that action video game players have reduced grey matter within the hippocampus. A subsequent randomised longitudinal training experiment demonstrated that first-person shooting games reduce grey matter within the hippocampus in par...

journal_title：Molecular psychiatry

authors： West GL,Konishi K,Diarra M,Benady-Chorney J,Drisdelle BL,Dahmani L,Sodums DJ,Lepore F,Jolicoeur P,Bohbot VD

更新日期：2018-07-01 00:00:00

abstract：:Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the dynamic plasticity of dendritic spines of pyramidal neurons (PNs) and "en passant" axonal bouton of parvalbumin-expressing interneurons (PVI...

journal_title：Molecular psychiatry

authors： Huang Y,Jiang H,Zheng Q,Fok AHK,Li X,Lau CG,Lai CSW

更新日期：2021-01-20 00:00:00

abstract：:Serotonergic (5HT) neurons exert diverse and widespread functions in the brain. Dysfunction of the serotonergic system gives rise to a variety of mental illnesses including depression, anxiety, obsessive compulsive disorder, autism and eating disorders. Here we show that human primary fibroblasts were directly convert...

journal_title：Molecular psychiatry

authors： Xu Z,Jiang H,Zhong P,Yan Z,Chen S,Feng J

更新日期：2016-01-01 00:00:00

abstract：:Depression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the mono...

journal_title：Molecular psychiatry

authors： Zhou B,Zhu Z,Ransom BR,Tong X

更新日期：2021-01-01 00:00:00

abstract：:Polymorphism in the human dopamine D4 receptor gene (DRD4) exon III has been associated in some but not all studies of the human personality trait of Novelty Seeking. We searched for polymorphisms in the 5' region of DRD4 and identified six polymorphisms as follows: -1217G Ins/Del, -809G/A, -616C/G, -603T Ins/Del, -60...

journal_title：Molecular psychiatry

authors： Okuyama Y,Ishiguro H,Nankai M,Shibuya H,Watanabe A,Arinami T

更新日期：2000-01-01 00:00:00

abstract：:The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such l...

journal_title：Molecular psychiatry

authors： Vélez JI,Chandrasekharappa SC,Henao E,Martinez AF,Harper U,Jones M,Solomon BD,Lopez L,Garcia G,Aguirre-Acevedo DC,Acosta-Baena N,Correa JC,Lopera-Gómez CM,Jaramillo-Elorza MC,Rivera D,Kosik KS,Schork NJ,Swanson JM,Lop

更新日期：2013-05-01 00:00:00

abstract：:We conducted a 10 centimorgan (cM) linkage genome scan in a set of American extended pedigrees ascertained through probands with panic disorder. Several anxiety disorders segregate in these families. In this article, we describe results for simple phobia from 14 of these families (including 129 subjects of whom 57 are...

journal_title：Molecular psychiatry

authors： Gelernter J,Page GP,Bonvicini K,Woods SW,Pauls DL,Kruger S

更新日期：2003-01-01 00:00:00

abstract：:Recent studies report association and linkage between attention deficit hyperactivity disorder (ADHD) and the 7-repeat allele of a 48 base-pair repeat in the dopamine D4 receptor gene (DRD4). We examined the frequency of this allele in a sample of probands with DSM-IV ADHD using a case-control design, as well as the t...

journal_title：Molecular psychiatry

authors： Mill J,Curran S,Kent L,Richards S,Gould A,Virdee V,Huckett L,Sharp J,Batten C,Fernando S,Simanoff E,Thompson M,Zhao J,Sham P,Taylor E,Asherson P

更新日期：2001-07-01 00:00:00

abstract：:The network theory conceptualizes mental disorders as complex networks of symptoms influencing each other by creating feedback loops, leading to a self-sustained syndromic constellation. Symptoms central to the network have the greatest impact in sustaining the rest of symptoms. This analysis focused on the network st...

journal_title：Molecular psychiatry

authors： Belvederi Murri M,Amore M,Respino M,Alexopoulos GS

更新日期：2020-07-01 00:00:00

abstract：:Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy number variations (CNVs) in SCZ cases and identified multiple rare recurrent CNVs that increase risk of SCZ although with incomplete penetranc...

journal_title：Molecular psychiatry

authors： Szatkiewicz JP,O'Dushlaine C,Chen G,Chambert K,Moran JL,Neale BM,Fromer M,Ruderfer D,Akterin S,Bergen SE,Kähler A,Magnusson PK,Kim Y,Crowley JJ,Rees E,Kirov G,O'Donovan MC,Owen MJ,Walters J,Scolnick E,Sklar P,Pu

更新日期：2014-07-01 00:00:00

abstract：:Several studies have indicated that patients with bipolar disorder (BD) who respond well to lithium prophylaxis constitute a biologically distinct subgroup. Lithium is thought to stabilize mood by acting at the phosphoinositide cycle. We have investigated a polymorphism located in the gene (PLCG1) that codes for a gam...

journal_title：Molecular psychiatry

authors： Turecki G,Grof P,Cavazzoni P,Duffy A,Grof E,Ahrens B,Berghöfer A,Müller-Oerlinghausen B,Dvoráková M,Libigerová E,Vojtechovský M,Zvolský P,Joober R,Nilsson A,Prochazka H,Licht RW,Rasmussen NA,Schou M,Vestergaard P,Ho

更新日期：1998-11-01 00:00:00

abstract：:Depression often accompanies the perimenopausal transition and it often precedes overt symptomology in common neurodegenerative diseases (NDDs, such as Alzheimer's, Parkinson's, Huntington, amyotrophic lateral sclerosis). Serotonin dysfunction is frequently found in the different etiologies of depression. We have show...

journal_title：Molecular psychiatry

authors： Bethea CL,Reddy AP

更新日期：2015-12-01 00:00:00