Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood.

abstract：:We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of p...

journal_title：Molecular psychiatry

authors： Niculescu AB,Le-Niculescu H,Levey DF,Roseberry K,Soe KC,Rogers J,Khan F,Jones T,Judd S,McCormick MA,Wessel AR,Williams A,Kurian SM,White FA

更新日期：2019-04-01 00:00:00

abstract：:Studies using tissue obtained at autopsy suggest that changes in cholinergic neurons could be important in the pathology of schizophrenia.1-4 We have previously reported a decrease in [3H]pirenzepine binding5 and [3H]AF-DX 384 binding6 to caudate-putamen (CP) from subjects who had schizophrenia. Under the conditions c...

journal_title：Molecular psychiatry

authors： Dean B,Crook JM,Pavey G,Opeskin K,Copolov DL

更新日期：2000-03-01 00:00:00

abstract：:Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D-serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of schizophrenia and other psychiatric disorders. In the present study, we demonstrate that these two pathways intersect with behavioral consequences. DISC1 binds to and stabili...

journal_title：Molecular psychiatry

authors： Ma TM,Abazyan S,Abazyan B,Nomura J,Yang C,Seshadri S,Sawa A,Snyder SH,Pletnikov MV

更新日期：2013-05-01 00:00:00

abstract：:The endogenous opioid system, which alleviates physical pain, is also known to regulate social distress and reward in animal models. To test this hypothesis in humans (n=18), we used an μ-opioid receptor (MOR) radiotracer to measure changes in MOR availability in vivo with positron emission tomography during social re...

journal_title：Molecular psychiatry

authors： Hsu DT,Sanford BJ,Meyers KK,Love TM,Hazlett KE,Wang H,Ni L,Walker SJ,Mickey BJ,Korycinski ST,Koeppe RA,Crocker JK,Langenecker SA,Zubieta JK

更新日期：2013-11-01 00:00:00

abstract：:Poorly regulated reward seeking is a central feature of substance use disorder. Recent research shows that rewarding drug-related experiences induce synchronous activation of a discrete number of neurons in the nucleus accumbens that are causally linked to reward-related contexts. Here we comprehensively characterize ...

journal_title：Molecular psychiatry

authors： Bobadilla AC,Dereschewitz E,Vaccaro L,Heinsbroek JA,Scofield MD,Kalivas PW

更新日期：2020-12-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA(A)) receptors are thought to play an important role in modulating the central nervous system in response to stress. Animal data have shown alterations in the GABA(A) receptor complex by uncontrollable stressors. SPECT imaging with benzodiazepine ligands showed lower distribution volumes o...

journal_title：Molecular psychiatry

authors： Geuze E,van Berckel BN,Lammertsma AA,Boellaard R,de Kloet CS,Vermetten E,Westenberg HG

更新日期：2008-01-01 00:00:00

abstract：:Acetylcholinesterase (AChE), the enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, has been implicated in non-cholinergic actions which may play a role in neurodegenerative diseases such as Alzheimer's disease. To study the potential cytotoxicity of brain AChE, the effects of affinity purified A...

journal_title：Molecular psychiatry

authors： Calderón FH,von Bernhardi R,De Ferrari G,Luza S,Aldunate R,Inestrosa NC

更新日期：1998-05-01 00:00:00

abstract：:Traumatic life experiences are associated with alcohol use problems, an association that is likely to be moderated by genetic predisposition. To understand these interactions, we conducted a gene-by-environment genome-wide interaction study (GEWIS) of alcohol use problems in two independent samples, the Army STARRS (S...

journal_title：Molecular psychiatry

authors： Polimanti R,Kaufman J,Zhao H,Kranzler HR,Ursano RJ,Kessler RC,Gelernter J,Stein MB

更新日期：2018-01-01 00:00:00

abstract：:With the advent of technologies that allow simultaneous genotyping of thousands of single-nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex diseases can be explored at an unprecedented detail. This study is among the first to apply the genome-wide association study (GWAS) approach...

journal_title：Molecular psychiatry

authors： Feulner TM,Laws SM,Friedrich P,Wagenpfeil S,Wurst SH,Riehle C,Kuhn KA,Krawczak M,Schreiber S,Nikolaus S,Förstl H,Kurz A,Riemenschneider M

更新日期：2010-07-01 00:00:00

abstract：:Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncoding RNAs. RNA-binding protein (RBP) is a key factor of the regulation. Regulator of calcineurin 1 (RCAN1) is a multifunctional protein involved in neurodegeneration, mit...

journal_title：Molecular psychiatry

authors： Yun Y,Zhang Y,Zhang C,Huang L,Tan S,Wang P,Vilariño-Gúell C,Song W,Sun X

更新日期：2019-08-27 00:00:00

abstract：:Given the manifold ways that depression impairs Darwinian fitness, the persistence in the human genome of risk alleles for the disorder remains a much debated mystery. Evolutionary theories that view depressive symptoms as adaptive fail to provide parsimonious explanations for why even mild depressive symptoms impair ...

journal_title：Molecular psychiatry

authors： Raison CL,Miller AH

更新日期：2013-01-01 00:00:00

abstract：:Neurobiological disorders have diverse manifestations and symptomology. Neurodegenerative disorders, such as Alzheimer's disease, manifest late in life and are characterized by, among other symptoms, progressive loss of synaptic markers. Developmental disorders, such as autism spectrum, appear in childhood. Neuropsych...

journal_title：Molecular psychiatry

authors： Lahiri DK,Maloney B,Zawia NH

更新日期：2009-11-01 00:00:00

abstract：:The lack of strong association between brain beta-amyloid deposition and cognitive impairment has been a challenge for the Alzheimer's disease (AD) field. Although beta-amyloid is necessary for the pathologic diagnosis of AD, it is not sufficient to make the pathologic diagnosis or cause dementia. We sought to identif...

journal_title：Molecular psychiatry

authors： Roostaei T,Nazeri A,Felsky D,De Jager PL,Schneider JA,Pollock BG,Bennett DA,Voineskos AN,Alzheimer’s Disease Neuroimaging Initiative (ADNI).

更新日期：2017-02-01 00:00:00

abstract：:Intellectual disability (ID) is a measurable phenotypic consequence of genetic and environmental factors. In this study, we prospectively assessed the diagnostic yield of genomic tools (molecular karyotyping, multi-gene panel and exome sequencing) in a cohort of 337 ID subjects as a first-tier test and compared it wit...

journal_title：Molecular psychiatry

authors： Anazi S,Maddirevula S,Faqeih E,Alsedairy H,Alzahrani F,Shamseldin HE,Patel N,Hashem M,Ibrahim N,Abdulwahab F,Ewida N,Alsaif HS,Al Sharif H,Alamoudi W,Kentab A,Bashiri FA,Alnaser M,AlWadei AH,Alfadhel M,Eyaid W,Has

更新日期：2017-04-01 00:00:00

abstract：:Corticotropin-releasing hormone (CRH) is the principal regulator of the hypothalamic-pituitary-adrenal (HPA) axis and an activator of the sympathoadrenal (SA) and systemic sympathetic (SS) systems. Mental disorders, including major depression and, more recently, Alzheimer's disease have been associated with dysregulat...

journal_title：Molecular psychiatry

authors： Willenberg HS,Bornstein SR,Hiroi N,Päth G,Goretzki PE,Scherbaum WA,Chrousos GP

更新日期：2000-03-01 00:00:00

abstract：:We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...

journal_title：Molecular psychiatry

authors： Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

更新日期：2020-11-11 00:00:00

abstract：:This Article was originally published under Nature Research's License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the Article have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Perry A,Roberts G,Mitchell PB,Breakspear M

更新日期：2019-09-01 00:00:00

abstract：:The long alleles (> or =6 repeats) of the dopamine D4 dopamine receptor exon III polymorphism have been linked in some, but not all, studies to Novelty Seeking (NS), one of four personality traits defined by Cloninger's tridimensional personality questionnarie (TPQ). In order to further examine the robustness of our o...

journal_title：Molecular psychiatry

authors： Ebstein RP,Nemanov L,Klotz I,Gritsenko I,Belmaker RH

更新日期：1997-10-01 00:00:00

abstract：:The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed within the central nervous system. Previous work showed that this protein is upregulated in Alzheimer's disease (AD), and plays an active role in the development of brain amyloidosis in amyloid beta (Aβ)-precursor protein transgenic mice (Tg2576). In the pr...

journal_title：Molecular psychiatry

authors： Chu J,Li JG,Giannopoulos PF,Blass BE,Childers W,Abou-Gharbia M,Praticò D

更新日期：2015-11-01 00:00:00

abstract：:Folate receptor alpha (FRα) autoantibodies have been associated with fetal abnormalities and cerebral folate deficiency-related developmental disorders. Over 70% of the children with autism spectrum disorders (ASD) are positive for these autoantibodies and high-dose folinic acid is beneficial in treating these childre...

journal_title：Molecular psychiatry

authors： Desai A,Sequeira JM,Quadros EV

更新日期：2017-09-01 00:00:00

abstract：:APAF1, encoding the protein apoptosis protease activating factor 1 (Apaf-1), has recently been established as a chromosome 12 gene conferring predisposition to major depression in humans. The molecular phenotypes of Apaf-1 variants were determined by in vitro reconstruction of the apoptosome complex in which Apaf-1 ac...

journal_title：Molecular psychiatry

authors： Harlan J,Chen Y,Gubbins E,Mueller R,Roch JM,Walter K,Lake M,Olsen T,Metzger P,Dorwin S,Ladror U,Egan DA,Severin J,Johnson RW,Holzman TF,Voelp K,Davenport C,Beck A,Potter J,Gopalakrishnan M,Hahn A,Spear BB,Halb

更新日期：2006-01-01 00:00:00

abstract：:Several microbes have been suspected as pathogenetic factors in schizophrenia. We have previously observed increased frequencies of chlamydial infections and of human lymphocyte antigen (HLA)-A10 in independent studies of schizophrenia. Our aim here was to analyze frequencies of three types of Chlamydiaceae in schizop...

journal_title：Molecular psychiatry

authors： Fellerhoff B,Laumbacher B,Mueller N,Gu S,Wank R

更新日期：2007-03-01 00:00:00

abstract：:Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-inv...

journal_title：Molecular psychiatry

authors： Hadar R,Winter R,Edemann-Callesen H,Wieske F,Habelt B,Khadka N,Felgel-Farnholz V,Barroeta-Hlusicka E,Reis J,Tatarau CA,Funke K,Fritsch B,Bernhardt N,Bikson M,Nitsche MA,Winter C

更新日期：2020-04-01 00:00:00

abstract：:Polymorphism in the human dopamine D4 receptor gene (DRD4) exon III has been associated in some but not all studies of the human personality trait of Novelty Seeking. We searched for polymorphisms in the 5' region of DRD4 and identified six polymorphisms as follows: -1217G Ins/Del, -809G/A, -616C/G, -603T Ins/Del, -60...

journal_title：Molecular psychiatry

authors： Okuyama Y,Ishiguro H,Nankai M,Shibuya H,Watanabe A,Arinami T

更新日期：2000-01-01 00:00:00

abstract：:Anxiety-related behaviors are closely linked to neural circuits relaying fear-specific information to the amygdala. Many of these circuits, like those underlying processing of innate fear, are remarkably well understood. Recent imaging studies have contributed to this knowledge by discriminating more detailed corticoa...

journal_title：Molecular psychiatry

authors： Brocke B,Armbruster D,Muller J,Hensch T,Jacob CP,Lesch KP,Kirschbaum C,Strobel A

更新日期：2006-12-01 00:00:00

abstract：:The serotonergic neurotransmitter system has been widely implicated in the pathophysiology of mood-related disorders such as anxiety and major depressive disorder (MDD). The onset of therapeutic efficacy of traditional antidepressants is delayed by several weeks. The 5-HT4 receptor has emerged as a new therapeutic tar...

journal_title：Molecular psychiatry

authors： Castello J,LeFrancois B,Flajolet M,Greengard P,Friedman E,Rebholz H

更新日期：2018-04-01 00:00:00

abstract：:Association between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of the dopamine transporter gene (DAT1) has been reported in independent clinical samples using a categorical clinical definition of ADHD. The present study adopts a quantitative trait loci (QTL) approach to examine the associ...

journal_title：Molecular psychiatry

authors： Cornish KM,Manly T,Savage R,Swanson J,Morisano D,Butler N,Grant C,Cross G,Bentley L,Hollis CP

更新日期：2005-07-01 00:00:00

abstract：:Exposure to severe stressors increases the risk for psychiatric disorders in vulnerable individuals, but can lead to positive outcomes for others. However, it remains unknown how severe stress affects neural functioning in humans and what factors mediate individual differences in the neural sequelae of stress. The amy...

journal_title：Molecular psychiatry

authors： van Wingen GA,Geuze E,Vermetten E,Fernández G

更新日期：2011-06-01 00:00:00

abstract：:Converging advances in the fields of molecular biology, molecular genetics, cellular biology and embryology have given researchers the tools for the targeted delivery and stable germline transmission of foreign genes (transgenes) in the mouse. In the realm of neuropsychiatry, this so-named transgenic technology has be...

journal_title：Molecular psychiatry

authors： Campbell IL,Gold LH

更新日期：1996-05-01 00:00:00

abstract：:Delivery of drugs into the brain is poor due to the blood brain barrier (BBB). This study describes the development of a novel liposome-based brain-targeting drug delivery system. The liposomes incorporate a diacylglycerol moiety coupled through a linker to a peptide of 5 amino acids selected from amyloid precursor pr...

journal_title：Molecular psychiatry

authors： Kahana M,Weizman A,Gabay M,Loboda Y,Segal-Gavish H,Gavish A,Barhum Y,Offen D,Finberg J,Allon N,Gavish M

更新日期：2020-05-05 00:00:00