Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22.

abstract：:Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underp...

journal_title：Molecular psychiatry

authors： Luykx JJ,Bakker SC,Lentjes E,Neeleman M,Strengman E,Mentink L,DeYoung J,de Jong S,Sul JH,Eskin E,van Eijk K,van Setten J,Buizer-Voskamp JE,Cantor RM,Lu A,van Amerongen M,van Dongen EP,Keijzers P,Kappen T,Borgdorff P

更新日期：2014-02-01 00:00:00

abstract：:Recent studies report association and linkage between attention deficit hyperactivity disorder (ADHD) and the 7-repeat allele of a 48 base-pair repeat in the dopamine D4 receptor gene (DRD4). We examined the frequency of this allele in a sample of probands with DSM-IV ADHD using a case-control design, as well as the t...

journal_title：Molecular psychiatry

authors： Mill J,Curran S,Kent L,Richards S,Gould A,Virdee V,Huckett L,Sharp J,Batten C,Fernando S,Simanoff E,Thompson M,Zhao J,Sham P,Taylor E,Asherson P

更新日期：2001-07-01 00:00:00

abstract：:Dysthymia is characterized by long-lasting periods of lowered mood. Epidemiological studies in the USA and Europe have demonstrated that the prevalence of dysthymia is at least 3% of the general population. Its pervasive occurrence makes dysthymia a public health problem worldwide. One feature of this disorder is its ...

journal_title：Molecular psychiatry

authors： Akiskal HS,Bolis CL,Cazzullo C,Costa e Silva JA,Gentil V,Lecrubier Y,Licinio J,Linden M,Lopez-Ibor JJ,Ndiaye IP,Pani L,Prilipko L,Robertson MM,Robinson RG,Starkstein SE,Thomas P,Wang Y,Wong ML

更新日期：1996-12-01 00:00:00

abstract：:Between 1997 and 2002, 48 data sets from the hippocampus were produced on samples from the Stanley Neuropathology Consortium. From these data sets, 224 total measures were available from the various subdivisions of the hippocampus. An integrative analysis of these measures was performed using a multivariate, nonparame...

journal_title：Molecular psychiatry

authors： Knable MB,Barci BM,Webster MJ,Meador-Woodruff J,Torrey EF,Stanley Neuropathology Consortium.

更新日期：2004-06-01 00:00:00

abstract：:Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship with psychotic symptoms. The 22q11.2 deletion syndrome (22q11DS) has proven to be a remarkable model for the pro...

journal_title：Molecular psychiatry

authors： Mancini V,Sandini C,Padula MC,Zöller D,Schneider M,Schaer M,Eliez S

更新日期：2020-11-01 00:00:00

abstract：:Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations betwee...

journal_title：Molecular psychiatry

authors： Sammallahti S,Cortes Hidalgo AP,Tuominen S,Malmberg A,Mulder RH,Brunst KJ,Alemany S,McBride NS,Yousefi P,Heiss JA,McRae N,Page CM,Jin J,Pesce G,Caramaschi D,Rifas-Shiman SL,Koen N,Adams CD,Magnus MC,Baïz N,Ratanat

更新日期：2021-01-07 00:00:00

abstract：:Various neuropathological findings have been reported in bipolar disorder (BD). However, it is unclear which findings are well established. To address this gap, we carried out a systematic review of the literature. We searched over 5000 publications, identifying 103 data papers, of which 81 were eligible for inclusion...

journal_title：Molecular psychiatry

authors： Harrison PJ,Colbourne L,Harrison CH

更新日期：2020-08-01 00:00:00

abstract：:The search for genetic factors predisposing to Attention Deficit Hyperactivity Disorder (ADHD) has focused on genes that regulate dopaminergic pathways such as dopamine receptors and enzymes that regulate levels of dopamine in the synapse. There have been several reports of association between ADHD and polymorphic var...

journal_title：Molecular psychiatry

authors： Tahir E,Yazgan Y,Cirakoglu B,Ozbay F,Waldman I,Asherson PJ

更新日期：2000-07-01 00:00:00

abstract：:Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation, making them highly useful adjuncts to animal models. Here, we ex...

journal_title：Molecular psychiatry

authors： Konopka G,Wexler E,Rosen E,Mukamel Z,Osborn GE,Chen L,Lu D,Gao F,Gao K,Lowe JK,Geschwind DH

更新日期：2012-02-01 00:00:00

abstract：:Significant evidence for linkage between bipolar affective disorder and markers on chromosome 4p16 has been reported in Scottish families. Linkage analyses using 16 DNA markers covering more than 50 cM from chromosome 4pter-4p12, including candidate genes encoding the dopamine D5 receptor and an adrenergic receptor (2...

journal_title：Molecular psychiatry

authors： Ewald H,Degn B,Mors O,Kruse TA

更新日期：1998-09-01 00:00:00

abstract：:Amyloid-β peptide (Aβ) accumulation in the brain is a hallmark of Alzheimer's Disease. An important mechanism of Aβ clearance in the brain is uptake and degradation by microglia. Presenilin 1 (PS1) is the catalytic subunit of γ-secretase, an enzyme complex responsible for the maturation of multiple substrates, such as...

journal_title：Molecular psychiatry

authors： Ledo JH,Liebmann T,Zhang R,Chang JC,Azevedo EP,Wong E,Silva HM,Troyanskaya OG,Bustos V,Greengard P

更新日期：2020-08-13 00:00:00

abstract：:Association between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of the dopamine transporter gene (DAT1) has been reported in independent clinical samples using a categorical clinical definition of ADHD. The present study adopts a quantitative trait loci (QTL) approach to examine the associ...

journal_title：Molecular psychiatry

authors： Cornish KM,Manly T,Savage R,Swanson J,Morisano D,Butler N,Grant C,Cross G,Bentley L,Hollis CP

更新日期：2005-07-01 00:00:00

abstract：:Corticotropin-releasing hormone (CRH) is the principal regulator of the hypothalamic-pituitary-adrenal (HPA) axis and an activator of the sympathoadrenal (SA) and systemic sympathetic (SS) systems. Mental disorders, including major depression and, more recently, Alzheimer's disease have been associated with dysregulat...

journal_title：Molecular psychiatry

authors： Willenberg HS,Bornstein SR,Hiroi N,Päth G,Goretzki PE,Scherbaum WA,Chrousos GP

更新日期：2000-03-01 00:00:00

abstract：:Previous studies have implicated DTNBP1 as a schizophrenia susceptibility gene and its encoded protein, dysbindin, as a potential regulator of synaptic vesicle physiology. In this study, we found that endogenous levels of the dysbindin protein in the mouse brain are developmentally regulated, with higher levels observ...

journal_title：Molecular psychiatry

authors： Ghiani CA,Starcevic M,Rodriguez-Fernandez IA,Nazarian R,Cheli VT,Chan LN,Malvar JS,de Vellis J,Sabatti C,Dell'Angelica EC

更新日期：2010-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is associated with neuropathology in patients with impaired immunity and/or inflammatory diseases. However, the association between gray matter volume (GMV) and HCMV has never been examined in major depressive disorder (MDD) despite the presence of inflammation and impaired viral...

journal_title：Molecular psychiatry

authors： Zheng H,Ford BN,Bergamino M,Kuplicki R,Tulsa 1000 Investigators.,Hunt PW,Bodurka J,Teague TK,Irwin MR,Yolken RH,Paulus MP,Savitz J

更新日期：2020-11-22 00:00:00

abstract：:The astrocytic cystine/glutamate antiporter system xc- represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance in brain physiology remain incompletely understood. Employing slice electrophysiology a...

journal_title：Molecular psychiatry

authors： Bentea E,Villers A,Moore C,Funk AJ,O'Donovan SM,Verbruggen L,Lara O,Janssen P,De Pauw L,Declerck NB,DePasquale EAK,Churchill MJ,Sato H,Hermans E,Arckens L,Meshul CK,Ris L,McCullumsmith RE,Massie A

更新日期：2020-05-04 00:00:00

abstract：:A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is a...

journal_title：Molecular psychiatry

authors： Wollmer MA,Streffer JR,Tsolaki M,Grimaldi LM,Lütjohann D,Thal D,von Bergmann K,Nitsch RM,Hock C,Papassotiropoulos A

更新日期：2003-06-01 00:00:00

abstract：:Leptin is a hormone with pleiotropic functions affecting several tissues. Because leptin has a crucial role in the adaptation of an organism to semi-starvation, anorexia nervosa (AN) serves as a model disorder to elucidate the functional implications of hypoleptinaemia; vice versa, several symptoms in patients with th...

journal_title：Molecular psychiatry

authors： Hebebrand J,Muller TD,Holtkamp K,Herpertz-Dahlmann B

更新日期：2007-01-01 00:00:00

abstract：:We posit in this article that hierarchical temporal processing deficit is the underlying basis of reality distortion and psychoses. Schizophrenia is a prototypical reality distortion disorder in which the patient manifests with auditory hallucinations, delusions, disorganized speech and thinking, cognitive impairment,...

journal_title：Molecular psychiatry

authors： Krishnan RR,Fivaz M,Kraus MS,Keefe RS

更新日期：2011-02-01 00:00:00

abstract：:Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...

journal_title：Molecular psychiatry

authors： Wedenoja J,Loukola A,Tuulio-Henriksson A,Paunio T,Ekelund J,Silander K,Varilo T,Heikkilä K,Suvisaari J,Partonen T,Lönnqvist J,Peltonen L

更新日期：2008-07-01 00:00:00

abstract：:Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each transmitter in the regulatio...

journal_title：Molecular psychiatry

authors： Sakae DY,Marti F,Lecca S,Vorspan F,Martín-García E,Morel LJ,Henrion A,Gutiérrez-Cuesta J,Besnard A,Heck N,Herzog E,Bolte S,Prado VF,Prado MA,Bellivier F,Eap CB,Crettol S,Vanhoutte P,Caboche J,Gratton A,Moquin L,

更新日期：2015-11-01 00:00:00

abstract：:Bipolar disorder (BPD) is characterized by vulnerability to episodic depression and mania and spontaneous cycling. Because of marked advances in candidate-gene and genome-wide association studies, the list of risk genes for BPD is growing rapidly, creating an unprecedented opportunity to understand the pathophysiology...

journal_title：Molecular psychiatry

authors： Chen G,Henter ID,Manji HK

更新日期：2010-09-01 00:00:00

abstract：:Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of Polg1, a mitochondrial DNA (mtDNA...

journal_title：Molecular psychiatry

authors： Kasahara T,Takata A,Kato TM,Kubota-Sakashita M,Sawada T,Kakita A,Mizukami H,Kaneda D,Ozawa K,Kato T

更新日期：2016-01-01 00:00:00

abstract：:Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ~1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated association of genetic variants in expert-curated synaptic gene groups with schizophrenia in 4673 ca...

journal_title：Molecular psychiatry

authors： Lips ES,Cornelisse LN,Toonen RF,Min JL,Hultman CM,International Schizophrenia Consortium.,Holmans PA,O'Donovan MC,Purcell SM,Smit AB,Verhage M,Sullivan PF,Visscher PM,Posthuma D

更新日期：2012-10-01 00:00:00

abstract：:The Wistar-Kyoto (WKY) rat strain demonstrates endogenous hormonal and behavioral abnormalities that emulate many of those found in symptom-presenting depressive patients. Evidence suggests that the WKY strain may harbor heterogeneity not found in other inbred strains, including greater behavioral and genetic variabil...

journal_title：Molecular psychiatry

authors： Will CC,Aird F,Redei EE

更新日期：2003-11-01 00:00:00

abstract：:We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...

journal_title：Molecular psychiatry

authors： Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

更新日期：2020-11-11 00:00:00

abstract：:Although schizophrenia is generally considered to occur as a consequence of multiple genes that interact with one another, very few methods have been developed to model epistasis. Phenotype definition has also been a major challenge for research on the genetics of schizophrenia. In this report, we use novel statistica...

journal_title：Molecular psychiatry

authors： Andreasen NC,Wilcox MA,Ho BC,Epping E,Ziebell S,Zeien E,Weiss B,Wassink T

更新日期：2012-11-01 00:00:00

abstract：:Accumulating research demonstrates the potential of intranasal delivery of psychopharmacological agents to treat a range of psychiatric disorders and symptoms. It is believed that intranasal administration offers both direct and indirect pathways to deliver psychopharmacological agents to the central nervous system. T...

journal_title：Molecular psychiatry

authors： Quintana DS,Guastella AJ,Westlye LT,Andreassen OA

更新日期：2016-01-01 00:00:00

abstract：:Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with ...

journal_title：Molecular psychiatry

authors： Coleman JRI,Bryois J,Gaspar HA,Jansen PR,Savage JE,Skene N,Plomin R,Muñoz-Manchado AB,Linnarsson S,Crawford G,Hjerling-Leffler J,Sullivan PF,Posthuma D,Breen G

更新日期：2019-02-01 00:00:00

abstract：:Traumatic life experiences are associated with alcohol use problems, an association that is likely to be moderated by genetic predisposition. To understand these interactions, we conducted a gene-by-environment genome-wide interaction study (GEWIS) of alcohol use problems in two independent samples, the Army STARRS (S...

journal_title：Molecular psychiatry

authors： Polimanti R,Kaufman J,Zhao H,Kranzler HR,Ursano RJ,Kessler RC,Gelernter J,Stein MB

更新日期：2018-01-01 00:00:00