Anorexia nervosa (restrictive subtype) is associated with a polymorphism in the novel norepinephrine transporter gene promoter polymorphic region.

abstract：:Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with ...

journal_title：Molecular psychiatry

authors： Coleman JRI,Bryois J,Gaspar HA,Jansen PR,Savage JE,Skene N,Plomin R,Muñoz-Manchado AB,Linnarsson S,Crawford G,Hjerling-Leffler J,Sullivan PF,Posthuma D,Breen G

更新日期：2019-02-01 00:00:00

abstract：:Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underp...

journal_title：Molecular psychiatry

authors： Luykx JJ,Bakker SC,Lentjes E,Neeleman M,Strengman E,Mentink L,DeYoung J,de Jong S,Sul JH,Eskin E,van Eijk K,van Setten J,Buizer-Voskamp JE,Cantor RM,Lu A,van Amerongen M,van Dongen EP,Keijzers P,Kappen T,Borgdorff P

更新日期：2014-02-01 00:00:00

abstract：:We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. Expression of LIM was decreased in the lymphoblastoid cells derived from patients with bipolar disorders and schizophrenia. LI...

journal_title：Molecular psychiatry

authors： Kato T,Iwayama Y,Kakiuchi C,Iwamoto K,Yamada K,Minabe Y,Nakamura K,Mori N,Fujii K,Nanko S,Yoshikawa T

更新日期：2005-11-01 00:00:00

abstract：:The s allele variant of the serotonin transporter gene (5-HTT) has recently been observed to moderate the relationship of stress to depression and anxiety. To date no study has considered interactive effects of 5-HTT genotype, stress and hypothalamic-pituitary-adrenal (HPA) function on cognition in healthy, older adul...

journal_title：Molecular psychiatry

authors： O'Hara R,Schröder CM,Mahadevan R,Schatzberg AF,Lindley S,Fox S,Weiner M,Kraemer HC,Noda A,Lin X,Gray HL,Hallmayer JF

更新日期：2007-06-01 00:00:00

abstract：:Genetic variation underlying hypothalamic pituitary adrenal (HPA) axis overactivity in healthy controls (HCs) and patients with severe forms of major depression has not been well explored, but could explain risk for cortisol dysregulation. In total, 95 participants were studied: 40 patients with psychotic major depres...

journal_title：Molecular psychiatry

authors： Schatzberg AF,Keller J,Tennakoon L,Lembke A,Williams G,Kraemer FB,Sarginson JE,Lazzeroni LC,Murphy GM

更新日期：2014-02-01 00:00:00

abstract：:The glutamate hypothesis of schizophrenia derived from evidence that phencyclidine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, produces schizophrenia-like symptoms in healthy humans. Sensorimotor gating, measured by prepulse inhibition (PPI), is a fundamental form of information processing that is defici...

journal_title：Molecular psychiatry

authors： Brody SA,Dulawa SC,Conquet F,Geyer MA

更新日期：2004-01-01 00:00:00

abstract：:Advances in genomics are opening new windows into the biology of schizophrenia. Though common variants individually have small effects on disease risk, GWAS provide a powerful opportunity to explore pathways and mechanisms contributing to pathophysiology. Here, we highlight an underappreciated biological theme emergin...

journal_title：Molecular psychiatry

authors： Mealer RG,Williams SE,Daly MJ,Scolnick EM,Cummings RD,Smoller JW

更新日期：2020-12-01 00:00:00

abstract：:Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABAARs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsant and hypnotic effec...

journal_title：Molecular psychiatry

authors： Nicholson MW,Sweeney A,Pekle E,Alam S,Ali AB,Duchen M,Jovanovic JN

更新日期：2018-09-01 00:00:00

abstract：:Cannabis is one of the most commonly and widely used psychoactive drugs. The rates of cannabis misuse have been increasing. Therefore, understanding the effects of cannabis use on the brain is important. Adolescent and adult rodents exposed to repeated administration of cannabinoids show persistent microstructural cha...

journal_title：Molecular psychiatry

authors： D'Souza DC,Radhakrishnan R,Naganawa M,Ganesh S,Nabulsi N,Najafzadeh S,Ropchan J,Ranganathan M,Cortes-Briones J,Huang Y,Carson RE,Skosnik P

更新日期：2020-09-24 00:00:00

abstract：:Anxiety and depression are devastating mental illnesses that are a significant public health concern. Selective serotonin-reuptake inhibitors are the first-line treatment strategy for these disorders, which despite being a significant advantage over older treatments, are hampered by a limited efficacy in a significant...

journal_title：Molecular psychiatry

authors： O'Connor RM,Dinan TG,Cryan JF

更新日期：2012-04-01 00:00:00

abstract：:Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation, making them highly useful adjuncts to animal models. Here, we ex...

journal_title：Molecular psychiatry

authors： Konopka G,Wexler E,Rosen E,Mukamel Z,Osborn GE,Chen L,Lu D,Gao F,Gao K,Lowe JK,Geschwind DH

更新日期：2012-02-01 00:00:00

abstract：:Genetic factors do not fully account for the relatively high heritability of neurodevelopmental conditions, suggesting that non-genetic heritable factors contribute to their etiology. To evaluate the potential contribution of aberrant thyroid hormone status to the epigenetic inheritance of neurological phenotypes, we ...

journal_title：Molecular psychiatry

authors： Martinez ME,Duarte CW,Stohn JP,Karaczyn A,Wu Z,DeMambro VE,Hernandez A

更新日期：2020-05-01 00:00:00

abstract：:Mental disorders cause more disability than any other class of medical illness in Americans between ages 15 and 44 years. The suicide rate is higher than the annual mortality from homicide, AIDS, and most forms of cancer. In contrast to nearly all communicable and most non-communicable diseases, there is little eviden...

journal_title：Molecular psychiatry

authors： Insel TR,Scolnick EM

更新日期：2006-01-01 00:00:00

abstract：:Exposure to severe stressors increases the risk for psychiatric disorders in vulnerable individuals, but can lead to positive outcomes for others. However, it remains unknown how severe stress affects neural functioning in humans and what factors mediate individual differences in the neural sequelae of stress. The amy...

journal_title：Molecular psychiatry

authors： van Wingen GA,Geuze E,Vermetten E,Fernández G

更新日期：2011-06-01 00:00:00

abstract：:Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD compared with controls, but consistent evidence is lacking. Few s...

journal_title：Molecular psychiatry

authors： Clarke TK,Lupton MK,Fernandez-Pujals AM,Starr J,Davies G,Cox S,Pattie A,Liewald DC,Hall LS,MacIntyre DJ,Smith BH,Hocking LJ,Padmanabhan S,Thomson PA,Hayward C,Hansell NK,Montgomery GW,Medland SE,Martin NG,Wright MJ

更新日期：2016-03-01 00:00:00

abstract：:Myo-inositol exerts behavioral effects in animal models of psychiatric disorders and is effective in clinical trials in psychiatric patients. Interestingly, epi-inositol exerts behavioral effects similar to myo-inositol, even though epi-inositol is not a substrate for synthesis of phosphatidylinositol. We postulated t...

journal_title：Molecular psychiatry

authors： Shaldubina A,Ju S,Vaden DL,Ding D,Belmaker RH,Greenberg ML

更新日期：2002-01-01 00:00:00

abstract：:We conducted a systematic review and meta-analysis of randomized controlled trials that compared second-generation antipsychotic (SGA) drugs with placebo in schizophrenic patients and which considered 13 different outcome measures. Thirty-eight randomized controlled trials with 7323 participants were included. All SGA...

journal_title：Molecular psychiatry

authors： Leucht S,Arbter D,Engel RR,Kissling W,Davis JM

更新日期：2009-04-01 00:00:00

abstract：:Translin-associated protein X (TRAX) is a scaffold protein with various functions and has been associated with mental illnesses, including schizophrenia. We have previously demonstrated that TRAX interacts with a Gsα protein-coupled receptor, the A2A adenosine receptor (A2AR), and mediates the function of this recepto...

journal_title：Molecular psychiatry

authors： Chien T,Weng YT,Chang SY,Lai HL,Chiu FL,Kuo HC,Chuang DM,Chern Y

更新日期：2018-12-01 00:00:00

abstract：:Recent studies have shown an association between trinucleotide repeat expansions (TREs) and adult-onset schizophrenia (AOS). Childhood-onset schizophrenia (COS) is a severe variant of schizophrenia with onset of symptoms before age 12 years. We have used the repeat expansion detection (RED) method to investigate the o...

journal_title：Molecular psychiatry

authors： Burgess CE,Lindblad K,Sidransky E,Yuan QP,Long RT,Breschel T,Ross CA,McInnis M,Lee P,Ginns EI,Lenane M,Kumra S,Jacobsen L,Rapoport JL,Schalling M

更新日期：1998-07-01 00:00:00

abstract：:Higher scores on the personality trait of neuroticism, the tendency to experience negative emotions, are associated with worse mental and physical health. Studies examining links between neuroticism and health typically operationalize neuroticism by summing the items from a neuroticism scale. However, neuroticism is m...

journal_title：Molecular psychiatry

authors： Hill WD,Weiss A,Liewald DC,Davies G,Porteous DJ,Hayward C,McIntosh AM,Gale CR,Deary IJ

更新日期：2020-11-01 00:00:00

abstract：:With the fast advance of connectome imaging techniques, we have the opportunity of mapping the human brain pathways in vivo at unprecedented resolution. In this article we review the current developments of diffusion magnetic resonance imaging (MRI) for the reconstruction of anatomical pathways in connectome studies. ...

journal_title：Molecular psychiatry

authors： Shi Y,Toga AW

更新日期：2017-09-01 00:00:00

abstract：:The goal of this study is to investigate the familial transmission of the spectrum of bipolar disorder in a nonclinical sample of probands with a broad range of manifestations of mood disorders. The sample included a total of 447 probands recruited from a clinically enriched community screening and their 2082 adult li...

journal_title：Molecular psychiatry

authors： Merikangas KR,Cui L,Heaton L,Nakamura E,Roca C,Ding J,Qin H,Guo W,Shugart YY,Zarate C,Angst J

更新日期：2014-02-01 00:00:00

abstract：:Critical periods are temporary windows of heightened neural plasticity early in development. For example, fear memories in juvenile rodents are subject to erasure following extinction training, while after closure of this critical period, extinction training only temporarily and weakly suppresses fear memories. Persis...

journal_title：Molecular psychiatry

authors： Bhagat SM,Butler SS,Taylor JR,McEwen BS,Strittmatter SM

更新日期：2016-09-01 00:00:00

abstract：:Microvascular pathology and ischemic lesions contribute substantially to neuronal dysfunction and loss that lead to Alzheimer disease (AD). To facilitate recovery, the brain stimulates neovascularization of damaged tissue via sprouting angiogenesis, a process regulated by endothelial cell (EC) sprouting and the EphB4/...

journal_title：Molecular psychiatry

authors： Yoon Y,Voloudakis G,Doran N,Zhang E,Dimovasili C,Chen L,Shao Z,Darmanis S,Tang C,Tang J,Wang VX,Hof PR,Robakis NK,Georgakopoulos A

更新日期：2020-06-15 00:00:00

abstract：:TET3 is a member of the ten-eleven translocation (TET) family of enzymes which oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Tet3 is highly expressed in the brain, where 5hmC levels are most abundant. In adult mice, we observed that TET3 is present in mature neurons and oligodendrocytes but is ab...

journal_title：Molecular psychiatry

authors： Antunes C,Da Silva JD,Guerra-Gomes S,Alves ND,Ferreira F,Loureiro-Campos E,Branco MR,Sousa N,Reik W,Pinto L,Marques CJ

更新日期：2020-02-26 00:00:00

abstract：:Research on avoidance conditioning began in the late 1930s as a way to use laboratory experiments to better understand uncontrollable fear and anxiety. Avoidance was initially conceived of as a two-factor learning process in which fear is first acquired through Pavlovian aversive conditioning (so-called fear condition...

journal_title：Molecular psychiatry

authors： LeDoux JE,Moscarello J,Sears R,Campese V

更新日期：2017-01-01 00:00:00

abstract：:Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people to cognitively defined subgroups on the b...

journal_title：Molecular psychiatry

authors： Mukherjee S,Mez J,Trittschuh EH,Saykin AJ,Gibbons LE,Fardo DW,Wessels M,Bauman J,Moore M,Choi SE,Gross AL,Rich J,Louden DKN,Sanders RE,Grabowski TJ,Bird TD,McCurry SM,Snitz BE,Kamboh MI,Lopez OL,De Jager PL,Benn

更新日期：2020-11-01 00:00:00

abstract：:Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown. We found that widely used antidepressants such as amitriptyline and fluoxetine induce autoph...

journal_title：Molecular psychiatry

authors： Gulbins A,Schumacher F,Becker KA,Wilker B,Soddemann M,Boldrin F,Müller CP,Edwards MJ,Goodman M,Caldwell CC,Kleuser B,Kornhuber J,Szabo I,Gulbins E

更新日期：2018-12-01 00:00:00

abstract：:Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structural and chemical alterations in specific neural substrates. Here we show that adult rats that had been exposed to in utero GCs (iuGC) display increased preference for opiates and ethanol, a...

journal_title：Molecular psychiatry

authors： Rodrigues AJ,Leão P,Pêgo JM,Cardona D,Carvalho MM,Oliveira M,Costa BM,Carvalho AF,Morgado P,Araújo D,Palha JA,Almeida OF,Sousa N

更新日期：2012-12-01 00:00:00

abstract：:Accumulating evidence from both genetic and clinico-pharmacological studies suggests that D-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for D-serine degradation, such as D-amino acid oxidase and G72, has been reported...

journal_title：Molecular psychiatry

authors： Fujii K,Maeda K,Hikida T,Mustafa AK,Balkissoon R,Xia J,Yamada T,Ozeki Y,Kawahara R,Okawa M,Huganir RL,Ujike H,Snyder SH,Sawa A

更新日期：2006-02-01 00:00:00