Abstract:
:A correction to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Bis JC,Jian X,Kunkle BW,Chen Y,Hamilton-Nelson KL,Bush WS,Salerno WJ,Lancour D,Ma Y,Renton AE,Marcora E,Farrell JJ,Zhao Y,Qu L,Ahmad S,Amin N,Amouyel P,Beecham GW,Below JE,Campion D,Cantwell L,Charbonnier C,Chdoi
10.1038/s41380-019-0529-7subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1901-1903issue
8eissn
1359-4184issn
1476-5578pii
10.1038/s41380-019-0529-7journal_volume
25pub_type
已发布勘误abstract::To examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-matched controls in the Japanese population. Allelic and genotypic distributions of ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001029
更新日期:2002-01-01 00:00:00
abstract::Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in motivation. Using positron emission tomography (PET), we showed decreased function in the brain dopamine reward pathway in adults with AD...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.97
更新日期:2011-11-01 00:00:00
abstract::Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABAARs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsant and hypnotic effec...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0100-y
更新日期:2018-09-01 00:00:00
abstract::Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the dynamic plasticity of dendritic spines of pyramidal neurons (PNs) and "en passant" axonal bouton of parvalbumin-expressing interneurons (PVI...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-01005-w
更新日期:2021-01-20 00:00:00
abstract::Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major depression, its biological role in these disorders is unclear. To better understand this gene and its role in psychiatric disease, we conducted ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.37
更新日期:2011-11-01 00:00:00
abstract::Depression often accompanies the perimenopausal transition and it often precedes overt symptomology in common neurodegenerative diseases (NDDs, such as Alzheimer's, Parkinson's, Huntington, amyotrophic lateral sclerosis). Serotonin dysfunction is frequently found in the different etiologies of depression. We have show...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.178
更新日期:2015-12-01 00:00:00
abstract::Activation of the inflammatory response system has been related to the pathophysiology of schizophrenia by several recent studies. Schizophrenic patients have varied levels of proinflammatory cytokines, such as interleukin (IL)-1, -6, and tumor necrosis factor (TNF)alpha in their peripheral blood or cerebrospinal flui...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000483
更新日期:1999-03-01 00:00:00
abstract::The dopamine transporter (DAT) plays a central role in dopaminergic neurotransmission in the human brain. Genetic association studies have used a variable number of tandem repeat (VNTR) polymorphism in the 3'-flanking region of the dopamine transporter gene (DAT1) to implicate the DAT in the development of various neu...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000711
更新日期:2000-05-01 00:00:00
abstract::The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed within the central nervous system. Previous work showed that this protein is upregulated in Alzheimer's disease (AD), and plays an active role in the development of brain amyloidosis in amyloid beta (Aβ)-precursor protein transgenic mice (Tg2576). In the pr...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.170
更新日期:2015-11-01 00:00:00
abstract::Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the hypothesis that rare variants in many different genes, including de novo variants, could predispose to these conditions i...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.54
更新日期:2011-08-01 00:00:00
abstract::Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale c...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0559-1
更新日期:2020-12-01 00:00:00
abstract::Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized that maternal departures from the optimum of dietary methyl donor intake can increase the risk for mental health issues and neurological disorders in offspring,...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2017.53
更新日期:2018-05-01 00:00:00
abstract::Chromosome 1q has been implicated in the etiology of schizophrenia in several independent studies. However, the peak linkage findings have been dispersed over a large chromosomal region, with negative findings in this region also being reported. Our group has previously observed linkage on chromosome 1q42, maximizing ...
journal_title:Molecular psychiatry
pub_type: 临床试验,杂志文章
doi:10.1038/sj.mp.4001536
更新日期:2004-11-01 00:00:00
abstract::Corticotropin-releasing hormone (CRH) is both a main regulator of the hypothalamic-pituitary-adrenocortical axis and the autonomic nervous system. CRH receptor type 1 (CRHR1)-deficient mice demonstrate alterations in behavior, impaired stress responses with adrenocortical insufficiency and aberrant neuroendocrine deve...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001143
更新日期:2002-01-01 00:00:00
abstract::Anorexia nervosa (AN) and other eating disorders continue to constitute significant challenges for individual and public health. AN is thought to develop as a result of complex interactions between environmental triggers, psychological risk factors, sociocultural influences, and genetic vulnerability. Recent research ...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/s41380-019-0366-8
更新日期:2019-10-01 00:00:00
abstract::Early-life disruption of the parent-child relationship, for example, in the form of abuse, neglect or loss, dramatically increases risk for psychiatric, as well as certain medical, disorders in adulthood. The neuropeptide oxytocin (OT) plays a seminal role in mediating social affiliation, attachment, social support, m...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2008.112
更新日期:2009-10-01 00:00:00
abstract::Endogenous opioid and non-opioid mechanisms (for example, dopamine (DA), endocannabinoids (eCB)) have been implicated in the formation of placebo analgesic effects, with initial reports dating back three decades. Besides the perspective that placebo effects confound randomized clinical trials, the information so far a...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2014.164
更新日期:2015-04-01 00:00:00
abstract::Niemann-Pick disease type A (NPA) is a rare lysosomal storage disorder characterized by severe neurological alterations that leads to death in childhood. Loss-of-function mutations in the acid sphingomyelinase (ASM) gene cause NPA, and result in the accumulation of sphingomyelin (SM) in lysosomes and plasma membrane o...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.148
更新日期:2017-05-01 00:00:00
abstract::Linkage studies in schizophrenia have identified a candidate region on chromosome 10p14-11 as reported for several independent samples. We investigated association of DNA sequence variants in a plausible candidate gene located in this region, the gene for phosphatidylinositol-4-phosphate 5-kinase IIalpha (PIP5K2A), in...
journal_title:Molecular psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.mp.4001864
更新日期:2006-09-01 00:00:00
abstract::Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underp...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.183
更新日期:2014-02-01 00:00:00
abstract::Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of Polg1, a mitochondrial DNA (mtDNA...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.156
更新日期:2016-01-01 00:00:00
abstract::Exposure to traumatic events is common. While many individuals recover following trauma exposure, a substantial subset develop adverse posttraumatic neuropsychiatric sequelae (APNS) such as posttraumatic stress, major depression, and regional or widespread chronic musculoskeletal pain. APNS cause substantial burden to...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/s41380-019-0636-5
更新日期:2020-09-01 00:00:00
abstract::We assessed the ability of lithium to reduce neurodegeneration and to stimulate cell proliferation in a rat model of Huntington's disease in which quinolinic acid (QA) was unilaterally infused into the striatum. LiCl (0.5-3.0 mEq/kg) was injected subcutaneously 24 h before and 1 h after QA infusion. At 7 days after QA...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001463
更新日期:2004-04-01 00:00:00
abstract::The Raf kinases Raf-1 and B-Raf are upstream activators of the extracellular signal-regulated kinase (ERK)-signaling pathway and therefore participates in many physiological functions in brain, including neuronal survival and synaptic plasticity. Previously, we observed that activation of ERK-1/2, the downstream compo...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001744
更新日期:2006-01-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not ju...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0496-z
更新日期:2020-12-01 00:00:00
abstract::A 3-day Nobel Conference entitled 'The role of genetics in promoting suicide prevention and the mental health of the population' was held at the Nobel Forum, Karolinska Institute (KI) in Stockholm, Sweden, during 8-10 June 2009. The conference was sponsored by the Nobel Assembly for Physiology or Medicine and organize...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.113
更新日期:2010-01-01 00:00:00
abstract::A polymorphism in the serotonin (5-HT) transporter gene regulatory region (5-HTTLPR) is associated with measures of 5-HT transporter (5-HTT) expression and 5-HT-mediated behaviors in humans. An analogous length variation of the 5-HTTLPR has been reported in rhesus monkeys (rh5-HTTLPR). A retrospective association stud...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001157
更新日期:2002-01-01 00:00:00
abstract::Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been vario...
journal_title:Molecular psychiatry
pub_type: 临床试验,杂志文章
doi:10.1038/sj.mp.4001575
更新日期:2005-02-01 00:00:00
abstract::The prefrontal cortex (PFC), seat of the highest-order cognitive functions, constitutes a conglomerate of highly specialized brain areas and has been implicated to have a role in the onset and installation of various neurodevelopmental disorders. The development of a properly functioning PFC is directed by transcripti...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2014.147
更新日期:2015-07-01 00:00:00
abstract::Several reports have suggested the presence of anticipation in bipolar affective disorder (BPAD). In addition, independent studies using the RED (repeat expansion detection) have shown association between BPAD and longer CAG/CTG repeats. Therefore loci with large CAG/CTG repeats are plausible candidates in the inherit...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000898
更新日期:2001-09-01 00:00:00