Lower CSF oxytocin concentrations in women with a history of childhood abuse.


:Early-life disruption of the parent-child relationship, for example, in the form of abuse, neglect or loss, dramatically increases risk for psychiatric, as well as certain medical, disorders in adulthood. The neuropeptide oxytocin (OT) plays a seminal role in mediating social affiliation, attachment, social support, maternal behavior and trust, as well as protection against stress and anxiety. We therefore examined central nervous system OT activity after early-life adversity in adult women. We measured OT concentrations in cerebrospinal fluid (CSF) collected from 22 medically healthy women, aged 18-45 years, categorized into those with none-mild versus those with moderate-severe exposure to various forms of childhood abuse or neglect. Exposure to maltreatment was associated with decreased CSF OT concentrations. A particularly strong effect was identified for emotional abuse. There were inverse associations between CSF OT concentrations and the number of exposure categories, the severity and duration of the abuse and current anxiety ratings. If replicated, the association of lower adult CSF OT levels with childhood trauma might indicate that alterations in central OT function may be involved in the adverse outcomes of childhood adversity.


Mol Psychiatry


Molecular psychiatry


Heim C,Young LJ,Newport DJ,Mletzko T,Miller AH,Nemeroff CB




Has Abstract


2009-10-01 00:00:00














  • Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection.

    abstract::Among the most consistent results of studies of post-mortem brain tissue from schizophrenia patients (SZP) is the finding that in this disease, several genes expressed by GABAergic neurons are downregulated. This downregulation may be caused by hypermethylation of the relevant promoters in affected neurons. Indeed, in...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Ruzicka WB,Zhubi A,Veldic M,Grayson DR,Costa E,Guidotti A

    更新日期:2007-04-01 00:00:00

  • Epigenetics in eating disorders: a systematic review.

    abstract::Eating disorders are complex heritable conditions influenced by both genetic and environmental factors. Given the progress of genomic discovery in anorexia nervosa, with the identification of the first genome-wide significant locus, as well as animated discussion of epigenetic mechanisms in linking environmental facto...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Hübel C,Marzi SJ,Breen G,Bulik CM

    更新日期:2019-06-01 00:00:00

  • Genome-wide association study of Alzheimer's disease with psychotic symptoms.

    abstract::Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysi...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,meta分析,多中心研究


    authors: Hollingworth P,Sweet R,Sims R,Harold D,Russo G,Abraham R,Stretton A,Jones N,Gerrish A,Chapman J,Ivanov D,Moskvina V,Lovestone S,Priotsi P,Lupton M,Brayne C,Gill M,Lawlor B,Lynch A,Craig D,McGuinness B,Johnston J

    更新日期:2012-12-01 00:00:00

  • Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIalpha gene (PIP5K2A) with schizophrenia.

    abstract::Linkage studies in schizophrenia have identified a candidate region on chromosome 10p14-11 as reported for several independent samples. We investigated association of DNA sequence variants in a plausible candidate gene located in this region, the gene for phosphatidylinositol-4-phosphate 5-kinase IIalpha (PIP5K2A), in...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,多中心研究


    authors: Schwab SG,Knapp M,Sklar P,Eckstein GN,Sewekow C,Borrmann-Hassenbach M,Albus M,Becker T,Hallmayer JF,Lerer B,Maier W,Wildenauer DB

    更新日期:2006-09-01 00:00:00

  • Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4.

    abstract::The human 16p11.2 gene locus is a hot spot for copy number variations, which predispose carriers to a range of neuropsychiatric phenotypes. Microduplications of 16p11.2 are associated with autism spectrum disorder (ASD), intellectual disability (ID), and schizophrenia (SZ). Despite the debilitating nature of 16p11.2 d...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Rein B,Tan T,Yang F,Wang W,Williams J,Zhang F,Mills A,Yan Z

    更新日期:2020-02-25 00:00:00

  • What is the cellular source of prostaglandins in the brain in response to systemic inflammation? Facts and controversies.

    abstract::Circulating inflammatory mediators can signal neurons through a pathway in which cytokine activation of the cells of the blood-brain barrier causes the induction of the nuclear factor kappa B (NF-kappaB), leading to the transcription of target genes, such as the one encoding cyclooxygenase 2 (COX-2), the enzyme that i...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审


    authors: Rivest S

    更新日期:1999-11-01 00:00:00

  • Preventing intrusive memories after trauma via a brief intervention involving Tetris computer game play in the emergency department: a proof-of-concept randomized controlled trial.

    abstract::After psychological trauma, recurrent intrusive visual memories may be distressing and disruptive. Preventive interventions post trauma are lacking. Here we test a behavioural intervention after real-life trauma derived from cognitive neuroscience. We hypothesized that intrusive memories would be significantly reduced...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,随机对照试验


    authors: Iyadurai L,Blackwell SE,Meiser-Stedman R,Watson PC,Bonsall MB,Geddes JR,Nobre AC,Holmes EA

    更新日期:2018-03-01 00:00:00

  • Impact of video games on plasticity of the hippocampus.

    abstract::The hippocampus is critical to healthy cognition, yet results in the current study show that action video game players have reduced grey matter within the hippocampus. A subsequent randomised longitudinal training experiment demonstrated that first-person shooting games reduce grey matter within the hippocampus in par...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: West GL,Konishi K,Diarra M,Benady-Chorney J,Drisdelle BL,Dahmani L,Sodums DJ,Lepore F,Jolicoeur P,Bohbot VD

    更新日期:2018-07-01 00:00:00

  • Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach.

    abstract::Identifying genes for bipolar mood disorders through classic genetics has proven difficult. Here, we present a comprehensive convergent approach that translationally integrates brain gene expression data from a relevant pharmacogenomic mouse model (involving treatments with a stimulant--methamphetamine, and a mood sta...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Ogden CA,Rich ME,Schork NJ,Paulus MP,Geyer MA,Lohr JB,Kuczenski R,Niculescu AB

    更新日期:2004-11-01 00:00:00

  • Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10.

    abstract::Several microbes have been suspected as pathogenetic factors in schizophrenia. We have previously observed increased frequencies of chlamydial infections and of human lymphocyte antigen (HLA)-A10 in independent studies of schizophrenia. Our aim here was to analyze frequencies of three types of Chlamydiaceae in schizop...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Fellerhoff B,Laumbacher B,Mueller N,Gu S,Wank R

    更新日期:2007-03-01 00:00:00

  • Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors.

    abstract::Abnormalities in the density of neuroreceptors that regulate norepinephrine and serotonin release have been repeatedly reported in brains of suicide victims with mood disorders. Recently, the modulation of the [(35)S]GTPgammaS binding to G-proteins has been introduced as a suitable measure of receptor activity in post...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: González-Maeso J,Rodríguez-Puertas R,Meana JJ,García-Sevilla JA,Guimón J

    更新日期:2002-01-01 00:00:00

  • Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice.

    abstract::TET3 is a member of the ten-eleven translocation (TET) family of enzymes which oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Tet3 is highly expressed in the brain, where 5hmC levels are most abundant. In adult mice, we observed that TET3 is present in mature neurons and oligodendrocytes but is ab...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Antunes C,Da Silva JD,Guerra-Gomes S,Alves ND,Ferreira F,Loureiro-Campos E,Branco MR,Sousa N,Reik W,Pinto L,Marques CJ

    更新日期:2020-02-26 00:00:00

  • COMT haplotypes suggest P2 promoter region relevance for schizophrenia.

    abstract::A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstrea...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Palmatier MA,Pakstis AJ,Speed W,Paschou P,Goldman D,Odunsi A,Okonofua F,Kajuna S,Karoma N,Kungulilo S,Grigorenko E,Zhukova OV,Bonne-Tamir B,Lu RB,Parnas J,Kidd JR,DeMille MM,Kidd KK

    更新日期:2004-09-01 00:00:00

  • Direct conversion of human fibroblasts to induced serotonergic neurons.

    abstract::Serotonergic (5HT) neurons exert diverse and widespread functions in the brain. Dysfunction of the serotonergic system gives rise to a variety of mental illnesses including depression, anxiety, obsessive compulsive disorder, autism and eating disorders. Here we show that human primary fibroblasts were directly convert...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Xu Z,Jiang H,Zhong P,Yan Z,Chen S,Feng J

    更新日期:2016-01-01 00:00:00

  • The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis.

    abstract::Low dietary folate intake has been implicated as a risk factor for depression. However, observational epidemiological studies are plagued by problems of confounding, reverse causality and measurement error. A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,meta分析,评审


    authors: Lewis SJ,Lawlor DA,Davey Smith G,Araya R,Timpson N,Day IN,Ebrahim S

    更新日期:2006-04-01 00:00:00

  • Time-delimited signaling of MET receptor tyrosine kinase regulates cortical circuit development and critical period plasticity.

    abstract::Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmen...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Chen K,Ma X,Nehme A,Wei J,Cui Y,Cui Y,Yao D,Wu J,Anderson T,Ferguson D,Levitt P,Qiu S

    更新日期:2020-01-03 00:00:00

  • Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study.

    abstract::This study explores whether inflammatory biomarkers act as moderators of clinical response to omega-3 (n-3) fatty acids in subjects with major depressive disorder (MDD). One hundred fifty-five subjects with Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) MDD, a baseline 17-item Hamilton Dep...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Rapaport MH,Nierenberg AA,Schettler PJ,Kinkead B,Cardoos A,Walker R,Mischoulon D

    更新日期:2016-01-01 00:00:00

  • Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.

    abstract::A whole genome association study was performed in a phase 3 clinical trial conducted to evaluate a novel antipsychotic, iloperidone, administered to treat patients with schizophrenia. Genotypes of 407 patients were analyzed for 334,563 single nucleotide polymorphisms (SNPs). SNPs associated with iloperidone efficacy w...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Lavedan C,Licamele L,Volpi S,Hamilton J,Heaton C,Mack K,Lannan R,Thompson A,Wolfgang CD,Polymeropoulos MH

    更新日期:2009-08-01 00:00:00

  • CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies.

    abstract::Latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDACi), are being investigated as a strategy to eliminate latency in HIV-infected patients on suppressive antiretroviral therapy. The effectiveness of LRAs in activating latent infection in HIV strains derived from the central nervous system (C...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Gray LR,Cowley D,Welsh C,Lu HK,Brew BJ,Lewin SR,Wesselingh SL,Gorry PR,Churchill MJ

    更新日期:2016-04-01 00:00:00

  • The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders.

    abstract::Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Here, we present data from independent large-scale clinical data sets (including 29 557 cases and 32 056 controls) rev...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,meta分析


    authors: Chang H,Hoshina N,Zhang C,Ma Y,Cao H,Wang Y,Wu DD,Bergen SE,Landén M,Hultman CM,Preisig M,Kutalik Z,Castelao E,Grigoroiu-Serbanescu M,Forstner AJ,Strohmaier J,Hecker J,Schulze TG,Müller-Myhsok B,Reif A,Mitchell PB

    更新日期:2018-02-01 00:00:00

  • Glycobiology and schizophrenia: a biological hypothesis emerging from genomic research.

    abstract::Advances in genomics are opening new windows into the biology of schizophrenia. Though common variants individually have small effects on disease risk, GWAS provide a powerful opportunity to explore pathways and mechanisms contributing to pathophysiology. Here, we highlight an underappreciated biological theme emergin...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审


    authors: Mealer RG,Williams SE,Daly MJ,Scolnick EM,Cummings RD,Smoller JW

    更新日期:2020-12-01 00:00:00

  • Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward.

    abstract::Opioids, such as morphine, are clinic analgesics which induce euphoria. Morphine exposure modifies the excitability and functional interactions between neurons, while the underlying cellular and molecular mechanisms, especially how morphine assembles heterogeneous interneurons (INs) in prelimbic cortex (PrL) to mediat...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Jiang C,Wang X,Le Q,Liu P,Liu C,Wang Z,He G,Zheng P,Wang F,Ma L

    更新日期:2019-08-14 00:00:00

  • Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression.

    abstract::The dorsolateral prefrontal cortex (dlpfc) is strongly implicated in the pathogenesis of schizophrenia (SCZ) and bipolar disorder (BPD) and, within this region, abnormalities in glutamatergic neurotransmission and synaptic function have been described. Proteins associated with these functions are enriched in membrane ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Behan AT,Byrne C,Dunn MJ,Cagney G,Cotter DR

    更新日期:2009-06-01 00:00:00

  • Differential effects on T-cell function following exposure to serum from schizophrenia smokers.

    abstract::Cigarette smoking is more prevalent in subjects with schizophrenia compared to those with other psychiatric disorders or the general population and could therefore affect molecular pathways that impact the pathophysiology of this disorder. As smoking is also known to suppress immune responses, we investigated the effe...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Herberth M,Krzyszton DN,Koethe D,Craddock MR,Bulger E,Schwarz E,Guest P,Leweke FM,Bahn S

    更新日期:2010-04-01 00:00:00

  • Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids.

    abstract::Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structural and chemical alterations in specific neural substrates. Here we show that adult rats that had been exposed to in utero GCs (iuGC) display increased preference for opiates and ethanol, a...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Rodrigues AJ,Leão P,Pêgo JM,Cardona D,Carvalho MM,Oliveira M,Costa BM,Carvalho AF,Morgado P,Araújo D,Palha JA,Almeida OF,Sousa N

    更新日期:2012-12-01 00:00:00

  • Role of BDNF in the development of an OFC-amygdala circuit regulating sociability in mouse and human.

    abstract::Social deficits are common in many psychiatric disorders. However, due to inadequate tools for manipulating circuit activity in humans and unspecific paradigms for modeling social behaviors in rodents, our understanding of the molecular and circuit mechanisms mediating social behaviors remains relatively limited. Usin...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Li A,Jing D,Dellarco DV,Hall BS,Yang R,Heilberg RT,Huang C,Liston C,Casey BJ,Lee FS

    更新日期:2019-04-16 00:00:00

  • Schizophrenia-associated genomic copy number variants and subcortical brain volumes in the UK Biobank.

    abstract::Schizophrenia is a highly heritable disorder for which anatomical brain alterations have been repeatedly reported in clinical samples. Unaffected at-risk groups have also been studied in an attempt to identify brain changes that do not reflect reverse causation or treatment effects. However, no robust associations hav...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Warland A,Kendall KM,Rees E,Kirov G,Caseras X

    更新日期:2020-04-01 00:00:00

  • Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the Neuregulin-1 locus.

    abstract::Two recent association studies have implicated the neuregulin-1 gene (NRG1) at chromosome 8p21-22 as a susceptibility gene for schizophrenia. Stefansson et al identified three 'at-risk' haplotypes (HapA, B and C) which spanned the NRG1 locus and shared a common core haplotype. Subsequently, they demonstrated evidence ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Corvin AP,Morris DW,McGhee K,Schwaiger S,Scully P,Quinn J,Meagher D,Clair DS,Waddington JL,Gill M

    更新日期:2004-02-01 00:00:00

  • Connectome-wide network analysis of youth with Psychosis-Spectrum symptoms.

    abstract::Adults with psychotic disorders have dysconnectivity in critical brain networks, including the default mode (DM) and the cingulo-opercular (CO) networks. However, it is unknown whether such deficits are present in youth with less severe symptoms. We conducted a multivariate connectome-wide association study examining ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章


    authors: Satterthwaite TD,Vandekar SN,Wolf DH,Bassett DS,Ruparel K,Shehzad Z,Craddock RC,Shinohara RT,Moore TM,Gennatas ED,Jackson C,Roalf DR,Milham MP,Calkins ME,Hakonarson H,Gur RC,Gur RE

    更新日期:2015-12-01 00:00:00

  • ATP5H/KCTD2 locus is associated with Alzheimer's disease risk.

    abstract::To identify loci associated with Alzheimer disease, we conducted a three-stage analysis using existing genome-wide association studies (GWAS) and genotyping in a new sample. In Stage I, all suggestive single-nucleotide polymorphisms (at P<0.001) in a previously reported GWAS of seven independent studies (8082 Alzheime...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,meta分析


    authors: Boada M,Antúnez C,Ramírez-Lorca R,DeStefano AL,González-Pérez A,Gayán J,López-Arrieta J,Ikram MA,Hernández I,Marín J,Galán JJ,Bis JC,Mauleón A,Rosende-Roca M,Moreno-Rey C,Gudnasson V,Morón FJ,Velasco J,Carrasco JM,A

    更新日期:2014-06-01 00:00:00