Abstract：
:Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Purves KL,Coleman JRI,Meier SM,Rayner C,Davis KAS,Cheesman R,Bækvad-Hansen M,Børglum AD,Wan Cho S,Jürgen Deckert J,Gaspar HA,Bybjerg-Grauholm J,Hettema JM,Hotopf M,Hougaard D,Hübel C,Kan C,McIntosh AM,Mors O,Bo Mortdoi
10.1038/s41380-019-0559-1subject
Has Abstractpub_date
2020-12-01 00:00:00pages
3292-3303issue
12eissn
1359-4184issn
1476-5578pii
10.1038/s41380-019-0559-1journal_volume
25pub_type
杂志文章abstract：:Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. In this study, we examined th...
journal_title：Molecular psychiatry
pub_type： 杂志文章
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abstract：:Between 1997 and 2002, 48 data sets from the hippocampus were produced on samples from the Stanley Neuropathology Consortium. From these data sets, 224 total measures were available from the various subdivisions of the hippocampus. An integrative analysis of these measures was performed using a multivariate, nonparame...
journal_title：Molecular psychiatry
pub_type： 杂志文章
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abstract：:Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encod...
journal_title：Molecular psychiatry
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更新日期：2020-11-01 00:00:00
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更新日期：2021-01-22 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
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journal_title：Molecular psychiatry
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更新日期：2017-04-01 00:00:00
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章,meta分析
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journal_title：Molecular psychiatry
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更新日期：2006-01-01 00:00:00
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