Abstract:
:Leptin is a hormone with pleiotropic functions affecting several tissues. Because leptin has a crucial role in the adaptation of an organism to semi-starvation, anorexia nervosa (AN) serves as a model disorder to elucidate the functional implications of hypoleptinaemia; vice versa, several symptoms in patients with this eating disorder are related to the low leptin levels, which are characteristic of acute AN. Weight gain in AN patients can induce relative hyperleptinaemia in comparison to controls matched for body mass index; circulating leptin concentrations in AN patients thus transverse from subnormal to supranormal levels within a few weeks. We review findings on leptin secretion in AN and focus on implications, particularly for the hypothalamus-pituitary-gonadal axis, bone mineral density and physical hyperactivity. Undoubtedly, the elucidation of leptin's function as a trigger of diverse neuroendocrine adaptations to a restricted energy intake has substantially advanced our knowledge of the pathogenesis of distinct symptoms of AN, including amenorrhoea that represents one of the four diagnostic criteria. The fact that hypoleptinaemia can induce hyperactivity in a rat model for AN has led to a series of studies in AN patients, which support the notion that application of leptin to severely hyperactive patients might prove beneficial.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Hebebrand J,Muller TD,Holtkamp K,Herpertz-Dahlmann Bdoi
10.1038/sj.mp.4001909subject
Has Abstractpub_date
2007-01-01 00:00:00pages
23-35issue
1eissn
1359-4184issn
1476-5578pii
4001909journal_volume
12pub_type
杂志文章,评审abstract::The dopamine transporter (DAT) plays a central role in dopaminergic neurotransmission in the human brain. Genetic association studies have used a variable number of tandem repeat (VNTR) polymorphism in the 3'-flanking region of the dopamine transporter gene (DAT1) to implicate the DAT in the development of various neu...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000711
更新日期:2000-05-01 00:00:00
abstract::Microvascular pathology and ischemic lesions contribute substantially to neuronal dysfunction and loss that lead to Alzheimer disease (AD). To facilitate recovery, the brain stimulates neovascularization of damaged tissue via sprouting angiogenesis, a process regulated by endothelial cell (EC) sprouting and the EphB4/...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-0812-7
更新日期:2020-06-15 00:00:00
abstract::A genetic predisposition to the development of neuroleptic malignant syndrome (NMS) has been suggested by clinical studies. Although the molecular basis of NMS is unclear, a dopaminergic blockade mechanism has been considered the main cause. We therefore investigated the association between NMS and three functional po...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001422
更新日期:2004-03-01 00:00:00
abstract::A correction to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Molecular psychiatry
pub_type: 已发布勘误
doi:10.1038/s41380-019-0529-7
更新日期:2020-08-01 00:00:00
abstract::Genetic factors do not fully account for the relatively high heritability of neurodevelopmental conditions, suggesting that non-genetic heritable factors contribute to their etiology. To evaluate the potential contribution of aberrant thyroid hormone status to the epigenetic inheritance of neurological phenotypes, we ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0281-4
更新日期:2020-05-01 00:00:00
abstract::Semi-starvation induced hyperactivity (SIH) occurs in rodents upon caloric restriction. We hypothesized that SIH is triggered by the decline in leptin secretion associated with food restriction. To test this hypothesis, rats, which had established a stable level of activity, were treated with leptin or vehicle via imp...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000771
更新日期:2000-09-01 00:00:00
abstract::Genetic and pharmacological studies have emphasised the role of serotonin 5-hydroxytryptamine (5-HT) as a possible etiologic factor in the development of attention-deficit hyperactivity disorder (ADHD). Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the biosynthesis of serotonin from tryptophan. Originally,...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001698
更新日期:2005-10-01 00:00:00
abstract::There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. We studied the association of CR...
journal_title:Molecular psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.mp.4001587
更新日期:2004-12-01 00:00:00
abstract::The long alleles (> or =6 repeats) of the dopamine D4 dopamine receptor exon III polymorphism have been linked in some, but not all, studies to Novelty Seeking (NS), one of four personality traits defined by Cloninger's tridimensional personality questionnarie (TPQ). In order to further examine the robustness of our o...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000333
更新日期:1997-10-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2017.24
更新日期:2018-01-01 00:00:00
abstract::Opioids, such as morphine, are clinic analgesics which induce euphoria. Morphine exposure modifies the excitability and functional interactions between neurons, while the underlying cellular and molecular mechanisms, especially how morphine assembles heterogeneous interneurons (INs) in prelimbic cortex (PrL) to mediat...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0480-7
更新日期:2019-08-14 00:00:00
abstract::The human 16p11.2 gene locus is a hot spot for copy number variations, which predispose carriers to a range of neuropsychiatric phenotypes. Microduplications of 16p11.2 are associated with autism spectrum disorder (ASD), intellectual disability (ID), and schizophrenia (SZ). Despite the debilitating nature of 16p11.2 d...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-0693-9
更新日期:2020-02-25 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0087-4
更新日期:2018-12-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1038/mp.2013.42
更新日期:2014-03-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.192
更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/mp.2009.82
更新日期:2009-11-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.187
更新日期:2018-02-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-00990-2
更新日期:2021-01-08 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.156
更新日期:2016-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001744
更新日期:2006-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.115
更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-03-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.63
更新日期:2011-02-01 00:00:00
abstract::The aim of the study is to compare the prevalence of suicidal ideation and attempts in the United States in 1991-1992 and 2001-2002, and identify sociodemographic groups at increased risk for suicidal ideation and attempts. Data were drawn from the National Institute on Alcohol Abuse and Alcoholism 1991-1992 National ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2008.98
更新日期:2010-03-01 00:00:00
abstract::Anxiety-related behaviors are closely linked to neural circuits relaying fear-specific information to the amygdala. Many of these circuits, like those underlying processing of innate fear, are remarkably well understood. Recent imaging studies have contributed to this knowledge by discriminating more detailed corticoa...
journal_title:Molecular psychiatry
pub_type: 临床试验,杂志文章
doi:10.1038/sj.mp.4001908
更新日期:2006-12-01 00:00:00
abstract::Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people to cognitively defined subgroups on the b...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0298-8
更新日期:2020-11-01 00:00:00
abstract::Niemann-Pick disease type A (NPA) is a rare lysosomal storage disorder characterized by severe neurological alterations that leads to death in childhood. Loss-of-function mutations in the acid sphingomyelinase (ASM) gene cause NPA, and result in the accumulation of sphingomyelin (SM) in lysosomes and plasma membrane o...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.148
更新日期:2017-05-01 00:00:00
abstract::Bipolar disorder (BPD) is characterized by vulnerability to episodic depression and mania and spontaneous cycling. Because of marked advances in candidate-gene and genome-wide association studies, the list of risk genes for BPD is growing rapidly, creating an unprecedented opportunity to understand the pathophysiology...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2010.3
更新日期:2010-09-01 00:00:00
abstract::Use of substances such as cannabis, alcohol, and tobacco, has been associated with increased risk of suicide attempt in several observational studies. However, establishing whether these associations are causal is challenging when using observational designs. To evaluate the potential causal contributions of cannabis ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-0785-6
更新日期:2020-06-08 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0205-3
更新日期:2020-11-01 00:00:00