The role of leptin in anorexia nervosa: clinical implications.

Abstract:

:Leptin is a hormone with pleiotropic functions affecting several tissues. Because leptin has a crucial role in the adaptation of an organism to semi-starvation, anorexia nervosa (AN) serves as a model disorder to elucidate the functional implications of hypoleptinaemia; vice versa, several symptoms in patients with this eating disorder are related to the low leptin levels, which are characteristic of acute AN. Weight gain in AN patients can induce relative hyperleptinaemia in comparison to controls matched for body mass index; circulating leptin concentrations in AN patients thus transverse from subnormal to supranormal levels within a few weeks. We review findings on leptin secretion in AN and focus on implications, particularly for the hypothalamus-pituitary-gonadal axis, bone mineral density and physical hyperactivity. Undoubtedly, the elucidation of leptin's function as a trigger of diverse neuroendocrine adaptations to a restricted energy intake has substantially advanced our knowledge of the pathogenesis of distinct symptoms of AN, including amenorrhoea that represents one of the four diagnostic criteria. The fact that hypoleptinaemia can induce hyperactivity in a rat model for AN has led to a series of studies in AN patients, which support the notion that application of leptin to severely hyperactive patients might prove beneficial.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Hebebrand J,Muller TD,Holtkamp K,Herpertz-Dahlmann B

doi

10.1038/sj.mp.4001909

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

23-35

issue

1

eissn

1359-4184

issn

1476-5578

pii

4001909

journal_volume

12

pub_type

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