Abstract:
:Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encoding and mood regulation. In addition, several brain diseases, such as neurological diseases and mood disorders, have deleterious effects on adult hippocampal neurogenesis, and some symptoms of those diseases can be partially explained by the dysregulation of adult hippocampal neurogenesis. Here we review a possible link between the physiological functions of adult-born neurons and their roles in pathological conditions.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Toda T,Parylak SL,Linker SB,Gage FHdoi
10.1038/s41380-018-0036-2subject
Has Abstractpub_date
2019-01-01 00:00:00pages
67-87issue
1eissn
1359-4184issn
1476-5578pii
10.1038/s41380-018-0036-2journal_volume
24pub_type
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