HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition.

abstract：:The epigenome is associated with biological factors, such as disease status, and environmental factors, such as smoking, alcohol consumption and body mass index. Although there is a widespread perception that environmental influences on the epigenome are pervasive and profound, there has been little evidence to date i...

journal_title：Molecular psychiatry

authors： Karlsson Linnér R,Marioni RE,Rietveld CA,Simpkin AJ,Davies NM,Watanabe K,Armstrong NJ,Auro K,Baumbach C,Bonder MJ,Buchwald J,Fiorito G,Ismail K,Iurato S,Joensuu A,Karell P,Kasela S,Lahti J,McRae AF,Mandaviya PR,Se

更新日期：2017-12-01 00:00:00

abstract：:Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people to cognitively defined subgroups on the b...

journal_title：Molecular psychiatry

authors： Mukherjee S,Mez J,Trittschuh EH,Saykin AJ,Gibbons LE,Fardo DW,Wessels M,Bauman J,Moore M,Choi SE,Gross AL,Rich J,Louden DKN,Sanders RE,Grabowski TJ,Bird TD,McCurry SM,Snitz BE,Kamboh MI,Lopez OL,De Jager PL,Benn

更新日期：2020-11-01 00:00:00

abstract：:Although schizophrenia is considered a brain disorder, the role of brain organization for symptomatic improvement remains inadequately defined. We investigated the relationship between baseline brain morphology, resting-state network connectivity and clinical response after 24-weeks of antipsychotic treatment in patie...

journal_title：Molecular psychiatry

authors： Doucet GE,Moser DA,Luber MJ,Leibu E,Frangou S

更新日期：2020-04-01 00:00:00

abstract：:Corticotropin-releasing hormone (CRH) is both a main regulator of the hypothalamic-pituitary-adrenocortical axis and the autonomic nervous system. CRH receptor type 1 (CRHR1)-deficient mice demonstrate alterations in behavior, impaired stress responses with adrenocortical insufficiency and aberrant neuroendocrine deve...

journal_title：Molecular psychiatry

authors： Yoshida-Hiroi M,Bradbury MJ,Eisenhofer G,Hiroi N,Vale WW,Novotny GE,Hartwig HG,Scherbaum WA,Bornstein SR

更新日期：2002-01-01 00:00:00

abstract：:Between 1997 and 2002, 48 data sets from the hippocampus were produced on samples from the Stanley Neuropathology Consortium. From these data sets, 224 total measures were available from the various subdivisions of the hippocampus. An integrative analysis of these measures was performed using a multivariate, nonparame...

journal_title：Molecular psychiatry

authors： Knable MB,Barci BM,Webster MJ,Meador-Woodruff J,Torrey EF,Stanley Neuropathology Consortium.

更新日期：2004-06-01 00:00:00

abstract：:This Article was originally published under Nature Research's License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the Article have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Perry A,Roberts G,Mitchell PB,Breakspear M

更新日期：2019-09-01 00:00:00

abstract：:Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postmortem dorsolateral ...

journal_title：Molecular psychiatry

authors： Wang HY,MacDonald ML,Borgmann-Winter KE,Banerjee A,Sleiman P,Tom A,Khan A,Lee KC,Roussos P,Siegel SJ,Hemby SE,Bilker WB,Gur RE,Hahn CG

更新日期：2020-04-01 00:00:00

abstract：:Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...

journal_title：Molecular psychiatry

authors： Wedenoja J,Loukola A,Tuulio-Henriksson A,Paunio T,Ekelund J,Silander K,Varilo T,Heikkilä K,Suvisaari J,Partonen T,Lönnqvist J,Peltonen L

更新日期：2008-07-01 00:00:00

abstract：:Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments manage the positive symptoms, yet have minimal effects on the negative and cognitive symptoms, two prominent features of the disease with critical impact on the long-term morbidity. In addition, antipsychotic treatments trigger se...

journal_title：Molecular psychiatry

authors： Revel FG,Moreau JL,Pouzet B,Mory R,Bradaia A,Buchy D,Metzler V,Chaboz S,Groebke Zbinden K,Galley G,Norcross RD,Tuerck D,Bruns A,Morairty SR,Kilduff TS,Wallace TL,Risterucci C,Wettstein JG,Hoener MC

更新日期：2013-05-01 00:00:00

abstract：:Polyglutamine expansion (PGE) encoded by a CAG repeat underlies eight inherited neurodegenerative diseases, among which is Huntington's disease. CAG expansion has also been reported in schizophrenia, suggesting a role for PGE. To investigate the potential role of PGE as a candidate for schizophrenia, we searched for P...

journal_title：Molecular psychiatry

authors： Moriniere S,Saada C,Holbert S,Sidransky E,Galat A,Ginns E,Rapoport JL,Neri C

更新日期：1999-01-01 00:00:00

abstract：:Genetic and pharmacological studies have emphasised the role of serotonin 5-hydroxytryptamine (5-HT) as a possible etiologic factor in the development of attention-deficit hyperactivity disorder (ADHD). Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the biosynthesis of serotonin from tryptophan. Originally,...

journal_title：Molecular psychiatry

authors： Sheehan K,Lowe N,Kirley A,Mullins C,Fitzgerald M,Gill M,Hawi Z

更新日期：2005-10-01 00:00:00

abstract：:In mammals, most adult neural stem cells (NSCs) are located in the ventricular-subventricular zone (V-SVZ) along the wall of the lateral ventricles and they are the source of olfactory bulb interneurons. Adult NSCs exhibit an apico-basal polarity; they harbor a short apical process and a long basal process, reminiscen...

journal_title：Molecular psychiatry

authors： García-González D,Dumitru I,Zuccotti A,Yen TY,Herranz-Pérez V,Tan LL,Neitz A,García-Verdugo JM,Kuner R,Alfonso J,Monyer H

更新日期：2020-07-01 00:00:00

abstract：:Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) ...

journal_title：Molecular psychiatry

authors： Papassotiropoulos A,Stefanova E,Vogler C,Gschwind L,Ackermann S,Spalek K,Rasch B,Heck A,Aerni A,Hanser E,Demougin P,Huynh KD,Luechinger R,Klarhöfer M,Novakovic I,Kostic V,Boesiger P,Scheffler K,de Quervain DJ

更新日期：2013-02-01 00:00:00

abstract：:Translin-associated protein X (TRAX) is a scaffold protein with various functions and has been associated with mental illnesses, including schizophrenia. We have previously demonstrated that TRAX interacts with a Gsα protein-coupled receptor, the A2A adenosine receptor (A2AR), and mediates the function of this recepto...

journal_title：Molecular psychiatry

authors： Chien T,Weng YT,Chang SY,Lai HL,Chiu FL,Kuo HC,Chuang DM,Chern Y

更新日期：2018-12-01 00:00:00

abstract：:High impulsive and aggressive traits associate with poor behavioural self-control. Despite their importance in predicting behavioural negative outcomes including suicide, the molecular mechanisms underlying the expression of impulsive and aggressive traits remain poorly understood. Here, we identified and characterize...

journal_title：Molecular psychiatry

authors： Labonté B,Abdallah K,Maussion G,Yerko V,Yang J,Bittar T,Quessy F,Golden SA,Navarro L,Checknita D,Gigek C,Lopez JP,Neve RL,Russo SJ,Tremblay RE,Côté G,Meaney MJ,Mechawar N,Nestler EJ,Turecki G

更新日期：2020-01-06 00:00:00

abstract：:Recent studies have shown an association between trinucleotide repeat expansions (TREs) and adult-onset schizophrenia (AOS). Childhood-onset schizophrenia (COS) is a severe variant of schizophrenia with onset of symptoms before age 12 years. We have used the repeat expansion detection (RED) method to investigate the o...

journal_title：Molecular psychiatry

authors： Burgess CE,Lindblad K,Sidransky E,Yuan QP,Long RT,Breschel T,Ross CA,McInnis M,Lee P,Ginns EI,Lenane M,Kumra S,Jacobsen L,Rapoport JL,Schalling M

更新日期：1998-07-01 00:00:00

abstract：:Induction of neuroprotective heat-shock proteins via pharmacological Hsp90 inhibitors is currently being investigated as a potential treatment for neurodegenerative diseases. Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicity and limited central nervous system permeability. We demonstrate ...

journal_title：Molecular psychiatry

authors： Wang B,Liu Y,Huang L,Chen J,Li JJ,Wang R,Kim E,Chen Y,Justicia C,Sakata K,Chen H,Planas A,Ostrom RS,Li W,Yang G,McDonald MP,Chen R,Heck DH,Liao FF

更新日期：2017-07-01 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cyto...

journal_title：Molecular psychiatry

authors： Hornig M,Gottschalk G,Peterson DL,Knox KK,Schultz AF,Eddy ML,Che X,Lipkin WI

更新日期：2016-02-01 00:00:00

abstract：:A polymorphism in the serotonin (5-HT) transporter gene regulatory region (5-HTTLPR) is associated with measures of 5-HT transporter (5-HTT) expression and 5-HT-mediated behaviors in humans. An analogous length variation of the 5-HTTLPR has been reported in rhesus monkeys (rh5-HTTLPR). A retrospective association stud...

journal_title：Molecular psychiatry

authors： Champoux M,Bennett A,Shannon C,Higley JD,Lesch KP,Suomi SJ

更新日期：2002-01-01 00:00:00

abstract：:Previous studies have shown inconsistent results regarding the actions of antidepressants on glucocorticoid receptor (GR) signalling. To resolve these inconsistencies, we used a lentiviral-based reporter system to directly monitor rat hippocampal GR activity during stress adaptation. Temporal GR activation was induced...

journal_title：Molecular psychiatry

authors： Lee MS,Kim YH,Park WS,Park OK,Kwon SH,Hong KS,Rhim H,Shim I,Morita K,Wong DL,Patel PD,Lyons DM,Schatzberg AF,Her S

更新日期：2016-02-01 00:00:00

abstract：:We assessed the ability of lithium to reduce neurodegeneration and to stimulate cell proliferation in a rat model of Huntington's disease in which quinolinic acid (QA) was unilaterally infused into the striatum. LiCl (0.5-3.0 mEq/kg) was injected subcutaneously 24 h before and 1 h after QA infusion. At 7 days after QA...

journal_title：Molecular psychiatry

authors： Senatorov VV,Ren M,Kanai H,Wei H,Chuang DM

更新日期：2004-04-01 00:00:00

abstract：:Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 years, as well as 67 adult individuals diagnosed with autism (ASD), schizophrenia (SZ), and Down synd...

journal_title：Molecular psychiatry

authors： Yu Q,He Z,Zubkov D,Huang S,Kurochkin I,Yang X,Halene T,Willmitzer L,Giavalisco P,Akbarian S,Khaitovich P

更新日期：2020-11-01 00:00:00

abstract：:Hyperactivation of the amygdala following chronic stress is believed to be one of the primary mechanisms underlying the increased propensity for anxiety-like behaviors and pathological states; however, the mechanisms by which chronic stress modulates amygdalar function are not well characterized. The aim of the curren...

journal_title：Molecular psychiatry

authors： Hill MN,Kumar SA,Filipski SB,Iverson M,Stuhr KL,Keith JM,Cravatt BF,Hillard CJ,Chattarji S,McEwen BS

更新日期：2013-10-01 00:00:00

abstract：:Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia. This study comprises genome-wide association (GWA) and follow-up analyses of all individuals born in Denmark since 1...

journal_title：Molecular psychiatry

authors： Børglum AD,Demontis D,Grove J,Pallesen J,Hollegaard MV,Pedersen CB,Hedemand A,Mattheisen M,GROUP investigators10.,Uitterlinden A,Nyegaard M,Ørntoft T,Wiuf C,Didriksen M,Nordentoft M,Nöthen MM,Rietschel M,Ophoff RA,Cic

更新日期：2014-03-01 00:00:00

abstract：:(+) 3,4-Methylenedioxymethamphetamine (MDMA) is a psychedelic drug of abuse that causes selective degeneration of serotonergic fibers of dorsal raphe neurons that project throughout the forebrain. Previous studies using pharmacological and behavioral approaches suggested that MDMA treatment leads to desensitization of...

journal_title：Molecular psychiatry

authors： Sexton TJ,McEvoy C,Neumaier JF

更新日期：1999-11-01 00:00:00

abstract：:We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25-q26 that had been typed in a genome-wide association study (GWAS) of schi...

journal_title：Molecular psychiatry

authors： O'Donovan MC,Norton N,Williams H,Peirce T,Moskvina V,Nikolov I,Hamshere M,Carroll L,Georgieva L,Dwyer S,Holmans P,Marchini JL,Spencer CC,Howie B,Leung HT,Giegling I,Hartmann AM,Möller HJ,Morris DW,Shi Y,Feng G,H

更新日期：2009-01-01 00:00:00

abstract：:The serotonergic neurotransmitter system has been widely implicated in the pathophysiology of mood-related disorders such as anxiety and major depressive disorder (MDD). The onset of therapeutic efficacy of traditional antidepressants is delayed by several weeks. The 5-HT4 receptor has emerged as a new therapeutic tar...

journal_title：Molecular psychiatry

authors： Castello J,LeFrancois B,Flajolet M,Greengard P,Friedman E,Rebholz H

更新日期：2018-04-01 00:00:00

abstract：:Recent studies have revealed that the gut microbiota modulates brain development and behavior, but the underlying mechanisms are still poorly understood. Here, we show that bacterial peptidoglycan (PGN) derived from the commensal gut microbiota can be translocated into the brain and sensed by specific pattern-recognit...

journal_title：Molecular psychiatry

authors： Arentsen T,Qian Y,Gkotzis S,Femenia T,Wang T,Udekwu K,Forssberg H,Diaz Heijtz R

更新日期：2017-02-01 00:00:00

abstract：:Psychiatric disorders are a group of genetically related diseases with highly polygenic architectures. Genome-wide association analyses have made substantial progress towards understanding the genetic architecture of these disorders. More recently, exome- and whole-genome sequencing of cases and families have identifi...

journal_title：Molecular psychiatry

authors： Ryan NM,Lihm J,Kramer M,McCarthy S,Morris SW,Arnau-Soler A,Davies G,Duff B,Ghiban E,Hayward C,Deary IJ,Blackwood DHR,Lawrie SM,McIntosh AM,Evans KL,Porteous DJ,McCombie WR,Thomson PA

更新日期：2018-12-01 00:00:00

abstract：:Patients with psychotic disorders are at high risk for type 2 diabetes mellitus, and there is increasing evidence that patients display glucose metabolism abnormalities before significant antipsychotic medication exposure. In the present study, we examined insulin action by quantifying insulin sensitivity in first-epi...

journal_title：Molecular psychiatry

authors： Chouinard VA,Henderson DC,Dalla Man C,Valeri L,Gray BE,Ryan KP,Cypess AM,Cobelli C,Cohen BM,Öngür D

更新日期：2019-10-01 00:00:00