Abstract:
:Translin-associated protein X (TRAX) is a scaffold protein with various functions and has been associated with mental illnesses, including schizophrenia. We have previously demonstrated that TRAX interacts with a Gsα protein-coupled receptor, the A2A adenosine receptor (A2AR), and mediates the function of this receptor in neuritogenesis. In addition, stimulation of the A2AR markedly ameliorates DNA damage evoked by elevated oxidative stress in neurons derived from induced pluripotent stem cells (iPSCs). Here, we report that glycogen synthase kinase 3 beta (GSK3β) and disrupted-in-schizophrenia 1 (DISC1) are two novel interacting proteins of TRAX. We present evidence to suggest that the stimulation of A2AR markedly facilitated DNA repair through the TRAX/DISC1/GSK3β complex in a rat neuronal cell line (PC12), primary mouse neurons, and human medium spiny neurons derived from iPSCs. A2AR stimulation led to the inhibition of GSK3β, thus dissociating the TRAX/DISC1/GSK3β complex and facilitating the non-homologous end-joining pathway (NHEJ) by enhancing the activation of a DNA-dependent protein kinase via phosphorylation at Thr2609. Similarly, pharmacological inhibition of GSK3β by SB216763 also facilitated the TRAX-mediated repair of oxidative DNA damage. Collectively, GSK3β binds with TRAX and negatively affects its ability to facilitate NHEJ repair. The suppression of GSK3β by A2AR activation or a GSK3β inhibitor releases TRAX for the repair of oxidative DNA damage. Our findings shed new light on the molecular mechanisms underlying diseases associated with DNA damage and provides a novel target (i.e., the TRAX/DISC1/GSK3β complex) for future therapeutic development for mental disorders.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Chien T,Weng YT,Chang SY,Lai HL,Chiu FL,Kuo HC,Chuang DM,Chern Ydoi
10.1038/s41380-017-0007-zsubject
Has Abstractpub_date
2018-12-01 00:00:00pages
2375-2390issue
12eissn
1359-4184issn
1476-5578pii
10.1038/s41380-017-0007-zjournal_volume
23pub_type
杂志文章abstract::Several lines of evidence have suggested altered functions of the brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). In the search for polymorphisms in the 5'-flanking and 5'-noncoding regions of the BDNF gene, we found a novel nucleotide subs...
journal_title:Molecular psychiatry
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journal_title:Molecular psychiatry
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
doi:10.1038/mp.2015.29
更新日期:2016-02-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:Molecular psychiatry
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doi:10.1038/s41380-018-0090-9
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更新日期:2016-08-01 00:00:00
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journal_title:Molecular psychiatry
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pub_type: 临床试验,杂志文章
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