Abstract:
:The term 'mood stabilizer' has been applied to a number of medications for the treatment of patients with bipolar disorder. The operational definition of the properties of a mood-stabilizing medication has varied according to the properties of specific medications and the clinical characteristics of the illness. Randomized controlled trials of agents accepted or proposed as mood stabilizers are reviewed to marshall the available evidence in support of this claim. In addition, potential pharmacological mechanisms underlying mood-stabilizing effects of established compounds are reviewed.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Keck PE Jr,McElroy SL,Richtand N,Tohen Mdoi
10.1038/sj.mp.4001013subject
Has Abstractpub_date
2002-01-01 00:00:00pages
S8-14eissn
1359-4184issn
1476-5578journal_volume
7 Suppl 1pub_type
杂志文章,评审abstract::Several studies have indicated that patients with bipolar disorder (BD) who respond well to lithium prophylaxis constitute a biologically distinct subgroup. Lithium is thought to stabilize mood by acting at the phosphoinositide cycle. We have investigated a polymorphism located in the gene (PLCG1) that codes for a gam...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000447
更新日期:1998-11-01 00:00:00
abstract::Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncoding RNAs. RNA-binding protein (RBP) is a key factor of the regulation. Regulator of calcineurin 1 (RCAN1) is a multifunctional protein involved in neurodegeneration, mit...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0487-0
更新日期:2019-08-27 00:00:00
abstract::Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmen...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0635-6
更新日期:2020-01-03 00:00:00
abstract::Induction of neuroprotective heat-shock proteins via pharmacological Hsp90 inhibitors is currently being investigated as a potential treatment for neurodegenerative diseases. Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicity and limited central nervous system permeability. We demonstrate ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.104
更新日期:2017-07-01 00:00:00
abstract::The dorsolateral prefrontal cortex (dlpfc) is strongly implicated in the pathogenesis of schizophrenia (SCZ) and bipolar disorder (BPD) and, within this region, abnormalities in glutamatergic neurotransmission and synaptic function have been described. Proteins associated with these functions are enriched in membrane ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2008.7
更新日期:2009-06-01 00:00:00
abstract::Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structural and chemical alterations in specific neural substrates. Here we show that adult rats that had been exposed to in utero GCs (iuGC) display increased preference for opiates and ethanol, a...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.126
更新日期:2012-12-01 00:00:00
abstract::To quantify aging- and disease-associated alterations in the integrative and interactive components of a pulsatile neuroendocrine axis, novel biomathematical strategies are required. Here, I illustrate as an investigative paradigm otherwise subtle aging-dependent disturbances of the gonadotropin-releasing-hormone (GnR...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/sj.mp.4000232
更新日期:1997-01-01 00:00:00
abstract::The human serotonin transporter gene (5-HTT) demonstrates two polymorphisms with possible functional impact: a 44-bp insertion/deletion polymorphism of the promoter region and a 17-bp variable number of tandem repeat polymorphism (VNTR) in intron 2 (STin2). Such genetic polymorphisms in the serotoninergic system may i...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000821
更新日期:2001-03-01 00:00:00
abstract::Between 1997 and 2002, 48 data sets from the hippocampus were produced on samples from the Stanley Neuropathology Consortium. From these data sets, 224 total measures were available from the various subdivisions of the hippocampus. An integrative analysis of these measures was performed using a multivariate, nonparame...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001471
更新日期:2004-06-01 00:00:00
abstract::The urocortin (Ucn) family of neuropeptides is suggested to be involved in homeostatic coping mechanisms of the central stress response through the activation of corticotropin-releasing factor receptor type 2 (CRFR2). The neuropeptides, Ucn1 and Ucn2, serve as endogenous ligands for the CRFR2, which is highly expresse...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.115
更新日期:2010-04-01 00:00:00
abstract::Genetic factors do not fully account for the relatively high heritability of neurodevelopmental conditions, suggesting that non-genetic heritable factors contribute to their etiology. To evaluate the potential contribution of aberrant thyroid hormone status to the epigenetic inheritance of neurological phenotypes, we ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0281-4
更新日期:2020-05-01 00:00:00
abstract::Accumulating research demonstrates the potential of intranasal delivery of psychopharmacological agents to treat a range of psychiatric disorders and symptoms. It is believed that intranasal administration offers both direct and indirect pathways to deliver psychopharmacological agents to the central nervous system. T...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2015.166
更新日期:2016-01-01 00:00:00
abstract::This corrects the article DOI: 10.1038/mp.2017.5. ...
journal_title:Molecular psychiatry
pub_type: 杂志文章,已发布勘误
doi:10.1038/mp.2017.70
更新日期:2018-03-01 00:00:00
abstract::Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy number variations (CNVs) in SCZ cases and identified multiple rare recurrent CNVs that increase risk of SCZ although with incomplete penetranc...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.40
更新日期:2014-07-01 00:00:00
abstract::The glutamate hypothesis of schizophrenia derived from evidence that phencyclidine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, produces schizophrenia-like symptoms in healthy humans. Sensorimotor gating, measured by prepulse inhibition (PPI), is a fundamental form of information processing that is defici...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001404
更新日期:2004-01-01 00:00:00
abstract::There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. We studied the association of CR...
journal_title:Molecular psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.mp.4001587
更新日期:2004-12-01 00:00:00
abstract::Activation of the inflammatory response system has been related to the pathophysiology of schizophrenia by several recent studies. Schizophrenic patients have varied levels of proinflammatory cytokines, such as interleukin (IL)-1, -6, and tumor necrosis factor (TNF)alpha in their peripheral blood or cerebrospinal flui...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000483
更新日期:1999-03-01 00:00:00
abstract::Episodic memory, a fundamental component of human cognition, is significantly impaired in autism. We believe we report the first evidence for this problem in the Fmr1-knockout (KO) mouse model of Fragile X syndrome and describe potentially treatable underlying causes. The hippocampus is critical for the formation and ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2017.221
更新日期:2018-08-01 00:00:00
abstract::Mol Psychiatry 2000; 5: 77-84 ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000752
更新日期:2000-07-01 00:00:00
abstract::Anxiety disorders constitute a major disease and social burden worldwide; however, many questions concerning the underlying molecular mechanisms still remain open. Besides the involvement of the major excitatory (glutamate) and inhibitory (gamma aminobutyric acid (GABA)) neurotransmitter circuits in anxiety disorders,...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.87
更新日期:2017-03-01 00:00:00
abstract::Several studies suggest that decreased expression of presynaptic proteins may be characteristic of schizophrenia. We examined one such protein, synapsin, in schizophrenia and bipolar disorder. Samples of hippocampal tissue from controls (n = 13), patients with schizophrenia (n = 16), or bipolar disorder (n = 6), and s...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001158
更新日期:2002-01-01 00:00:00
abstract::Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the dynamic plasticity of dendritic spines of pyramidal neurons (PNs) and "en passant" axonal bouton of parvalbumin-expressing interneurons (PVI...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-01005-w
更新日期:2021-01-20 00:00:00
abstract::The 102-T/C polymorphism of the 5-HT(2A) receptor gene was analysed in 159 patients with major depression and 164 unrelated and healthy controls using a case-control design. Allele and genotype frequencies did not differ between cases and controls. No differences according to sex, age of onset, melancholia, suicidal b...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000818
更新日期:2001-03-01 00:00:00
abstract::Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhanci...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-01002-z
更新日期:2021-01-17 00:00:00
abstract::Panic disorder (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide geno...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0590-2
更新日期:2019-11-11 00:00:00
abstract::Schizophrenia and bipolar disorder have both been linked to structural abnormalities of the hippocampus, which is consistent with a neurodevelopmental anomaly. One isoform of the neural cell adhesion molecule (N-CAM) protein, cytosolic N-CAM 105-115 kDa, was previously shown to be increased in schizophrenia in the hip...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000547
更新日期:1999-09-01 00:00:00
abstract::Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental syndrome characterized by hyperactivity, inattention and increased impulsivity. To detect micro-deletions and micro-duplications that may have a role in the pathogenesis of ADHD, we carried out a genome-wide screen for cop...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.29
更新日期:2011-05-01 00:00:00
abstract::Patients with psychotic disorders are at high risk for type 2 diabetes mellitus, and there is increasing evidence that patients display glucose metabolism abnormalities before significant antipsychotic medication exposure. In the present study, we examined insulin action by quantifying insulin sensitivity in first-epi...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0045-1
更新日期:2019-10-01 00:00:00
abstract::We earlier reported a genome-wide significant linkage to schizophrenia at chromosome 17 that was identified in a single pedigree (C702) consisting of six affected, male siblings with DSM-IV schizophrenia and prominent mood symptoms. In this study, we adopted several approaches in an attempt to map the putative disease...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.96
更新日期:2010-11-01 00:00:00
abstract::Chronic stress contributes to the development of psychiatric disorders including anxiety and depression. Several inflammatory-related effects of stress are associated with increased interleukin-1 (IL-1) signaling within the central nervous system and are mediated by IL-1 receptor 1 (IL-1R1) on several distinct cell ty...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-0788-3
更新日期:2020-05-22 00:00:00