Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.

abstract：:This corrects the article DOI: 10.1038/mp.2017.5. ...

journal_title：Molecular psychiatry

authors： Deary V,Hagenaars SP,Harris SE,Hill WD,Davies G,Liewald DCM,International Consortium for Blood Pressure GWAS.,CHARGE consortium Aging and Longevity Group.,CHARGE consortium Inflammation Group.,McIntosh AM,Gale CR,Deary IJ

更新日期：2018-03-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders. Genetic factors contribute to the underlying liability to develop ADHD. Reports implicate variants of genes important for the synthesis, uptake, transport and receptor binding of dopamine in the etiology of ADHD, ...

journal_title：Molecular psychiatry

authors： Kustanovich V,Ishii J,Crawford L,Yang M,McGough JJ,McCracken JT,Smalley SL,Nelson SF

更新日期：2004-07-01 00:00:00

abstract：:Niemann-Pick disease type A (NPA) is a rare lysosomal storage disorder characterized by severe neurological alterations that leads to death in childhood. Loss-of-function mutations in the acid sphingomyelinase (ASM) gene cause NPA, and result in the accumulation of sphingomyelin (SM) in lysosomes and plasma membrane o...

journal_title：Molecular psychiatry

authors： Pérez-Cañamás A,Benvegnù S,Rueda CB,Rábano A,Satrústegui J,Ledesma MD

更新日期：2017-05-01 00:00:00

abstract：:Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8), suggesting that about 80% of phenotypic variance is due to genetic factors. We used the integration of statistical and functional approaches to discover a novel gene that contributes to ADHD. For our statistical approach, we started wi...

journal_title：Molecular psychiatry

authors： Arcos-Burgos M,Jain M,Acosta MT,Shively S,Stanescu H,Wallis D,Domené S,Vélez JI,Karkera JD,Balog J,Berg K,Kleta R,Gahl WA,Roessler E,Long R,Lie J,Pineda D,Londoño AC,Palacio JD,Arbelaez A,Lopera F,Elia J,Hakon

更新日期：2010-11-01 00:00:00

abstract：:The term 'mood stabilizer' has been applied to a number of medications for the treatment of patients with bipolar disorder. The operational definition of the properties of a mood-stabilizing medication has varied according to the properties of specific medications and the clinical characteristics of the illness. Rando...

journal_title：Molecular psychiatry

authors： Keck PE Jr,McElroy SL,Richtand N,Tohen M

更新日期：2002-01-01 00:00:00

abstract：:A genetic predisposition to the development of neuroleptic malignant syndrome (NMS) has been suggested by clinical studies. Although the molecular basis of NMS is unclear, a dopaminergic blockade mechanism has been considered the main cause. We therefore investigated the association between NMS and three functional po...

journal_title：Molecular psychiatry

authors： Kishida I,Kawanishi C,Furuno T,Kato D,Ishigami T,Kosaka K

更新日期：2004-03-01 00:00:00

abstract：:Converging advances in the fields of molecular biology, molecular genetics, cellular biology and embryology have given researchers the tools for the targeted delivery and stable germline transmission of foreign genes (transgenes) in the mouse. In the realm of neuropsychiatry, this so-named transgenic technology has be...

journal_title：Molecular psychiatry

authors： Campbell IL,Gold LH

更新日期：1996-05-01 00:00:00

abstract：:Polymorphic variants of the dopamine D(4) receptor have been consistently associated with attention-deficit hyperactivity disorder (ADHD). However, the functional significance of the risk polymorphism (variable number of tandem repeats in exon 3) is still unclear. Here, we show that whereas the most frequent 4-repeat ...

journal_title：Molecular psychiatry

authors： González S,Rangel-Barajas C,Peper M,Lorenzo R,Moreno E,Ciruela F,Borycz J,Ortiz J,Lluís C,Franco R,McCormick PJ,Volkow ND,Rubinstein M,Floran B,Ferré S

更新日期：2012-06-01 00:00:00

abstract：:Between 1997 and 2002, 48 data sets from the hippocampus were produced on samples from the Stanley Neuropathology Consortium. From these data sets, 224 total measures were available from the various subdivisions of the hippocampus. An integrative analysis of these measures was performed using a multivariate, nonparame...

journal_title：Molecular psychiatry

authors： Knable MB,Barci BM,Webster MJ,Meador-Woodruff J,Torrey EF,Stanley Neuropathology Consortium.

更新日期：2004-06-01 00:00:00

abstract：:Serum antibodies against amyloid-β peptide (Aβ) in humans with or without diagnosis of Alzheimer's disease (AD) indicate the possibility of immune responses against brain antigens. In an unbiased screening for antibodies directed against brain proteins, we found in AD patients high serum levels of antibodies against t...

journal_title：Molecular psychiatry

authors： Santuccione AC,Merlini M,Shetty A,Tackenberg C,Bali J,Ferretti MT,McAfoose J,Kulic L,Bernreuther C,Welt T,Grimm J,Glatzel M,Rajendran L,Hock C,Nitsch RM

更新日期：2013-03-01 00:00:00

abstract：:Early-life disruption of the parent-child relationship, for example, in the form of abuse, neglect or loss, dramatically increases risk for psychiatric, as well as certain medical, disorders in adulthood. The neuropeptide oxytocin (OT) plays a seminal role in mediating social affiliation, attachment, social support, m...

journal_title：Molecular psychiatry

authors： Heim C,Young LJ,Newport DJ,Mletzko T,Miller AH,Nemeroff CB

更新日期：2009-10-01 00:00:00

abstract：:The 102-T/C polymorphism of the 5-HT(2A) receptor gene was analysed in 159 patients with major depression and 164 unrelated and healthy controls using a case-control design. Allele and genotype frequencies did not differ between cases and controls. No differences according to sex, age of onset, melancholia, suicidal b...

journal_title：Molecular psychiatry

authors： Arias B,Gutiérrez B,Pintor L,Gastó C,Fañanás L

更新日期：2001-03-01 00:00:00

abstract：:Only in the past decade has a role of heredity in substance abuse been established as a result of extensive twin and family studies. More recently, several candidate genes have been investigated for their possible role in alcoholism and cocaine abuse. Specific genetic factors in opioid substance abuse have not been in...

journal_title：Molecular psychiatry

authors： Kotler M,Cohen H,Segman R,Gritsenko I,Nemanov L,Lerer B,Kramer I,Zer-Zion M,Kletz I,Ebstein RP

更新日期：1997-05-01 00:00:00

abstract：:Depression is a heritable disorder that is often precipitated by stress. Abnormalities of the stress-reactive hypothalamic-pituitary-adrenal (HPA) axis are also common in depressed patients. In animal models, the forced swim test (FST) is the most frequently used test of depressive-like behavior. We have used a propos...

journal_title：Molecular psychiatry

authors： Solberg LC,Ahmadiyeh N,Baum AE,Vitaterna MH,Takahashi JS,Turek FW,Redei EE

更新日期：2003-04-01 00:00:00

abstract：:Delivery of drugs into the brain is poor due to the blood brain barrier (BBB). This study describes the development of a novel liposome-based brain-targeting drug delivery system. The liposomes incorporate a diacylglycerol moiety coupled through a linker to a peptide of 5 amino acids selected from amyloid precursor pr...

journal_title：Molecular psychiatry

authors： Kahana M,Weizman A,Gabay M,Loboda Y,Segal-Gavish H,Gavish A,Barhum Y,Offen D,Finberg J,Allon N,Gavish M

更新日期：2020-05-05 00:00:00

abstract：:Genetic and pharmacological studies have emphasised the role of serotonin 5-hydroxytryptamine (5-HT) as a possible etiologic factor in the development of attention-deficit hyperactivity disorder (ADHD). Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the biosynthesis of serotonin from tryptophan. Originally,...

journal_title：Molecular psychiatry

authors： Sheehan K,Lowe N,Kirley A,Mullins C,Fitzgerald M,Gill M,Hawi Z

更新日期：2005-10-01 00:00:00

abstract：:Peripheral blood brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in bipolar disorder, speculated to mirror alterations in brain expression of BDNF. The research area is rapidly evolving; however, recent investigations have yielded con...

journal_title：Molecular psychiatry

authors： Munkholm K,Vinberg M,Kessing LV

更新日期：2016-02-01 00:00:00

abstract：:Adults with psychotic disorders have dysconnectivity in critical brain networks, including the default mode (DM) and the cingulo-opercular (CO) networks. However, it is unknown whether such deficits are present in youth with less severe symptoms. We conducted a multivariate connectome-wide association study examining ...

journal_title：Molecular psychiatry

authors： Satterthwaite TD,Vandekar SN,Wolf DH,Bassett DS,Ruparel K,Shehzad Z,Craddock RC,Shinohara RT,Moore TM,Gennatas ED,Jackson C,Roalf DR,Milham MP,Calkins ME,Hakonarson H,Gur RC,Gur RE

更新日期：2015-12-01 00:00:00

abstract：:Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmen...

journal_title：Molecular psychiatry

authors： Chen K,Ma X,Nehme A,Wei J,Cui Y,Cui Y,Yao D,Wu J,Anderson T,Ferguson D,Levitt P,Qiu S

更新日期：2020-01-03 00:00:00

abstract：:Contemporary models of psychosis suggest that a continuum of severity of psychotic symptoms exists, with subthreshold psychotic experiences (PEs) potentially reflecting some genetic and environmental risk factors shared with clinical psychosis. Thus, identifying abnormalities in brain activity that manifest across thi...

journal_title：Molecular psychiatry

authors： Wang D,Peng X,Pelletier-Baldelli A,Orlov N,Farabaugh A,Nasr S,Eryilmaz H,Fava M,Holmes AJ,Roffman JL,Liu H,Holt DJ

更新日期：2021-01-18 00:00:00

abstract：:Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The pathophysiology of the illness is not understood, but is thought to have a strong genetic component with some environmental influences on aetiology. To gain further insight into disease mechanism, we used microarray technology to de...

journal_title：Molecular psychiatry

authors： Maycox PR,Kelly F,Taylor A,Bates S,Reid J,Logendra R,Barnes MR,Larminie C,Jones N,Lennon M,Davies C,Hagan JJ,Scorer CA,Angelinetta C,Akbar MT,Hirsch S,Mortimer AM,Barnes TR,de Belleroche J

更新日期：2009-12-01 00:00:00

abstract：:The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with 'Western' diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched 'Western' ...

journal_title：Molecular psychiatry

authors： Cinquina V,Calvigioni D,Farlik M,Halbritter F,Fife-Gernedl V,Shirran SL,Fuszard MA,Botting CH,Poullet P,Piscitelli F,Máté Z,Szabó G,Yanagawa Y,Kasper S,Di Marzo V,Mackie K,McBain CJ,Bock C,Keimpema E,Harkany T

更新日期：2020-01-01 00:00:00

abstract：:The urocortin (Ucn) family of neuropeptides is suggested to be involved in homeostatic coping mechanisms of the central stress response through the activation of corticotropin-releasing factor receptor type 2 (CRFR2). The neuropeptides, Ucn1 and Ucn2, serve as endogenous ligands for the CRFR2, which is highly expresse...

journal_title：Molecular psychiatry

authors： Neufeld-Cohen A,Evans AK,Getselter D,Spyroglou A,Hill A,Gil S,Tsoory M,Beuschlein F,Lowry CA,Vale W,Chen A

更新日期：2010-04-01 00:00:00

abstract：:We earlier reported a genome-wide significant linkage to schizophrenia at chromosome 17 that was identified in a single pedigree (C702) consisting of six affected, male siblings with DSM-IV schizophrenia and prominent mood symptoms. In this study, we adopted several approaches in an attempt to map the putative disease...

journal_title：Molecular psychiatry

authors： Carroll LS,Williams NM,Moskvina V,Russell E,Norton N,Williams HJ,Peirce T,Georgieva L,Dwyer S,Grozeva D,Greene E,Farmer A,McGuffin P,Morris DW,Corvin A,Gill M,Rujescu D,Sham P,Holmans P,Jones I,Kirov G,Craddock

更新日期：2010-11-01 00:00:00

abstract：:Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-inv...

journal_title：Molecular psychiatry

authors： Hadar R,Winter R,Edemann-Callesen H,Wieske F,Habelt B,Khadka N,Felgel-Farnholz V,Barroeta-Hlusicka E,Reis J,Tatarau CA,Funke K,Fritsch B,Bernhardt N,Bikson M,Nitsche MA,Winter C

更新日期：2020-04-01 00:00:00

abstract：:Psychotropic medications target glycogen synthase kinase 3β (GSK3β), but the functional integration with other factors relevant for drug efficacy is poorly understood. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3β at serine 9 (pGSK3β(S9))....

journal_title：Molecular psychiatry

authors： Gassen NC,Hartmann J,Zannas AS,Kretzschmar A,Zschocke J,Maccarrone G,Hafner K,Zellner A,Kollmannsberger LK,Wagner KV,Mehta D,Kloiber S,Turck CW,Lucae S,Chrousos GP,Holsboer F,Binder EB,Ising M,Schmidt MV,Rein T

更新日期：2016-02-01 00:00:00

abstract：:High impulsive and aggressive traits associate with poor behavioural self-control. Despite their importance in predicting behavioural negative outcomes including suicide, the molecular mechanisms underlying the expression of impulsive and aggressive traits remain poorly understood. Here, we identified and characterize...

journal_title：Molecular psychiatry

authors： Labonté B,Abdallah K,Maussion G,Yerko V,Yang J,Bittar T,Quessy F,Golden SA,Navarro L,Checknita D,Gigek C,Lopez JP,Neve RL,Russo SJ,Tremblay RE,Côté G,Meaney MJ,Mechawar N,Nestler EJ,Turecki G

更新日期：2020-01-06 00:00:00

abstract：:Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the hypothesis that rare variants in many different genes, including de novo variants, could predispose to these conditions i...

journal_title：Molecular psychiatry

authors： Piton A,Gauthier J,Hamdan FF,Lafrenière RG,Yang Y,Henrion E,Laurent S,Noreau A,Thibodeau P,Karemera L,Spiegelman D,Kuku F,Duguay J,Destroismaisons L,Jolivet P,Côté M,Lachapelle K,Diallo O,Raymond A,Marineau C,Cham

更新日期：2011-08-01 00:00:00

abstract：:The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate,...

journal_title：Molecular psychiatry

authors： Serretti A,Kato M,De Ronchi D,Kinoshita T

更新日期：2007-03-01 00:00:00

abstract：:Exposure to severe stressors increases the risk for psychiatric disorders in vulnerable individuals, but can lead to positive outcomes for others. However, it remains unknown how severe stress affects neural functioning in humans and what factors mediate individual differences in the neural sequelae of stress. The amy...

journal_title：Molecular psychiatry

authors： van Wingen GA,Geuze E,Vermetten E,Fernández G

更新日期：2011-06-01 00:00:00