Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients.

Abstract:

:Epidermal growth factor (EGF) comprises a structurally related family of proteins containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that regulates the development of dopaminergic neurons as well as monoamine metabolism. We assessed the contribution of EGF to schizophrenia by measuring EGF family protein levels in postmortem brains and in fresh serum of schizophrenic patients and control subjects. EGF protein levels were decreased in the prefrontal cortex and striatum of schizophrenic patients, whereas the levels of HB-EGF and TGFalpha were not significantly different in any of the regions examined. Conversely, EGF receptor expression was elevated in the prefrontal cortex. Serum EGF levels were markedly reduced in schizophrenic patients, even in young, drug-free patients. Chronic treatment of animals with the antipsychotic drug haloperidol had no influence on EGF levels in the brain or serum. These findings suggest that there is abnormal EGF production in various central and peripheral tissues of patients with both acute and chronic schizophrenia. EGF might thus provide a molecular substrate for the pathologic manifestation of the illness, although additional studies are required to determine a potential link between impaired EGF signaling and the pathology/etiology of schizophrenia.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Futamura T,Toyooka K,Iritani S,Niizato K,Nakamura R,Tsuchiya K,Someya T,Kakita A,Takahashi H,Nawa H

doi

10.1038/sj.mp.4001081

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

673-82

issue

7

eissn

1359-4184

issn

1476-5578

journal_volume

7

pub_type

杂志文章
  • Variants in Apaf-1 segregating with major depression promote apoptosome function.

    abstract::APAF1, encoding the protein apoptosis protease activating factor 1 (Apaf-1), has recently been established as a chromosome 12 gene conferring predisposition to major depression in humans. The molecular phenotypes of Apaf-1 variants were determined by in vitro reconstruction of the apoptosome complex in which Apaf-1 ac...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/sj.mp.4001755

    authors: Harlan J,Chen Y,Gubbins E,Mueller R,Roch JM,Walter K,Lake M,Olsen T,Metzger P,Dorwin S,Ladror U,Egan DA,Severin J,Johnson RW,Holzman TF,Voelp K,Davenport C,Beck A,Potter J,Gopalakrishnan M,Hahn A,Spear BB,Halb

    更新日期:2006-01-01 00:00:00

  • Reduced motor cortex GABABR function following chronic alcohol exposure.

    abstract::The GABAB receptor (GABABR) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlying neural mechanism remains unclear. The present study aimed to investigate cortical GABABR dynamics following chronic alcohol exposure. Ex vivo brain slice recordings from m...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-01009-6

    authors: Peng SY,Shi Z,Zhou DS,Wang XY,Li XX,Liu XL,Wang WD,Lin GN,Pan BX,Voon V,Grace AA,Heilig M,Wong ML,Yuan TF

    更新日期:2021-01-11 00:00:00

  • Polymorphisms of the interleukin-1 gene complex in schizophrenia.

    abstract::Activation of the inflammatory response system has been related to the pathophysiology of schizophrenia by several recent studies. Schizophrenic patients have varied levels of proinflammatory cytokines, such as interleukin (IL)-1, -6, and tumor necrosis factor (TNF)alpha in their peripheral blood or cerebrospinal flui...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/sj.mp.4000483

    authors: Katila H,Hänninen K,Hurme M

    更新日期:1999-03-01 00:00:00

  • Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness.

    abstract::Biological characterization of genetic variants identified in genome-wide association studies (GWAS) remains a substantial challenge. Here we used human-induced pluripotent stem cells (iPSC) and their neural derivatives to characterize common variants on chromosome 3p22 that have been associated by GWAS with major men...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-018-0207-1

    authors: Jiang X,Detera-Wadleigh SD,Akula N,Mallon BS,Hou L,Xiao T,Felsenfeld G,Gu X,McMahon FJ

    更新日期:2019-04-01 00:00:00

  • Variability in the 5-HT(2A) receptor gene is associated with seasonal pattern in major depression.

    abstract::The 102-T/C polymorphism of the 5-HT(2A) receptor gene was analysed in 159 patients with major depression and 164 unrelated and healthy controls using a case-control design. Allele and genotype frequencies did not differ between cases and controls. No differences according to sex, age of onset, melancholia, suicidal b...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/sj.mp.4000818

    authors: Arias B,Gutiérrez B,Pintor L,Gastó C,Fañanás L

    更新日期:2001-03-01 00:00:00

  • Response of the μ-opioid system to social rejection and acceptance.

    abstract::The endogenous opioid system, which alleviates physical pain, is also known to regulate social distress and reward in animal models. To test this hypothesis in humans (n=18), we used an μ-opioid receptor (MOR) radiotracer to measure changes in MOR availability in vivo with positron emission tomography during social re...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/mp.2013.96

    authors: Hsu DT,Sanford BJ,Meyers KK,Love TM,Hazlett KE,Wang H,Ni L,Walker SJ,Mickey BJ,Korycinski ST,Koeppe RA,Crocker JK,Langenecker SA,Zubieta JK

    更新日期:2013-11-01 00:00:00

  • Dopamine depletion results in increased neostriatal D(2), but not D(1), receptor binding in humans.

    abstract::The effect of endogenous dopamine (DA) on neostriatal DA D(1) and D(2) receptor binding potentials (D(1)RBP and D(2)RBP, respectively) in vivo was evaluated with positron emission tomography (PET) and the radiotracers [(11)C]SCH23390 and [(11)C]raclopride, respectively, by comparing the D(1)RBP and D(2)RBP before and ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/sj.mp.4001062

    authors: Verhoeff NP,Hussey D,Lee M,Tauscher J,Papatheodorou G,Wilson AA,Houle S,Kapur S

    更新日期:2002-01-01 00:00:00

  • Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.

    abstract::The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta, which encode 411, 415 and 431 amino acid proteins and transduce signals via the stimulation of intracellular cAMP production. The recent identification of high-af...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审

    doi:

    authors: Behan DP,Grigoriadis DE,Lovenberg T,Chalmers D,Heinrichs S,Liaw C,De Souza EB

    更新日期:1996-09-01 00:00:00

  • Prevention of behavioral deficits in rats exposed to folate receptor antibodies: implication in autism.

    abstract::Folate receptor alpha (FRα) autoantibodies have been associated with fetal abnormalities and cerebral folate deficiency-related developmental disorders. Over 70% of the children with autism spectrum disorders (ASD) are positive for these autoantibodies and high-dose folinic acid is beneficial in treating these childre...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/mp.2016.153

    authors: Desai A,Sequeira JM,Quadros EV

    更新日期:2017-09-01 00:00:00

  • Novel modalities for appraising individual and coordinate pulsatile hormone secretion: the paradigm of luteinizing hormone and testosterone release in the aging male.

    abstract::To quantify aging- and disease-associated alterations in the integrative and interactive components of a pulsatile neuroendocrine axis, novel biomathematical strategies are required. Here, I illustrate as an investigative paradigm otherwise subtle aging-dependent disturbances of the gonadotropin-releasing-hormone (GnR...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审

    doi:10.1038/sj.mp.4000232

    authors: Veldhuis JD

    更新日期:1997-01-01 00:00:00

  • Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder.

    abstract::Cannabis is one of the most commonly and widely used psychoactive drugs. The rates of cannabis misuse have been increasing. Therefore, understanding the effects of cannabis use on the brain is important. Adolescent and adult rodents exposed to repeated administration of cannabinoids show persistent microstructural cha...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00891-4

    authors: D'Souza DC,Radhakrishnan R,Naganawa M,Ganesh S,Nabulsi N,Najafzadeh S,Ropchan J,Ranganathan M,Cortes-Briones J,Huang Y,Carson RE,Skosnik P

    更新日期:2020-09-24 00:00:00

  • A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication.

    abstract::Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8), suggesting that about 80% of phenotypic variance is due to genetic factors. We used the integration of statistical and functional approaches to discover a novel gene that contributes to ADHD. For our statistical approach, we started wi...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/mp.2010.6

    authors: Arcos-Burgos M,Jain M,Acosta MT,Shively S,Stanescu H,Wallis D,Domené S,Vélez JI,Karkera JD,Balog J,Berg K,Kleta R,Gahl WA,Roessler E,Long R,Lie J,Pineda D,Londoño AC,Palacio JD,Arbelaez A,Lopera F,Elia J,Hakon

    更新日期:2010-11-01 00:00:00

  • Serotonin transporter polymorphisms: no association with response to antipsychotic treatment, but associations with the schizoparanoid and residual subtypes of schizophrenia.

    abstract::The human serotonin transporter gene (5-HTT) demonstrates two polymorphisms with possible functional impact: a 44-bp insertion/deletion polymorphism of the promoter region and a 17-bp variable number of tandem repeat polymorphism (VNTR) in intron 2 (STin2). Such genetic polymorphisms in the serotoninergic system may i...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/sj.mp.4000821

    authors: Kaiser R,Tremblay PB,Schmider J,Henneken M,Dettling M,Müller-Oerlinghausen B,Uebelhack R,Roots I,Brockmöller J

    更新日期:2001-03-01 00:00:00

  • An epigenome-wide association study meta-analysis of educational attainment.

    abstract::The epigenome is associated with biological factors, such as disease status, and environmental factors, such as smoking, alcohol consumption and body mass index. Although there is a widespread perception that environmental influences on the epigenome are pervasive and profound, there has been little evidence to date i...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1038/mp.2017.210

    authors: Karlsson Linnér R,Marioni RE,Rietveld CA,Simpkin AJ,Davies NM,Watanabe K,Armstrong NJ,Auro K,Baumbach C,Bonder MJ,Buchwald J,Fiorito G,Ismail K,Iurato S,Joensuu A,Karell P,Kasela S,Lahti J,McRae AF,Mandaviya PR,Se

    更新日期:2017-12-01 00:00:00

  • Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group.

    abstract::DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-019-0605-z

    authors: Jia T,Chu C,Liu Y,van Dongen J,Papastergios E,Armstrong NJ,Bastin ME,Carrillo-Roa T,den Braber A,Harris M,Jansen R,Liu J,Luciano M,Ori APS,Roiz Santiañez R,Ruggeri B,Sarkisyan D,Shin J,Sungeun K,Tordesillas Gutiérre

    更新日期:2019-12-06 00:00:00

  • The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.

    abstract::Exercise has a variety of beneficial effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Previous studies have shown that exercise enhances hippocampal neurogenesis, induces antidepressant effects and improves learning behavior. Brain serotonin (5-hydroxytryptamine, 5-HT) levels...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/mp.2014.153

    authors: Kondo M,Nakamura Y,Ishida Y,Shimada S

    更新日期:2015-11-01 00:00:00

  • Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits.

    abstract::The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/mp.2017.164

    authors: Alachkar A,Wang L,Yoshimura R,Hamzeh AR,Wang Z,Sanathara N,Lee SM,Xu X,Abbott GW,Civelli O

    更新日期:2018-02-01 00:00:00

  • Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor.

    abstract::A recent study has suggested a possible association of a polymorphism near the dopamine D5 receptor gene (DRD5) and attention-deficit hyperactivity disorder. The polymorphism studied was a (CA)n repeat located in the cosmid containing the D5 receptor gene2 and the allele that was reported to be associated with attenti...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/sj.mp.4000777

    authors: Barr CL,Wigg KG,Feng Y,Zai G,Malone M,Roberts W,Schachar R,Tannock R,Kennedy JL

    更新日期:2000-09-01 00:00:00

  • Correction to: Psychiatric genetics and the structure of psychopathology.

    abstract::In the Table 1 legend, the reference numbers and symbols were not correctly presented in the footnotes. The corrected footnotes are presented below. ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41380-018-0026-4

    authors: Smoller JW,Andreassen OA,Edenberg HJ,Faraone SV,Glatt SJ,Kendler KS

    更新日期:2019-03-01 00:00:00

  • Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS.

    abstract::Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship with psychotic symptoms. The 22q11.2 deletion syndrome (22q11DS) has proven to be a remarkable model for the pro...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-019-0443-z

    authors: Mancini V,Sandini C,Padula MC,Zöller D,Schneider M,Schaer M,Eliez S

    更新日期:2020-11-01 00:00:00

  • Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice.

    abstract::TET3 is a member of the ten-eleven translocation (TET) family of enzymes which oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Tet3 is highly expressed in the brain, where 5hmC levels are most abundant. In adult mice, we observed that TET3 is present in mature neurons and oligodendrocytes but is ab...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-0695-7

    authors: Antunes C,Da Silva JD,Guerra-Gomes S,Alves ND,Ferreira F,Loureiro-Campos E,Branco MR,Sousa N,Reik W,Pinto L,Marques CJ

    更新日期:2020-02-26 00:00:00

  • Chromosomal abnormalities and mental illness.

    abstract::Linkage studies of mental illness have provided suggestive evidence of susceptibility loci over many broad chromosomal regions. Pinpointing causative gene mutations by conventional linkage strategies alone is problematic. The breakpoints of chromosomal abnormalities occurring in patients with mental illness may be mor...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审

    doi:10.1038/sj.mp.4001232

    authors: MacIntyre DJ,Blackwood DH,Porteous DJ,Pickard BS,Muir WJ

    更新日期:2003-03-01 00:00:00

  • Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection.

    abstract::Among the most consistent results of studies of post-mortem brain tissue from schizophrenia patients (SZP) is the finding that in this disease, several genes expressed by GABAergic neurons are downregulated. This downregulation may be caused by hypermethylation of the relevant promoters in affected neurons. Indeed, in...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/sj.mp.4001954

    authors: Ruzicka WB,Zhubi A,Veldic M,Grayson DR,Costa E,Guidotti A

    更新日期:2007-04-01 00:00:00

  • Dissecting bipolar disorder complexity through epigenomic approach.

    abstract::In recent years, numerous studies of gene regulation mechanisms have emerged in neuroscience. Epigenetic modifications, described as heritable but reversible changes, include DNA methylation, DNA hydroxymethylation, histone modifications and noncoding RNAs. The pathogenesis of psychiatric disorders, such as bipolar di...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审

    doi:10.1038/mp.2016.123

    authors: Ludwig B,Dwivedi Y

    更新日期:2016-11-01 00:00:00

  • A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease.

    abstract::Several lines of evidence have suggested altered functions of the brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). In the search for polymorphisms in the 5'-flanking and 5'-noncoding regions of the BDNF gene, we found a novel nucleotide subs...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/sj.mp.4000792

    authors: Kunugi H,Ueki A,Otsuka M,Isse K,Hirasawa H,Kato N,Nabika T,Kobayashi S,Nanko S

    更新日期:2001-01-01 00:00:00

  • Anorexia nervosa (restrictive subtype) is associated with a polymorphism in the novel norepinephrine transporter gene promoter polymorphic region.

    abstract::Long-term weight-restored patients with anorexia nervosa (AN) have lower norepinephrine levels than controls. Since this may reflect altered reuptake by the norepinephrine transporter (NET), we hypothesised that the NET gene was involved in the genetic component of AN. PCR-amplification of an AAGG repeat island (AAGG1...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/sj.mp.4001080

    authors: Urwin RE,Bennetts B,Wilcken B,Lampropoulos B,Beumont P,Clarke S,Russell J,Tanner S,Nunn KP

    更新日期:2002-01-01 00:00:00

  • Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders.

    abstract::Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 years, as well as 67 adult individuals diagnosed with autism (ASD), schizophrenia (SZ), and Down synd...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-018-0200-8

    authors: Yu Q,He Z,Zubkov D,Huang S,Kurochkin I,Yang X,Halene T,Willmitzer L,Giavalisco P,Akbarian S,Khaitovich P

    更新日期:2020-11-01 00:00:00

  • Mood stabilizers and/or antipsychotics for bipolar disorder in the maintenance phase: a systematic review and network meta-analysis of randomized controlled trials.

    abstract::We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00946-6

    authors: Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

    更新日期:2020-11-11 00:00:00

  • Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates.

    abstract::A polymorphism in the serotonin (5-HT) transporter gene regulatory region (5-HTTLPR) is associated with measures of 5-HT transporter (5-HTT) expression and 5-HT-mediated behaviors in humans. An analogous length variation of the 5-HTTLPR has been reported in rhesus monkeys (rh5-HTTLPR). A retrospective association stud...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/sj.mp.4001157

    authors: Champoux M,Bennett A,Shannon C,Higley JD,Lesch KP,Suomi SJ

    更新日期:2002-01-01 00:00:00

  • DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders.

    abstract::Psychiatric disorders are a group of genetically related diseases with highly polygenic architectures. Genome-wide association analyses have made substantial progress towards understanding the genetic architecture of these disorders. More recently, exome- and whole-genome sequencing of cases and families have identifi...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-018-0087-4

    authors: Ryan NM,Lihm J,Kramer M,McCarthy S,Morris SW,Arnau-Soler A,Davies G,Duff B,Ghiban E,Hayward C,Deary IJ,Blackwood DHR,Lawrie SM,McIntosh AM,Evans KL,Porteous DJ,McCombie WR,Thomson PA

    更新日期:2018-12-01 00:00:00