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The other, forgotten genome: mitochondrial DNA and mental disorders.

Abstract：

:This paper summarizes recent research on mitochondrial DNA (mtDNA)--which might be described as the "other, forgotten genome". Recent studies suggest the possible pathophysiological significance of mtDNA in schizophrenia and neurodegenerative and mood disorders. Decreased activity of the mitochondrial electron transport chain has been implicated in both Parkinson's and Alzheimer's disease and while age-related accumulation of mtDNA deletions has been suggested as a possible cause, there is no concrete evidence that particular mtDNA polymorphisms are responsible. In schizophrenia, the activity and/or mRNA expression of complex IV are involved, but the direction of the alteration is not the same and there is no evidence linking schizophrenia with mtDNA. In bipolar disorder, there is some evidence of parent-of-origin effects and association with mtDNA polymorphisms but further investigation is needed to elucidate the role of mtDNA in mental disorders.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Kato T

doi

10.1038/sj.mp.4000926

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

625-33

issue

6

eissn

1359-4184

issn

1476-5578

journal_volume

6

pub_type

杂志文章,评审

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