Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma.

abstract：:Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the m...

journal_title：Molecular psychiatry

authors： Chase HW,Boudewyn MA,Carter CS,Phillips ML

更新日期：2020-02-01 00:00:00

abstract：:The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with 'Western' diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched 'Western' ...

journal_title：Molecular psychiatry

authors： Cinquina V,Calvigioni D,Farlik M,Halbritter F,Fife-Gernedl V,Shirran SL,Fuszard MA,Botting CH,Poullet P,Piscitelli F,Máté Z,Szabó G,Yanagawa Y,Kasper S,Di Marzo V,Mackie K,McBain CJ,Bock C,Keimpema E,Harkany T

更新日期：2020-01-01 00:00:00

abstract：:Given the manifold ways that depression impairs Darwinian fitness, the persistence in the human genome of risk alleles for the disorder remains a much debated mystery. Evolutionary theories that view depressive symptoms as adaptive fail to provide parsimonious explanations for why even mild depressive symptoms impair ...

journal_title：Molecular psychiatry

authors： Raison CL,Miller AH

更新日期：2013-01-01 00:00:00

abstract：:The core nature of nicotine dependence is evident in wide variations in how individuals become and remain smokers. Individuals with pre-existing behavioral traits are more likely to develop nicotine dependence and experience difficulty when attempting to quit. Many molecular factors likely contribute to individual var...

journal_title：Molecular psychiatry

authors： Hiroi N,Scott D

更新日期：2009-07-01 00:00:00

abstract：:Early-life disruption of the parent-child relationship, for example, in the form of abuse, neglect or loss, dramatically increases risk for psychiatric, as well as certain medical, disorders in adulthood. The neuropeptide oxytocin (OT) plays a seminal role in mediating social affiliation, attachment, social support, m...

journal_title：Molecular psychiatry

authors： Heim C,Young LJ,Newport DJ,Mletzko T,Miller AH,Nemeroff CB

更新日期：2009-10-01 00:00:00

abstract：:Obscure work on the inheritance of two peculiar genetic traits in yeast has recently collided with work on infectious, neurodegenerative diseases in mammals. The impact illuminates both fields. The yeast work reveals a new mechanism of genetic variation that is based on differences in protein conformation rather than ...

journal_title：Molecular psychiatry

authors： Lindquist S

更新日期：1996-11-01 00:00:00

abstract：:Here, we report a novel target of the drug memantine, ATP-sensitive K+ (KATP) channels, potentially relevant to memory improvement. We confirmed that memantine antagonizes memory impairment in Alzheimer's model APP23 mice. Memantine increased CaMKII activity in the APP23 mouse hippocampus, and memantine-induced enhanc...

journal_title：Molecular psychiatry

authors： Moriguchi S,Ishizuka T,Yabuki Y,Shioda N,Sasaki Y,Tagashira H,Yawo H,Yeh JZ,Sakagami H,Narahashi T,Fukunaga K

更新日期：2018-02-01 00:00:00

abstract：:We previously found that ovarian steroids promote neuroprotection in serotonin neurons by decreasing the expression of pro-apoptotic genes and proteins in the dorsal raphe nucleus of rhesus macaques, even in the absence of overt injury. In this study, we questioned whether these actions would lead to a reduction in DN...

journal_title：Molecular psychiatry

authors： Lima FB,Bethea CL

更新日期：2010-06-01 00:00:00

abstract：:Nitric oxide (NO) is a widespread and multifunctional biological messenger molecule. It mediates vasodilation of blood vessels, host defence against infectious agents and tumors, and neurotransmission of the central and peripheral nervous systems. In the nervous system, NO is generated by three nitric oxide synthase (...

journal_title：Molecular psychiatry

authors： Yun HY,Dawson VL,Dawson TM

更新日期：1997-07-01 00:00:00

abstract：:Circular RNAs (circRNAs), highly expressed in the central nervous system, are involved in various regulatory processes and implicated in some pathophysiology. However, the potential role of circRNAs in psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown. Here, we demonstrated th...

journal_title：Molecular psychiatry

authors： Zhang Y,Du L,Bai Y,Han B,He C,Gong L,Huang R,Shen L,Chao J,Liu P,Zhang H,Zhang H,Gu L,Li J,Hu G,Xie C,Zhang Z,Yao H

更新日期：2020-06-01 00:00:00

abstract：:Social deficits are common in many psychiatric disorders. However, due to inadequate tools for manipulating circuit activity in humans and unspecific paradigms for modeling social behaviors in rodents, our understanding of the molecular and circuit mechanisms mediating social behaviors remains relatively limited. Usin...

journal_title：Molecular psychiatry

authors： Li A,Jing D,Dellarco DV,Hall BS,Yang R,Heilberg RT,Huang C,Liston C,Casey BJ,Lee FS

更新日期：2019-04-16 00:00:00

abstract：:The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equ...

journal_title：Molecular psychiatry

authors： Alachkar A,Wang L,Yoshimura R,Hamzeh AR,Wang Z,Sanathara N,Lee SM,Xu X,Abbott GW,Civelli O

更新日期：2018-02-01 00:00:00

abstract：:In mammals, most adult neural stem cells (NSCs) are located in the ventricular-subventricular zone (V-SVZ) along the wall of the lateral ventricles and they are the source of olfactory bulb interneurons. Adult NSCs exhibit an apico-basal polarity; they harbor a short apical process and a long basal process, reminiscen...

journal_title：Molecular psychiatry

authors： García-González D,Dumitru I,Zuccotti A,Yen TY,Herranz-Pérez V,Tan LL,Neitz A,García-Verdugo JM,Kuner R,Alfonso J,Monyer H

更新日期：2020-07-01 00:00:00

abstract：:Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhanci...

journal_title：Molecular psychiatry

authors： Radonjić NV,Hess JL,Rovira P,Andreassen O,Buitelaar JK,Ching CRK,Franke B,Hoogman M,Jahanshad N,McDonald C,Schmaal L,Sisodiya SM,Stein DJ,van den Heuvel OA,van Erp TGM,van Rooij D,Veltman DJ,Thompson P,Faraone SV

更新日期：2021-01-17 00:00:00

abstract：:Contemporary models of psychosis suggest that a continuum of severity of psychotic symptoms exists, with subthreshold psychotic experiences (PEs) potentially reflecting some genetic and environmental risk factors shared with clinical psychosis. Thus, identifying abnormalities in brain activity that manifest across thi...

journal_title：Molecular psychiatry

authors： Wang D,Peng X,Pelletier-Baldelli A,Orlov N,Farabaugh A,Nasr S,Eryilmaz H,Fava M,Holmes AJ,Roffman JL,Liu H,Holt DJ

更新日期：2021-01-18 00:00:00

abstract：:Circulating inflammatory mediators can signal neurons through a pathway in which cytokine activation of the cells of the blood-brain barrier causes the induction of the nuclear factor kappa B (NF-kappaB), leading to the transcription of target genes, such as the one encoding cyclooxygenase 2 (COX-2), the enzyme that i...

journal_title：Molecular psychiatry

authors： Rivest S

更新日期：1999-11-01 00:00:00

abstract：:An increase in corticotropin-releasing factor (CRF) is a putative factor in the pathophysiology of stress-related disorders. As CRF expression in the central nucleus of the amygdala (CeA) is important in adaptation to chronic stress, we hypothesized that unrestrained synthesis of CRF in CeA would mimic the consequence...

journal_title：Molecular psychiatry

authors： Keen-Rhinehart E,Michopoulos V,Toufexis DJ,Martin EI,Nair H,Ressler KJ,Davis M,Owens MJ,Nemeroff CB,Wilson ME

更新日期：2009-01-01 00:00:00

abstract：:Schizophrenia and bipolar disorder have both been linked to structural abnormalities of the hippocampus, which is consistent with a neurodevelopmental anomaly. One isoform of the neural cell adhesion molecule (N-CAM) protein, cytosolic N-CAM 105-115 kDa, was previously shown to be increased in schizophrenia in the hip...

journal_title：Molecular psychiatry

authors： Vawter MP,Howard AL,Hyde TM,Kleinman JE,Freed WJ

更新日期：1999-09-01 00:00:00

abstract：:We conducted a 10 centimorgan (cM) linkage genome scan in a set of American extended pedigrees ascertained through probands with panic disorder. Several anxiety disorders segregate in these families. In this article, we describe results for simple phobia from 14 of these families (including 129 subjects of whom 57 are...

journal_title：Molecular psychiatry

authors： Gelernter J,Page GP,Bonvicini K,Woods SW,Pauls DL,Kruger S

更新日期：2003-01-01 00:00:00

abstract：:Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABAARs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsant and hypnotic effec...

journal_title：Molecular psychiatry

authors： Nicholson MW,Sweeney A,Pekle E,Alam S,Ali AB,Duchen M,Jovanovic JN

更新日期：2018-09-01 00:00:00

abstract：:The GABAB receptor (GABABR) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlying neural mechanism remains unclear. The present study aimed to investigate cortical GABABR dynamics following chronic alcohol exposure. Ex vivo brain slice recordings from m...

journal_title：Molecular psychiatry

authors： Peng SY,Shi Z,Zhou DS,Wang XY,Li XX,Liu XL,Wang WD,Lin GN,Pan BX,Voon V,Grace AA,Heilig M,Wong ML,Yuan TF

更新日期：2021-01-11 00:00:00

abstract：:Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy number variations (CNVs) in SCZ cases and identified multiple rare recurrent CNVs that increase risk of SCZ although with incomplete penetranc...

journal_title：Molecular psychiatry

authors： Szatkiewicz JP,O'Dushlaine C,Chen G,Chambert K,Moran JL,Neale BM,Fromer M,Ruderfer D,Akterin S,Bergen SE,Kähler A,Magnusson PK,Kim Y,Crowley JJ,Rees E,Kirov G,O'Donovan MC,Owen MJ,Walters J,Scolnick E,Sklar P,Pu

更新日期：2014-07-01 00:00:00

abstract：:Endocannabinoids and their attending cannabinoid type 1 (CB1) receptor have been implicated in animal models of post-traumatic stress disorder (PTSD). However, their specific role has not been studied in people with PTSD. Herein, we present an in vivo imaging study using positron emission tomography (PET) and the CB1-...

journal_title：Molecular psychiatry

authors： Neumeister A,Normandin MD,Pietrzak RH,Piomelli D,Zheng MQ,Gujarro-Anton A,Potenza MN,Bailey CR,Lin SF,Najafzadeh S,Ropchan J,Henry S,Corsi-Travali S,Carson RE,Huang Y

更新日期：2013-09-01 00:00:00

abstract：:Previous studies have implicated DTNBP1 as a schizophrenia susceptibility gene and its encoded protein, dysbindin, as a potential regulator of synaptic vesicle physiology. In this study, we found that endogenous levels of the dysbindin protein in the mouse brain are developmentally regulated, with higher levels observ...

journal_title：Molecular psychiatry

authors： Ghiani CA,Starcevic M,Rodriguez-Fernandez IA,Nazarian R,Cheli VT,Chan LN,Malvar JS,de Vellis J,Sabatti C,Dell'Angelica EC

更新日期：2010-02-01 00:00:00

abstract：:Chromosome 1q has been implicated in the etiology of schizophrenia in several independent studies. However, the peak linkage findings have been dispersed over a large chromosomal region, with negative findings in this region also being reported. Our group has previously observed linkage on chromosome 1q42, maximizing ...

journal_title：Molecular psychiatry

authors： Ekelund J,Hennah W,Hiekkalinna T,Parker A,Meyer J,Lönnqvist J,Peltonen L

更新日期：2004-11-01 00:00:00

abstract：:Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of Polg1, a mitochondrial DNA (mtDNA...

journal_title：Molecular psychiatry

authors： Kasahara T,Takata A,Kato TM,Kubota-Sakashita M,Sawada T,Kakita A,Mizukami H,Kaneda D,Ozawa K,Kato T

更新日期：2016-01-01 00:00:00

abstract：:Hyperactivation of the amygdala following chronic stress is believed to be one of the primary mechanisms underlying the increased propensity for anxiety-like behaviors and pathological states; however, the mechanisms by which chronic stress modulates amygdalar function are not well characterized. The aim of the curren...

journal_title：Molecular psychiatry

authors： Hill MN,Kumar SA,Filipski SB,Iverson M,Stuhr KL,Keith JM,Cravatt BF,Hillard CJ,Chattarji S,McEwen BS

更新日期：2013-10-01 00:00:00

abstract：:(+) 3,4-Methylenedioxymethamphetamine (MDMA) is a psychedelic drug of abuse that causes selective degeneration of serotonergic fibers of dorsal raphe neurons that project throughout the forebrain. Previous studies using pharmacological and behavioral approaches suggested that MDMA treatment leads to desensitization of...

journal_title：Molecular psychiatry

authors： Sexton TJ,McEvoy C,Neumaier JF

更新日期：1999-11-01 00:00:00

abstract：:The s allele variant of the serotonin transporter gene (5-HTT) has recently been observed to moderate the relationship of stress to depression and anxiety. To date no study has considered interactive effects of 5-HTT genotype, stress and hypothalamic-pituitary-adrenal (HPA) function on cognition in healthy, older adul...

journal_title：Molecular psychiatry

authors： O'Hara R,Schröder CM,Mahadevan R,Schatzberg AF,Lindley S,Fox S,Weiner M,Kraemer HC,Noda A,Lin X,Gray HL,Hallmayer JF

更新日期：2007-06-01 00:00:00

abstract：:A genetic predisposition to the development of neuroleptic malignant syndrome (NMS) has been suggested by clinical studies. Although the molecular basis of NMS is unclear, a dopaminergic blockade mechanism has been considered the main cause. We therefore investigated the association between NMS and three functional po...

journal_title：Molecular psychiatry

authors： Kishida I,Kawanishi C,Furuno T,Kato D,Ishigami T,Kosaka K

更新日期：2004-03-01 00:00:00