Peripheral blood brain-derived neurotrophic factor in bipolar disorder: a comprehensive systematic review and meta-analysis.

abstract：:Several epidemiological studies confirmed that Anxiety Disorders as a group are the most prevalent psychiatric conditions in the United States. The importance of these conditions is underlined by the fact that they cause significant disability, poor quality of life, alcohol and drug abuse. Anxiety disorders are treata...

journal_title：Molecular psychiatry

authors： Bystritsky A

更新日期：2006-09-01 00:00:00

abstract：:Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other members of the neurotrophin family, are central mediators of the activity-dependent plasticity through which environmental experiences, such as sensory information are translated into the structure and function of neuronal networks. ...

journal_title：Molecular psychiatry

authors： Castrén E,Antila H

更新日期：2017-08-01 00:00:00

abstract：:We tested the hypothesis that, compared with subjects with no history of psychiatric illness (controls), changes in gene expression in the dorsolateral prefrontal cortex from two subgroups of subjects with schizophrenia, one with a marked deficit in muscarinic M1 receptors (muscarinic receptor-deficit schizophrenia (M...

journal_title：Molecular psychiatry

authors： Scarr E,Udawela M,Thomas EA,Dean B

更新日期：2018-02-01 00:00:00

abstract：:A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is a...

journal_title：Molecular psychiatry

authors： Wollmer MA,Streffer JR,Tsolaki M,Grimaldi LM,Lütjohann D,Thal D,von Bergmann K,Nitsch RM,Hock C,Papassotiropoulos A

更新日期：2003-06-01 00:00:00

abstract：:A recent study has suggested a possible association of a polymorphism near the dopamine D5 receptor gene (DRD5) and attention-deficit hyperactivity disorder. The polymorphism studied was a (CA)n repeat located in the cosmid containing the D5 receptor gene2 and the allele that was reported to be associated with attenti...

journal_title：Molecular psychiatry

authors： Barr CL,Wigg KG,Feng Y,Zai G,Malone M,Roberts W,Schachar R,Tannock R,Kennedy JL

更新日期：2000-09-01 00:00:00

abstract：:Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized that maternal departures from the optimum of dietary methyl donor intake can increase the risk for mental health issues and neurological disorders in offspring,...

journal_title：Molecular psychiatry

authors： Ryan DP,Henzel KS,Pearson BL,Siwek ME,Papazoglou A,Guo L,Paesler K,Yu M,Müller R,Xie K,Schröder S,Becker L,Garrett L,Hölter SM,Neff F,Rácz I,Rathkolb B,Rozman J,Ehninger G,Klingenspor M,Klopstock T,Wolf E,Wurs

更新日期：2018-05-01 00:00:00

abstract：:Polymorphism in the human dopamine D4 receptor gene (DRD4) exon III has been associated in some but not all studies of the human personality trait of Novelty Seeking. We searched for polymorphisms in the 5' region of DRD4 and identified six polymorphisms as follows: -1217G Ins/Del, -809G/A, -616C/G, -603T Ins/Del, -60...

journal_title：Molecular psychiatry

authors： Okuyama Y,Ishiguro H,Nankai M,Shibuya H,Watanabe A,Arinami T

更新日期：2000-01-01 00:00:00

abstract：:Folic acid supplementation confers modest benefit in schizophrenia, but its effectiveness is influenced by common genetic variants in the folate pathway that hinder conversion to its active form. We examined physiological and clinical effects of l-methylfolate, the fully reduced and bioactive form of folate, in schizo...

journal_title：Molecular psychiatry

authors： Roffman JL,Petruzzi LJ,Tanner AS,Brown HE,Eryilmaz H,Ho NF,Giegold M,Silverstein NJ,Bottiglieri T,Manoach DS,Smoller JW,Henderson DC,Goff DC

更新日期：2018-02-01 00:00:00

abstract：:Endocannabinoids and their attending cannabinoid type 1 (CB1) receptor have been implicated in animal models of post-traumatic stress disorder (PTSD). However, their specific role has not been studied in people with PTSD. Herein, we present an in vivo imaging study using positron emission tomography (PET) and the CB1-...

journal_title：Molecular psychiatry

authors： Neumeister A,Normandin MD,Pietrzak RH,Piomelli D,Zheng MQ,Gujarro-Anton A,Potenza MN,Bailey CR,Lin SF,Najafzadeh S,Ropchan J,Henry S,Corsi-Travali S,Carson RE,Huang Y

更新日期：2013-09-01 00:00:00

abstract：:The s allele variant of the serotonin transporter gene (5-HTT) has recently been observed to moderate the relationship of stress to depression and anxiety. To date no study has considered interactive effects of 5-HTT genotype, stress and hypothalamic-pituitary-adrenal (HPA) function on cognition in healthy, older adul...

journal_title：Molecular psychiatry

authors： O'Hara R,Schröder CM,Mahadevan R,Schatzberg AF,Lindley S,Fox S,Weiner M,Kraemer HC,Noda A,Lin X,Gray HL,Hallmayer JF

更新日期：2007-06-01 00:00:00

abstract：:Here, we report a novel target of the drug memantine, ATP-sensitive K+ (KATP) channels, potentially relevant to memory improvement. We confirmed that memantine antagonizes memory impairment in Alzheimer's model APP23 mice. Memantine increased CaMKII activity in the APP23 mouse hippocampus, and memantine-induced enhanc...

journal_title：Molecular psychiatry

authors： Moriguchi S,Ishizuka T,Yabuki Y,Shioda N,Sasaki Y,Tagashira H,Yawo H,Yeh JZ,Sakagami H,Narahashi T,Fukunaga K

更新日期：2018-02-01 00:00:00

abstract：:Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Here, we present data from independent large-scale clinical data sets (including 29 557 cases and 32 056 controls) rev...

journal_title：Molecular psychiatry

authors： Chang H,Hoshina N,Zhang C,Ma Y,Cao H,Wang Y,Wu DD,Bergen SE,Landén M,Hultman CM,Preisig M,Kutalik Z,Castelao E,Grigoroiu-Serbanescu M,Forstner AJ,Strohmaier J,Hecker J,Schulze TG,Müller-Myhsok B,Reif A,Mitchell PB

更新日期：2018-02-01 00:00:00

abstract：:Large numbers of single nucleotide polymorphisms (SNPs) are being identified by several laboratories for the purpose of developing dense genetic maps. Single-strand conformation polymorphism (SSCP) analysis has been widely used as a method for detecting novel sequence variations in PCR products. Differences in migrati...

journal_title：Molecular psychiatry

authors： Gonen D,Veenstra-VanderWeele J,Yang Z,Leventhal B,Cook EH Jr

更新日期：1999-07-01 00:00:00

abstract：:We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of p...

journal_title：Molecular psychiatry

authors： Niculescu AB,Le-Niculescu H,Levey DF,Roseberry K,Soe KC,Rogers J,Khan F,Jones T,Judd S,McCormick MA,Wessel AR,Williams A,Kurian SM,White FA

更新日期：2019-04-01 00:00:00

abstract：:Serotonergic (5HT) neurons exert diverse and widespread functions in the brain. Dysfunction of the serotonergic system gives rise to a variety of mental illnesses including depression, anxiety, obsessive compulsive disorder, autism and eating disorders. Here we show that human primary fibroblasts were directly convert...

journal_title：Molecular psychiatry

authors： Xu Z,Jiang H,Zhong P,Yan Z,Chen S,Feng J

更新日期：2016-01-01 00:00:00

abstract：:Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major depression, its biological role in these disorders is unclear. To better understand this gene and its role in psychiatric disease, we conducted ...

journal_title：Molecular psychiatry

authors： Carless MA,Glahn DC,Johnson MP,Curran JE,Bozaoglu K,Dyer TD,Winkler AM,Cole SA,Almasy L,MacCluer JW,Duggirala R,Moses EK,Göring HH,Blangero J

更新日期：2011-11-01 00:00:00

abstract：:Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially) recessive deleterious mutations. Even among outbred populations, auto...

journal_title：Molecular psychiatry

authors： Howrigan DP,Simonson MA,Davies G,Harris SE,Tenesa A,Starr JM,Liewald DC,Deary IJ,McRae A,Wright MJ,Montgomery GW,Hansell N,Martin NG,Payton A,Horan M,Ollier WE,Abdellaoui A,Boomsma DI,DeRosse P,Knowles EE,Glahn DC

更新日期：2016-06-01 00:00:00

abstract：:Research on avoidance conditioning began in the late 1930s as a way to use laboratory experiments to better understand uncontrollable fear and anxiety. Avoidance was initially conceived of as a two-factor learning process in which fear is first acquired through Pavlovian aversive conditioning (so-called fear condition...

journal_title：Molecular psychiatry

authors： LeDoux JE,Moscarello J,Sears R,Campese V

更新日期：2017-01-01 00:00:00

abstract：:Autistic individuals experience significantly elevated rates of childhood trauma, self-harm and suicidal behaviour and ideation (SSBI). Is this purely the result of negative environmental experiences, or does this interact with genetic predisposition? In this study we investigated if a genetic predisposition for autis...

journal_title：Molecular psychiatry

authors： Warrier V,Baron-Cohen S

更新日期：2019-10-29 00:00:00

abstract：:Genetic variation underlying hypothalamic pituitary adrenal (HPA) axis overactivity in healthy controls (HCs) and patients with severe forms of major depression has not been well explored, but could explain risk for cortisol dysregulation. In total, 95 participants were studied: 40 patients with psychotic major depres...

journal_title：Molecular psychiatry

authors： Schatzberg AF,Keller J,Tennakoon L,Lembke A,Williams G,Kraemer FB,Sarginson JE,Lazzeroni LC,Murphy GM

更新日期：2014-02-01 00:00:00

abstract：:Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown. We found that widely used antidepressants such as amitriptyline and fluoxetine induce autoph...

journal_title：Molecular psychiatry

authors： Gulbins A,Schumacher F,Becker KA,Wilker B,Soddemann M,Boldrin F,Müller CP,Edwards MJ,Goodman M,Caldwell CC,Kleuser B,Kornhuber J,Szabo I,Gulbins E

更新日期：2018-12-01 00:00:00

abstract：:Identifying biomarkers in schizophrenia during the first episode without the confounding effects of treatment has been challenging. Leveraging these biomarkers to establish diagnosis and make individualized predictions of future treatment responses to antipsychotics would be of great value, but there has been limited ...

journal_title：Molecular psychiatry

authors： Cao B,Cho RY,Chen D,Xiu M,Wang L,Soares JC,Zhang XY

更新日期：2020-04-01 00:00:00

abstract：:Bipolar disorder (BPD) is characterized by vulnerability to episodic depression and mania and spontaneous cycling. Because of marked advances in candidate-gene and genome-wide association studies, the list of risk genes for BPD is growing rapidly, creating an unprecedented opportunity to understand the pathophysiology...

journal_title：Molecular psychiatry

authors： Chen G,Henter ID,Manji HK

更新日期：2010-09-01 00:00:00

abstract：:Between 1997 and 2002, 48 data sets from the hippocampus were produced on samples from the Stanley Neuropathology Consortium. From these data sets, 224 total measures were available from the various subdivisions of the hippocampus. An integrative analysis of these measures was performed using a multivariate, nonparame...

journal_title：Molecular psychiatry

authors： Knable MB,Barci BM,Webster MJ,Meador-Woodruff J,Torrey EF,Stanley Neuropathology Consortium.

更新日期：2004-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Molecular psychiatry

authors： Haarsma J,Fletcher PC,Griffin JD,Taverne HJ,Ziauddeen H,Spencer TJ,Miller C,Katthagen T,Goodyer I,Diederen KMJ,Murray GK

更新日期：2020-10-14 00:00:00

abstract：:Anxiety and depression are devastating mental illnesses that are a significant public health concern. Selective serotonin-reuptake inhibitors are the first-line treatment strategy for these disorders, which despite being a significant advantage over older treatments, are hampered by a limited efficacy in a significant...

journal_title：Molecular psychiatry

authors： O'Connor RM,Dinan TG,Cryan JF

更新日期：2012-04-01 00:00:00

abstract：:Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship with psychotic symptoms. The 22q11.2 deletion syndrome (22q11DS) has proven to be a remarkable model for the pro...

journal_title：Molecular psychiatry

authors： Mancini V,Sandini C,Padula MC,Zöller D,Schneider M,Schaer M,Eliez S

更新日期：2020-11-01 00:00:00

abstract：:With the advent of technologies that allow simultaneous genotyping of thousands of single-nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex diseases can be explored at an unprecedented detail. This study is among the first to apply the genome-wide association study (GWAS) approach...

journal_title：Molecular psychiatry

authors： Feulner TM,Laws SM,Friedrich P,Wagenpfeil S,Wurst SH,Riehle C,Kuhn KA,Krawczak M,Schreiber S,Nikolaus S,Förstl H,Kurz A,Riemenschneider M

更新日期：2010-07-01 00:00:00

abstract：:Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of CNTN5 and CNTN6 have previously been reported in individuals with autism spectrum disorders (ASDs), but very little is known on their prevalence and clinical impact....

journal_title：Molecular psychiatry

authors： Mercati O,Huguet G,Danckaert A,André-Leroux G,Maruani A,Bellinzoni M,Rolland T,Gouder L,Mathieu A,Buratti J,Amsellem F,Benabou M,Van-Gils J,Beggiato A,Konyukh M,Bourgeois JP,Gazzellone MJ,Yuen RK,Walker S,Delépine M

更新日期：2017-04-01 00:00:00

abstract：:Dysthymia is characterized by long-lasting periods of lowered mood. Epidemiological studies in the USA and Europe have demonstrated that the prevalence of dysthymia is at least 3% of the general population. Its pervasive occurrence makes dysthymia a public health problem worldwide. One feature of this disorder is its ...

journal_title：Molecular psychiatry

authors： Akiskal HS,Bolis CL,Cazzullo C,Costa e Silva JA,Gentil V,Lecrubier Y,Licinio J,Linden M,Lopez-Ibor JJ,Ndiaye IP,Pani L,Prilipko L,Robertson MM,Robinson RG,Starkstein SE,Thomas P,Wang Y,Wong ML

更新日期：1996-12-01 00:00:00