Independence of familial transmission of mania and depression: results of the NIMH family study of affective spectrum disorders.

abstract：:Patients with psychotic disorders are at high risk for type 2 diabetes mellitus, and there is increasing evidence that patients display glucose metabolism abnormalities before significant antipsychotic medication exposure. In the present study, we examined insulin action by quantifying insulin sensitivity in first-epi...

journal_title：Molecular psychiatry

authors： Chouinard VA,Henderson DC,Dalla Man C,Valeri L,Gray BE,Ryan KP,Cypess AM,Cobelli C,Cohen BM,Öngür D

更新日期：2019-10-01 00:00:00

abstract：:A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is a...

journal_title：Molecular psychiatry

authors： Wollmer MA,Streffer JR,Tsolaki M,Grimaldi LM,Lütjohann D,Thal D,von Bergmann K,Nitsch RM,Hock C,Papassotiropoulos A

更新日期：2003-06-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related diseases and neurodegeneration. In this paper, we review evidence relevant to the hypothesis that chronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and accelerates cellula...

journal_title：Molecular psychiatry

authors： Miller MW,Sadeh N

更新日期：2014-11-01 00:00:00

abstract：:Educational attainment has been associated with drinking behaviors in observation studies. We performed Mendelian randomization analysis to determine whether educational attainment causally affected drinking behaviors, including amount of alcohol intakes (in total and various types), drinking frequency, and drinking w...

journal_title：Molecular psychiatry

authors： Zhou T,Sun D,Li X,Ma H,Heianza Y,Qi L

更新日期：2019-11-25 00:00:00

abstract：:Folic acid supplementation confers modest benefit in schizophrenia, but its effectiveness is influenced by common genetic variants in the folate pathway that hinder conversion to its active form. We examined physiological and clinical effects of l-methylfolate, the fully reduced and bioactive form of folate, in schizo...

journal_title：Molecular psychiatry

authors： Roffman JL,Petruzzi LJ,Tanner AS,Brown HE,Eryilmaz H,Ho NF,Giegold M,Silverstein NJ,Bottiglieri T,Manoach DS,Smoller JW,Henderson DC,Goff DC

更新日期：2018-02-01 00:00:00

abstract：:Here, we report a novel target of the drug memantine, ATP-sensitive K+ (KATP) channels, potentially relevant to memory improvement. We confirmed that memantine antagonizes memory impairment in Alzheimer's model APP23 mice. Memantine increased CaMKII activity in the APP23 mouse hippocampus, and memantine-induced enhanc...

journal_title：Molecular psychiatry

authors： Moriguchi S,Ishizuka T,Yabuki Y,Shioda N,Sasaki Y,Tagashira H,Yawo H,Yeh JZ,Sakagami H,Narahashi T,Fukunaga K

更新日期：2018-02-01 00:00:00

abstract：:Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each transmitter in the regulatio...

journal_title：Molecular psychiatry

authors： Sakae DY,Marti F,Lecca S,Vorspan F,Martín-García E,Morel LJ,Henrion A,Gutiérrez-Cuesta J,Besnard A,Heck N,Herzog E,Bolte S,Prado VF,Prado MA,Bellivier F,Eap CB,Crettol S,Vanhoutte P,Caboche J,Gratton A,Moquin L,

更新日期：2015-11-01 00:00:00

abstract：:There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesity. This study aimed to investigate the genetic influence of polymorphisms in FTO in relation to body mass ...

journal_title：Molecular psychiatry

authors： Rivera M,Cohen-Woods S,Kapur K,Breen G,Ng MY,Butler AW,Craddock N,Gill M,Korszun A,Maier W,Mors O,Owen MJ,Preisig M,Bergmann S,Tozzi F,Rice J,Rietschel M,Rucker J,Schosser A,Aitchison KJ,Uher R,Craig IW,Lewis

更新日期：2012-06-01 00:00:00

abstract：:The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta, which encode 411, 415 and 431 amino acid proteins and transduce signals via the stimulation of intracellular cAMP production. The recent identification of high-af...

journal_title：Molecular psychiatry

authors： Behan DP,Grigoriadis DE,Lovenberg T,Chalmers D,Heinrichs S,Liaw C,De Souza EB

更新日期：1996-09-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is characterized by neurocognitive dysfunctions, such as impaired social interaction and language learning. Gene-environment interactions have a pivotal role in ASD pathogenesis. Nuclear receptor corepressors (NCORs) are transcription co-regulators physically associated with histone deac...

journal_title：Molecular psychiatry

authors： Kong Y,Zhou W,Sun Z

更新日期：2020-10-01 00:00:00

abstract：:The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed within the central nervous system. Previous work showed that this protein is upregulated in Alzheimer's disease (AD), and plays an active role in the development of brain amyloidosis in amyloid beta (Aβ)-precursor protein transgenic mice (Tg2576). In the pr...

journal_title：Molecular psychiatry

authors： Chu J,Li JG,Giannopoulos PF,Blass BE,Childers W,Abou-Gharbia M,Praticò D

更新日期：2015-11-01 00:00:00

abstract：:Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments manage the positive symptoms, yet have minimal effects on the negative and cognitive symptoms, two prominent features of the disease with critical impact on the long-term morbidity. In addition, antipsychotic treatments trigger se...

journal_title：Molecular psychiatry

authors： Revel FG,Moreau JL,Pouzet B,Mory R,Bradaia A,Buchy D,Metzler V,Chaboz S,Groebke Zbinden K,Galley G,Norcross RD,Tuerck D,Bruns A,Morairty SR,Kilduff TS,Wallace TL,Risterucci C,Wettstein JG,Hoener MC

更新日期：2013-05-01 00:00:00

abstract：:Polyglutamine expansion (PGE) encoded by a CAG repeat underlies eight inherited neurodegenerative diseases, among which is Huntington's disease. CAG expansion has also been reported in schizophrenia, suggesting a role for PGE. To investigate the potential role of PGE as a candidate for schizophrenia, we searched for P...

journal_title：Molecular psychiatry

authors： Moriniere S,Saada C,Holbert S,Sidransky E,Galat A,Ginns E,Rapoport JL,Neri C

更新日期：1999-01-01 00:00:00

abstract：:Depression is a heritable disorder that is often precipitated by stress. Abnormalities of the stress-reactive hypothalamic-pituitary-adrenal (HPA) axis are also common in depressed patients. In animal models, the forced swim test (FST) is the most frequently used test of depressive-like behavior. We have used a propos...

journal_title：Molecular psychiatry

authors： Solberg LC,Ahmadiyeh N,Baum AE,Vitaterna MH,Takahashi JS,Turek FW,Redei EE

更新日期：2003-04-01 00:00:00

abstract：:Corticotropin-releasing hormone (CRH) is the principal regulator of the hypothalamic-pituitary-adrenal (HPA) axis and an activator of the sympathoadrenal (SA) and systemic sympathetic (SS) systems. Mental disorders, including major depression and, more recently, Alzheimer's disease have been associated with dysregulat...

journal_title：Molecular psychiatry

authors： Willenberg HS,Bornstein SR,Hiroi N,Päth G,Goretzki PE,Scherbaum WA,Chrousos GP

更新日期：2000-03-01 00:00:00

abstract：:Activation of the inflammatory response system has been related to the pathophysiology of schizophrenia by several recent studies. Schizophrenic patients have varied levels of proinflammatory cytokines, such as interleukin (IL)-1, -6, and tumor necrosis factor (TNF)alpha in their peripheral blood or cerebrospinal flui...

journal_title：Molecular psychiatry

authors： Katila H,Hänninen K,Hurme M

更新日期：1999-03-01 00:00:00

abstract：:Retinoid metabolites of vitamin A are intrinsically linked to neural development, connectivity and plasticity, and have been implicated in the pathophysiology of schizophrenia. We hypothesised that a greater burden of common and rare genomic variation in genes involved with retinoid biogenesis and signalling could be ...

journal_title：Molecular psychiatry

authors： Reay WR,Atkins JR,Quidé Y,Carr VJ,Green MJ,Cairns MJ

更新日期：2020-04-01 00:00:00

abstract：:Recent studies have shown an association between trinucleotide repeat expansions (TREs) and adult-onset schizophrenia (AOS). Childhood-onset schizophrenia (COS) is a severe variant of schizophrenia with onset of symptoms before age 12 years. We have used the repeat expansion detection (RED) method to investigate the o...

journal_title：Molecular psychiatry

authors： Burgess CE,Lindblad K,Sidransky E,Yuan QP,Long RT,Breschel T,Ross CA,McInnis M,Lee P,Ginns EI,Lenane M,Kumra S,Jacobsen L,Rapoport JL,Schalling M

更新日期：1998-07-01 00:00:00

abstract：:Induction of neuroprotective heat-shock proteins via pharmacological Hsp90 inhibitors is currently being investigated as a potential treatment for neurodegenerative diseases. Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicity and limited central nervous system permeability. We demonstrate ...

journal_title：Molecular psychiatry

authors： Wang B,Liu Y,Huang L,Chen J,Li JJ,Wang R,Kim E,Chen Y,Justicia C,Sakata K,Chen H,Planas A,Ostrom RS,Li W,Yang G,McDonald MP,Chen R,Heck DH,Liao FF

更新日期：2017-07-01 00:00:00

abstract：:The network theory conceptualizes mental disorders as complex networks of symptoms influencing each other by creating feedback loops, leading to a self-sustained syndromic constellation. Symptoms central to the network have the greatest impact in sustaining the rest of symptoms. This analysis focused on the network st...

journal_title：Molecular psychiatry

authors： Belvederi Murri M,Amore M,Respino M,Alexopoulos GS

更新日期：2020-07-01 00:00:00

abstract：:The current study provides a novel in-depth assessment of the extent of antipsychotic drugs transport across the blood-brain barrier (BBB) into various brain regions, as well as across the blood-spinal cord barrier (BSCB) and the blood-cerebrospinal fluid barrier (BCSFB). This is combined with an estimation of cellula...

journal_title：Molecular psychiatry

authors： Loryan I,Melander E,Svensson M,Payan M,König F,Jansson B,Hammarlund-Udenaes M

更新日期：2016-11-01 00:00:00

abstract：:Semi-starvation induced hyperactivity (SIH) occurs in rodents upon caloric restriction. We hypothesized that SIH is triggered by the decline in leptin secretion associated with food restriction. To test this hypothesis, rats, which had established a stable level of activity, were treated with leptin or vehicle via imp...

journal_title：Molecular psychiatry

authors： Exner C,Hebebrand J,Remschmidt H,Wewetzer C,Ziegler A,Herpertz S,Schweiger U,Blum WF,Preibisch G,Heldmaier G,Klingenspor M

更新日期：2000-09-01 00:00:00

abstract：:Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with ...

journal_title：Molecular psychiatry

authors： Coleman JRI,Bryois J,Gaspar HA,Jansen PR,Savage JE,Skene N,Plomin R,Muñoz-Manchado AB,Linnarsson S,Crawford G,Hjerling-Leffler J,Sullivan PF,Posthuma D,Breen G

更新日期：2019-02-01 00:00:00

abstract：:Autism is a neurodevelopmental disorder manifesting early in childhood. Some symptoms of autism are alleviated by treatment with selective serotonin reuptake inhibitors, which are known to interact with the serotonin transporter. Moreover, variation in the gene that encodes the transporter (SLC6A4), especially the HTT...

journal_title：Molecular psychiatry

authors： Devlin B,Cook EH Jr,Coon H,Dawson G,Grigorenko EL,McMahon W,Minshew N,Pauls D,Smith M,Spence MA,Rodier PM,Stodgell C,Schellenberg GD,CPEA Genetics Network.

更新日期：2005-12-01 00:00:00

abstract：:Impulsivity, a multifaceted behavioral hallmark of attention-deficit/hyperactivity disorder (ADHD), strongly influences addiction vulnerability and other psychiatric disorders that incur enormous medical and societal burdens yet the neurobiological underpinnings linking impulsivity to disease remain poorly understood....

journal_title：Molecular psychiatry

authors： Miller ML,Ren Y,Szutorisz H,Warren NA,Tessereau C,Egervari G,Mlodnicka A,Kapoor M,Chaarani B,Morris CV,Schumann G,Garavan H,Goate AM,Bannon MJ,IMAGEN Consortium.,Halperin JM,Hurd YL

更新日期：2018-05-01 00:00:00

abstract：:Social deficits are common in many psychiatric disorders. However, due to inadequate tools for manipulating circuit activity in humans and unspecific paradigms for modeling social behaviors in rodents, our understanding of the molecular and circuit mechanisms mediating social behaviors remains relatively limited. Usin...

journal_title：Molecular psychiatry

authors： Li A,Jing D,Dellarco DV,Hall BS,Yang R,Heilberg RT,Huang C,Liston C,Casey BJ,Lee FS

更新日期：2019-04-16 00:00:00

abstract：:Identifying biological mechanisms through which the experience of adversity emerges as individual risk for mental illness is an important step toward developing strategies for personalized treatment and, ultimately, prevention. Preclinical studies have identified epigenetic modification of gene expression as one such ...

journal_title：Molecular psychiatry

authors： Swartz JR,Hariri AR,Williamson DE

更新日期：2017-02-01 00:00:00

abstract：:Medical treatment with various cytokines can provoke psychiatric symptoms. Conversely, psychiatric patients can display abnormalities in cytokine and neurotrophic factor expression. Such observations have pointed to the potential contribution of cytokines and growth factors to schizophrenic pathology and/or etiology. ...

journal_title：Molecular psychiatry

authors： Nawa H,Takahashi M,Patterson PH

更新日期：2000-11-01 00:00:00

abstract：:Although therapeutic interventions in attention-deficit/hyperactivity disorder (ADHD) still focus on the dopaminergic system, recent studies indicate a serotonergic dysfunction in this disease as well. In that respect, several variants of the tryptophan hydroxylase gene (TPH2), which codes for the rate-limiting enzyme...

journal_title：Molecular psychiatry

authors： Baehne CG,Ehlis AC,Plichta MM,Conzelmann A,Pauli P,Jacob C,Gutknecht L,Lesch KP,Fallgatter AJ

更新日期：2009-11-01 00:00:00

abstract：:Although schizophrenia is generally considered to occur as a consequence of multiple genes that interact with one another, very few methods have been developed to model epistasis. Phenotype definition has also been a major challenge for research on the genetics of schizophrenia. In this report, we use novel statistica...

journal_title：Molecular psychiatry

authors： Andreasen NC,Wilcox MA,Ho BC,Epping E,Ziebell S,Zeien E,Weiss B,Wassink T

更新日期：2012-11-01 00:00:00