当前位置： SCI文献检索 > MOLECULAR PSYCHIATRY期刊下所有文献 > Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward.

Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward.

Abstract：

:Opioids, such as morphine, are clinic analgesics which induce euphoria. Morphine exposure modifies the excitability and functional interactions between neurons, while the underlying cellular and molecular mechanisms, especially how morphine assembles heterogeneous interneurons (INs) in prelimbic cortex (PrL) to mediate disinhibition and reward, are not clear. Using approaches of optogenetics, electrophysiology, and cell type-specific RNA-seq, we show that morphine attenuates the inhibitory synaptic transmission from parvalbumin+ (PV)-INs onto pyramidal neurons in PrL via μ-opioid receptor (MOR) in PV-INs. Meanwhile, morphine enhances the inhibitory inputs from somatostatin+ (SST)-INs onto PV-INs, and thus disinhibits pyramidal neurons via δ-opioid receptor (DOR)-dependent Rac1 upregulation in SST-INs. We show that MOR in PV-INs is required for morphine-induced behavioral sensitization, while DOR as well as Rac1 activity in SST-INs is required for morphine-induced conditioned place preference and hyper-locomotion. These results reveal that SST- and PV-INs, functioning in PrL as a disinhibitory architecture, are coordinated by morphine via different opioid receptors to disinhibit pyramidal neurons and enhance reward.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Jiang C,Wang X,Le Q,Liu P,Liu C,Wang Z,He G,Zheng P,Wang F,Ma L

doi

10.1038/s41380-019-0480-7

subject

Has Abstract

pub_date

2019-08-14 00:00:00

eissn

1359-4184

issn

1476-5578

pii

10.1038/s41380-019-0480-7

pub_type

杂志文章

相关文献

MOLECULAR PSYCHIATRY文献大全
  • Selectively bred Wistar-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants.

    abstract：:The Wistar-Kyoto (WKY) rat strain demonstrates endogenous hormonal and behavioral abnormalities that emulate many of those found in symptom-presenting depressive patients. Evidence suggests that the WKY strain may harbor heterogeneity not found in other inbred strains, including greater behavioral and genetic variabil...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001345

    authors： Will CC,Aird F,Redei EE

    更新日期：2003-11-01 00:00:00

  • Mood stabilizers and/or antipsychotics for bipolar disorder in the maintenance phase: a systematic review and network meta-analysis of randomized controlled trials.

    abstract：:We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-00946-6

    authors： Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

    更新日期：2020-11-11 00:00:00

  • Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype.

    abstract：:Retinoid metabolites of vitamin A are intrinsically linked to neural development, connectivity and plasticity, and have been implicated in the pathophysiology of schizophrenia. We hypothesised that a greater burden of common and rare genomic variation in genes involved with retinoid biogenesis and signalling could be ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-018-0305-0

    authors： Reay WR,Atkins JR,Quidé Y,Carr VJ,Green MJ,Cairns MJ

    更新日期：2020-04-01 00:00:00

  • Prevention of schizophrenia deficits via non-invasive adolescent frontal cortex stimulation in rats.

    abstract：:Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-inv...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0356-x

    authors： Hadar R,Winter R,Edemann-Callesen H,Wieske F,Habelt B,Khadka N,Felgel-Farnholz V,Barroeta-Hlusicka E,Reis J,Tatarau CA,Funke K,Fritsch B,Bernhardt N,Bikson M,Nitsche MA,Winter C

    更新日期：2020-04-01 00:00:00

  • Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22.

    abstract：:Linkage disequilibrium (LD) mapping was used to follow up reports of linkage between reading disability (RD) and an 18 cM region of chromosome 6p21.3-22. Using a two-stage approach, we tested for association between RD and 22 microsatellite markers in two independent samples of 101 (Stage 1) and 77 (Stage 2) parent/pr...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001216

    authors： Turic D,Robinson L,Duke M,Morris DW,Webb V,Hamshere M,Milham C,Hopkin E,Pound K,Fernando S,Grierson A,Easton M,Williams N,Van Den Bree M,Chowdhury R,Gruen J,Stevenson J,Krawczak M,Owen MJ,O'Donovan MC,Williams J

    更新日期：2003-02-01 00:00:00

  • The role of adult hippocampal neurogenesis in brain health and disease.

    abstract：:Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encod...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/s41380-018-0036-2

    authors： Toda T,Parylak SL,Linker SB,Gage FH

    更新日期：2019-01-01 00:00:00

  • Altered connections on the road to psychopathy.

    abstract：:Psychopathy is strongly associated with serious criminal behaviour (for example, rape and murder) and recidivism. However, the biological basis of psychopathy remains poorly understood. Earlier studies suggested that dysfunction of the amygdala and/or orbitofrontal cortex (OFC) may underpin psychopathy. Nobody, howeve...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2009.40

    authors： Craig MC,Catani M,Deeley Q,Latham R,Daly E,Kanaan R,Picchioni M,McGuire PK,Fahy T,Murphy DG

    更新日期：2009-10-01 00:00:00

  • CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders.

    abstract：:Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of CNTN5 and CNTN6 have previously been reported in individuals with autism spectrum disorders (ASDs), but very little is known on their prevalence and clinical impact....

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.61

    authors： Mercati O,Huguet G,Danckaert A,André-Leroux G,Maruani A,Bellinzoni M,Rolland T,Gouder L,Mathieu A,Buratti J,Amsellem F,Benabou M,Van-Gils J,Beggiato A,Konyukh M,Bourgeois JP,Gazzellone MJ,Yuen RK,Walker S,Delépine M

    更新日期：2017-04-01 00:00:00

  • The microbiome regulates amygdala-dependent fear recall.

    abstract：:The amygdala is a key brain region that is critically involved in the processing and expression of anxiety and fear-related signals. In parallel, a growing number of preclinical and human studies have implicated the microbiome-gut-brain in regulating anxiety and stress-related responses. However, the role of the micro...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2017.100

    authors： Hoban AE,Stilling RM,Moloney G,Shanahan F,Dinan TG,Clarke G,Cryan JF

    更新日期：2018-05-01 00:00:00

  • Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding.

    abstract：:Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association is presently unknown. Both diseases are considered protein misfolding disorders associated with...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.230

    authors： Moreno-Gonzalez I,Edwards Iii G,Salvadores N,Shahnawaz M,Diaz-Espinoza R,Soto C

    更新日期：2017-09-01 00:00:00

  • The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.

    abstract：:Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each transmitter in the regulatio...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2015.104

    authors： Sakae DY,Marti F,Lecca S,Vorspan F,Martín-García E,Morel LJ,Henrion A,Gutiérrez-Cuesta J,Besnard A,Heck N,Herzog E,Bolte S,Prado VF,Prado MA,Bellivier F,Eap CB,Crettol S,Vanhoutte P,Caboche J,Gratton A,Moquin L,

    更新日期：2015-11-01 00:00:00

  • Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection.

    abstract：:Among the most consistent results of studies of post-mortem brain tissue from schizophrenia patients (SZP) is the finding that in this disease, several genes expressed by GABAergic neurons are downregulated. This downregulation may be caused by hypermethylation of the relevant promoters in affected neurons. Indeed, in...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001954

    authors： Ruzicka WB,Zhubi A,Veldic M,Grayson DR,Costa E,Guidotti A

    更新日期：2007-04-01 00:00:00

  • Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress.

    abstract：:Chronic stress contributes to the development of psychiatric disorders including anxiety and depression. Several inflammatory-related effects of stress are associated with increased interleukin-1 (IL-1) signaling within the central nervous system and are mediated by IL-1 receptor 1 (IL-1R1) on several distinct cell ty...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-0788-3

    authors： DiSabato DJ,Nemeth DP,Liu X,Witcher KG,O'Neil SM,Oliver B,Bray CE,Sheridan JF,Godbout JP,Quan N

    更新日期：2020-05-22 00:00:00

  • Advances in molecular genetics of panic disorder.

    abstract：:The molecular genetic research on panic disorder (PD) has grown tremendously in the past decade. Although the data from twin and family studies suggest an involvement of genetic factors in the familial transmission of PD with the heritability estimate near 40%, the genetic substrate underlying panicogenesis is not yet...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/mp.2009.145

    authors： Maron E,Hettema JM,Shlik J

    更新日期：2010-07-01 00:00:00

  • Evidence for a role of phospholipase C-gamma1 in the pathogenesis of bipolar disorder.

    abstract：:Several studies have indicated that patients with bipolar disorder (BD) who respond well to lithium prophylaxis constitute a biologically distinct subgroup. Lithium is thought to stabilize mood by acting at the phosphoinositide cycle. We have investigated a polymorphism located in the gene (PLCG1) that codes for a gam...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000447

    authors： Turecki G,Grof P,Cavazzoni P,Duffy A,Grof E,Ahrens B,Berghöfer A,Müller-Oerlinghausen B,Dvoráková M,Libigerová E,Vojtechovský M,Zvolský P,Joober R,Nilsson A,Prochazka H,Licht RW,Rasmussen NA,Schou M,Vestergaard P,Ho

    更新日期：1998-11-01 00:00:00

  • The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.

    abstract：:Exercise has a variety of beneficial effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Previous studies have shown that exercise enhances hippocampal neurogenesis, induces antidepressant effects and improves learning behavior. Brain serotonin (5-hydroxytryptamine, 5-HT) levels...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2014.153

    authors： Kondo M,Nakamura Y,Ishida Y,Shimada S

    更新日期：2015-11-01 00:00:00

  • Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS.

    abstract：:Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship with psychotic symptoms. The 22q11.2 deletion syndrome (22q11DS) has proven to be a remarkable model for the pro...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0443-z

    authors： Mancini V,Sandini C,Padula MC,Zöller D,Schneider M,Schaer M,Eliez S

    更新日期：2020-11-01 00:00:00

  • Constitutional mechanisms of vulnerability and resilience to nicotine dependence.

    abstract：:The core nature of nicotine dependence is evident in wide variations in how individuals become and remain smokers. Individuals with pre-existing behavioral traits are more likely to develop nicotine dependence and experience difficulty when attempting to quit. Many molecular factors likely contribute to individual var...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/mp.2009.16

    authors： Hiroi N,Scott D

    更新日期：2009-07-01 00:00:00

  • Effects of a novel corticotropin-releasing-hormone receptor type I antagonist on human adrenal function.

    abstract：:Corticotropin-releasing hormone (CRH) is the principal regulator of the hypothalamic-pituitary-adrenal (HPA) axis and an activator of the sympathoadrenal (SA) and systemic sympathetic (SS) systems. Mental disorders, including major depression and, more recently, Alzheimer's disease have been associated with dysregulat...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000720

    authors： Willenberg HS,Bornstein SR,Hiroi N,Päth G,Goretzki PE,Scherbaum WA,Chrousos GP

    更新日期：2000-03-01 00:00:00

  • Muscarinic1 and 2 receptor mRNA in the human caudate-putamen: no change in m1 mRNA in schizophrenia.

    abstract：:Studies using tissue obtained at autopsy suggest that changes in cholinergic neurons could be important in the pathology of schizophrenia.1-4 We have previously reported a decrease in [3H]pirenzepine binding5 and [3H]AF-DX 384 binding6 to caudate-putamen (CP) from subjects who had schizophrenia. Under the conditions c...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000684

    authors： Dean B,Crook JM,Pavey G,Opeskin K,Copolov DL

    更新日期：2000-03-01 00:00:00

  • Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach.

    abstract：:Identifying genes for bipolar mood disorders through classic genetics has proven difficult. Here, we present a comprehensive convergent approach that translationally integrates brain gene expression data from a relevant pharmacogenomic mouse model (involving treatments with a stimulant--methamphetamine, and a mood sta...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001547

    authors： Ogden CA,Rich ME,Schork NJ,Paulus MP,Geyer MA,Lohr JB,Kuczenski R,Niculescu AB

    更新日期：2004-11-01 00:00:00

  • Reduced GABAA benzodiazepine receptor binding in veterans with post-traumatic stress disorder.

    abstract：:Gamma-aminobutyric acid (GABA(A)) receptors are thought to play an important role in modulating the central nervous system in response to stress. Animal data have shown alterations in the GABA(A) receptor complex by uncontrollable stressors. SPECT imaging with benzodiazepine ligands showed lower distribution volumes o...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4002054

    authors： Geuze E,van Berckel BN,Lammertsma AA,Boellaard R,de Kloet CS,Vermetten E,Westenberg HG

    更新日期：2008-01-01 00:00:00

  • Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.

    abstract：:Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the hypothesis that rare variants in many different genes, including de novo variants, could predispose to these conditions i...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2010.54

    authors： Piton A,Gauthier J,Hamdan FF,Lafrenière RG,Yang Y,Henrion E,Laurent S,Noreau A,Thibodeau P,Karemera L,Spiegelman D,Kuku F,Duguay J,Destroismaisons L,Jolivet P,Côté M,Lachapelle K,Diallo O,Raymond A,Marineau C,Cham

    更新日期：2011-08-01 00:00:00

  • The neuroinflammatory component of negative affect in patients with chronic pain.

    abstract：:Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patie...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0433-1

    authors： Albrecht DS,Kim M,Akeju O,Torrado-Carvajal A,Edwards RR,Zhang Y,Bergan C,Protsenko E,Kucyi A,Wasan AD,Hooker JM,Napadow V,Loggia ML

    更新日期：2019-05-28 00:00:00

  • Perceived threat predicts the neural sequelae of combat stress.

    abstract：:Exposure to severe stressors increases the risk for psychiatric disorders in vulnerable individuals, but can lead to positive outcomes for others. However, it remains unknown how severe stress affects neural functioning in humans and what factors mediate individual differences in the neural sequelae of stress. The amy...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2010.132

    authors： van Wingen GA,Geuze E,Vermetten E,Fernández G

    更新日期：2011-06-01 00:00:00

  • Replication of 1q42 linkage in Finnish schizophrenia pedigrees.

    abstract：:Chromosome 1q has been implicated in the etiology of schizophrenia in several independent studies. However, the peak linkage findings have been dispersed over a large chromosomal region, with negative findings in this region also being reported. Our group has previously observed linkage on chromosome 1q42, maximizing ...

    journal_title：Molecular psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.mp.4001536

    authors： Ekelund J,Hennah W,Hiekkalinna T,Parker A,Meyer J,Lönnqvist J,Peltonen L

    更新日期：2004-11-01 00:00:00

  • Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans.

    abstract：:There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. We studied the association of CR...

    journal_title：Molecular psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/sj.mp.4001587

    authors： Licinio J,O'Kirwan F,Irizarry K,Merriman B,Thakur S,Jepson R,Lake S,Tantisira KG,Weiss ST,Wong ML

    更新日期：2004-12-01 00:00:00

  • Lower CSF oxytocin concentrations in women with a history of childhood abuse.

    abstract：:Early-life disruption of the parent-child relationship, for example, in the form of abuse, neglect or loss, dramatically increases risk for psychiatric, as well as certain medical, disorders in adulthood. The neuropeptide oxytocin (OT) plays a seminal role in mediating social affiliation, attachment, social support, m...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2008.112

    authors： Heim C,Young LJ,Newport DJ,Mletzko T,Miller AH,Nemeroff CB

    更新日期：2009-10-01 00:00:00

  • Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice.

    abstract：:The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed within the central nervous system. Previous work showed that this protein is upregulated in Alzheimer's disease (AD), and plays an active role in the development of brain amyloidosis in amyloid beta (Aβ)-precursor protein transgenic mice (Tg2576). In the pr...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2014.170

    authors： Chu J,Li JG,Giannopoulos PF,Blass BE,Childers W,Abou-Gharbia M,Praticò D

    更新日期：2015-11-01 00:00:00

  • Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the Neuregulin-1 locus.

    abstract：:Two recent association studies have implicated the neuregulin-1 gene (NRG1) at chromosome 8p21-22 as a susceptibility gene for schizophrenia. Stefansson et al identified three 'at-risk' haplotypes (HapA, B and C) which spanned the NRG1 locus and shared a common core haplotype. Subsequently, they demonstrated evidence ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001412

    authors： Corvin AP,Morris DW,McGhee K,Schwaiger S,Scully P,Quinn J,Meagher D,Clair DS,Waddington JL,Gill M

    更新日期：2004-02-01 00:00:00