当前位置： SCI文献检索 > MOLECULAR PSYCHIATRY期刊下所有文献 > Identification of novel loci associated with infant cognitive ability.

Identification of novel loci associated with infant cognitive ability.

Abstract：

:It is believed that genetic factors play a large role in the development of many cognitive and neurological processes; however, epidemiological evidence for the genetic basis of childhood neurodevelopment is very limited. Identification of the genetic polymorphisms associated with early-stage neurodevelopment will help elucidate biological mechanisms involved in neuro-behavior and provide a better understanding of the developing brain. To search for such variants, we performed a genome-wide association study (GWAS) for infant mental and motor ability at two years of age with mothers and children recruited from cohorts in Bangladesh and Mexico. Infant ability was assessed using mental and motor composite scores calculated with country-specific versions of the Bayley Scales of Infant Development. A missense variant (rs1055153) located in the gene WWTR1 reached genome-wide significance in association with mental composite score (meta-analysis effect size of minor allele βmeta = -6.04; 95% CI: -8.13 to -3.94; P = 1.56×10-8). Infants carrying the minor allele reported substantially lower cognitive scores in both cohorts, and this variant is predicted to be in the top 0.3% of most deleterious substitutions in the human genome. Fine mapping and region-based association testing provided additional suggestive evidence that both WWTR1 and a second gene, LRP1B, were associated with infant cognitive ability. Comparisons with recently conducted GWAS in intelligence and educational attainment indicate that our phenotypes do not possess a high genetic correlation with either adolescent or adult cognitive traits, suggesting that infant neurological assessments should be treated as an independent outcome of interest. Additional functional studies and replication efforts in other cohorts may help uncover new biological pathways and genetic architectures that are crucial to the developing brain.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Sun R,Wang Z,Claus Henn B,Su L,Lu Q,Lin X,Wright RO,Bellinger DC,Kile M,Mazumdar M,Tellez-Rojo MM,Schnaas L,Christiani DC

doi

10.1038/s41380-018-0205-3

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

3010-3019

issue

eissn

1359-4184

issn

1476-5578

pii

10.1038/s41380-018-0205-3

journal_volume

pub_type

杂志文章

在线工具

Identification of novel loci associated with infant cognitive ability.