abstract：Purpose:Autophagy plays essential roles in the development of COPD. We aim to identify and validate the potential autophagy-related genes of COPD through bioinformatics analysis and experiment validation. Methods:The mRNA expression profile dataset GSE38974 was obtained from GEO database. The potential differentially ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sun S,Shen Y,Wang J,Li J,Cao J,Zhang J

更新日期：2021-01-12 00:00:00

abstract：Background:Chronic obstructive pulmonary disease (COPD) is an age-related disease, and its incidence rate is increasing every year. MicroRNAs (miRNAs) play critical roles in the COPD process and function as key biomarkers or potential therapeutic targets for patients with COPD. However, the potential roles and function...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Liu X,Wang J,Luo H,Xu C,Chen X,Zhang R

更新日期：2020-12-31 00:00:00

abstract：Introduction:Inhaled corticosteroids (ICSs) are recommended for patients with frequent exacerbation of chronic obstructive pulmonary disease (COPD). However, accumulating evidence has indicated the risk of pneumonia from the use of ICS. This study aimed to investigate the association between ICS and pneumonia in the re...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lee JH,Park YH,Kang DR,Lee SJ,Lee MK,Kim SH,Yong SJ,Lee WY

更新日期：2020-12-29 00:00:00

abstract：Objective:To determine the clinical and economic consequences of inhaled corticosteroid doses and particle size in patients on triple-inhalation therapy for COPD. Methods:Patients aged ≥40 years who initiated treatment with multi-inhaler triple-inhaled therapy between 1 January 2015 and 31 March were included and foll...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sicras-Mainar A,de Abajo FJ,Izquierdo-Alonso JL

更新日期：2020-12-09 00:00:00

abstract：Purpose:This research examines the emerging role of respiratory oscillometry associated with integer (InOr) and fractional order (FrOr) respiratory models in the context of groups of patients with increasing severity. The contributions to our understanding of the respiratory abnormalities along the course of increasing...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ribeiro CO,Lopes AJ,de Melo PL

更新日期：2020-12-08 00:00:00

abstract：Purpose:The forced mid-expiratory flow (FEF25-75%) value is a potentially sensitive marker of obstructive peripheral airflow. We aimed to assess whether FEF25-75% can be an early predictor of chronic obstructive pulmonary disease (COPD). Patients and Methods:Between July 1, 2007 and June 31, 2009, we identified 3624 p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kwon DS,Choi YJ,Kim TH,Byun MK,Cho JH,Kim HJ,Park HJ

更新日期：2020-11-12 00:00:00

abstract：Background:COPD is characterized by a persistent inflammatory response, especially against cigarette smoke. COPD patients may develop varying degrees of emphysematous destruction of the lungs. A pathophysiological role for miRNAs in COPD has been suggested in several studies. We examined changes in microRNAs expression...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Cazorla-Rivero S,Mura-Escorche G,Gonzalvo-Hernández F,Mayato D,Córdoba-Lanús E,Casanova C

更新日期：2020-10-29 00:00:00

abstract：Purpose:On March 16, 2020, the Spanish government declared a state of alarm due to the rapid spread of coronavirus disease 2019 (COVID-19). Patients with chronic obstructive pulmonary disease (COPD) were restricted to remain confined at home, and medical visits were cancelled for 3 months. The impact of this lockdown o...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Pleguezuelos E,Del Carmen A,Moreno E,Ortega P,Vila X,Ovejero L,Serra-Prat M,Palomera E,Garnacho-Castaño MV,Loeb E,Farago G,Miravitlles M

更新日期：2020-10-23 00:00:00

abstract：Purpose:To date, no consensus exists on the effects of systemic steroid use on pneumonic chronic obstructive pulmonary disease (COPD) exacerbation owing to trial design issues in previous trials involving these conditions. This multicenter study aimed to evaluate more precisely the effectiveness of the use of systemic ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Shiroshita A,Shiba H,Tanaka Y,Nishi A,Sato K,Shirakawa C,Kataoka Y

更新日期：2020-10-19 00:00:00

abstract：Background and Objectives:Long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of many diseases, including cancer, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD). In this study, we intended to identify the differentially expressed lncRNAs and the role of HOXA cluster antisense ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhou AY,Zhao YY,Zhou ZJ,Duan JX,Zhu YZ,Cai S,Chen P

更新日期：2020-10-09 00:00:00

abstract：Background:Despite chronic obstructive pulmonary disease (COPD) being the commonest non-communicable disease in Nepal, there is limited research evidence estimating the spirometry-based burden of COPD. This study aims to estimate the prevalence of COPD and its correlates through a community-based survey in Pokhara Metr...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Adhikari TB,Acharya P,Högman M,Neupane D,Karki A,Drews A,Cooper BG,Sigsgaard T,Kallestrup P

更新日期：2020-09-29 00:00:00

abstract：Purpose:Chronic obstructive pulmonary disease (COPD) is a major cause of chronic diseases causing considerable social and economic burden globally. Despite substantial evidence on temperature-COPD association, few studies have investigated the acute effect of temperature variability (TV), a potential trigger of exacerb...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhan ZY,Tian Q,Chen TT,Ye Y,Lin Q,Han D,Ou CQ

更新日期：2020-09-22 00:00:00

abstract：Background:Chronic obstructive pulmonary disease (COPD) is prevalent and poses a heavy burden worldwide. However, patients know little about COPD, and primary health care providers have poor therapy capability in China. Enjoying Breathing Program aims to establish a new comprehensive COPD patient management system, inc...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Jia C,Zhang C,Fang F,Huang K,Dong F,Gu X,Niu H,Li S,Wang C,Yang T

更新日期：2020-09-15 00:00:00

abstract：Purpose:To evaluate clinical periodontal status and microbiologic pathogens in patients with chronic obstructive pulmonary disease (COPD) and periodontitis. Patients and Methods:We conducted a case-control study of 60 periodontitis patients with COPD (case group) and 60 periodontitis patients with normal pulmonary fun...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhou X,Wang J,Liu W,Huang X,Song Y,Wang Z,Jia X

更新日期：2020-09-03 00:00:00

abstract：Background:Patients with chronic obstructive pulmonary disease (COPD) and cardiovascular comorbidities may have an increased risk of medication-related cardiac arrhythmias. We therefore performed an analysis of Holter electrocardiogram (ECG) data from two large, long-term, controlled clinical COPD trials to investigate...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Andreas S,Bothner U,de la Hoz A,Kloer I,Trampisch M,Alter P

更新日期：2020-08-10 00:00:00

abstract：Rationale:Emphysema and osteoporosis are tobacco-related diseases. Many studies have shown that emphysema is a strong and independent predictor of low bone mineral density (BMD) in smokers; however, none of them explored its association with different emphysema subtypes. Objective:To explore the association between th...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Gonzalez J,Rivera-Ortega P,Rodríguez-Fraile M,Restituto P,Colina I,Calleja MLD,Alcaide AB,Campo A,Bertó J,Seijo L,Pérez-Warnisher MT,Zulueta JJ,Varo N,de-Torres JP

更新日期：2020-07-27 00:00:00

abstract：Background:Adherence to treatment is key to achieve desired outcomes. In COPD, adherence is generally suboptimal and is impaired by treatment complexity. Objective:To estimate the clinical and economic impact of an improvement in treatment adherence due to an increased use of once-daily single-inhaler triple therapy (...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Miravitlles M,Marín A,Huerta A,Carcedo D,Villacampa A,Puig-Junoy J

更新日期：2020-07-10 00:00:00

abstract：Purpose:Primary care COPD guidelines indicate that COPD patients with asthma characteristics should be treated as having asthma. This study aims to describe the prevalence of asthma characteristics in patients with a pulmonologist-confirmed working diagnosis of COPD or ACO. Patients and Methods:This retrospective cros...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Baron AJ,Flokstra-de Blok BMJ,van Heijst E,Riemersma RA,Sonnenschein-van der Voort AMM,Metting EI,Kocks JWH

更新日期：2020-07-06 00:00:00

abstract：Background:Comorbidities including cardiovascular diseases are very common in chronic obstructive pulmonary disease (COPD) secondary to tobacco smoking and contribute to the overall severity of the disease. In non-smoking COPD, which accounts for about 25% of COPD cases worldwide, current knowledge on the frequency and...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Soumagne T,Guillien A,Roche N,Annesi-Maesano I,Andujar P,Laurent L,Jouneau S,Botebol M,Laplante JJ,Dalphin JC,Degano B

更新日期：2020-07-01 00:00:00

abstract：Background:Despite wide use of the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) 2011, little is known about between-stage transitions and what factors predict worsening transitions in patients with chronic obstructive pulmonary disease (COPD). Objective:To investigate the transition frequency bet...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bernabeu-Mora R,Sánchez-Martínez MP,Montilla-Herrador J,Oliveira-Sousa SL,Gacto-Sánchez M,Medina-Mirapeix F

更新日期：2020-06-30 00:00:00

abstract：Introduction:Self-management (SM) is a core component of well-being and perceived health for patients with chronic obstructive pulmonary disease (COPD). Most theories on SM share that self-efficacy, illness-perception and coping are determinants of SM behavior. Optimal support to improve SM should be tailored to the in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Voorhaar M,Tiemensma J,Asijee GM,Slok AHM,Muris JWM,Kaptein AA

更新日期：2020-06-19 00:00:00

abstract：Introduction:Training in correct inhaler use, ideally in person or by video demonstration, can minimize errors but is rarely provided in clinics. This open-label, low-intervention study evaluated critical error rates with dry-powder inhalers (DPIs), before and after training, in patients with chronic obstructive pulmon...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Collier DJ,Wielders P,van der Palen J,Heyes L,Midwinter D,Collison K,Preece A,Barnes N,Sharma R

更新日期：2020-06-09 00:00:00

abstract：Introduction:COPD is an inflammatory airway pathology associated with recurrent infection by nontypeable Haemophilus influenzae (NTHi) that is not effectively managed by macrolide antibiotic therapy. We hypothesised that NTHi is able to reside intracellularly within COPD-derived airway epithelial cells (AEC), and that ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Poh WP,Kicic A,Lester SE,Nguyen PT,Bakaletz LO,Reynolds PN,Hodge S,Roscioli E

更新日期：2020-06-04 00:00:00

abstract：Purpose:Peripheral blood eosinophilic counts are susceptible to many factors and have variability over time. There are limited studies on association of blood eosinophilia with long-term mortality of chronic obstructive pulmonary disease (COPD) patients and these results remain controversial. Our aims were to explore t...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhang Y,Liang LR,Zhang S,Lu Y,Chen YY,Shi HZ,Lin YX

更新日期：2020-05-19 00:00:00

abstract：Rationale:Individual socioeconomic status has been shown to influence the outcomes of patients with chronic obstructive pulmonary disease (COPD). However, contextual factors may also play a role. The objective of this study is to evaluate the association between neighborhood socioeconomic disadvantage measured by the a...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Galiatsatos P,Woo H,Paulin LM,Kind A,Putcha N,Gassett AJ,Cooper CB,Dransfield MT,Parekh TM,Oates GR,Barr RG,Comellas AP,Han MK,Peters SP,Krishnan JA,Labaki WW,McCormack MC,Kaufman JD,Hansel NN

更新日期：2020-05-05 00:00:00

abstract：Background:People living with both chronic obstructive pulmonary disease (COPD) and frailty have high potential to benefit from exercise-based interventions, including pulmonary rehabilitation, but face challenges completing them. Research to understand ways to optimise exercise-based interventions in this group is lac...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Brighton LJ,Evans CJ,Man WDC,Maddocks M

更新日期：2020-04-20 00:00:00

abstract：Purpose:We hypothesized that increased level of serum β2-microglobulin (β2M) is an independent factor associated with higher mortality in hospitalized patients with exacerbated chronic obstructive pulmonary disease (COPD). Patients and Methods:We retrospectively analyzed 488 hospitalized patients with exacerbated COPD...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mao W,Wang J,Zhang L,Wang Y,Wang W,Zeng N,Zhang J,Li Q,Jiao F,Li J,Cui N,Mi S,Xue Y,Wang Z,Ying S,Huang K

更新日期：2020-04-07 00:00:00

abstract：Introduction:With increasing availability of different treatments for chronic obstructive pulmonary disease (COPD), we sought to understand patient preferences for COPD treatment in the UK, USA, and Germany using a discrete choice experiment (DCE). Methods:Qualitative research identified six attributes associated with...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lewis HB,Schroeder M,Gunsoy NB,Janssen EM,Llewellyn S,Doll HA,Jones PW,Ismaila AS

更新日期：2020-03-18 00:00:00

abstract：Rationale:Current guidelines recommend that patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (COPD) initiate pulmonary rehabilitation (PR) shortly after discharge from the hospital. However, fewer than 2 percent of Medicare beneficiaries do so. Few studies have examined hospitalize...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Spitzer KA,Stefan MS,Drake AA,Pack QR,Lagu T,Mazor KM,Pinto-Plata V,Lindenauer PK

更新日期：2020-03-17 00:00:00

abstract：Purpose:COPD is a multisystem disease and there is a need for clinical serum markers that can assess the decline in lung and muscle function in COPD. The goal of this study was to evaluate the potential association of serum club-cell protein 16 (CC16), α-1 acid glycoprotein (AGP) and total sialic acid (TSA) with spirom...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Qaisar R,Karim A,Muhammad T

更新日期：2020-02-11 00:00:00

abstract：Purpose:Depression is reported in association with chronic obstructive pulmonary disease (COPD). However, to date, no multidimensional indices have taken depression into consideration to predict COPD patients' prognosis. This study aimed to determine whether a new multidimensional index named CODEXS, based on comorbidi...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Deng D,Zhou A,Chen P,Shuang Q

更新日期：2020-02-03 00:00:00

abstract：Purpose:This study compared the effects of inpatient-based rehabilitation program of patients with chronic obstructive pulmonary disease (COPD) using non-immersive virtual reality (VR) training with a traditional pulmonary rehabilitation program. The aims of this study were to determine 1) whether rehabilitation featur...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Rutkowski S,Rutkowska A,Kiper P,Jastrzebski D,Racheniuk H,Turolla A,Szczegielniak J,Casaburi R

更新日期：2020-01-13 00:00:00

abstract：Purpose:Epigenetic modification is one of most important mechanisms underlying the pathogenesis of chronic obstructive pulmonary disease (COPD). The purpose of this study was to determine whether histone acetyltransferase binding to ORC1 (HBO1) can protect against cigarette smoke (CS)-induced cell apoptosis and sustain...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Chen L,Luo L,Kang N,He X,Li T,Chen Y

更新日期：2020-01-06 00:00:00

abstract：Objective:The presence of both emphysema and airway wall thickening determined via volumetric computed tomography (CT) is defined as mixed phenotype. The long-term clinical course of this phenotype has not been studied in depth. This study compared the mixed phenotype to other phenotypes of chronic obstructive pulmonar...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lim JU,Kim EK,Lim SY,Lee JH,Lee JS,Lee SD,Oh YM,Rhee CK,KOLD Study Group.

更新日期：2019-12-30 00:00:00

abstract：Background:Since most internal medicine nurses work with chronic obstructive pulmonary disease (COPD) patients daily, their ability to meet the needs of COPD patients is an important issue. Our study aimed to assess COPD-related knowledge in internal medicine nurses. Methods:A descriptive cross-sectional study includi...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ma Y,Peng Y,Chen P,Nie N,Chen Y

更新日期：2019-12-17 00:00:00

abstract：Background:Metabolic syndrome (MetS) is a well-known comorbidity of chronic obstructive pulmonary disease (COPD). However, their interrelationship, particularly in early COPD, remains unclear. Therefore, we aimed to assess the prevalence and clinical characteristics of MetS in patients with early COPD, and to explore t...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Choi HS,Rhee CK,Park YB,Yoo KH,Lim SY

更新日期：2019-12-10 00:00:00

abstract：Background:Patients with diseases linked with smoking, such as COPD, report a health-related stigma on their smoking behavior, which is related to a poorer quality of life and psychological distress. According to patients with COPD, health-care professionals sometimes reinforce the sense of stigma. However, little is k...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mooren K,van der Linden G,Pool K,Engels Y

更新日期：2019-11-29 00:00:00

abstract：Introduction:Long-term use of nebulized or oral antibiotics is common in the treatment of cystic fibrosis and non-cystic fibrosis bronchiectasis. To date, however, few studies have focused on the use of nebulized antibiotics in COPD patients. The aims of this study are: to establish whether a combination of nebulized c...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Montón C,Prina E,Pomares X,Cugat JR,Casabella A,Oliva JC,Gallego M,Monsó E

更新日期：2019-10-17 00:00:00

abstract：Purpose:Revefenacin, a long-acting muscarinic antagonist for nebulization, has been shown to improve lung function in patients with chronic obstructive pulmonary disease. Here we report pharmacokinetic (PK) and safety results from two multicenter, open-label, single-dose trials evaluating revefenacin in subjects with s...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Borin MT,Lo A,Barnes CN,Pendyala S,Bourdet DL

更新日期：2019-10-08 00:00:00

abstract：Objectives:To describe the trends in pharmacologic treatment for patients newly diagnosed with chronic obstructive pulmonary disease (COPD) in Alberta, Canada. Methods:We linked Alberta health databases to identify patients aged ≥35 years with incident COPD between April 2010 and March 2017. Incident cases were define...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tran DT,Akpinar I,Mayers I,Makhinova T,Jacobs P

更新日期：2019-09-26 00:00:00