abstract：:Acute ischemic stroke (AIS) is a time sensitive medical emergency and a leading cause of morbidity and mortality worldwide. Intravenous (IV) recombinant tissue plasminogen activator (IV alteplase) is currently the only proven effective medication for the treatment of AIS with promising adjuvant medications currently u...

journal_title：Seminars in neurology

authors： Gottula AL,Barreto AD,Adeoye O

更新日期：2021-01-20 00:00:00

abstract：:Pain is common but often underrecognized after stroke. Poststroke pain (PSP) hinders recovery, impairs quality of life, and is associated with the psychological state of patients with stroke. The most common subtypes of PSP include central PSP, complex regional pain syndrome, shoulder pain, spasticity-related pain, an...

journal_title：Seminars in neurology

authors： Yang S,Chang MC

更新日期：2021-01-14 00:00:00

abstract：:Status epilepticus is a neurological emergency with an outcome that is highly associated with the initial pharmacotherapy management that must be administered in a timely fashion. Beyond first-line therapy of status epilepticus, treatment is not guided by robust evidence. Optimal pharmacotherapy selection for individu...

journal_title：Seminars in neurology

authors： Der-Nigoghossian C,Tesoro EP,Strein M,Brophy GM

更新日期：2020-12-01 00:00:00

abstract：:The catecholamines dopamine and norepinephrine are key central neurotransmitters that participate in many neurobehavioral processes and disease states. Norepinephrine is also the main neurotransmitter mediating regulation of the circulation by the sympathetic nervous system. Several neurodegenerative disorders feature...

journal_title：Seminars in neurology

authors： Goldstein DS

更新日期：2020-10-01 00:00:00

abstract：:With age, the presence of multiple neuropathologies in a single individual becomes increasingly common. Given that traumatic brain injury and the repetitive head impacts (RHIs) that occur in contact sports have been associated with the development of many neurodegenerative diseases, including chronic traumatic encepha...

journal_title：Seminars in neurology

authors： Stein TD,Crary JF

更新日期：2020-08-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head impacts (RHI), such as those received in contact/collision sports, blast injury in military veterans, and domestic violence. Currently, CTE can only be diagnosed following death. Although the clinical features of form...

journal_title：Seminars in neurology

authors： Mariani M,Alosco ML,Mez J,Stern RA

更新日期：2020-08-01 00:00:00

abstract：:Hypoxic-ischemic encephalopathy (HIE) is a manifestation of perinatal asphyxial insult that continues to evolve over days to weeks following the initial injury. Therapeutic hypothermia has demonstrated that a proportion of this secondary brain injury may indeed be preventable. However, therapeutic hypothermia has also...

journal_title：Seminars in neurology

authors： Goswami I,Guillot M,Tam EWY

更新日期：2020-06-01 00:00:00

abstract：:Pseudotumor cerebri syndrome (PTCS) is a rare condition in children presenting with headache and papilledema from increased intracranial pressure that can cause significant morbidity. This can be idiopathic, also known as idiopathic intracranial hypertension or primary intracranial hypertension, or can be secondary to...

journal_title：Seminars in neurology

authors： Beres SJ

更新日期：2020-06-01 00:00:00

abstract：:Rasmussen encephalitis (RE) is a rare, devastating, progressive pediatric epilepsy. First described 60 years ago, RE continues to present challenges in diagnosis and management. RE causes a unilateral focal epilepsy in children that typically becomes medically refractory, results in significant hemiparesis, and causes...

journal_title：Seminars in neurology

authors： Cay-Martinez KC,Hickman RA,McKhann Ii GM,Provenzano FA,Sands TT

更新日期：2020-04-01 00:00:00

abstract：:Environmental circumstances that result in ambiguity or conflict with the patterns of sensory stimulation may adversely affect the vestibular system. The effect of this conflict in sensory information may be dizziness, a sense of imbalance, nausea, and motion sickness sometimes even to seemingly minor daily head movem...

journal_title：Seminars in neurology

authors： Bronstein AM,Golding JF,Gresty MA

更新日期：2020-02-01 00:00:00

abstract：:Benign paroxysmal positional vertigo (BPPV) is common, sometimes terrifying, but rarely portends serious disease. It is usually easily diagnosed and treated, and both the patient and the physician are immediately gratified. While much has been learned about the pathogenesis of BPPV in the past decades, many of its fea...

journal_title：Seminars in neurology

authors： Nuti D,Zee DS,Mandalà M

更新日期：2020-02-01 00:00:00

abstract：:Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a disease primarily affecting obese women of child-bearing age, typically presenting with positional headaches, diplopia from abducens nerve palsies, pulse-synchronous tinnitus, and visual disturbances related to papilledema, including t...

journal_title：Seminars in neurology

authors： Dinkin M,Oliveira C

更新日期：2019-12-01 00:00:00

abstract：:Small fiber neuropathy (SFN) is common, and can be associated with many medical conditions. The majority of the patients with SFN suffer from painful paresthesia which can negatively impact their quality of life. Skin biopsy with intraepidermal nerve fiber density evaluation is the gold standard diagnostic test. Auton...

journal_title：Seminars in neurology

authors： Zhou L

更新日期：2019-10-01 00:00:00

abstract：:Infective endocarditis (IE) is a systemic disease with many potential neurologic manifestations including ischemic and hemorrhagic strokes, cerebral microbleeding, infectious intracranial aneurysms, meningitis, brain abscesses, and encephalopathy. The majority of left-sided (heart) IE patients have brain lesions that ...

journal_title：Seminars in neurology

authors： Carneiro TS,Awtry E,Dobrilovic N,Fagan MA,Kimmel S,Weinstein ZM,Cervantes-Arslanian AM

更新日期：2019-08-01 00:00:00

abstract：:Fungal central nervous system infections present in a myriad of clinical manifestation and remain a significant diagnostic challenge. Presenting symptoms, cerebrospinal fluid analysis, conventional fungal serum markers and imaging correlates of disease are seldom sensitive or specific; fungal culture growth or histopa...

journal_title：Seminars in neurology

authors： Jia DT,Thakur K

更新日期：2019-06-01 00:00:00

abstract：:Treatment of dementias represents an important but relatively neglected part of neurological care of the elderly population. Individual therapeutic interventions may make only small changes to the quality of life of individuals afflicted with dementia, but when used in combination these interventions synergize and can...

journal_title：Seminars in neurology

authors： Tisher A,Salardini A

更新日期：2019-04-01 00:00:00

abstract：:Rapidly progressive dementia (RPD) or cognitive decline is a common presenting complaint in neurology. While primary dementia is often a concern, other forms of reversible dementia must be thoroughly considered. This article focuses on the growing field of autoimmune encephalitis (AE) as it pertains to the differentia...

journal_title：Seminars in neurology

authors： Wesley SF,Ferguson D

更新日期：2019-04-01 00:00:00

abstract：:Dizziness is a common chief complaint with an extensive differential diagnosis that includes both benign and serious conditions. Physicians must distinguish the majority of patients who suffer from self-limiting conditions from those with serious illnesses that require acute treatment. The preferred approach to the di...

journal_title：Seminars in neurology

authors： Gurley KL,Edlow JA

更新日期：2019-02-01 00:00:00

abstract：:Neuropathic pain management is challenging, and typically requires a multifaceted approach. There are several treatment options, both pharmacologic and nonpharmacologic. Of the available pharmacologic agents, those with the strongest supporting evidence include tricyclic antidepressants, serotonin-norepinephrine reupt...

journal_title：Seminars in neurology

authors： Macone A,Otis JAD

更新日期：2018-12-01 00:00:00

abstract：:Physician-hastened-death remains a controversial topic for patients and those who care for them. It is a particularly relevant topic for neurologists who currently, or will in the future, reside in jurisdictions where physician-hastened-death is legal. In this article, I attempt to provide a comprehensive and contempo...

journal_title：Seminars in neurology

authors： Russell JA

更新日期：2018-10-01 00:00:00

abstract：:The use of technology in neurology education has revolutionized many aspects of medical teaching, addressing some important challenges of modern education such as information overload and the unique needs of millennial learners. However, it also has inherent problems, such as depersonalization and high development cos...

journal_title：Seminars in neurology

authors： Lau KHV,Lakhan SE,Achike F

更新日期：2018-08-01 00:00:00

abstract：:Autoimmune epilepsy is increasingly recognized as a distinct clinical entity, driven in large part by the recent discovery of neural autoantibodies in patients with isolated or predominant epilepsy presentations. Detection of neural autoantibodies in high-risk epilepsy patients supports an immune-mediated cause of sei...

journal_title：Seminars in neurology

authors： Quek AML,O'Toole O

更新日期：2018-06-01 00:00:00

abstract：:Neurology has not typically been associated with international relief work; however, with the growth of chronic cardiovascular disease and stroke associated with unhealthy eating and sedentary ways, the appearance of "new" neurologic diseases, such as the Zika and West Nile viruses, and the high numbers of seizure dis...

journal_title：Seminars in neurology

authors： Schiess N,Saylor D,Zunt J

更新日期：2018-04-01 00:00:00

abstract：:With the advent of combination antiretroviral therapies, the mortality rate from HIV has declined, while the prevalence of long-term HIV-related neurologic complications continues to rise. Thirty-six million individuals are living with HIV around the world, many of whom reside in resource-limited settings. The majorit...

journal_title：Seminars in neurology

authors： Patel PB,Spudich SS

更新日期：2018-04-01 00:00:00

abstract：:Magnetic resonance imaging plays a key role in diagnosis and treatment monitoring of brain tumors. Novel imaging techniques that specifically interrogate aspects of underlying tumor biology and biochemical pathways have great potential in neuro-oncology. This review focuses on the emerging role of 2-hydroxyglutarate-t...

journal_title：Seminars in neurology

authors： Kickingereder P,Andronesi OC

更新日期：2018-02-01 00:00:00

abstract：:Pregnancy and the postpartum period confer an increased risk of stroke. The risk appears to be increased for all strokes during the puerperium and for hemorrhagic strokes during pregnancy. During pregnancy, physiologic systems are under increased stress to accommodate the growing fetus, which results in substantial he...

journal_title：Seminars in neurology

authors： Sells CM,Feske SK

更新日期：2017-12-01 00:00:00

abstract：:Severe brain injury may cause disruption of neural networks that sustain arousal and awareness, the two essential components of consciousness. Despite the potentially devastating immediate and long-term consequences, disorders of consciousness (DoC) are poorly understood in terms of their underlying neurobiology, the ...

journal_title：Seminars in neurology

authors： Bodien YG,Chatelle C,Edlow BL

更新日期：2017-10-01 00:00:00

abstract：:Botulinum toxin (BoNT) therapy is frequently employed in the treatment of Parkinson's disease (PD) symptoms. It can effectively ameliorate the symptoms of cervical dystonia, blepharospasm, sialorrhea, and hyperactive bladder. It is increasingly being used for additional PD-related indications including limb dystonia, ...

journal_title：Seminars in neurology

authors： Wagle Shukla A,Malaty IA

更新日期：2017-04-01 00:00:00

abstract：:Neuroimaging is commonly utilized in the evaluation of post-cardiac arrest patients, providing a unique ability to visualize and quantify structural brain injury that can complement clinical and electrophysiologic data. Despite its lack of validation, we would advocate that neuroimaging is a valuable prognostication t...

journal_title：Seminars in neurology

authors： Greer DM,Wu O

更新日期：2017-02-01 00:00:00

abstract：:The field of neurocritical care has evolved tremendously in recent years, a development explained vastly by the advent of neurophysiological monitoring. From basic intracranial pressure measurements to brain tissue oxygenation, microdialysis, cerebral blood flow (CBF), and surface and intracortical electroencephalogra...

journal_title：Seminars in neurology

authors： Francoeur CL,Pain M,Mayer SA

更新日期：2016-12-01 00:00:00

abstract：:Sleep medicine can be a particularly rewarding clinical area for neurologists. After all, the driving organ of sleep is the brain. Many of the sleep disorders are primary brain disorders, whereas other sleep disorders (and their medications) influence brain function. But without an organized approach, even the engaged...

journal_title：Seminars in neurology

authors： Ellenbogen JM

更新日期：2016-10-01 00:00:00

abstract：:Parkinsonism is a clinical syndrome, which is characterized by bradykinesia, rigidity, rest tremor, and postural instability. Idiopathic Parkinson disease (PD) is the most common cause of this syndrome, though there are several other important etiologies that must be considered. These include the atypical Parkinsonian...

journal_title：Seminars in neurology

authors： Keener AM,Bordelon YM

更新日期：2016-08-01 00:00:00

abstract：:Accurate outcome prognostication is critical to the management of patients with primary or spontaneous intracerebral hemorrhage (ICH). Prognostication may guide the decision to pursue aggressive acute management or to plan proper goals of care for patients who will likely suffer long-term severe disability. In particu...

journal_title：Seminars in neurology

authors： Chu SY,Hwang DY

更新日期：2016-06-01 00:00:00

abstract：:Improved disease control is critical for enhancing the lives of those living with multiple sclerosis. With specific immunologic targets, monoclonal antibody (mAb) treatments are highly effective options for relapsing forms of multiple sclerosis. The mechanism, efficacy, and current safety profiles are detailed for the...

journal_title：Seminars in neurology

authors： Singer BA

更新日期：2016-04-01 00:00:00

abstract：:Alteration in neural control from suprapontine areas to the nerves innervating the bladder can lead to bladder dysfunction and the development of a neurogenic bladder (NGB). Patients with NGB often suffer from urinary incontinence, which can lead to adverse events such as urinary tract infections and decubiti, in addi...

journal_title：Seminars in neurology

authors： Smith CP,Chancellor MB

更新日期：2016-02-01 00:00:00

abstract：:Blepharospasm is a focal dystonia characterized by involuntary, repetitive eye closure. Orofacial and oromandibular dystonia describe involuntary dystonic movements of orofacial and oromandibular musculature. Hemifacial spasm is characterized by repetitive synchronous contraction of facial nerve innervated muscles on ...

journal_title：Seminars in neurology

authors： Karp BI,Alter K

更新日期：2016-02-01 00:00:00

abstract：:As the population ages, the prevalence of many neurologic diseases is increasing. At the same time, older patients are undergoing more surgical procedures. This confluence of events puts neurohospitalists in a unique position to provide both pre- and postoperative guidance to minimize complications, improve clinical o...

journal_title：Seminars in neurology

authors： Hudson KA,Greene JG

更新日期：2015-12-01 00:00:00

abstract：:Visual field deficits are common in neurologic disease conditions such as cerebrovascular disease, traumatic brain injury, and brain tumors. Loss of visual fields may lead to impairment of reading skills (hemianopic dyslexia) and limitations of daily activities such as driving, which can have a significant impact on a...

journal_title：Seminars in neurology

authors： Agarwal A,Kedar S

更新日期：2015-10-01 00:00:00

abstract：:Myotonic dystrophies and channelopathies are rare but important causes of muscle diseases which may present with myotonia, episodic attacks of weakness, fixed muscle weakness, and atrophy or their combination. Here, the authors provide an overview of these disorders and describe their clinical and pathophysiological f...

journal_title：Seminars in neurology

authors： Quinn C,Salajegheh MK

更新日期：2015-08-01 00:00:00

abstract：:Primary brain tumors are common causes of focal epilepsy, accounting for 5% of new-onset seizures in adults and over 10% of lesional focal epilepsies. These epilepsies are often refractory to medical treatment, and high rates of seizure freedom can be achieved with gross total resections. However, the management strat...

journal_title：Seminars in neurology

authors： Nowell M,Miserocchi A,McEvoy AW

更新日期：2015-06-01 00:00:00