Abstract:
:Rapidly progressive dementia (RPD) or cognitive decline is a common presenting complaint in neurology. While primary dementia is often a concern, other forms of reversible dementia must be thoroughly considered. This article focuses on the growing field of autoimmune encephalitis (AE) as it pertains to the differential diagnostic considerations in a work-up for RPD. Understanding clues in the history and examination is the first step in identifying patients with a potential autoimmune cause for RPD. While testing for infectious and toxic-metabolic etiologies is commonly preformed, it is necessary to consider early ancillary testing for AE in appropriate cases of RPD. Autoantibody testing in the spinal fluid and serum, brain imaging, and electroencephalography all form the first line of investigations for AE. Treatment options and strategies depend on the AE subtype and a number of individual patient considerations.
journal_name
Semin Neuroljournal_title
Seminars in neurologyauthors
Wesley SF,Ferguson Ddoi
10.1055/s-0039-1678583subject
Has Abstractpub_date
2019-04-01 00:00:00pages
283-292issue
2eissn
0271-8235issn
1098-9021journal_volume
39pub_type
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