Abstract:
:Fungal central nervous system infections present in a myriad of clinical manifestation and remain a significant diagnostic challenge. Presenting symptoms, cerebrospinal fluid analysis, conventional fungal serum markers and imaging correlates of disease are seldom sensitive or specific; fungal culture growth or histopathologic analysis are often required for definitive diagnoses but limited by feasibility. Novel diagnostic tools (such as the cryptococcal antigen and next-generation sequencing) have increased diagnostic potency when available but require further studies to define their utility.Invasive fungal infections are an emerging health threat in the setting of increased immunomodulatory treatments, advancements in transplant medicine and increased world-wide travel. Therefore, strong clinical suspicion from epidemiologic clues, clinical progression and presence of CNS dissemination risk factors must be exercised to pursue broad diagnostic workups and rapidly initiate medical and surgical management. This article will describe the epidemiology, clinical presentations, diagnostic approach and therapeutic interventions for fungal infections in the central nervous system.
journal_name
Semin Neuroljournal_title
Seminars in neurologyauthors
Jia DT,Thakur Kdoi
10.1055/s-0039-1688916subject
Has Abstractpub_date
2019-06-01 00:00:00pages
343-357issue
3eissn
0271-8235issn
1098-9021journal_volume
39pub_type
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1688826
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
doi:10.1055/s-0031-1299791
更新日期:2011-11-01 00:00:00
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1354601
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
doi:10.1055/s-2005-871323
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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