Pearls: multiple sclerosis.

abstract：:Mitochondrial disorders are frequently associated with seizures. In this review, the authors discuss the seizure patterns and distinguishing features of mitochondrial epilepsy, alongside the indications for investigating, and how to investigate epilepsy from a mitochondrial perspective. Finally, they discuss managemen...

journal_title：Seminars in neurology

authors： Steele HE,Chinnery PF

更新日期：2015-06-01 00:00:00

abstract：:Clinicians commonly encounter patients with cerebrovascular disorders in the hospital. Now, as never before, there are many effective diagnostic and therapeutic modalities. Several examples of typical cases of stroke and transient ischemic attack are presented in order to illustrate a rational approach to diagnosis an...

journal_title：Seminars in neurology

authors： Demaerschalk BM

更新日期：2003-09-01 00:00:00

abstract：:Metastatic plexopathy is often a disabling accompaniment of advanced systemic cancer and may involve any of the peripheral nerve plexuses. Brachial plexopathy most commonly occurs in carcinoma of the breast and lung; lumbosacral plexopathy is most common with colorectal and gynecologic tumors, sarcomas, and lymphomas....

journal_title：Seminars in neurology

authors： Jaeckle KA

更新日期：2004-12-01 00:00:00

abstract：:Autoimmune encephalopathy represents a complex category of disease with diverse immunologic associations, clinical manifestations, and therapeutic outcomes. Three main subgroups include autoimmune encephalopathies without cancer but with neural nonspecific serologic evidence of autoimmunity (encompassing "Hashimoto's ...

journal_title：Seminars in neurology

authors： Flanagan EP,Caselli RJ

更新日期：2011-04-01 00:00:00

abstract：:Fungal central nervous system infections present in a myriad of clinical manifestation and remain a significant diagnostic challenge. Presenting symptoms, cerebrospinal fluid analysis, conventional fungal serum markers and imaging correlates of disease are seldom sensitive or specific; fungal culture growth or histopa...

journal_title：Seminars in neurology

authors： Jia DT,Thakur K

更新日期：2019-06-01 00:00:00

abstract：:Reported PET findings in subcortical and corticobasal degenerations, and in dystonia, are summarized in Table 3. It can be seen that, although PET is not a diagnostic technique, clinical examination combined with PET findings can help to distinguish between the various akinetic-rigid syndromes, with the proviso that p...

journal_title：Seminars in neurology

authors： Brooks DJ

更新日期：1989-12-01 00:00:00

abstract：:Rasmussen encephalitis (RE) is a rare, devastating, progressive pediatric epilepsy. First described 60 years ago, RE continues to present challenges in diagnosis and management. RE causes a unilateral focal epilepsy in children that typically becomes medically refractory, results in significant hemiparesis, and causes...

journal_title：Seminars in neurology

authors： Cay-Martinez KC,Hickman RA,McKhann Ii GM,Provenzano FA,Sands TT

更新日期：2020-04-01 00:00:00

abstract：:Sergei Sergeevich Prokofiev (1891-1953) was one of the great Russian composers. He died, at age 61, of a supposed intracerebral brain hemorrhage. During the 8 years before his death, he suffered from episodic headaches, nausea and dizziness. This article reviews the historical information about Prokofiev's illness lea...

journal_title：Seminars in neurology

authors： Hingtgen CM

更新日期：1999-01-01 00:00:00

abstract：:Establishing an open and honest physician-patient relationship is essential for the proper evaluation and management of headache disorders. Obtaining a complete headache and medical history is the most important part of the initial diagnostic evaluation. This history should include information about headache onset, pa...

journal_title：Seminars in neurology

authors： Marks DR,Rapoport AM

更新日期：1997-01-01 00:00:00

abstract：:Synucleinopathies, with and without dementia, encompass a wide range of diseases including Parkinson's disease, multiple system atrophy, rapid eye movement (REM) sleep behavior disorder, and dementia with Lewy bodies (DLB). DLB is a neurodegenerative disorder resulting in slowly progressive and unrelenting dementia un...

journal_title：Seminars in neurology

authors： Weisman D,McKeith I

更新日期：2007-02-01 00:00:00

abstract：:Cell transplantation is an experimental therapy for Parkinson's disease (PD) and other movement disorders. Several open-label research trials have shown clinically meaningful improvement in parkinsonian signs and symptoms after striatal transplantation of allogeneic fetal ventral mesencephalic (FVM) tissue. However, e...

journal_title：Seminars in neurology

authors： Subramanian T

更新日期：2001-01-01 00:00:00

abstract：:The clinical hallmark of myasthenia gravis (MG) is fluctuating, painless weakness of muscles that most often affect extraocular, lower bulbar, or limb musculature. Predicting the probability of successful treatment for the patient assumes that the physician has made an accurate diagnosis. In this review, the practical...

journal_title：Seminars in neurology

authors： Engstrom JW

更新日期：2004-06-01 00:00:00

abstract：:Neurotoxic venoms are common among tropical marine creatures, which have specialized apparatuses for delivery of the venoms. These include jellyfish and anemones, venomous cone snails, venomous fish, stingrays, sea snakes, and venomous octopuses. Numerous toxic neuropeptides are found within these venoms, and some can...

journal_title：Seminars in neurology

authors： Watters MR

更新日期：2005-09-01 00:00:00

abstract：:Headaches are a common complaint for most women during their lifetime, including gestation and puerperium. Tension-type headaches and migraine flare-ups are the most common headache complications after delivery, but the differential diagnosis of postpartum headache is broad. The clinician must distinguish common heada...

journal_title：Seminars in neurology

authors： Cardona L,Klein AM

更新日期：2011-09-01 00:00:00

abstract：:Pregnancy can precipitate new neurological diseases as a result of the alterations in physiology that accompany the pregnant state. The pregnant patient presenting with neurological problems poses both diagnostic and therapeutic challenges, often forcing the clinician to rely on neuroimaging as part of the workup. Thi...

journal_title：Seminars in neurology

authors： Brass SD,Copen WA

更新日期：2007-11-01 00:00:00

abstract：:Hypoxic-ischemic encephalopathy (HIE) is a manifestation of perinatal asphyxial insult that continues to evolve over days to weeks following the initial injury. Therapeutic hypothermia has demonstrated that a proportion of this secondary brain injury may indeed be preventable. However, therapeutic hypothermia has also...

journal_title：Seminars in neurology

authors： Goswami I,Guillot M,Tam EWY

更新日期：2020-06-01 00:00:00

abstract：:The optic nerve is our most important cranial nerve. As it courses from the eyeball to the brain, it is divided into four segments: intraocular, intraorbital, intracanalicular, and intracranial. Four tests are primarily used to assess its functional integrity and detect optic nerve disorders. These tests are described...

journal_title：Seminars in neurology

authors： Selhorst JB,Chen Y

更新日期：2009-02-01 00:00:00

abstract：:Alteration in neural control from suprapontine areas to the nerves innervating the bladder can lead to bladder dysfunction and the development of a neurogenic bladder (NGB). Patients with NGB often suffer from urinary incontinence, which can lead to adverse events such as urinary tract infections and decubiti, in addi...

journal_title：Seminars in neurology

authors： Smith CP,Chancellor MB

更新日期：2016-02-01 00:00:00

abstract：:With the development of multiple options for immunotherapy in multiple sclerosis, the clinician is faced with the challenge of keeping pace with the literature, acquiring familiarity with the various treatment options and opinions, and then offering the patients the most current and appropriate management. Given the i...

journal_title：Seminars in neurology

authors： Mattson DH

更新日期：2002-03-01 00:00:00

abstract：:Syndromes characterized by persistent fatigue, musculoskeletal pain, sleep disturbance, and subjective cognitive impairment have been common problems in clinical practice for decades. The chronic fatigue syndrome case definition was created to standardize the patient population in research studies and to foster a syst...

journal_title：Seminars in neurology

authors： Goshorn RK

更新日期：1998-01-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is a very common condition in patients with stroke and is found in over half of stroke patients. There is a complex relationship between OSA and stroke, attributable to shared risk factors. There are numerous mechanisms by which OSA may contribute to increased stroke risk, including promo...

journal_title：Seminars in neurology

authors： Brown DL

更新日期：2006-02-01 00:00:00

abstract：:Chronic insomnia afflicts millions of people in the United States. It is associated with decreased quality of life, accidents, several comorbid conditions, increased morbidity, and substantial direct and indirect costs. Chronic insomnia is a multifactorial and individualized disorder. Its etiology may be cognitive or ...

journal_title：Seminars in neurology

authors： Neubauer DN,Flaherty KN

更新日期：2009-09-01 00:00:00

abstract：:The demonstration that several agents with presumed differing mechanisms of action each provide partial effectiveness in the treatment of relapsing-remitting multiple sclerosis (MS) has significantly changed the approach to MS clinical trial research. A number of recently published trials have provided support to thes...

journal_title：Seminars in neurology

authors： Noseworthy JH

更新日期：1998-01-01 00:00:00

abstract：:Three-quarters of all strokes are managed outside of academic medical centers, making optimization of stroke care in the community setting a central part of minimizing the disability from stroke. In addition, the care of stroke patients crosses multiple different components of the health care system and requires a mul...

journal_title：Seminars in neurology

authors： Russman AN,Katzan IL

更新日期：2005-12-01 00:00:00

abstract：:The growth of bioethics as a practical, meaningful player in the arena of health care has paralleled that of clinical neurology not only in time but also in interaction between the two disciplines. Almost every advance in neurology has spawned an ethical dilemma, the unraveling of which has brought new insights to bot...

journal_title：Seminars in neurology

authors： McQuillen MP

更新日期：2001-12-01 00:00:00

abstract：:Despite decades of basic and clinical research, treatments to improve outcomes after traumatic brain injury (TBI) are limited. However, based on the recent recognition of the prevalence of mild TBI, and its potential link to neurodegenerative disease, many new and exciting secondary injury mechanisms have been identif...

journal_title：Seminars in neurology

authors： Kochanek PM,Jackson TC,Ferguson NM,Carlson SW,Simon DW,Brockman EC,Ji J,Bayır H,Poloyac SM,Wagner AK,Kline AE,Empey PE,Clark RS,Jackson EK,Dixon CE

更新日期：2015-02-01 00:00:00

abstract：:A recent development in the evaluation of peripheral neuropathy patients has been the identification of autoantibodies directed against various peripheral nerve antigens. For some conditions, assay for the antibodies can be very helpful in confirming a diagnosis. In others, an antibody may be associated with clinical ...

journal_title：Seminars in neurology

authors： Kissel JT

更新日期：1998-01-01 00:00:00

abstract：:The PPS is now a well-recognized entity encompassing the late manifestations that occur because of previous poliomyelitis. Common signs and symptoms include fatigue, cold intolerance, joint deteriorations with pain, and prominent neurologic problems that include new weakness, muscle pain, atrophy, respiratory insuffic...

journal_title：Seminars in neurology

authors： Jubelt B,Drucker J

更新日期：1993-09-01 00:00:00

abstract：:Magnetic resonance imaging plays a key role in diagnosis and treatment monitoring of brain tumors. Novel imaging techniques that specifically interrogate aspects of underlying tumor biology and biochemical pathways have great potential in neuro-oncology. This review focuses on the emerging role of 2-hydroxyglutarate-t...

journal_title：Seminars in neurology

authors： Kickingereder P,Andronesi OC

更新日期：2018-02-01 00:00:00

abstract：:Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a disease primarily affecting obese women of child-bearing age, typically presenting with positional headaches, diplopia from abducens nerve palsies, pulse-synchronous tinnitus, and visual disturbances related to papilledema, including t...

journal_title：Seminars in neurology

authors： Dinkin M,Oliveira C

更新日期：2019-12-01 00:00:00