Botulinum Toxin to Treat Neurogenic Bladder.

Abstract:

:Alteration in neural control from suprapontine areas to the nerves innervating the bladder can lead to bladder dysfunction and the development of a neurogenic bladder (NGB). Patients with NGB often suffer from urinary incontinence, which can lead to adverse events such as urinary tract infections and decubiti, in addition to creating a large care burden for family members or healthcare providers and significantly impairing patient quality of life. The common failure of anticholinergic medications has spurned the development of second-line treatments, including the use of botulinum toxin. OnabotulinumtoxinA (onaBoNT-A; BOTOX, Allergan, Inc.) was approved by the U.S. Food and Drug Administration (FDA) in 2011 to treat neurogenic detrusor overactivity in patients with urinary incontinence resulting from a NGB. In this review the authors summarize pertinent results from key trials leading to FDA approval of onaBoNT-A as well as more recent long-term data.

journal_name

Semin Neurol

journal_title

Seminars in neurology

authors

Smith CP,Chancellor MB

doi

10.1055/s-0035-1571216

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

5-9

issue

1

eissn

0271-8235

issn

1098-9021

journal_volume

36

pub_type

杂志文章,评审
  • Post-polio syndrome: an update.

    abstract::The PPS is now a well-recognized entity encompassing the late manifestations that occur because of previous poliomyelitis. Common signs and symptoms include fatigue, cold intolerance, joint deteriorations with pain, and prominent neurologic problems that include new weakness, muscle pain, atrophy, respiratory insuffic...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1041136

    authors: Jubelt B,Drucker J

    更新日期:1993-09-01 00:00:00

  • Sleepiness.

    abstract::Sleep medicine can be a particularly rewarding clinical area for neurologists. After all, the driving organ of sleep is the brain. Many of the sleep disorders are primary brain disorders, whereas other sleep disorders (and their medications) influence brain function. But without an organized approach, even the engaged...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1586264

    authors: Ellenbogen JM

    更新日期:2016-10-01 00:00:00

  • Infectious etiologies of myelopathy.

    abstract::Myelopathy refers to a spinal cord disorder that presents with motor and/or sensory deficits. Infectious agents that cause myelopathy do so by either direct infection of neural structures (e.g., polio), a parainfectious mechanism (with a presumed autoimmune pathogenesis), or as a result of involvement of structures ad...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1322588

    authors: Ho EL

    更新日期:2012-04-01 00:00:00

  • Emerging therapies in traumatic brain injury.

    abstract::Despite decades of basic and clinical research, treatments to improve outcomes after traumatic brain injury (TBI) are limited. However, based on the recent recognition of the prevalence of mild TBI, and its potential link to neurodegenerative disease, many new and exciting secondary injury mechanisms have been identif...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1544237

    authors: Kochanek PM,Jackson TC,Ferguson NM,Carlson SW,Simon DW,Brockman EC,Ji J,Bayır H,Poloyac SM,Wagner AK,Kline AE,Empey PE,Clark RS,Jackson EK,Dixon CE

    更新日期:2015-02-01 00:00:00

  • Causes of imbalance and abnormal gait that may be misdiagnosed.

    abstract::Disorders of gait and balance are common in medicine and often lead to referral for neurologic evaluation. Because the maintenance of balance and normal gait are mediated by complex neurologic pathways as well as musculoskeletal, metabolic, and behavioral considerations, the list of possible contributing causes is ver...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1354601

    authors: Shill HA,Fife TD

    更新日期:2013-07-01 00:00:00

  • Ocular inflammation in neurorheumatic disease.

    abstract::Neuroimmunologic and systemic rheumatic diseases are frequently accompanied by inflammation of the eye, ocular adnexa, and orbital tissues. An understanding of the diverse forms of ophthalmic pathology in these conditions aids the clinician in making appropriate preventative, diagnostic, therapeutic, and prognostic de...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1390393

    authors: Vodopivec I,Lobo AM,Prasad S

    更新日期:2014-09-01 00:00:00

  • Gastrointestinal dysfunction in neurologic disease.

    abstract::Gastrointestinal motor dysfunctions result when extrinsic autonomic nerves are diseased and are unable to modulate the motor functions of the digestive tract, which depend on the enteric nervous system and the automaticity of the smooth muscles. Gut motor dysfunction may result from disorders at all anatomic levels of...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1040977

    authors: Camilleri M,Bharucha AE

    更新日期:1996-09-01 00:00:00

  • Towards unveiling the genetics of neurodegenerative diseases.

    abstract::In addition to sharing several clinical, pathologic, and molecular characteristics, many neurodegenerative disorders show extensive familial histories suggesting a substantial contribution of genetic factors to disease causation and progression. In this review, the authors provide overviews of the status of current ge...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1299791

    authors: Lill CM,Bertram L

    更新日期:2011-11-01 00:00:00

  • Acute stroke treatment in the community: improving our performance and expanding our options.

    abstract::Three-quarters of all strokes are managed outside of academic medical centers, making optimization of stroke care in the community setting a central part of minimizing the disability from stroke. In addition, the care of stroke patients crosses multiple different components of the health care system and requires a mul...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2005-923528

    authors: Russman AN,Katzan IL

    更新日期:2005-12-01 00:00:00

  • Imbalance and vertigo: the aging human vestibular periphery.

    abstract::Dizziness, vertigo, and imbalance are likely the most common presenting complaints among patients 75 years and older in office practices. Although the cause of falls among the aging population is multifactorial, several studies have implicated senescence of the vestibular periphery. It is imperative that clinicians co...

    journal_title:Seminars in neurology

    pub_type: 杂志文章

    doi:10.1055/s-0029-1241039

    authors: Ishiyama G

    更新日期:2009-11-01 00:00:00

  • Myotonic Disorders and Channelopathies.

    abstract::Myotonic dystrophies and channelopathies are rare but important causes of muscle diseases which may present with myotonia, episodic attacks of weakness, fixed muscle weakness, and atrophy or their combination. Here, the authors provide an overview of these disorders and describe their clinical and pathophysiological f...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1558979

    authors: Quinn C,Salajegheh MK

    更新日期:2015-08-01 00:00:00

  • Tumors in Epilepsy.

    abstract::Primary brain tumors are common causes of focal epilepsy, accounting for 5% of new-onset seizures in adults and over 10% of lesional focal epilepsies. These epilepsies are often refractory to medical treatment, and high rates of seizure freedom can be achieved with gross total resections. However, the management strat...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1552628

    authors: Nowell M,Miserocchi A,McEvoy AW

    更新日期:2015-06-01 00:00:00

  • Alteplase and Adjuvant Therapies for Acute Ischemic Stroke.

    abstract::Acute ischemic stroke (AIS) is a time sensitive medical emergency and a leading cause of morbidity and mortality worldwide. Intravenous (IV) recombinant tissue plasminogen activator (IV alteplase) is currently the only proven effective medication for the treatment of AIS with promising adjuvant medications currently u...

    journal_title:Seminars in neurology

    pub_type: 杂志文章

    doi:10.1055/s-0040-1722720

    authors: Gottula AL,Barreto AD,Adeoye O

    更新日期:2021-01-20 00:00:00

  • Neurological manifestations of neoplastic and radiation-induced plexopathies.

    abstract::Metastatic plexopathy is often a disabling accompaniment of advanced systemic cancer and may involve any of the peripheral nerve plexuses. Brachial plexopathy most commonly occurs in carcinoma of the breast and lung; lumbosacral plexopathy is most common with colorectal and gynecologic tumors, sarcomas, and lymphomas....

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2004-861533

    authors: Jaeckle KA

    更新日期:2004-12-01 00:00:00

  • Molecular genetics of Alzheimer disease.

    abstract::Epidemiological and individual case studies indicate that genetic factors play a significant role in the genesis of Alzheimer Disease (AD). To date, molecular genetic studies in families multiply affected with AD have identified three genes (Presenilin 1-PS1, Presenilin 2-PS2, and beta-amyloid precursor protein--betaA...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1040852

    authors: St George-Hyslop PH

    更新日期:1999-01-01 00:00:00

  • Botulinum Toxin Therapy for Parkinson's Disease.

    abstract::Botulinum toxin (BoNT) therapy is frequently employed in the treatment of Parkinson's disease (PD) symptoms. It can effectively ameliorate the symptoms of cervical dystonia, blepharospasm, sialorrhea, and hyperactive bladder. It is increasingly being used for additional PD-related indications including limb dystonia, ...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1602246

    authors: Wagle Shukla A,Malaty IA

    更新日期:2017-04-01 00:00:00

  • Poststroke Pain.

    abstract::Pain is common but often underrecognized after stroke. Poststroke pain (PSP) hinders recovery, impairs quality of life, and is associated with the psychological state of patients with stroke. The most common subtypes of PSP include central PSP, complex regional pain syndrome, shoulder pain, spasticity-related pain, an...

    journal_title:Seminars in neurology

    pub_type: 杂志文章

    doi:10.1055/s-0040-1722641

    authors: Yang S,Chang MC

    更新日期:2021-01-14 00:00:00

  • Nonsurgical management of increased intracranial pressure.

    abstract::CPP reflects perfusion problems related to increased ICP or inadequate MAP. CPP is a most helpful and practical management tool. The relationship of CBF and CPP depends on cerebral vascular resistance (flow equals pressure divided by resistance). At present, we do not have a practical method to measure vascular resist...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1041328

    authors: Stone JL

    更新日期:1989-09-01 00:00:00

  • Chronic insomnia.

    abstract::Chronic insomnia afflicts millions of people in the United States. It is associated with decreased quality of life, accidents, several comorbid conditions, increased morbidity, and substantial direct and indirect costs. Chronic insomnia is a multifactorial and individualized disorder. Its etiology may be cognitive or ...

    journal_title:Seminars in neurology

    pub_type: 杂志文章

    doi:10.1055/s-0029-1237125

    authors: Neubauer DN,Flaherty KN

    更新日期:2009-09-01 00:00:00

  • Natalizumab therapy for multiple sclerosis.

    abstract::Natalizumab is a monoclonal therapeutic antibody that inhibits migration of lymphocytes into the central nervous system (CNS) by blocking integrins. Several clinical trials have shown an excellent efficacy in the treatment of relapsing remitting multiple sclerosis. This efficacy is also underlined by postmarketing dat...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1343793

    authors: Derfuss T,Kuhle J,Lindberg R,Kappos L

    更新日期:2013-02-01 00:00:00

  • Management of migraine headache in the emergency department.

    abstract::Headache is one of the more common reasons for adults to visit an emergency department. Most of these visits are for primary headache disorders, most commonly migraine headache. The authors discuss management options for patients presenting to the emergency department with prolonged, severe, or refractory migraine hea...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0030-1249228

    authors: Robertson CE,Black DF,Swanson JW

    更新日期:2010-04-01 00:00:00

  • The "Sick-but-not-Dead" Phenomenon Applied to Catecholamine Deficiency in Neurodegenerative Diseases.

    abstract::The catecholamines dopamine and norepinephrine are key central neurotransmitters that participate in many neurobehavioral processes and disease states. Norepinephrine is also the main neurotransmitter mediating regulation of the circulation by the sympathetic nervous system. Several neurodegenerative disorders feature...

    journal_title:Seminars in neurology

    pub_type: 杂志文章

    doi:10.1055/s-0040-1713874

    authors: Goldstein DS

    更新日期:2020-10-01 00:00:00

  • Progressive multifocal leukoencephalopathy.

    abstract::Before the AIDS epidemic, progressive multifocal leukoencephalopathy (PML) was a rare disorder occurring most often in association with leukemia and lymphoma. Current estimates indicate that PML ultimately develops in up to 5% of all patients with AIDS. This demyelinating disease results from infection with JC virus, ...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1040837

    authors: Berger JR,Major EO

    更新日期:1999-01-01 00:00:00

  • Myasthenia gravis: diagnosis.

    abstract::The clinical history and neurological examination provide the most important data on which the diagnosis of autoimmune myasthenia gravis (MG) is based. MG produces symptomatic weakness that predominates in certain muscle groups and typically fluctuates in response to effort and rest. The diagnosis of MG therefore depe...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2004-829594

    authors: Meriggioli MN,Sanders DB

    更新日期:2004-03-01 00:00:00

  • Antiepileptic medications for the treatment of epilepsy.

    abstract::Epilepsy is one of the most common neurological conditions encountered worldwide. The development of newer antiepileptic drugs (AEDs) has expanded over recent years, and the use of such drugs for indications other than epilepsy has also broadened. These factors insure that the majority of health care providers will be...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2002-36645

    authors: Morrell MJ

    更新日期:2002-09-01 00:00:00

  • Prognosis: the adult with a learning disability.

    abstract::Deficiencies in reading and writing appear to be major and lasting handicaps for learning-disabled college students. However, gains have been made in program modifications for learning-disabled students in many higher education institutions. Many adults with learning disabilities find that their handicap makes it diff...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1041207

    authors: Gottesman RL

    更新日期:1991-03-01 00:00:00

  • Imaging findings in cancer therapy-associated neurotoxicity.

    abstract::Cancer therapy can cause several neurotoxic syndromes that are associated with distinct findings on cranial imaging. With the use of more aggressive and combined treatment modalities in oncology and prolonged overall patient survival, neurotoxicity has been reported with increasing frequency in patients with brain can...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1331817

    authors: Arrillaga-Romany IC,Dietrich J

    更新日期:2012-09-01 00:00:00

  • Pediatric brain death determination.

    abstract::Clinical guidelines for the determination of brain death in children were first published in 1987. These guidelines were revised in 2011 under the auspices of the Society of Critical Care Medicine, the American Academy of Pediatrics, and the Child Neurology Society, and provide the minimum standards that must be satis...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1547540

    authors: Mathur M,Ashwal S

    更新日期:2015-04-01 00:00:00

  • Benign Paroxysmal Positional Vertigo: What We Do and Do Not Know.

    abstract::Benign paroxysmal positional vertigo (BPPV) is common, sometimes terrifying, but rarely portends serious disease. It is usually easily diagnosed and treated, and both the patient and the physician are immediately gratified. While much has been learned about the pathogenesis of BPPV in the past decades, many of its fea...

    journal_title:Seminars in neurology

    pub_type: 杂志文章

    doi:10.1055/s-0039-3402733

    authors: Nuti D,Zee DS,Mandalà M

    更新日期:2020-02-01 00:00:00

  • Optic neuropathies for the neurologist.

    abstract::Before embarking on expensive ancillary testing, it is crucial for the neurologist to distinguish visual loss due to optic nerve dysfunction from other causes of visual loss. This can usually be accomplished based on specific features of the history and bedside examination. Once it has been established that a patient ...

    journal_title:Seminars in neurology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2000-6836

    authors: Purvin VA

    更新日期:2000-01-01 00:00:00