Alteplase and Adjuvant Therapies for Acute Ischemic Stroke.

abstract：:Immunotherapy of multiple sclerosis (MS) will continue to benefit from an increasing understanding of this disease. This knowledge results in newly defined targets for novel therapies. In this article the development of future immunotherapies will be discussed by classifying the approaches into three main types: (1) a...

journal_title：Seminars in neurology

authors： Blevins G,Martin R

更新日期：2003-06-01 00:00:00

abstract：:Headaches are a common complaint for most women during their lifetime, including gestation and puerperium. Tension-type headaches and migraine flare-ups are the most common headache complications after delivery, but the differential diagnosis of postpartum headache is broad. The clinician must distinguish common heada...

journal_title：Seminars in neurology

authors： Cardona L,Klein AM

更新日期：2011-09-01 00:00:00

abstract：:The PPS is now a well-recognized entity encompassing the late manifestations that occur because of previous poliomyelitis. Common signs and symptoms include fatigue, cold intolerance, joint deteriorations with pain, and prominent neurologic problems that include new weakness, muscle pain, atrophy, respiratory insuffic...

journal_title：Seminars in neurology

authors： Jubelt B,Drucker J

更新日期：1993-09-01 00:00:00

abstract：:Status epilepticus is a neurological emergency with an outcome that is highly associated with the initial pharmacotherapy management that must be administered in a timely fashion. Beyond first-line therapy of status epilepticus, treatment is not guided by robust evidence. Optimal pharmacotherapy selection for individu...

journal_title：Seminars in neurology

authors： Der-Nigoghossian C,Tesoro EP,Strein M,Brophy GM

更新日期：2020-12-01 00:00:00

abstract：:During the last decade, we have witnessed significant advances in the study of inherited dystonias. This article will review some of those discoveries and summarize their significance for the practicing neurologist. A clinical classification of dystonia based on features that can be determined by the clinician is prop...

journal_title：Seminars in neurology

authors： Gonzalez-Alegre P

更新日期：2007-04-01 00:00:00

abstract：:Clinical guidelines for the determination of brain death in children were first published in 1987. These guidelines were revised in 2011 under the auspices of the Society of Critical Care Medicine, the American Academy of Pediatrics, and the Child Neurology Society, and provide the minimum standards that must be satis...

journal_title：Seminars in neurology

authors： Mathur M,Ashwal S

更新日期：2015-04-01 00:00:00

abstract：:Psychogenic (nonepileptic) seizures are among the most common and serious of all psychogenic neurological disorders. They account for approximately 20% of all intractable seizure disorders referred to comprehensive epilepsy centers and present with a reported annual incidence of approximately 4% that of true epilepsy....

journal_title：Seminars in neurology

authors： Krumholz A,Hopp J

更新日期：2006-07-01 00:00:00

abstract：:Parkinsonism is a clinical syndrome, which is characterized by bradykinesia, rigidity, rest tremor, and postural instability. Idiopathic Parkinson disease (PD) is the most common cause of this syndrome, though there are several other important etiologies that must be considered. These include the atypical Parkinsonian...

journal_title：Seminars in neurology

authors： Keener AM,Bordelon YM

更新日期：2016-08-01 00:00:00

abstract：:Neuropathic pain management is challenging, and typically requires a multifaceted approach. There are several treatment options, both pharmacologic and nonpharmacologic. Of the available pharmacologic agents, those with the strongest supporting evidence include tricyclic antidepressants, serotonin-norepinephrine reupt...

journal_title：Seminars in neurology

authors： Macone A,Otis JAD

更新日期：2018-12-01 00:00:00

abstract：:Mitochondrial diseases are multiorgan system disorders and the brain is the most commonly affected organ. The high-energy requirement of the brain leaves it vulnerable to energy failure. All components of the neuraxis including muscle, the neuromuscular junction, peripheral nerve, spinal cord, and brain can be affecte...

journal_title：Seminars in neurology

authors： Haas RH,Zolkipli Z

更新日期：2014-07-01 00:00:00

abstract：:Over the past decade, there has been a dramatic evolution of genetic methodologies that can be used to identify genes contributing to disease. Initially, the focus was primarily on classical linkage analysis; more recently, genomewide association studies, and high-throughput whole genome and whole exome sequencing hav...

journal_title：Seminars in neurology

authors： Farlow JL,Foroud T

更新日期：2013-09-01 00:00:00

abstract：:Insomnia is the most common sleep complaint. Insomnia is not a disease itself but mostly a clinical sign of an underlying disease. Degenerative and vascular diseases involving the central nervous system (CNS) may impair sleep either as a result of the brain lesion or because of illness-related discomfort (motor immobi...

journal_title：Seminars in neurology

authors： Provini F,Lombardi C,Lugaresi E

更新日期：2005-03-01 00:00:00

abstract：:Myotonic dystrophies and channelopathies are rare but important causes of muscle diseases which may present with myotonia, episodic attacks of weakness, fixed muscle weakness, and atrophy or their combination. Here, the authors provide an overview of these disorders and describe their clinical and pathophysiological f...

journal_title：Seminars in neurology

authors： Quinn C,Salajegheh MK

更新日期：2015-08-01 00:00:00

abstract：:Epidemiological and individual case studies indicate that genetic factors play a significant role in the genesis of Alzheimer Disease (AD). To date, molecular genetic studies in families multiply affected with AD have identified three genes (Presenilin 1-PS1, Presenilin 2-PS2, and beta-amyloid precursor protein--betaA...

journal_title：Seminars in neurology

authors： St George-Hyslop PH

更新日期：1999-01-01 00:00:00

abstract：:Autoimmune epilepsy is increasingly recognized as a distinct clinical entity, driven in large part by the recent discovery of neural autoantibodies in patients with isolated or predominant epilepsy presentations. Detection of neural autoantibodies in high-risk epilepsy patients supports an immune-mediated cause of sei...

journal_title：Seminars in neurology

authors： Quek AML,O'Toole O

更新日期：2018-06-01 00:00:00

abstract：:The use of technology in neurology education has revolutionized many aspects of medical teaching, addressing some important challenges of modern education such as information overload and the unique needs of millennial learners. However, it also has inherent problems, such as depersonalization and high development cos...

journal_title：Seminars in neurology

authors： Lau KHV,Lakhan SE,Achike F

更新日期：2018-08-01 00:00:00

abstract：:Gastrointestinal motor dysfunctions result when extrinsic autonomic nerves are diseased and are unable to modulate the motor functions of the digestive tract, which depend on the enteric nervous system and the automaticity of the smooth muscles. Gut motor dysfunction may result from disorders at all anatomic levels of...

journal_title：Seminars in neurology

authors： Camilleri M,Bharucha AE

更新日期：1996-09-01 00:00:00

abstract：:Synucleinopathies, with and without dementia, encompass a wide range of diseases including Parkinson's disease, multiple system atrophy, rapid eye movement (REM) sleep behavior disorder, and dementia with Lewy bodies (DLB). DLB is a neurodegenerative disorder resulting in slowly progressive and unrelenting dementia un...

journal_title：Seminars in neurology

authors： Weisman D,McKeith I

更新日期：2007-02-01 00:00:00

abstract：:Patients who suffer from neuromuscular diseases often have complications from respiratory insufficiencies. Some neuromuscular diseases, for example Landry Guillain-Barré syndrome, may only require temporary tracheal intubation; patients with other neuromuscular diseases, such as amyotrophic lateral sclerosis, may deci...

journal_title：Seminars in neurology

authors： Gelinas DF

更新日期：2003-03-01 00:00:00

abstract：:The accumulation of fibrillar α-synuclein protein is the pathological hallmark occurring in both multiple system atrophy (MSA) and diffuse Lewy body disease (DLBD). The oligodendrocytes are especially involved in MSA, while subtypes of neurons are the targets in DLBD. In both instances, the changes are widespread with...

journal_title：Seminars in neurology

authors： Ramirez EP,Vonsattel JP

更新日期：2014-04-01 00:00:00

abstract：:Excessive daytime sleepiness (EDS) or somnolence is common in our patients and in society in general. The most common cause of EDS is "voluntary" sleep restriction. Other common causes include sleep-fragmenting disorders such as the obstructive sleep apnea syndrome. Somewhat less familiar to the clinician are EDS cond...

journal_title：Seminars in neurology

authors： Black JE,Brooks SN,Nishino S

更新日期：2004-09-01 00:00:00

abstract：:In addition to sharing several clinical, pathologic, and molecular characteristics, many neurodegenerative disorders show extensive familial histories suggesting a substantial contribution of genetic factors to disease causation and progression. In this review, the authors provide overviews of the status of current ge...

journal_title：Seminars in neurology

authors： Lill CM,Bertram L

更新日期：2011-11-01 00:00:00

abstract：:Osteoporosis is a debilitating disease that occurs in epidemic proportions in Western societies and has a large economic impact. Percutaneous vertebroplasty is successful in alleviating subacute and chronic pain caused by osteoporotic compression fractures and pathological vertebral fractures from tumor infiltration. ...

journal_title：Seminars in neurology

authors： Ng PP,Caragine LP Jr,Dowd CF

更新日期：2002-06-01 00:00:00

abstract：:Sergei Sergeevich Prokofiev (1891-1953) was one of the great Russian composers. He died, at age 61, of a supposed intracerebral brain hemorrhage. During the 8 years before his death, he suffered from episodic headaches, nausea and dizziness. This article reviews the historical information about Prokofiev's illness lea...

journal_title：Seminars in neurology

authors： Hingtgen CM

更新日期：1999-01-01 00:00:00

abstract：:Three-quarters of all strokes are managed outside of academic medical centers, making optimization of stroke care in the community setting a central part of minimizing the disability from stroke. In addition, the care of stroke patients crosses multiple different components of the health care system and requires a mul...

journal_title：Seminars in neurology

authors： Russman AN,Katzan IL

更新日期：2005-12-01 00:00:00

abstract：:The diagnosis of inherited neuropathies can be challenging in several ways. First, a hereditary neuropathy must be suspected. Although some family histories are clear with multiple members affected, other families require directed inquiry. Second, even when a hereditary neuropathy is clear, it can be difficult to make...

journal_title：Seminars in neurology

authors： Lawson V,Gharibshahi S

更新日期：2010-09-01 00:00:00

abstract：:Chronic insomnia afflicts millions of people in the United States. It is associated with decreased quality of life, accidents, several comorbid conditions, increased morbidity, and substantial direct and indirect costs. Chronic insomnia is a multifactorial and individualized disorder. Its etiology may be cognitive or ...

journal_title：Seminars in neurology

authors： Neubauer DN,Flaherty KN

更新日期：2009-09-01 00:00:00

abstract：:Multiple sclerosis (MS) affects more than 500,000 Americans, and it is commonly on the differential diagnosis associated with patient referrals to neurology offices. Diagnostically, there are several nuances to the established criteria. Understanding the usefulness of various tests and the potential diagnoses that can...

journal_title：Seminars in neurology

authors： Frohman EM,Greenberg BM

更新日期：2010-02-01 00:00:00

abstract：:Telemedicine is the use of electronic communication methods, such as the telephone, the Internet, and videoconferencing, to exchange medical information from one geographic site to another. Telestroke is the use of telemedicine specifically for stroke care. A strokologist is a physician with the special skills require...

journal_title：Seminars in neurology

authors： Demaerschalk BM

更新日期：2010-11-01 00:00:00

abstract：:Both general neurologists and neurologists with a broad spectrum of subspecialty interests are often asked to evaluate patients with disorders of the spinal cord. Over the past decade, there have been significant advances in our understanding of a wide spectrum of immune-mediated, infectious, metabolic, hereditary, pa...

journal_title：Seminars in neurology

authors： Kumar N

更新日期：2010-02-01 00:00:00