Autoimmune Epilepsy: The Evolving Science of Neural Autoimmunity and Its Impact on Epilepsy Management.

abstract：:Magnetic resonance imaging plays a key role in diagnosis and treatment monitoring of brain tumors. Novel imaging techniques that specifically interrogate aspects of underlying tumor biology and biochemical pathways have great potential in neuro-oncology. This review focuses on the emerging role of 2-hydroxyglutarate-t...

journal_title：Seminars in neurology

authors： Kickingereder P,Andronesi OC

更新日期：2018-02-01 00:00:00

abstract：:Natalizumab is a monoclonal therapeutic antibody that inhibits migration of lymphocytes into the central nervous system (CNS) by blocking integrins. Several clinical trials have shown an excellent efficacy in the treatment of relapsing remitting multiple sclerosis. This efficacy is also underlined by postmarketing dat...

journal_title：Seminars in neurology

authors： Derfuss T,Kuhle J,Lindberg R,Kappos L

更新日期：2013-02-01 00:00:00

abstract：:Epidemiological and individual case studies indicate that genetic factors play a significant role in the genesis of Alzheimer Disease (AD). To date, molecular genetic studies in families multiply affected with AD have identified three genes (Presenilin 1-PS1, Presenilin 2-PS2, and beta-amyloid precursor protein--betaA...

journal_title：Seminars in neurology

authors： St George-Hyslop PH

更新日期：1999-01-01 00:00:00

abstract：:Syndromes characterized by persistent fatigue, musculoskeletal pain, sleep disturbance, and subjective cognitive impairment have been common problems in clinical practice for decades. The chronic fatigue syndrome case definition was created to standardize the patient population in research studies and to foster a syst...

journal_title：Seminars in neurology

authors： Goshorn RK

更新日期：1998-01-01 00:00:00

abstract：:Besides sleep apnea, the main disorders of excessive daytime sleepiness include narcolepsy and hypersomnia. Narcolepsy is characterized by periods of irresistible sleepiness and sleep attacks of brief duration and, most often, by one or more of the auxiliary symptoms: cataplexy, sleep paralysis, and hypnogogic halluci...

journal_title：Seminars in neurology

authors： Manfredi RL,Brennan RW,Cadieux RJ

更新日期：1987-09-01 00:00:00

abstract：:With the increasing acceptance of the right of patients to refuse life-sustaining treatment, some have argued that terminally ill patients have a corollary right to physician-assisted suicide (PAS) on request. However, there are important moral and legal distinctions between patients' refusals of therapy and requests ...

journal_title：Seminars in neurology

authors： Bernat JL

更新日期：1997-01-01 00:00:00

abstract：:Sleep medicine can be a particularly rewarding clinical area for neurologists. After all, the driving organ of sleep is the brain. Many of the sleep disorders are primary brain disorders, whereas other sleep disorders (and their medications) influence brain function. But without an organized approach, even the engaged...

journal_title：Seminars in neurology

authors： Ellenbogen JM

更新日期：2016-10-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head impacts (RHI), such as those received in contact/collision sports, blast injury in military veterans, and domestic violence. Currently, CTE can only be diagnosed following death. Although the clinical features of form...

journal_title：Seminars in neurology

authors： Mariani M,Alosco ML,Mez J,Stern RA

更新日期：2020-08-01 00:00:00

abstract：:Environmental circumstances that result in ambiguity or conflict with the patterns of sensory stimulation may adversely affect the vestibular system. The effect of this conflict in sensory information may be dizziness, a sense of imbalance, nausea, and motion sickness sometimes even to seemingly minor daily head movem...

journal_title：Seminars in neurology

authors： Bronstein AM,Golding JF,Gresty MA

更新日期：2020-02-01 00:00:00

abstract：:Pseudotumor cerebri syndrome (PTCS) is a rare condition in children presenting with headache and papilledema from increased intracranial pressure that can cause significant morbidity. This can be idiopathic, also known as idiopathic intracranial hypertension or primary intracranial hypertension, or can be secondary to...

journal_title：Seminars in neurology

authors： Beres SJ

更新日期：2020-06-01 00:00:00

abstract：:Evaluation of patients with cranial neuropathies requires an understanding of brainstem anatomy and nerve pathways. Advances in neuroimaging, particularly high spatial resolution magnetic resonance imaging (MRI), have enabled visualization of these tiny structures and their related pathology. This review provides an a...

journal_title：Seminars in neurology

authors： Jha RM,Klein JP

更新日期：2012-09-01 00:00:00

abstract：:Lightning and electrical injuries have widespread manifestations involving almost all organ systems of the body, including the central nervous system (CNS) and the eye. This article considers the neuro-ophthalmologic effects of lightning and electrical injury. ...

journal_title：Seminars in neurology

authors： Grover S,Goodwin J

更新日期：1995-12-01 00:00:00

abstract：:Benign paroxysmal positional vertigo (BPPV) is common, sometimes terrifying, but rarely portends serious disease. It is usually easily diagnosed and treated, and both the patient and the physician are immediately gratified. While much has been learned about the pathogenesis of BPPV in the past decades, many of its fea...

journal_title：Seminars in neurology

authors： Nuti D,Zee DS,Mandalà M

更新日期：2020-02-01 00:00:00

abstract：:Cell transplantation is an experimental therapy for Parkinson's disease (PD) and other movement disorders. Several open-label research trials have shown clinically meaningful improvement in parkinsonian signs and symptoms after striatal transplantation of allogeneic fetal ventral mesencephalic (FVM) tissue. However, e...

journal_title：Seminars in neurology

authors： Subramanian T

更新日期：2001-01-01 00:00:00

abstract：:Telemedicine is the use of electronic communication methods, such as the telephone, the Internet, and videoconferencing, to exchange medical information from one geographic site to another. Telestroke is the use of telemedicine specifically for stroke care. A strokologist is a physician with the special skills require...

journal_title：Seminars in neurology

authors： Demaerschalk BM

更新日期：2010-11-01 00:00:00

abstract：:Chronic insomnia afflicts millions of people in the United States. It is associated with decreased quality of life, accidents, several comorbid conditions, increased morbidity, and substantial direct and indirect costs. Chronic insomnia is a multifactorial and individualized disorder. Its etiology may be cognitive or ...

journal_title：Seminars in neurology

authors： Neubauer DN,Flaherty KN

更新日期：2009-09-01 00:00:00

abstract：:Dizziness is a common chief complaint with an extensive differential diagnosis that includes both benign and serious conditions. Physicians must distinguish the majority of patients who suffer from self-limiting conditions from those with serious illnesses that require acute treatment. The preferred approach to the di...

journal_title：Seminars in neurology

authors： Gurley KL,Edlow JA

更新日期：2019-02-01 00:00:00

abstract：:In addition to sharing several clinical, pathologic, and molecular characteristics, many neurodegenerative disorders show extensive familial histories suggesting a substantial contribution of genetic factors to disease causation and progression. In this review, the authors provide overviews of the status of current ge...

journal_title：Seminars in neurology

authors： Lill CM,Bertram L

更新日期：2011-11-01 00:00:00

abstract：:Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a disease primarily affecting obese women of child-bearing age, typically presenting with positional headaches, diplopia from abducens nerve palsies, pulse-synchronous tinnitus, and visual disturbances related to papilledema, including t...

journal_title：Seminars in neurology

authors： Dinkin M,Oliveira C

更新日期：2019-12-01 00:00:00

abstract：:Immunotherapy of multiple sclerosis (MS) will continue to benefit from an increasing understanding of this disease. This knowledge results in newly defined targets for novel therapies. In this article the development of future immunotherapies will be discussed by classifying the approaches into three main types: (1) a...

journal_title：Seminars in neurology

authors： Blevins G,Martin R

更新日期：2003-06-01 00:00:00

abstract：:The traditional view of neuromyelitis optica (NMO) as a monophasic inflammatory disorder that affects both the optic nerves and the spinal cord is expanding. Over the last decade, a combination of clinical, radiological, pathological, and serological findings have resulted in evolving definitions of NMO and the apprec...

journal_title：Seminars in neurology

authors： Pittock SJ

更新日期：2008-02-01 00:00:00

abstract：:Delusions may be the most prominent manifestations of brain dysfunction, and a host of medical and neurologic conditions can present with or produce delusions. Recognition of the underlying disorder frequently aids in successful treatment. Comparison of organic delusional syndromes with schizophrenia suggests that lim...

journal_title：Seminars in neurology

authors： Gorman DG,Cummings JL

更新日期：1990-09-01 00:00:00

abstract：:Psychoanalysis emerged out of Freud's neuropsychologic studies of consciousness and cognition. This article describes the historical development of neuropsychodynamic theories of consciousness and personality, and traces their application to several neuropsychiatric syndromes of intense contemporary clinical interest....

journal_title：Seminars in neurology

authors： Miller L

更新日期：1997-06-01 00:00:00

abstract：:Fungal central nervous system infections present in a myriad of clinical manifestation and remain a significant diagnostic challenge. Presenting symptoms, cerebrospinal fluid analysis, conventional fungal serum markers and imaging correlates of disease are seldom sensitive or specific; fungal culture growth or histopa...

journal_title：Seminars in neurology

authors： Jia DT,Thakur K

更新日期：2019-06-01 00:00:00

abstract：:One of the most prolific chemical and anatomical imaging techniques of recent decades, magnetic resonance imaging (MRI), includes the ability to noninvasively assess neurochemical changes with magnetic resonance spectroscopy (MRS). Practical concerns are paramount in applying MRS, such as what the manufacturer provide...

journal_title：Seminars in neurology

authors： Xu V,Chan H,Lin AP,Sailasuta N,Valencerina S,Tran T,Hovener J,Ross BD

更新日期：2008-09-01 00:00:00

abstract：:Small fiber neuropathy (SFN) is common, and can be associated with many medical conditions. The majority of the patients with SFN suffer from painful paresthesia which can negatively impact their quality of life. Skin biopsy with intraepidermal nerve fiber density evaluation is the gold standard diagnostic test. Auton...

journal_title：Seminars in neurology

authors： Zhou L

更新日期：2019-10-01 00:00:00

abstract：:Cancer therapy can cause several neurotoxic syndromes that are associated with distinct findings on cranial imaging. With the use of more aggressive and combined treatment modalities in oncology and prolonged overall patient survival, neurotoxicity has been reported with increasing frequency in patients with brain can...

journal_title：Seminars in neurology

authors： Arrillaga-Romany IC,Dietrich J

更新日期：2012-09-01 00:00:00

abstract：:Mitochondrial oxidative phosphorylation (OXPHOS) disorders are a heterogeneous group of diseases with variable expression that often pose diagnostic dilemmas. Although definitive diagnosis of these disorders usually requires a muscle biopsy and mtDNA and enzymatic testing, standard metabolic studies including organic ...

journal_title：Seminars in neurology

authors： Dougherty FE

更新日期：2001-09-01 00:00:00

abstract：:The vast majority of people living with human immunodeficiency virus (HIV) infection reside in resource-limited settings. As compared with resource-rich settings, there are important differences in the epidemiology and outcomes of HIV infection in resource-limited settings. Nonetheless, little HIV neurology research o...

journal_title：Seminars in neurology

authors： Meyer AC

更新日期：2014-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in elderly individuals. Although the diagnosis of AD requires pathological confirmation, several common clinical features of AD have been identified. These include insidious onset, gradual progression, medial temporal atrophy, temporoparietal hypoperfusion, ...

journal_title：Seminars in neurology

authors： Kramer JH,Miller BL

更新日期：2000-01-01 00:00:00