Future immunotherapies in multiple sclerosis.

abstract：:The clinical history and neurological examination provide the most important data on which the diagnosis of autoimmune myasthenia gravis (MG) is based. MG produces symptomatic weakness that predominates in certain muscle groups and typically fluctuates in response to effort and rest. The diagnosis of MG therefore depe...

journal_title：Seminars in neurology

authors： Meriggioli MN,Sanders DB

更新日期：2004-03-01 00:00:00

abstract：:The traditional view of neuromyelitis optica (NMO) as a monophasic inflammatory disorder that affects both the optic nerves and the spinal cord is expanding. Over the last decade, a combination of clinical, radiological, pathological, and serological findings have resulted in evolving definitions of NMO and the apprec...

journal_title：Seminars in neurology

authors： Pittock SJ

更新日期：2008-02-01 00:00:00

abstract：:With the development of multiple options for immunotherapy in multiple sclerosis, the clinician is faced with the challenge of keeping pace with the literature, acquiring familiarity with the various treatment options and opinions, and then offering the patients the most current and appropriate management. Given the i...

journal_title：Seminars in neurology

authors： Mattson DH

更新日期：2002-03-01 00:00:00

abstract：:Blepharospasm is a focal dystonia characterized by involuntary, repetitive eye closure. Orofacial and oromandibular dystonia describe involuntary dystonic movements of orofacial and oromandibular musculature. Hemifacial spasm is characterized by repetitive synchronous contraction of facial nerve innervated muscles on ...

journal_title：Seminars in neurology

authors： Karp BI,Alter K

更新日期：2016-02-01 00:00:00

abstract：:The catecholamines dopamine and norepinephrine are key central neurotransmitters that participate in many neurobehavioral processes and disease states. Norepinephrine is also the main neurotransmitter mediating regulation of the circulation by the sympathetic nervous system. Several neurodegenerative disorders feature...

journal_title：Seminars in neurology

authors： Goldstein DS

更新日期：2020-10-01 00:00:00

abstract：:Treatment of dementias represents an important but relatively neglected part of neurological care of the elderly population. Individual therapeutic interventions may make only small changes to the quality of life of individuals afflicted with dementia, but when used in combination these interventions synergize and can...

journal_title：Seminars in neurology

authors： Tisher A,Salardini A

更新日期：2019-04-01 00:00:00

abstract：:Psychoanalysis emerged out of Freud's neuropsychologic studies of consciousness and cognition. This article describes the historical development of neuropsychodynamic theories of consciousness and personality, and traces their application to several neuropsychiatric syndromes of intense contemporary clinical interest....

journal_title：Seminars in neurology

authors： Miller L

更新日期：1997-06-01 00:00:00

abstract：:Before embarking on expensive ancillary testing, it is crucial for the neurologist to distinguish visual loss due to optic nerve dysfunction from other causes of visual loss. This can usually be accomplished based on specific features of the history and bedside examination. Once it has been established that a patient ...

journal_title：Seminars in neurology

authors： Purvin VA

更新日期：2000-01-01 00:00:00

abstract：:Epilepsy is one of the most common neurological conditions encountered worldwide. The development of newer antiepileptic drugs (AEDs) has expanded over recent years, and the use of such drugs for indications other than epilepsy has also broadened. These factors insure that the majority of health care providers will be...

journal_title：Seminars in neurology

authors： Morrell MJ

更新日期：2002-09-01 00:00:00

abstract：:The demonstration that several agents with presumed differing mechanisms of action each provide partial effectiveness in the treatment of relapsing-remitting multiple sclerosis (MS) has significantly changed the approach to MS clinical trial research. A number of recently published trials have provided support to thes...

journal_title：Seminars in neurology

authors： Noseworthy JH

更新日期：1998-01-01 00:00:00

abstract：:The management of severe brain injury requires a comprehensive approach in which imaging is an indispensable complement to the clinical and physiological information acquired at the bedside. Neuroimaging methods are routinely used in the diagnosis and prognosis of a broad spectrum of patients with acute neurological d...

journal_title：Seminars in neurology

authors： Stevens RD,Pustavoitau A,Chalela JA

更新日期：2008-11-01 00:00:00

abstract：:The growth of bioethics as a practical, meaningful player in the arena of health care has paralleled that of clinical neurology not only in time but also in interaction between the two disciplines. Almost every advance in neurology has spawned an ethical dilemma, the unraveling of which has brought new insights to bot...

journal_title：Seminars in neurology

authors： McQuillen MP

更新日期：2001-12-01 00:00:00

abstract：:Leptomeningeal metastasis occurs in ~5% of all patients with cancer and is the third most common metastatic complication of the central nervous system. Staging of leptomeningeal metastasis includes contrast-enhanced brain and spine magnetic resonance imaging and radionuclide cerebrospinal fluid (CSF) flow study. Treat...

journal_title：Seminars in neurology

authors： Chamberlain MC

更新日期：2010-07-01 00:00:00

abstract：:Hypoxic-ischemic encephalopathy (HIE) is a manifestation of perinatal asphyxial insult that continues to evolve over days to weeks following the initial injury. Therapeutic hypothermia has demonstrated that a proportion of this secondary brain injury may indeed be preventable. However, therapeutic hypothermia has also...

journal_title：Seminars in neurology

authors： Goswami I,Guillot M,Tam EWY

更新日期：2020-06-01 00:00:00

abstract：:Improved disease control is critical for enhancing the lives of those living with multiple sclerosis. With specific immunologic targets, monoclonal antibody (mAb) treatments are highly effective options for relapsing forms of multiple sclerosis. The mechanism, efficacy, and current safety profiles are detailed for the...

journal_title：Seminars in neurology

authors： Singer BA

更新日期：2016-04-01 00:00:00

abstract：:Neurothermography is a new, clinically useful method of detecting autonomic sympathetic peripheral nerve dysfunction. Body symmetry of the skin temperature as maintained by symmetrically functional peripheral nerves is the key to detecting a normal state. Persistent 1 degree C temperature asymmetry in the pattern of a...

journal_title：Seminars in neurology

authors： Green J

更新日期：1987-12-01 00:00:00

abstract：:Cardiac arrest is a common disease in the United States, and many patients will die as a result of the neurological damage suffered during the anoxic period, or will live in a neurologically debilitated state. When cardiopulmonary-cerebral resuscitation results in the return of spontaneous circulation, intensive care ...

journal_title：Seminars in neurology

authors： Wright WL,Geocadin RG

更新日期：2006-09-01 00:00:00

abstract：:Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a disease primarily affecting obese women of child-bearing age, typically presenting with positional headaches, diplopia from abducens nerve palsies, pulse-synchronous tinnitus, and visual disturbances related to papilledema, including t...

journal_title：Seminars in neurology

authors： Dinkin M,Oliveira C

更新日期：2019-12-01 00:00:00

abstract：:Upper limb recovery after a stroke is suboptimal. Only a few individuals achieve full functional use of the hemiparetic arm. Complex primary and secondary impairments may affect recovery of upper limb function in stroke survivors. In addition, multiple personal, social, behavioral, economic, and environmental factors ...

journal_title：Seminars in neurology

authors： Tsu AP,Abrams GM,Byl NN

更新日期：2014-11-01 00:00:00

abstract：:There are many unique characteristics in elderly patients with epilepsy. The incidence of seizure in this age group is the highest of any age group and continues to increase as people live longer. Etiology of seizures is different than for adults and includes cerebrovascular disease, dementia, closed head injury, and ...

journal_title：Seminars in neurology

authors： Jetter GM,Cavazos JE

更新日期：2008-07-01 00:00:00

abstract：:The management of epilepsy in women encompasses a complex interplay between seizures, sex steroid hormones, and antiepileptic drugs (AEDs). These interactions impact every aspect of the sexual and reproductive health of women with epilepsy throughout their lifetimes. Neurologists comfortable treating seizures may feel...

journal_title：Seminars in neurology

authors： Noe KH

更新日期：2007-09-01 00:00:00

abstract：:Clinical guidelines for the determination of brain death in children were first published in 1987. These guidelines were revised in 2011 under the auspices of the Society of Critical Care Medicine, the American Academy of Pediatrics, and the Child Neurology Society, and provide the minimum standards that must be satis...

journal_title：Seminars in neurology

authors： Mathur M,Ashwal S

更新日期：2015-04-01 00:00:00

abstract：:Mitochondrial diseases are multiorgan system disorders and the brain is the most commonly affected organ. The high-energy requirement of the brain leaves it vulnerable to energy failure. All components of the neuraxis including muscle, the neuromuscular junction, peripheral nerve, spinal cord, and brain can be affecte...

journal_title：Seminars in neurology

authors： Haas RH,Zolkipli Z

更新日期：2014-07-01 00:00:00

abstract：:Autoimmune epilepsy is increasingly recognized as a distinct clinical entity, driven in large part by the recent discovery of neural autoantibodies in patients with isolated or predominant epilepsy presentations. Detection of neural autoantibodies in high-risk epilepsy patients supports an immune-mediated cause of sei...

journal_title：Seminars in neurology

authors： Quek AML,O'Toole O

更新日期：2018-06-01 00:00:00

abstract：:Disorders of gait and balance are common in medicine and often lead to referral for neurologic evaluation. Because the maintenance of balance and normal gait are mediated by complex neurologic pathways as well as musculoskeletal, metabolic, and behavioral considerations, the list of possible contributing causes is ver...

journal_title：Seminars in neurology

authors： Shill HA,Fife TD

更新日期：2013-07-01 00:00:00

abstract：:Clinicians commonly encounter patients with cerebrovascular disorders in the hospital. Now, as never before, there are many effective diagnostic and therapeutic modalities. Several examples of typical cases of stroke and transient ischemic attack are presented in order to illustrate a rational approach to diagnosis an...

journal_title：Seminars in neurology

authors： Demaerschalk BM

更新日期：2003-09-01 00:00:00

abstract：:Patients who suffer from neuromuscular diseases often have complications from respiratory insufficiencies. Some neuromuscular diseases, for example Landry Guillain-Barré syndrome, may only require temporary tracheal intubation; patients with other neuromuscular diseases, such as amyotrophic lateral sclerosis, may deci...

journal_title：Seminars in neurology

authors： Gelinas DF

更新日期：2003-03-01 00:00:00

abstract：:With the growth of wheelchair athletics at both grassroots and national levels, there has been an increased incidence of sports-related and overuse syndromes in the wheelchair-user population. This article provides an overview of the available literature on the incidence, prevalence, evaluation, prevention, and rehabi...

journal_title：Seminars in neurology

authors： Groah SL,Lanig IS

更新日期：2000-01-01 00:00:00

abstract：:Over the past decade, there has been a dramatic evolution of genetic methodologies that can be used to identify genes contributing to disease. Initially, the focus was primarily on classical linkage analysis; more recently, genomewide association studies, and high-throughput whole genome and whole exome sequencing hav...

journal_title：Seminars in neurology

authors： Farlow JL,Foroud T

更新日期：2013-09-01 00:00:00

abstract：:The clinical hallmark of myasthenia gravis (MG) is fluctuating, painless weakness of muscles that most often affect extraocular, lower bulbar, or limb musculature. Predicting the probability of successful treatment for the patient assumes that the physician has made an accurate diagnosis. In this review, the practical...

journal_title：Seminars in neurology

authors： Engstrom JW

更新日期：2004-06-01 00:00:00