Parenteral Treatment of Multiple Sclerosis: The Advent of Monoclonal Antibodies.

Abstract:

:Improved disease control is critical for enhancing the lives of those living with multiple sclerosis. With specific immunologic targets, monoclonal antibody (mAb) treatments are highly effective options for relapsing forms of multiple sclerosis. The mechanism, efficacy, and current safety profiles are detailed for the two mAb therapies, natalizumab and alemtuzumab, with regulatory approval in multiple countries. Daclizumab, which targets the interleukin-2 receptor, and ocrelizumab, which depletes B cells, have convincing phase 3 clinical trial data and may very well provide new options in the near future. Trial results of other B-cell-directed therapies, ofatumumab and rituximab, are reviewed. Less-frequent dosing of glatiramer acetate and interferon β-1a highlight developments in the first generation of parenteral immunomodulatory therapy. Remyelination using mAbs has moved into clinical trials with the first agents, anti-LINGO-1, rHIgM22, and anti-SEMA 4D.

journal_name

Semin Neurol

journal_title

Seminars in neurology

authors

Singer BA

doi

10.1055/s-0036-1579695

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

140-7

issue

2

eissn

0271-8235

issn

1098-9021

journal_volume

36

pub_type

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