Abstract:
:Over the past decade, there has been a dramatic evolution of genetic methodologies that can be used to identify genes contributing to disease. Initially, the focus was primarily on classical linkage analysis; more recently, genomewide association studies, and high-throughput whole genome and whole exome sequencing have provided efficient approaches to detect common and rare variation contributing to disease risk. Application of these methodologies to dementias has led to the nomination of dozens of causative and susceptibility genes, solidifying the recognition that genetic factors are important contributors to the disease processes. In this review, the authors focus on current knowledge of the genetics of Alzheimer's disease and frontotemporal lobar degeneration. A working understanding of the genes relevant to common dementias will become increasingly critical, as options for genetic testing and eventually gene-specific therapeutics are developed.
journal_name
Semin Neuroljournal_title
Seminars in neurologyauthors
Farlow JL,Foroud Tdoi
10.1055/s-0033-1359313subject
Has Abstractpub_date
2013-09-01 00:00:00pages
417-22issue
4eissn
0271-8235issn
1098-9021journal_volume
33pub_type
杂志文章abstract::Obstructive sleep apnea (OSA) is a very common condition in patients with stroke and is found in over half of stroke patients. There is a complex relationship between OSA and stroke, attributable to shared risk factors. There are numerous mechanisms by which OSA may contribute to increased stroke risk, including promo...
journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 传,历史文章,杂志文章
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 传,历史文章,杂志文章
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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journal_title:Seminars in neurology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1267281
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
doi:10.1055/s-0031-1293537
更新日期:2011-09-01 00:00:00
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章
doi:10.1055/s-0029-1237125
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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