Abstract:
:Hypoxic-ischemic encephalopathy (HIE) is a manifestation of perinatal asphyxial insult that continues to evolve over days to weeks following the initial injury. Therapeutic hypothermia has demonstrated that a proportion of this secondary brain injury may indeed be preventable. However, therapeutic hypothermia has also altered the prognostic utility of many bedside tools that are commonly used as predictors of long-term neurodevelopmental outcome in HIE. Clinicians are often confronted with uncertainty when assessing the prognosis of infants with HIE. Improved understanding of the implications and limitations of individual investigations may inform clinical decisions and allow for timely intervention. This review summarizes the predictive value of currently available prognostic markers in HIE infants in the therapeutic hypothermia era, including clinical, biochemical, neurophysiological, physiological, and neuroimaging predictors.
journal_name
Semin Neuroljournal_title
Seminars in neurologyauthors
Goswami I,Guillot M,Tam EWYdoi
10.1055/s-0040-1702939subject
Has Abstractpub_date
2020-06-01 00:00:00pages
322-334issue
3eissn
0271-8235issn
1098-9021journal_volume
40pub_type
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