Abstract:
:Calcineurin inhibitor encephalopathy (CIE) is a rare condition occurring in patients who are undergoing treatment with drugs from the calcineurin inhibitor (CI) family of immunosuppressants, either cyclosporine (CsA) or tacrolimus (TAC, FK506). Generally acute in onset, the symptoms are commonly reversible if properly managed in a timely fashion. The differential diagnosis is broad and an evaluation should include toxic, metabolic, infectious and ischemic causes, with abnormal cerebrospinal fluid (CSF) results (aside from elevated protein concentration in isolation), suggesting an etiology other than CIE. Neurologic deficits are generally reversible; however, the risk of permanent deficits or poor outcomes increases the longer the condition goes unrecognized.
journal_name
Semin Neuroljournal_title
Seminars in neurologyauthors
Mammoser Adoi
10.1055/s-0033-1334471subject
Has Abstractpub_date
2012-11-01 00:00:00pages
517-24issue
5eissn
0271-8235issn
1098-9021journal_volume
32pub_type
杂志文章,评审abstract::The management of epilepsy in women encompasses a complex interplay between seizures, sex steroid hormones, and antiepileptic drugs (AEDs). These interactions impact every aspect of the sexual and reproductive health of women with epilepsy throughout their lifetimes. Neurologists comfortable treating seizures may feel...
journal_title:Seminars in neurology
pub_type: 杂志文章,评审
doi:10.1055/s-2007-985335
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
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doi:10.1055/s-0037-1608940
更新日期:2017-12-01 00:00:00
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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更新日期:2002-06-01 00:00:00
abstract::Pregnancy can precipitate new neurological diseases as a result of the alterations in physiology that accompany the pregnant state. The pregnant patient presenting with neurological problems poses both diagnostic and therapeutic challenges, often forcing the clinician to rely on neuroimaging as part of the workup. Thi...
journal_title:Seminars in neurology
pub_type: 杂志文章
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abstract::Parkinson's disease (PD) is a significant neurodegenerative disease of the elderly, affecting 1 to 2% of those over 60 years of age. The disorder is characterized by resting tremor, bradykinesia, rigidity, postural instability, and pathologically by alpha-synuclein-positive Lewy bodies. For most, the etiology is unkno...
journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
doi:10.1055/s-2002-36645
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
doi:10.1055/s-2005-867074
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abstract::The diagnosis of inherited neuropathies can be challenging in several ways. First, a hereditary neuropathy must be suspected. Although some family histories are clear with multiple members affected, other families require directed inquiry. Second, even when a hereditary neuropathy is clear, it can be difficult to make...
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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abstract::With the advent of combination antiretroviral therapies, the mortality rate from HIV has declined, while the prevalence of long-term HIV-related neurologic complications continues to rise. Thirty-six million individuals are living with HIV around the world, many of whom reside in resource-limited settings. The majorit...
journal_title:Seminars in neurology
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abstract::In addition to sharing several clinical, pathologic, and molecular characteristics, many neurodegenerative disorders show extensive familial histories suggesting a substantial contribution of genetic factors to disease causation and progression. In this review, the authors provide overviews of the status of current ge...
journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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abstract::Myelopathy refers to a spinal cord disorder that presents with motor and/or sensory deficits. Infectious agents that cause myelopathy do so by either direct infection of neural structures (e.g., polio), a parainfectious mechanism (with a presumed autoimmune pathogenesis), or as a result of involvement of structures ad...
journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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abstract::Treatment of dementias represents an important but relatively neglected part of neurological care of the elderly population. Individual therapeutic interventions may make only small changes to the quality of life of individuals afflicted with dementia, but when used in combination these interventions synergize and can...
journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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abstract::Emery-Dreifuss muscular dystrophy (EDMD) is the third most common X-linked muscular dystrophy. This disorder is characterized by childhood onset of early contractures, humeroperoneal muscle atrophy, and cardiac conduction abnormalities. Weakness is slowly progressive, but there is a broad spectrum of clinical severity...
journal_title:Seminars in neurology
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abstract::Dizziness is a common chief complaint with an extensive differential diagnosis that includes both benign and serious conditions. Physicians must distinguish the majority of patients who suffer from self-limiting conditions from those with serious illnesses that require acute treatment. The preferred approach to the di...
journal_title:Seminars in neurology
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abstract::Botulinum toxin (BoNT) therapy is frequently employed in the treatment of Parkinson's disease (PD) symptoms. It can effectively ameliorate the symptoms of cervical dystonia, blepharospasm, sialorrhea, and hyperactive bladder. It is increasingly being used for additional PD-related indications including limb dystonia, ...
journal_title:Seminars in neurology
pub_type: 杂志文章,评审
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