Parkinsonism.

abstract：:Benign paroxysmal positional vertigo (BPPV) is common, sometimes terrifying, but rarely portends serious disease. It is usually easily diagnosed and treated, and both the patient and the physician are immediately gratified. While much has been learned about the pathogenesis of BPPV in the past decades, many of its fea...

journal_title：Seminars in neurology

authors： Nuti D,Zee DS,Mandalà M

更新日期：2020-02-01 00:00:00

abstract：:The clinical evaluation of peripheral neuropathies can be challenging. This article presents an approach based on a structured assessment that asks a series of yes or no questions during the history and examination that leads to localization and characterization of the neuropathy. The final assessment includes further...

journal_title：Seminars in neurology

authors： Bromberg MB

更新日期：2005-06-01 00:00:00

abstract：:Clinicians commonly encounter patients with cerebrovascular disorders in the hospital. Now, as never before, there are many effective diagnostic and therapeutic modalities. Several examples of typical cases of stroke and transient ischemic attack are presented in order to illustrate a rational approach to diagnosis an...

journal_title：Seminars in neurology

authors： Demaerschalk BM

更新日期：2003-09-01 00:00:00

abstract：:Before embarking on expensive ancillary testing, it is crucial for the neurologist to distinguish visual loss due to optic nerve dysfunction from other causes of visual loss. This can usually be accomplished based on specific features of the history and bedside examination. Once it has been established that a patient ...

journal_title：Seminars in neurology

authors： Purvin VA

更新日期：2000-01-01 00:00:00

abstract：:Before the AIDS epidemic, progressive multifocal leukoencephalopathy (PML) was a rare disorder occurring most often in association with leukemia and lymphoma. Current estimates indicate that PML ultimately develops in up to 5% of all patients with AIDS. This demyelinating disease results from infection with JC virus, ...

journal_title：Seminars in neurology

authors： Berger JR,Major EO

更新日期：1999-01-01 00:00:00

abstract：:Vaccines have undoubtedly been a medical milestone, preventing immeasurable morbidity and mortality from infectious diseases worldwide. Modern vaccines have tremendously reduced the global impact of numerous infections; they have succeeded in eliminating smallpox completely. However, the nature by which vaccines confe...

journal_title：Seminars in neurology

authors： Sejvar JJ

更新日期：2011-07-01 00:00:00

abstract：:The testing of reflexes involving the lower extremities is a pivotal part of the modern neurological examination. The normal response to noxious stimulation of the foot is plantar flexion of the toes, causing them to curl downward toward the undersurface of the foot. In 1896, Joseph Babinski described an extensor toe ...

journal_title：Seminars in neurology

authors： Goetz CG

更新日期：2002-12-01 00:00:00

abstract：:Infective endocarditis (IE) is a systemic disease with many potential neurologic manifestations including ischemic and hemorrhagic strokes, cerebral microbleeding, infectious intracranial aneurysms, meningitis, brain abscesses, and encephalopathy. The majority of left-sided (heart) IE patients have brain lesions that ...

journal_title：Seminars in neurology

authors： Carneiro TS,Awtry E,Dobrilovic N,Fagan MA,Kimmel S,Weinstein ZM,Cervantes-Arslanian AM

更新日期：2019-08-01 00:00:00

abstract：:With the growth of wheelchair athletics at both grassroots and national levels, there has been an increased incidence of sports-related and overuse syndromes in the wheelchair-user population. This article provides an overview of the available literature on the incidence, prevalence, evaluation, prevention, and rehabi...

journal_title：Seminars in neurology

authors： Groah SL,Lanig IS

更新日期：2000-01-01 00:00:00

abstract：:Pseudotumor cerebri syndrome (PTCS) is a rare condition in children presenting with headache and papilledema from increased intracranial pressure that can cause significant morbidity. This can be idiopathic, also known as idiopathic intracranial hypertension or primary intracranial hypertension, or can be secondary to...

journal_title：Seminars in neurology

authors： Beres SJ

更新日期：2020-06-01 00:00:00

abstract：:The traditional view of neuromyelitis optica (NMO) as a monophasic inflammatory disorder that affects both the optic nerves and the spinal cord is expanding. Over the last decade, a combination of clinical, radiological, pathological, and serological findings have resulted in evolving definitions of NMO and the apprec...

journal_title：Seminars in neurology

authors： Pittock SJ

更新日期：2008-02-01 00:00:00

abstract：:Improved disease control is critical for enhancing the lives of those living with multiple sclerosis. With specific immunologic targets, monoclonal antibody (mAb) treatments are highly effective options for relapsing forms of multiple sclerosis. The mechanism, efficacy, and current safety profiles are detailed for the...

journal_title：Seminars in neurology

authors： Singer BA

更新日期：2016-04-01 00:00:00

abstract：:Severe spastic tone and/or spastic hypertonia can be the most disabling consequences of a neurologic insult, resulting from an excess of muscle tone. Baclofen, a GABA-B agonist, is one of the most widely used drugs in treating abnormal or disabling spastic tone. However, the effectiveness of baclofen taken orally is o...

journal_title：Seminars in neurology

authors： Furr-Stimming E,Boyle AM,Schiess MC

更新日期：2014-11-01 00:00:00

abstract：:Syndromes characterized by persistent fatigue, musculoskeletal pain, sleep disturbance, and subjective cognitive impairment have been common problems in clinical practice for decades. The chronic fatigue syndrome case definition was created to standardize the patient population in research studies and to foster a syst...

journal_title：Seminars in neurology

authors： Goshorn RK

更新日期：1998-01-01 00:00:00

abstract：:Autoimmune encephalopathy represents a complex category of disease with diverse immunologic associations, clinical manifestations, and therapeutic outcomes. Three main subgroups include autoimmune encephalopathies without cancer but with neural nonspecific serologic evidence of autoimmunity (encompassing "Hashimoto's ...

journal_title：Seminars in neurology

authors： Flanagan EP,Caselli RJ

更新日期：2011-04-01 00:00:00

abstract：:Dizziness is a common chief complaint with an extensive differential diagnosis that includes both benign and serious conditions. Physicians must distinguish the majority of patients who suffer from self-limiting conditions from those with serious illnesses that require acute treatment. The preferred approach to the di...

journal_title：Seminars in neurology

authors： Gurley KL,Edlow JA

更新日期：2019-02-01 00:00:00

abstract：:The combination of neurologic disease and ichthyosis defines a heterogeneous group of rare inherited disorders that present in infancy through early adulthood. Although affected patients share the cutaneous feature of ichthyosis, there is variability in the nature and severity of neurologic disease. Impaired cognition...

journal_title：Seminars in neurology

authors： Rizzo WB,Jenkens SM,Boucher P

更新日期：2012-02-01 00:00:00

abstract：:Immunotherapy of multiple sclerosis (MS) will continue to benefit from an increasing understanding of this disease. This knowledge results in newly defined targets for novel therapies. In this article the development of future immunotherapies will be discussed by classifying the approaches into three main types: (1) a...

journal_title：Seminars in neurology

authors： Blevins G,Martin R

更新日期：2003-06-01 00:00:00

abstract：:Stroke in the distribution of the posterior circulation may present as acute onset spontaneous vertigo and imbalance. Although vertigo due to posterior circulation stroke is usually associated with other neurologic symptoms or signs, small infarcts in the cerebellum or brainstem can present with vertigo without other ...

journal_title：Seminars in neurology

authors： Kim JS,Lee H

更新日期：2013-07-01 00:00:00

abstract：:Metastatic plexopathy is often a disabling accompaniment of advanced systemic cancer and may involve any of the peripheral nerve plexuses. Brachial plexopathy most commonly occurs in carcinoma of the breast and lung; lumbosacral plexopathy is most common with colorectal and gynecologic tumors, sarcomas, and lymphomas....

journal_title：Seminars in neurology

authors： Jaeckle KA

更新日期：2004-12-01 00:00:00

abstract：:Status epilepticus is a neurological emergency with an outcome that is highly associated with the initial pharmacotherapy management that must be administered in a timely fashion. Beyond first-line therapy of status epilepticus, treatment is not guided by robust evidence. Optimal pharmacotherapy selection for individu...

journal_title：Seminars in neurology

authors： Der-Nigoghossian C,Tesoro EP,Strein M,Brophy GM

更新日期：2020-12-01 00:00:00

abstract：:Cognitive complaints are common in any adult neurology practice, and may present in a variety of ways other than classic "memory loss." In this article, the author reviews a simple approach to a symptom-based differential diagnosis, including recognition of impairment in several key cognitive domains as well as associ...

journal_title：Seminars in neurology

authors： Woodruff BK

更新日期：2011-02-01 00:00:00

abstract：:Nontraumatic spontaneous intracranial hemorrhage occurs most commonly into the subarachnoid space and brain parenchyma, in contrast to subdural and epidural hematomas that are usually traumatic. The differential diagnosis of nontraumatic subarachnoid hemorrhage includes intracranial aneurysm rupture and vascular malfo...

journal_title：Seminars in neurology

authors： Dainer HM,Smirniotopoulos JG

更新日期：2008-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a significant neurodegenerative disease of the elderly, affecting 1 to 2% of those over 60 years of age. The disorder is characterized by resting tremor, bradykinesia, rigidity, postural instability, and pathologically by alpha-synuclein-positive Lewy bodies. For most, the etiology is unkno...

journal_title：Seminars in neurology

authors： Lorincz MT

更新日期：2006-11-01 00:00:00

abstract：:Hypoxic-ischemic encephalopathy (HIE) is a manifestation of perinatal asphyxial insult that continues to evolve over days to weeks following the initial injury. Therapeutic hypothermia has demonstrated that a proportion of this secondary brain injury may indeed be preventable. However, therapeutic hypothermia has also...

journal_title：Seminars in neurology

authors： Goswami I,Guillot M,Tam EWY

更新日期：2020-06-01 00:00:00

abstract：:Cell transplantation is an experimental therapy for Parkinson's disease (PD) and other movement disorders. Several open-label research trials have shown clinically meaningful improvement in parkinsonian signs and symptoms after striatal transplantation of allogeneic fetal ventral mesencephalic (FVM) tissue. However, e...

journal_title：Seminars in neurology

authors： Subramanian T

更新日期：2001-01-01 00:00:00

abstract：:With the increasing acceptance of the right of patients to refuse life-sustaining treatment, some have argued that terminally ill patients have a corollary right to physician-assisted suicide (PAS) on request. However, there are important moral and legal distinctions between patients' refusals of therapy and requests ...

journal_title：Seminars in neurology

authors： Bernat JL

更新日期：1997-01-01 00:00:00

abstract：:As the population ages, the prevalence of many neurologic diseases is increasing. At the same time, older patients are undergoing more surgical procedures. This confluence of events puts neurohospitalists in a unique position to provide both pre- and postoperative guidance to minimize complications, improve clinical o...

journal_title：Seminars in neurology

authors： Hudson KA,Greene JG

更新日期：2015-12-01 00:00:00

abstract：:The muscular dystrophies are disorders of progressive muscular degeneration and weakness. As a group they display clinical heterogeneity that reflects the heterogeneity of molecular mechanisms responsible for them, and range from congenital to adulthood onset. Recent advances in the field include improved methods of d...

journal_title：Seminars in neurology

authors： Flanigan KM

更新日期：2012-07-01 00:00:00

abstract：:Physician-hastened-death remains a controversial topic for patients and those who care for them. It is a particularly relevant topic for neurologists who currently, or will in the future, reside in jurisdictions where physician-hastened-death is legal. In this article, I attempt to provide a comprehensive and contempo...

journal_title：Seminars in neurology

authors： Russell JA

更新日期：2018-10-01 00:00:00